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Research Output

  • 1369 Citations
  • 22 h-Index
  • 55 Article
  • 18 Patent
  • 6 Conference contribution
  • 1 Review article
2020

Cloning and characterisation of type I interferon receptor 1 in orange-spotted grouper (Epinephelus coioides) for response to nodavirus infection

Tang, Z. Z., Wang, T. Y., Chen, Y. M. & Chen, T. Y., 2020 Jun, In : Fish and Shellfish Immunology. 101, p. 302-311 10 p.

Research output: Contribution to journalArticle

2019

Impact of Tilapia hepcidin 2-3 dietary supplementation on the gut microbiota profile and immunomodulation in the grouper (Epinephelus lanceolatus)

Ting, C. H., Pan, C. Y., Chen, Y. C., Lin, Y. C., Chen, T. Y., Rajanbabu, V. & Chen, J. Y., 2019 Dec 1, In : Scientific reports. 9, 1, 19047.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Novel subunit vaccine with linear array epitope protect giant grouper against nervous necrosis virus infection

Lin, C. F., Jiang, H. K., Chen, N. C., Wang, T. Y. & Chen, T. Y., 2018 Mar 1, In : Fish and Shellfish Immunology. 74, p. 551-558 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

Viral infection upregulates myostatin promoter activity in orange-spotted grouper (Epinephelus coioides)

Chen, Y. T., Lin, C. F., Chen, Y. M., Lo, C. E., Chen, W. E. & Chen, T. Y., 2017 Oct, In : PloS one. 12, 10, e0186506.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2016

A member of the immunoglobulin superfamily, orange-spotted grouper novel immune gene EcVig, is induced by immune stimulants and type I interferon

Yeh, Y. C., Wang, T. Y., Chou, H. Y., Lin, H. Y., Chen, T. Y., Aoki, T. & Wang, H. C., 2016 Nov 1, In : Fish and Shellfish Immunology. 58, p. 415-422 8 p.

Research output: Contribution to journalArticle

Analysis of interferon gamma protein expression in zebrafish (Danio rerio)

Yoon, S., Alnabulsi, A., Wang, T. Y., Lee, P. T., Chen, T. Y., Bird, S., Zou, J. & Secombes, C. J., 2016 Oct 1, In : Fish and Shellfish Immunology. 57, p. 79-86 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
4 Citations (Scopus)
2015

A microfluidic system integrated with buried optical fibers for detection of Phalaenopsis orchid pathogens

Lin, C. L., Chang, W. H., Wang, C. H., Lee, C. H., Chen, T. Y., Jan, F. J. & Lee, G. B., 2015 Jan 15, In : Biosensors and Bioelectronics. 63, p. 572-579 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Cordyceps s.L. (ascomycetes) species used as medicinal mushrooms are closely related with higher ability to produce cordycepin

Kuo, H. C., Huang, I. C. & Chen, T. Y., 2015 Jan 1, In : International Journal of Medicinal Mushrooms. 17, 11, p. 1077-1085 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Crystal Structures of a Piscine Betanodavirus: Mechanisms of Capsid Assembly and Viral Infection

Chen, N. C., Yoshimura, M., Guan, H. H., Wang, T. Y., Misumi, Y., Lin, C. C., Chuankhayan, P., Nakagawa, A., Chan, S. I., Tsukihara, T., Chen, T. Y. & Chen, C. J., 2015 Jan 1, In : PLoS pathogens. 11, 10, e1005203.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Genome sequence of Trichoderma virens FT-333 from tropical marine climate

Kuo, H. C., Wang, T. Y., Chen, P. P., Chen, R. S. & Chen, T. Y., 2015 Jan 1, In : FEMS Microbiology Letters. 362, 7, fnv036.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Molecular cloning and characterization of orange-spotted grouper (Epinephelus coioides) CXC chemokine ligand 12

Wu, C. S., Wang, T. Y., Liu, C. F., Lin, H. P., Chen, Y. M. & Chen, T. Y., 2015 Dec 1, In : Fish and Shellfish Immunology. 47, 2, p. 996-1005 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Rapid and amplification-free detection of fish pathogens by utilizing a molecular beacon-based microfluidic system

Su, Y. C., Wang, C. H., Chang, W. H., Chen, T. Y. & Lee, G. B., 2015 Jan 15, In : Biosensors and Bioelectronics. 63, p. 196-203 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Regulatory factors controlling muscle mass: Competition between innate immune function and anabolic signals in regulation of atrogin-1 in Atlantic salmon

Heidari, Z., Bickerdike, R., Tinsley, J., Zou, J., Wang, T. Y., Chen, T. Y. & Martin, S. A. M., 2015 Oct 1, In : Molecular Immunology. 67, 2, p. 341-349 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2014

Development of pedigree classification using microsatellite and mitochondrial markers for giant grouper broodstock (Epinephelus lanceolatus) management in Taiwan

Kuo, H. C., Hsu, H. A., Chua, C. S., Wang, T. Y., Chen, Y. M. & Chen, T. Y., 2014 May, In : Marine Drugs. 12, 5, p. 2397-2407 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

EcVig, a novel grouper immune-gene associated with antiviral activity against NNV infection

Yeh, Y. C., Hsu, Y. J., Chen, Y. M., Lin, H. Y., Yang, H. L., Chen, T. Y. & Wang, H. C., 2014 Mar 1, In : Developmental and Comparative Immunology. 43, 1, p. 68-75 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Functional analysis of an orange-spotted grouper (Epinephelus coioides) interferon gene and characterisation of its expression in response to nodavirus infection

Chen, Y. M., Kuo, C. E., Chen, G. R., Kao, Y. T., Zou, J., Secombes, C. J. & Chen, T-Y., 2014 Jan 1, In : Developmental and Comparative Immunology. 46, 2, p. 117-128 12 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Immunity to betanodavirus infections of marine fish

Chen, Y. M., Wang, T. Y. & Chen, T. Y., 2014 Apr 1, In : Developmental and Comparative Immunology. 43, 2, p. 174-183 10 p.

Research output: Contribution to journalReview article

29 Citations (Scopus)

PRIMER SET, METHOD AND KIT FOR DETECTING PATHOGEN IN ANIMALS OR PLANTS

Chen, T-Y., 2014 Jan 23, Patent No. 9238839

Research output: Patent

Salmonids have an extraordinary complex type I IFN system: Characterization of the IFN locus in rainbow trout oncorhynchus mykiss reveals two novel IFN subgroups

Zou, J., Gorgoglione, B., Taylor, N. G. H., Summathed, T., Lee, P. T., Panigrahi, A., Genet, C., Chen, Y. M., Chen, T. Y., Ul Hassan, M., Mughal, S. M., Boudinot, P. & Secombes, C. J., 2014 Sep 1, In : Journal of Immunology. 193, 5, p. 2273-2286 14 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)
2013

An integrated microfluidic system using buried optical fibers for detection of phalaenopsis orchid pathogens

Lin, C. L., Chang, W. H., Wang, C. H., Li, P. C., Jan, F. J., Chen, T-Y. & Lee, G. B., 2013 Dec 1, 2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013. p. 1231-1234 4 p. 6626997. (2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Detection of viruses directly from the fresh leaves of a Phalaenopsis orchid using a microfluidic system

Chang, W. H., Yang, S. Y., Lin, C. L., Wang, C. H., Li, P. C., Chen, T. Y., Jan, F. J. & Lee, G. B., 2013 Nov 1, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 9, 8, p. 1274-1282 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Enhancing microalgal oil/lipid production from Chlorella sorokiniana CY1 using deep-sea water supplemented cultivation medium

Chen, C. Y., Chang, J. S., Chang, H. Y., Chen, T. Y., Wu, J. H. & Lee, W. L., 2013 Aug 5, In : Biochemical Engineering Journal. 77, p. 74-81 8 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

PRIMER SET, METHOD AND KIT FOR DETECTING PATHOGEN IN FISH

Chen, T-Y., 2013 Jun 13, Patent No. 8658781

Research output: Patent

Rapid isolation and detection of aquaculture pathogens in an integrated microfluidic system using loop-mediated isothermal amplification

Chang, W. H., Yang, S. Y., Wang, C. H., Tsai, M. A., Wang, P. C., Chen, T-Y., Chen, S. C. & Lee, G. B., 2013 Apr 1, In : Sensors and Actuators, B: Chemical. 180, p. 96-106 11 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2012

An automated microfluidic chip system for detection of piscine nodavirus and characterization of its potential carrier in grouper farms

Kuo, H. C., Wang, T. Y., Hsu, H. H., Lee, S. H., Chen, Y. M., Tsai, T. J., Ou, M. C., Ku, H. T., Lee, G. B. & Chen, T. Y., 2012 Aug 9, In : PloS one. 7, 8, e42203.

Research output: Contribution to journalArticle

7 Citations (Scopus)

An optical diagnostic system using isothermal amplification technique for Phalaenopsis orchids

Chang, W. H., Yang, S. Y., Wang, C. H., Li, P. C., Jan, F. J., Chen, T-Y. & Lee, G. B., 2012 Jun 1, 2012 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2012. p. 204-207 4 p. 6196757. (2012 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2012).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Food composition for vertebrate

Chen, T-Y., 2012 Dec 13, Patent No. 5939888

Research output: Patent

Grouper (Epinephelus coioides) CXCR4 is expressed in response to pathogens infection and early stage of development

Lin, C. Y., Chen, Y. M., Hsu, H. H., Shiu, C. T., Kuo, H. C. & Chen, T-Y., 2012 Jan 1, In : Developmental and Comparative Immunology. 36, 1, p. 112-120 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Identification and characterization of DSCAM isoforms isolated from orange-spotted grouper Epinephelus coioides

Yeh, Y. C., Lee, C. W., Pan, Y. W., Hsu, Y. J., Hung, H. Y., Chen, Y. M., Lin, H. Y., Chen, T. Y., Yang, H. L. & Wang, H. C., 2012 Sep 1, In : Developmental and Comparative Immunology. 38, 1, p. 148-159 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Nervous necrosis virus replicates following the embryo development and dual infection with iridovirus at juvenile stage in grouper

Kuo, H. C., Wang, T. Y., Hsu, H. H., Chen, P. P., Lee, S. H., Chen, Y. M., Tsai, T. J., Wang, C. K., Ku, H. T., Lee, G. B. & Chen, T. Y., 2012 Apr 26, In : PloS one. 7, 4, e36183.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Pathogen detection from phalaenopsis orchids by using an integrated microfluidic system

Chang, W. H., Yang, S. Y., Wang, C. H., Lee, G. B., Chen, T-Y., Li, P. C. & Jan, F. J., 2012 Dec 1, NANOMED 2012 - 6th IEEE International Conference on Nano/Molecular Medicine and Engineering. p. 6-10 5 p. 6509132. (IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)
2011

A gene delivery system based on the N-terminal domain of human topoisomerase I

Chen, Y. A., Kuo, H. C., Chen, Y. M., Huang, S. Y., Liu, Y. R., Lin, S. C., Yang, H. L. & Chen, T. Y., 2011 Jun 1, In : Biomaterials. 32, 17, p. 4174-4184 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

An integrated microfluidic loop-mediated-isothermal-amplification system for rapid sample pre-treatment and detection of viruses

Wang, C. H., Lien, K. Y., Wang, T. Y., Chen, T. Y. & Lee, G. B., 2011 Jan 15, In : Biosensors and Bioelectronics. 26, 5, p. 2045-2052 8 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

An oral nervous necrosis virus vaccine using Vibrio anguillarum as an expression host provides early protection

Chen, Y-M., Shih, C. H., Liu, H. C., Wu, C. L., Lin, C. C., Wang, H-C., Chen, T-Y., Yang, H. L. & Lin, J. H. Y., 2011 Nov 16, In : Aquaculture. 321, 1-2, p. 26-33 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Cloning of crystallin from orange-spotted grouper and characterization of its activity as potential protective agent

Chen, Y. M., Kuo, C. E., Lin, C. M., Shiea, P. S. & Chen, T-Y., 2011 Jan 1, In : Results in Immunology. 1, 1, p. 60-69 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Identification of antigens for the development of a subunit vaccine against Photobacterium damselae ssp. piscicida

Ho, L. P., Han-You Lin, J., Liu, H. C., Chen, H. E., Chen, T-Y. & Yang, H. L., 2011 Jan 1, In : Fish and Shellfish Immunology. 30, 1, p. 412-419 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Integrated microfluidic loop-mediated-isothermal-amplification systems for rapid isolation and detection of aquaculture pathogens

Chang, W. H., Yang, S. Y., Wang, C. H., Tsai, M. A., Wang, P. C., Chen, S. C., Chen, T. Y. & Lee, G. B., 2011 Sep 1, 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11. p. 210-213 4 p. 5969305. (2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Molecular cloning and functional analysis of an orange-spotted grouper (Epinephelus coioides) secreted protein acidic and rich in cysteine (SPARC) and characterization of its expression response to nodavirus

Chen, Y. M., Kuo, C. E., Huang, Y. L., Shie, P. S., Liao, J. J., Yang, Y. C. & Chen, T. Y., 2011 Aug, In : Fish and Shellfish Immunology. 31, 2, p. 232-242 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Real-time quantitative PCR assay for monitoring of nervous necrosis virus infection in grouper aquaculture

Kuo, H. C., Wang, T. Y., Chen, P. P., Chen, Y. M., Chuang, H. C. & Chen, T. Y., 2011 Mar 1, In : Journal of Clinical Microbiology. 49, 3, p. 1090-1096 7 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

The expression of two novel orange-spotted grouper (Epinephelus coioides) TNF genes in peripheral blood leukocytes, various organs, and fish larvae

Lam, F. W. S., Wu, S. Y., Lin, S. J., Lin, C. C., Chen, Y. M., Wang, H. C., Chen, T. Y., Lin, H. T. & Lin, J. H. Y., 2011 Feb, In : Fish and Shellfish Immunology. 30, 2, p. 618-629 12 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)
2010

Cloning of an orange-spotted grouper Epinephelus coioides heat shock protein 90AB (HSP90AB) and characterization of its expression in response to nodavirus

Chen, Y. M., Kuo, C. E., Wang, T. Y., Shie, P. S., Wang, W. C., Huang, S. L., Tsai, T. J., Chen, P. P., Chen, J. C. & Chen, T-Y., 2010 Jan 1, In : Fish and Shellfish Immunology. 28, 5-6, p. 895-904 10 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Integrated microfluidic loop-mediated-isothermal-amplification system for rapid diagnosis of aquaculture virus

Wang, C. H., Lien, K. Y., Wang, T. Y., Chen, T. Y. & Lee, G. B., 2010 Dec 1, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. p. 812-814 3 p. (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)
100 Citations (Scopus)
2009

A microfluidic-based system using reverse transcription polymerase chain reactions for rapid detection of aquaculture diseases

Lien, K. Y., Lee, S. H., Tsai, T. J., Chen, T. Y. & Lee, G. B., 2009 Dec 1, In : Microfluidics and Nanofluidics. 7, 6, p. 795-806 12 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2008

A comparison of the expression of immunity-related rag 1 and ikaros genes with histogenesis of the thymus in Epinephelus malabaricus (Bloch & Schneider)

Lin, J. H. Y., Lin, H. T., Lopez, C., Chen, T. Y., Chen, M. S. & Yang, H. L., 2008 Feb 1, In : Aquaculture Research. 39, 3, p. 252-262 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Establishment and application of PCR-SSCP profile for molecular typing of Cordyceps fungi

Kuo, H. C., Su, Y. L., Yang, H. L. & Chen, T-Y., 2008 Oct 1, In : Food Biotechnology. 22, 4, p. 311-325 15 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Grouper Mx confers resistance to nodavirus and interacts with coat protein

Chen, Y. M., Su, Y. L., Shie, P. S., Huang, S. L., Yang, H. L. & Chen, T. Y., 2008 Jan 1, In : Developmental and Comparative Immunology. 32, 7, p. 825-836 12 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)
2007
14 Citations (Scopus)

Integrated microfluidic chip for fast diagnosis of piscine nodavirus

Lee, S. H., Ou, M. C., Chen, T-Y. & Lee, G. B., 2007 Dec 1, TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems. p. 943-946 4 p. 4300287. (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)