• 1154 Citations
  • 17 h-Index
1993 …2019
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Research Output 1993 2019

46 Citations (Scopus)

Amiloride modulates alternative splicing in leukemic cells and resensitizes Bcr-AblT315I mutant cells to imatinib

Chang, W. H., Liu, T. C., Yang, W. K., Lee, C. C., Lin, Y. H., Chen, T-Y. & Chang, J. G., 2011 Jan 15, In : Cancer Research. 71, 2, p. 383-392 10 p.

Research output: Contribution to journalArticle

Amiloride
Alternative Splicing
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Serine
Arginine

A noninterventional observational registry of patients with multiple myeloma treated with lenalidomide in Taiwan

Huang, S. Y., Yu, Y. B., Yeh, S. P., Chen, T. Y., Kao, W. Y., Chen, C. C., Wang, M. C., Lin, H. Y., Lin, S. F., Lin, T. H., Hua, Y., Puccio-Pick, M., DeMarco, D., Jacques, C. & Dunn, P., 2017 Sep, In : Journal of the Formosan Medical Association. 116, 9, p. 705-710 6 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Taiwan
Registries
Dexamethasone
Safety
2 Citations (Scopus)

A novel tubulin polymerization inhibitor, MPT0B206, downregulates Bcr-Abl expression and induces apoptosis in imatinib-sensitive and imatinib-resistant CML cells

Chen, C. W., Lee, Y. L., Liou, J. P., Liu, Y. H., Liu, C. W., Chen, T-Y. & Huang, H. M., 2016 Sep 1, In : Apoptosis. 21, 9, p. 1008-1018 11 p.

Research output: Contribution to journalArticle

Tubulin Modulators
K562 Cells
Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Down-Regulation
6 Citations (Scopus)
Neutropenia
Taiwan
Bacillus
meropenem
Aminoglycosides
9 Citations (Scopus)

A Phase II Study of Arginine Deiminase (ADI-PEG20) in Relapsed/Refractory or Poor-Risk Acute Myeloid Leukemia Patients

Tsai, H. J., Jiang, S. S., Hung, W. C., Borthakur, G., Lin, S. F., Pemmaraju, N., Jabbour, E., Bomalaski, J. S., Chen, Y-P., Hsiao, H. H., Wang, M. C., Kuo, C. Y., Chang, H., Yeh, S. P., Cortes, J., Chen, L. T. & Chen, T-Y., 2017 Dec 1, In : Scientific reports. 7, 1, 11253.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Citrullinemia
Argininosuccinate Synthase
Arginine
Neoplasms
85 Citations (Scopus)

A prognostic index for natural killer cell lymphoma after non-anthracycline-based treatment: A multicentre, retrospective analysis

Kim, S. J., Yoon, D. H., Jaccard, A., Chng, W. J., Lim, S. T., Hong, H., Park, Y., Chang, K. M., Maeda, Y., Ishida, F., Shin, D. Y., Kim, J. S., Jeong, S. H., Yang, D. H., Jo, J. C., Lee, G. W., Choi, C. W., Lee, W. S., Chen, T-Y., Kim, K. & 11 others, Jung, S. H., Murayama, T., Oki, Y., Advani, R., d'Amore, F., Schmitz, N., Suh, C., Suzuki, R., Kwong, Y. L., Lin, T. Y. & Kim, W. S., 2016 Mar 1, In : The Lancet Oncology. 17, 3, p. 389-400 12 p.

Research output: Contribution to journalArticle

Natural Killer Cells
Lymphoma
Natural Killer T-Cells
T-Cell Lymphoma
Survival
9 Citations (Scopus)
Pulmonary Infarction
Taiwan
Systemic Lupus Erythematosus
Retrospective Studies
Antiphospholipid Syndrome
4 Citations (Scopus)

AUY922 effectively targets against activated B cell subtype of diffuse large B-cell lymphoma and low-grade lymphoma cells harboring genetic alteration-associated nuclear factor-B activation

Tsai, H. J., Shih, N. Y., Kuo, S. H., Cheng, A. L., Lin, H. Y., Chen, T-Y., Chang, K-C., Lin, S. F., Chang, J. S. & Chen, L. T., 2015 Sep 2, In : Leukemia and Lymphoma. 56, 9, p. 2674-2682 9 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Non-Hodgkin's Lymphoma
B-Lymphocytes
Marginal Zone B-Cell Lymphoma
B-Cell Lymphoma
1 Citation (Scopus)

Bilateral pulmonary cavities in a young female

Yang, S. C., Chen, T. Y. & Chen, W., 2012 May 1, In : QJM. 105, 5, p. 477-478 2 p., hcr021.

Research output: Contribution to journalComment/debate

X Ray Computed Tomography
Hodgkin Disease
Lung Diseases
Lymph Nodes
Lung
2 Citations (Scopus)

Bone marrow metastasis in nasopharyngeal cancer: Early detection using EBER1 in situ hybridization

Chen, T-Y., Tsai, S-T., Jin, Y. T., Su, W-C. & Tsao, C. J., 1999 Apr 20, In : Anticancer Research. 19, 1 B, p. 885-888 4 p.

Research output: Contribution to journalArticle

Nasopharyngeal Neoplasms
In Situ Hybridization
Bone Marrow
Neoplasm Metastasis
Epstein-Barr virus encoded RNA 1
30 Citations (Scopus)
Natural Killer T-Cells
T-Cell Lymphoma
Nose
In Situ Hybridization
Bone Marrow

Bortezomib therapy in a real-world setting in patients with relapsed or refractory multiple myeloma

Huang, S. Y., Chen, T-Y., Kuo, C. Y., Chen, Y. C., Lin, S. F., Chang, M. C., Lv, X., Yang, B. & Chang, C. S., 2019 Jan 14, In : Oncology Reviews. 13, 1, p. 15-22 8 p.

Research output: Contribution to journalReview article

Open Access
Multiple Myeloma
Therapeutics
Bortezomib
Safety
Proteasome Inhibitors
5 Citations (Scopus)

BPR1J373, an oral multiple tyrosine kinase inhibitor, targets c-KIT for the treatment of c-KIT-driven myeloid leukemia

Chen, L. T., Chen, C. T., Jiaang, W. T., Chen, T-Y., Butterfield, J. H., Shih, N. Y., Hsu, J. T. A., Lin, H. Y., Lin, S. F. & Tsai, H. J., 2016 Oct 1, In : Molecular Cancer Therapeutics. 15, 10, p. 2323-2333 11 p.

Research output: Contribution to journalArticle

Myeloid Leukemia
Acute Myeloid Leukemia
Protein-Tyrosine Kinases
Core Binding Factors
Mutation
5 Citations (Scopus)

CDKN1A-mediated responsiveness of MLL-AF4-positive acute lymphoblastic leukemia to Aurora kinase-A inhibitors

Chen, Y-P., Lin, H. J., Chen, C-H., Tsai, M. Y., Hsieh, H. P., Chang, J-Y., Chen, N. F., Chang, K-C., Huang, W. T., Su, W-C., Yang, S. T., Chang, W. C., Hung, L-Y. & Chen, T-Y., 2014 Aug 1, In : International Journal of Cancer. 135, 3, p. 751-762 12 p.

Research output: Contribution to journalArticle

Aurora Kinase A
Aurora Kinases
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cell Line
Pharmaceutical Preparations
33 Citations (Scopus)
Bleomycin
Taiwan
Fluorouracil
Cisplatin
Drug Therapy
4 Citations (Scopus)
Combination Drug Therapy
Taiwan
Non-Hodgkin's Lymphoma
Epirubicin
Vincristine
4 Citations (Scopus)
Hepatitis C Antibodies
Antilymphocyte Serum
Aplastic Anemia
Taiwan
Immunosuppression
30 Citations (Scopus)

Clonal karyotype abnormalities in EBV-associated hemophagocytic syndrome

Chen, C-H., Tzeng, C. C., Tsao, C. J., Su, W-C., Chen, T-Y., Jung, Y. C. & Su, I. J., 1997 Sep 1, In : Haematologica. 82, 5, p. 572-576 5 p.

Research output: Contribution to journalArticle

Hemophagocytic Lymphohistiocytosis
Human Herpesvirus 4
Karyotype
Bone Marrow
Pancytopenia
28 Citations (Scopus)
Malignant Pleural Effusion
Lung Neoplasms
Drug Therapy
Lung
Radiation
30 Citations (Scopus)
Carboplatin
Hematopoietic Stem Cells
Cisplatin
Growth
Platinum
5 Citations (Scopus)

Comparison of two commercial automated nucleic acid extraction and integrated quantitation real-time PCR platforms for the detection of cytomegalovirus in plasma

Tsai, H. P., Tsai, Y. Y., Lin, I. T., Kuo, P. H., Chen, T-Y., Chang, K-C. & Wang, J-R., 2016 Aug 1, In : PLoS ONE. 11, 8, e0160493.

Research output: Contribution to journalArticle

Cytomegalovirus
Viral Load
Nucleic Acids
nucleic acids
Real-Time Polymerase Chain Reaction
20 Citations (Scopus)

Correlation of homocysteine levels with the extent of coronary atherosclerosis in patients with low cardiovascular risk profiles

Tsai, W-C., Li, Y-H., Tsai, L-M., Chao, T-H., Lin, L. J., Chen, T-Y. & Chen, J. H., 2000 Jan 1, In : American Journal of Cardiology. 85, 1, p. 49-52 4 p.

Research output: Contribution to journalArticle

Homocysteine
Coronary Artery Disease
Coronary Angiography
Serum
Vascular Diseases

Cutaneous lymphomas in Taiwan: A review of 118 cases from a medical center in southern Taiwan

Lee, C. N., Hsu, C-K., Chang, K-C., Wu, C. L., Chen, T-Y. & Lee, Y-Y., 2018 Mar 1, In : Dermatologica Sinica. 36, 1, p. 16-24 9 p.

Research output: Contribution to journalArticle

Mycosis Fungoides
Taiwan
Lymphoma
Skin
Extranodal NK-T-Cell Lymphoma

Cyclophosphamide vs salvage chemotherapy plus G-CSF as chemo-mobilization in Asian patients undergoing autologous hematopoietic stem cell transplant

Issaragrisil, S., Cheng-Hwai, T., Bunworasate, U., Su-Peng, Y., Hung, L. Y., Tee, G. Y., Wahid, S. F. A., Chin, N. S., Puavilai, T., Gin, G. G., Piu, K. L., Wen-Li, H., Chen, T-Y. & Numbenjapon, T., 2017 Feb 1, In : Bone Marrow Transplantation. 52, 2, p. 299-300 2 p.

Research output: Contribution to journalLetter

Granulocyte Colony-Stimulating Factor
Hematopoietic Stem Cells
Cyclophosphamide
Transplants
Drug Therapy
4 Citations (Scopus)
Epstein-Barr Virus Infections
Lymphoproliferative Disorders
Hematopoietic Stem Cell Transplantation
Homologous Transplantation
Cytomegalovirus Infections
2 Citations (Scopus)
Neutropenic Enterocolitis
Viral Matrix Proteins
Phosphoproteins
Cytomegalovirus Infections
Cytomegalovirus
1 Citation (Scopus)

Distinct clinical characteristics of paroxysmal nocturnal hemoglobinuria in patients in Southern Taiwan: A multicenter investigation

Wang, H. C., Kuo, C. Y., Liu, I-T., Chen, T-Y., Chang, Y. H., Lin, S. J., Cho, S. F., Liu, Y. C., Liu, T. C., Lin, S. F. & Chang, C. S., 2017 Aug 1, In : Kaohsiung Journal of Medical Sciences. 33, 8, p. 405-410 6 p.

Research output: Contribution to journalArticle

Paroxysmal Hemoglobinuria
Taiwan
Clone Cells
L-Lactate Dehydrogenase
Granulocytes
3 Citations (Scopus)

EBER-1 positive diffuse large cell lymphoma presenting as lupus nephritis

Lin, M. H., Huang, J. J., Chen, T-Y., Chen, F. F., Chang, K-C., Liu, M-F., Huang, W. T., Su, W-C. & Tsao, C. J., 2003 Jul 21, In : Lupus. 12, 6, p. 486-489 4 p.

Research output: Contribution to journalArticle

Lupus Nephritis
Lymphoma, Large B-Cell, Diffuse
Systemic Lupus Erythematosus
Membranous Glomerulonephritis
Non-Hodgkin's Lymphoma
1 Citation (Scopus)

Efficacy, safety, and pharmacokinetics of subcutaneous azacitidine in Taiwanese patients with higher-risk myelodysplastic syndromes

Chou, W. C., Yeh, S. P., Hsiao, L. T., Lin, S. F., Chen, Y. C., Chen, T-Y., Laille, E., Galettis, A., Dong, Q., Songer, S. & Beach, C. L., 2017 Oct 1, In : Asia-Pacific Journal of Clinical Oncology. 13, 5, p. e430-e439

Research output: Contribution to journalArticle

Azacitidine
Myelodysplastic Syndromes
Pharmacokinetics
Safety
Platelet Transfusion
8 Citations (Scopus)

Efficacy of rabbit antithymocyte globulin as first-line treatment of severe aplastic anemia: an Asian multicenter retrospective study

Chuncharunee, S., Wong, R., Rojnuckarin, P., Chang, C. S., Chang, K. M., Lu, M. Y., Hwang, W. L., Koh, L. P., Chen, T-Y., Leung, A. Y., Norasetthada, L., Wang, S. C., Chang, M. C., Wu, K. H. & Issaragrisil, S., 2016 Oct 1, In : International Journal of Hematology. 104, 4, p. 454-461 8 p.

Research output: Contribution to journalArticle

Antilymphocyte Serum
Aplastic Anemia
Multicenter Studies
Retrospective Studies
Rabbits
1 Citation (Scopus)

Eltrombopag enhances platelet adhesion by upregulating the expression of glycoprotein VI in patients with chronic immune thrombocytopenic purpura

Chiou, T. J., Chang, Y. F., Wang, M. C., Kao, C. W., Lin, H. Y., Chen, T-Y., Hsueh, E. J., Lan, Y. J., Sung, Y. C., Lin, S. F., Bai, L. Y. & Chen, C. G., 2015 Dec 1, In : Translational Research. 166, 6, p. 750-761.e4

Research output: Contribution to journalArticle

Idiopathic Thrombocytopenic Purpura
Platelets
Glycoproteins
Blood Platelets
Adhesion
3 Citations (Scopus)
Viral Antibodies
Reverse Transcriptase Inhibitors
Lamivudine
Premedication
T-Cell Lymphoma
9 Citations (Scopus)

Emerging kinetics of BCR-ABL1 mutations and their effect on disease outcomes in chronic myeloid leukemia patients with imatinib failure

Shih, L. Y., Kuo, M. C., Kuo, C. Y., Lin, T. H., Bai, L. Y., Chen, T. Y., Wang, M. C., Lin, T. L., Lan, Y. J., Chen, C. C., Yang, Y., Hsiao, P. C., Lai, C. L., Chang, C. H. & Lin, T. H., 2013 Jan 1, In : Leukemia Research. 37, 1, p. 43-49 7 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Mutation
Protein-Tyrosine Kinases
Disease Progression
Imatinib Mesylate
Myelodysplastic Syndromes
Bone Marrow
Therapeutics
10 Citations (Scopus)
T-Cell Lymphoma
Human Herpesvirus 4
B-Lymphocytes
T-Lymphocytes
Virus Latency
Tubulin Modulators
Emitter coupled logic circuits
Down-Regulation
Apoptosis
Imatinib Mesylate
7 Citations (Scopus)

Expression of DNA repair gene Ku80 in lymphoid neoplasm

Chen, T-Y., Chen, C-H., Su, W-C., Wu, M. S. & Tsao, C. J., 2005 Jun 1, In : European Journal of Haematology. 74, 6, p. 481-488 8 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
DNA Repair
Double-Stranded DNA Breaks
Genes
Neoplasms
34 Citations (Scopus)

Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis

Huang, W. C., Tsai, C. C., Chen, C. L., Chen, T. Y., Chen, Y. P., Lin, Y. S., Lu, P. J., Lin, C. M., Wang, S. H., Tsao, C. W., Wang, C. Y., Cheng, Y. L., Hsieh, C. Y., Tseng, P. C. & Lin, C. F., 2011 Oct 1, In : FASEB Journal. 25, 10, p. 3661-3673 13 p.

Research output: Contribution to journalArticle

ceramide glucosyltransferase
Glycogen Synthase Kinase 3
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Apoptosis
Ceramides
8 Citations (Scopus)

Gly392Cys missense mutation in the A2 domain of factor V causing severe factor V deficiency: Molecular characterization by expression of the recombinant protein [1]

Chen, T-Y., Lin, T. M., Chen, H. Y., Wu, C. L. & Tsao, C. J., 2005 Mar 1, In : Thrombosis and Haemostasis. 93, 3, p. 614-615 2 p.

Research output: Contribution to journalLetter

Factor V Deficiency
Factor V
Molecular Cloning
Missense Mutation
Pedigree
5 Citations (Scopus)

Guidelines for treating iron overload in myelodysplastic syndromes: A Taiwan consensus statement

Ko, B. S., Chang, C. S., Chang, M. C., Chen, T-Y., Chiou, T. J., Chiu, C. F., Huang, W. L., Kao, W. Y., Lan, Y. J., Lin, S. F., Tan, T. D., Tang, J. L., Tzeng, C. H., Wang, P. N., Yet, S. P. & Tien, H. F., 2014 Jan 1, In : International Journal of Hematology. 100, 1, p. 7-15 9 p.

Research output: Contribution to journalReview article

Iron Overload
Myelodysplastic Syndromes
Taiwan
Guidelines
Chelation Therapy
25 Citations (Scopus)

Hemostatic molecular markers in nephrotic syndrome

Chen, T-Y., Huang, CC. C. & Tsao, CJ. J., 1993 Jan 1, In : American Journal of Hematology. 44, 4, p. 276-279 4 p.

Research output: Contribution to journalArticle

Nephrotic Syndrome
Hemostatics
Fibrinopeptide A
Antithrombin III
Prothrombin
7 Citations (Scopus)

HER-2/neu raises SHP-2, stops IFN-γ anti-proliferation in bladder cancer

Su, W. P., Tu, I. H., Hu, S. W., Yeh, H. H., Shieh, D. B., Chen, T. Y. & Su, W. C., 2007 Apr 27, In : Biochemical and Biophysical Research Communications. 356, 1, p. 181-186 6 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Janus Kinases
Cells
Non-Receptor Type 11 Protein Tyrosine Phosphatase
Phosphoprotein Phosphatases
1 Citation (Scopus)
Nasopharyngeal Neoplasms
Hematopoietic Stem Cell Transplantation
Feasibility Studies
Drug Therapy
Peripheral Blood Stem Cell Transplantation
11 Citations (Scopus)

High levels of regulatory T cells in blood are a poor prognostic factor in patients with diffuse large B-cell lymphoma

Chang, C., Wu, S. Y., Kang, Y. W., Lin, K. P., Chen, T. Y., Medeiros, L. J. & Chang, K. C., 2015 Dec, In : American Journal of Clinical Pathology. 144, 6, p. 935-944 10 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Regulatory T-Lymphocytes
Dendritic Cells
Healthy Volunteers
Neutrophils
13 Citations (Scopus)

High percentage of JAK2 exon 12 mutation in asian patients with polycythemia vera

Yeh, Y-M., Chen, Y. L., Cheng, H. Y., Su, W-C., Chow, N-H., Chen, T-Y. & Ho, C-L., 2010 Aug 1, In : American Journal of Clinical Pathology. 134, 2, p. 266-270 5 p.

Research output: Contribution to journalArticle

Polycythemia Vera
Exons
Mutation
Incidence
Platelet Count

Identification and characterization of permissive cells to dengue virus infection in human hematopoietic stem and progenitor cells

Hsu, A. Y., Ho, T. C., Lai, M. L., Tan, S. S., Chen, T. Y., Lee, M., Chien, Y. W., Chen, Y. P. & Perng, G. C., 2019 Sep 1, In : Transfusion. 59, 9, p. 2938-2951 14 p.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Hematopoietic Stem Cells
Bone Marrow
Hematopoietic Stem Cell Transplantation
1 Citation (Scopus)
Electrospray Ionization Mass Spectrometry
Polymerase Chain Reaction
Mycoses
Body Fluids
Fungi

Idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobinemia mimicking plasma cell myeloma

Yen, C. C. & Chen, T-Y., 2018 Dec 20, In : Blood. 132, 25, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Multiple Myeloma
Plasmas
Lymphadenopathy
4 Citations (Scopus)

Impaired responsiveness of platelets to epinephrine due to α2A adrenoreceptor deficiency in Male Chinese

Lin, T. M., Lin, J. S., Tseng, J. Y., Wu, S-Y. & Chen, T-Y., 2016 Feb 17, In : Platelets. 27, 2, p. 149-154 6 p.

Research output: Contribution to journalArticle

Epinephrine
Blood Platelets
Adrenergic Receptors
Platelet Glycoprotein GPIIb-IIIa Complex
P-Selectin
16 Citations (Scopus)

Implantable venous port-related infections in cancer patients

Huang, W. T., Chen, T-Y., Su, W-C., Yen, C-J. & Tsao, C. J., 2004 Mar 1, In : Supportive Care in Cancer. 12, 3, p. 197-201 5 p.

Research output: Contribution to journalArticle

Infection
Neoplasms
Bacillus
Stenotrophomonas maltophilia
Gram-Positive Cocci