• 898 Citations
  • 17 h-Index
20102019
If you made any changes in Pure these will be visible here soon.

Research Output 2010 2019

2019
1 Citation (Scopus)

Polysaccharides obtained from mycelia of cordyceps militaris attenuated doxorubicin-induced cytotoxic effects in chemotherapy

Lin, R. K., Choong, C. Y., Hsu, W-H., Tai, C. J. & Tai, C. J., 2019 Jun 1, In : African Health Sciences. 19, 2, p. 2156-2163 8 p.

Research output: Contribution to journalArticle

Open Access
Cordyceps
Mycelium
Doxorubicin
Polysaccharides
Drug Therapy
Staphylococcus aureus
Swine
Adhesion
Epithelial Cells
Antimicrobial agents
2018

Impact of pathogenic microbes and healthy microbiota by Lactobacillus-derived extracellular vesicles

Lee, B-H., Hsu, W-H. & Shen, T-L., 2018, ISEV 2018 annual Meeting (International Society for Extracellular Vesicles). Barcelona, Spain

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lactobacillus plantarum-derived extracellular vesicles improved the quality and safety of tuna meat

Hsu, W-H., Chen, K-C. & Shen, T-L., 2018, ISEV 2018 annual Meeting (International Society for Extracellular Vesicles). Barcelona, Spain

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Citations (Scopus)

Optimal conditions for cordycepin production in surface liquid-cultured Cordyceps militaris treated with porcine liver extracts for suppression of oral cancer

Lin, L. T., Lai, Y. J., Wu, S. C., Hsu, W-H. & Tai, C. J., 2018 Jan 1, In : Journal of Food and Drug Analysis. 26, 1, p. 135-144 10 p.

Research output: Contribution to journalArticle

Cordyceps militaris
Cordyceps
cordycepin
Liver Extracts
Mouth Neoplasms
1 Citation (Scopus)

The neuronal protection of a zinc-binding protein isolated from oyster

Hsu, W-H., Lin, Y. C., Chen, B. R., Wu, S. C. & Lee, B. H., 2018 Apr 1, In : Food and Chemical Toxicology. 114, p. 61-68 8 p.

Research output: Contribution to journalArticle

Ostreidae
Galactose
oysters
Oxidative stress
binding proteins
2017
12 Citations (Scopus)

Antimetastatic effects of cordycepin mediated by the inhibition of mitochondrial activity and estrogen-related receptor a in human ovarian carcinoma cells

Wang, C. W., Hsu, W-H. & Tai, C. J., 2017 Jan 1, In : Oncotarget. 8, 2, p. 3049-3058 10 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Carcinoma
Mitochondrial Dynamics
Neoplasm Metastasis
Epithelial-Mesenchymal Transition
4 Citations (Scopus)
antimicrobial peptides
shrimp
Gels
sodium
gels
2016
16 Citations (Scopus)

In vitro and in vivo anticancer activity of pardaxin against proliferation and growth of oral squamous cell carcinoma

Han, Y., Cui, Z., Li, Y. H., Hsu, W-H. & Lee, B. H., 2016 Jan 1, In : Marine Drugs. 14, 1, 2.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Growth
Cheek
Mouth Neoplasms
9,10-Dimethyl-1,2-benzanthracene
10 Citations (Scopus)

Miracle fruit (Synsepalum dulcificum) exhibits as a novel anti-hyperuricaemia agent

Shi, Y. C., Lin, K. S., Jhai, Y. F., Lee, B. H., Han, Y., Cui, Z., Hsu, W-H. & Wu, S. C., 2016 Feb 1, In : Molecules. 21, 2, 140.

Research output: Contribution to journalArticle

Synsepalum
fruits
Fruits
Butanols
xanthines

一種含有水晶冰花萃取物之組合物可用於改善阿茲海默症或糖尿病造成記憶損傷症狀(TW)

Translated title of the contribution: 一種含有水晶冰花萃取物之組合物可用於改善阿茲海默症或糖尿病造成記憶損傷症狀(TW)Hsu, W-H., 2016 May 11, Patent No. I532489

Research output: Patent

2015
16 Citations (Scopus)

Leptin-induced mitochondrial fusion mediates hepatic lipid accumulation

Hsu, W-H., Lee, B. H. & Pan, T. M., 2015 Dec 1, In : International Journal of Obesity. 39, 12, p. 1750-1756 7 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Leptin
Lipids
Liver
Peroxisomes
13 Citations (Scopus)

Monascus secondary metabolites monascin and ankaflavin inhibit activation of RBL-2H3 Cells

Chang, Y. Y., Hsu, W-H. & Pan, T. M., 2015 Jan 14, In : Journal of Agricultural and Food Chemistry. 63, 1, p. 192-199 8 p.

Research output: Contribution to journalArticle

ankaflavin
Monascus
mast cells
Metabolites
Mast Cells
2014
12 Citations (Scopus)

A novel PPARgamma agonist monascin's potential application in diabetes prevention

Hsu, W-H. & Pan, T. M., 2014 Jan 1, In : Food and Function. 5, 7, p. 1334-1340 7 p.

Research output: Contribution to journalReview article

PPAR gamma
Monascus
agonists
diabetes
pancreas
49 Citations (Scopus)

Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice

Hsu, W-H., Chen, T. H., Lee, B. H., Hsu, Y. W. & Pan, T. M., 2014 Jan 1, In : Food and Chemical Toxicology. 64, p. 94-103 10 p.

Research output: Contribution to journalArticle

ankaflavin
Peroxisome Proliferator-Activated Receptors
AMP-Activated Protein Kinases
High Fat Diet
high fat diet
15 Citations (Scopus)
Oxidative stress
PPAR gamma
Pneumonia
Oxidative Stress
oxidative stress
2 Citations (Scopus)

Monascus-Fermented Products

Pan, T. M. & Hsu, W-H., 2014 Apr 2, Encyclopedia of Food Microbiology: Second Edition. Elsevier Inc., p. 815-825 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Monascus
Aminobutyrates
Far East
Chinese Traditional Medicine
Hypercholesterolemia
4 Citations (Scopus)

Proteomic insight into the effect of ethanol on citrinin biosynthesis pathway in Monascus purpureus NTU 568

Tan, Y. Y., Hsu, W-H., Shih, T. W., Lin, C. H. & Pan, T. M., 2014 Jan 1, In : Food Research International. 64, p. 733-742 10 p.

Research output: Contribution to journalArticle

Citrinin
Monascus
Monascus purpureus
citrinin
Polyketides
10 Citations (Scopus)

Treatment of metabolic syndrome with ankaflavin, a secondary metabolite isolated from the edible fungus Monascus spp.

Hsu, W-H. & Pan, T. M., 2014 Jan 1, In : Applied Microbiology and Biotechnology. 98, 11, p. 4853-4863 11 p.

Research output: Contribution to journalShort survey

Monascus
Fungi
PPAR alpha
PPAR gamma
Anti-Inflammatory Agents
2013
16 Citations (Scopus)

Ankaflavin regulates adipocyte function and attenuates hyperglycemia caused by high-fat diet via PPAR-γ activation

Hsu, W. H., Liao, T. H., Lee, B. H., Hsu, Y. W. & Pan, T. M., 2013 Jan 1, In : Journal of Functional Foods. 5, 1, p. 124-132 9 p.

Research output: Contribution to journalArticle

ankaflavin
Peroxisome Proliferator-Activated Receptors
High Fat Diet
hyperglycemia
high fat diet
35 Citations (Scopus)

A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia

Hsu, W-H., Lee, B. H., Chang, Y. Y., Hsu, Y. W. & Pan, T. M., 2013 Nov 1, In : Toxicology and Applied Pharmacology. 272, 3, p. 842-851 10 p.

Research output: Contribution to journalArticle

Pyruvaldehyde
Peroxisome Proliferator-Activated Receptors
rosiglitazone
Hyperglycemia
Toxicity
24 Citations (Scopus)
Pyruvaldehyde
Medical problems
Metabolism
Lactic Acid
Chemical activation
8 Citations (Scopus)

Dimerumic acid protects pancreas damage and elevates insulin production in methylglyoxal-treated pancreatic RINm5F cells

Lee, B. H., Hsu, W-H., Hsu, Y. W. & Pan, T. M., 2013 Apr 1, In : Journal of Functional Foods. 5, 2, p. 642-650 9 p.

Research output: Contribution to journalArticle

Pyruvaldehyde
pancreas
Pancreas
insulin
Insulin
21 Citations (Scopus)

Effect of pigeon pea (Cajanus cajan L.) on high-fat diet-induced hypercholesterolemia in hamsters

Dai, F. J., Hsu, W-H., Huang, J. J. & Wu, S. C., 2013 Mar 1, In : Food and Chemical Toxicology. 53, p. 384-391 8 p.

Research output: Contribution to journalArticle

Cajanus
pigeon peas
hypercholesterolemia
Cajanus cajan
Peas
24 Citations (Scopus)

Effects of monascin on anti-inflammation mediated by Nrf2 activation in advanced glycation end product-treated THP-1 monocytes and methylglyoxal-treated wistar rats

Lee, B. H., Hsu, W-H., Huang, T., Chang, Y. Y., Hsu, Y. W. & Pan, T. M., 2013 Feb 13, In : Journal of Agricultural and Food Chemistry. 61, 6, p. 1288-1298 11 p.

Research output: Contribution to journalArticle

Pyruvaldehyde
Advanced Glycosylation End Products
retinoic acid
monocytes
Wistar Rats
10 Citations (Scopus)

Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia

Lee, B. H., Lee, C. C., Cheng, Y. H., Chang, W. C., Hsu, W-H. & Wu, S. C., 2013 Jan 1, In : Food and Chemical Toxicology. 62, p. 492-498 7 p.

Research output: Contribution to journalArticle

Graptopetalum paraguayense
resveratrol
hyperglycemia
pancreas
Hyperglycemia
6 Citations (Scopus)

Inhibition of Th2 cytokine production in T cells by monascin via PPAR-γ activation

Hsu, W-H., Lee, B. H., Hsu, Y. W. & Pan, T. M., 2013 Aug 28, In : Journal of Agricultural and Food Chemistry. 61, 34, p. 8126-8133 8 p.

Research output: Contribution to journalArticle

rosiglitazone
Peroxisome Proliferator-Activated Receptors
T-cells
cytokines
T-lymphocytes
6 Citations (Scopus)

Monacolin K and monascin attenuated pancreas impairment and hyperglycemia induced by advanced glycation endproducts in BALB/c mice

Hsu, W-H., Lu, S. S., Lee, B. H., Hsu, Y. W. & Pan, T. M., 2013 Dec 1, In : Food and Function. 4, 12, p. 1742-1750 9 p.

Research output: Contribution to journalArticle

lovastatin
Lovastatin
hyperglycemia
pancreas
Hyperglycemia
15 Citations (Scopus)
Pyruvaldehyde
Peroxisome Proliferator-Activated Receptors
Phosphorylation
Oxidative stress
protein kinase C
7 Citations (Scopus)

Monascin improves diabetes and dyslipidemia by regulating PPARγ and inhibiting lipogenesis in fructose-rich diet-induced C57BL/6 mice

Lee, B. H., Hsu, W-H., Huang, T., Chang, Y. Y., Hsu, Y. W. & Pan, T. M., 2013 Jan 1, In : Food and Function. 4, 6, p. 950-959 10 p.

Research output: Contribution to journalArticle

Lipogenesis
PPAR gamma
lipogenesis
hyperlipidemia
Dyslipidemias
17 Citations (Scopus)
rosiglitazone
Hepatic Stellate Cells
Peroxisome Proliferator-Activated Receptors
liver cirrhosis
Oxidative stress
13 Citations (Scopus)
Hepatic Stellate Cells
liver cirrhosis
Oxidative stress
lysine
Oxidative Stress
8 Citations (Scopus)

The improvements of ankaflavin isolated from Monascus-fermented products on dyslipidemia in high-fat diet-induced hasmster

Hsu, W. H., Huang, Y. C., Lee, B. H., Hsu, Y. W. & Pan, T. M., 2013 Jan 1, In : Journal of Functional Foods. 5, 1, p. 434-443 10 p.

Research output: Contribution to journalArticle

ankaflavin
Monascus
High Fat Diet
hyperlipidemia
high fat diet
2012
51 Citations (Scopus)

Ankaflavin: A natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo

Lee, B. H., Hsu, W. H., Chang, Y. Y., Kuo, H. F., Hsu, Y. W. & Pan, T. M., 2012 Dec 1, In : Free Radical Biology and Medicine. 53, 11, p. 2008-2016 9 p.

Research output: Contribution to journalArticle

Pyruvaldehyde
Peroxisome Proliferator-Activated Receptors
Medical problems
Up-Regulation
Rats
17 Citations (Scopus)

Ankaflavin, a novel Nrf-2 activator for attenuating allergic airway inflammation

Hsu, W. H., Lee, B. H., Huang, Y. C., Hsu, Y. W. & Pan, T. M., 2012 Oct 1, In : Free Radical Biology and Medicine. 53, 9, p. 1643-1651 9 p.

Research output: Contribution to journalArticle

Inflammation
Oxidative stress
Ovalbumin
Infiltration
Oxidative Stress
20 Citations (Scopus)
ankaflavin
tumor necrosis factors
Nitric Oxide Synthase Type III
Endothelial cells
Human Umbilical Vein Endothelial Cells
28 Citations (Scopus)

Antioxidant and anti-inflammatory effects of pigeon pea (Cajanus cajan L.) extracts on hydrogen peroxide- and lipopolysaccharide-treated RAW264.7 macrophages

Lai, Y. S., Hsu, W-H., Huang, J. J. & Wu, S. C., 2012 Dec 1, In : Food and Function. 3, 12, p. 1294-1301 8 p.

Research output: Contribution to journalArticle

pigeon peas
Cajanus cajan
Peas
Columbidae
anti-inflammatory activity
7 Citations (Scopus)

Buckwheat extracts (Fagopyrum tataricum) and rutin attenuate Th2 cytokines production and cellular allergic effects in vitro and in vivo

Shen, S. R., Hsu, W-H., Lee, C. C., Chang, W. C. & Wu, S. C., 2012 Oct 1, In : Journal of Functional Foods. 4, 4, p. 793-799 7 p.

Research output: Contribution to journalArticle

Fagopyrum tataricum
Fagopyrum
Rutin
Th2 Cells
buckwheat
38 Citations (Scopus)

Fagopyrum tataricum (Buckwheat) improved high-glucose-induced insulin resistance in mouse hepatocytes and diabetes in fructose-rich diet-induced mice

Lee, C. C., Hsu, W-H., Shen, S. R., Cheng, Y. H. & Wu, S. C., 2012 May 21, In : Experimental Diabetes Research. 2012, 375673.

Research output: Contribution to journalArticle

Fagopyrum
Fructose
Insulin Resistance
Hepatocytes
Rutin
6 Citations (Scopus)

Inhibition of leukemia proliferation by a novel polysaccharide identified from Monascus-fermented dioscorea via inducing differentiation

Lee, B. H., Hsu, W-H., Liao, T. H. & Pan, T. M., 2012 Jul 1, In : Food and Function. 3, 7, p. 758-764 7 p.

Research output: Contribution to journalArticle

Monascus
Dioscorea
leukemia
Polysaccharides
Leukemia
36 Citations (Scopus)

Monascus-fermented metabolite monascin suppresses inflammation via PPAR-γ regulation and JNK inactivation in THP-1 monocytes

Hsu, W. H., Lee, B. H., Liao, T. H., Hsu, Y. W. & Pan, T. M., 2012 May 1, In : Food and Chemical Toxicology. 50, 5, p. 1178-1186 9 p.

Research output: Contribution to journalArticle

Monascus
Peroxisome Proliferator-Activated Receptors
Metabolites
mitogen-activated protein kinase
monocytes

Monascus-fermented product monascin acts as a novel PPAR-γ ligand to suppress histamine-induced Th2 cytokines production thereby exerting anti-allergic activity

Hsu, W-H., Lee, B-H. & Pan, T-M., 2012, The ISEKI (Integrating Food Science and Engineering Knowledge Into the Food Chain)-Food Association (IFA). Palmerston North, New Zealand

Research output: Chapter in Book/Report/Conference proceedingConference contribution

19 Citations (Scopus)

Monascus purpureus-fermented products and oral cancer: A review

Hsu, W-H. & Pan, T. M., 2012 Mar 1, In : Applied Microbiology and Biotechnology. 93, 5, p. 1831-1842 12 p.

Research output: Contribution to journalShort survey

Monascus
Mouth Neoplasms
Citrinin
Lovastatin
Neoplasms
2 Citations (Scopus)

Red Mold Rice against Hepatic Inflammatory Damage in Zn-deficient Rats

Lee, B. H., Hsu, W-H. & Pan, T. M., 2012 Jan 1, In : Journal of Traditional and Complementary Medicine. 2, 1, p. 52-60 9 p.

Research output: Contribution to journalArticle

Fungi
Liver
Alanine Transaminase
Body Weight
Aspartate Aminotransferases
2011

A novel adjuvant therapeutic material: Chemoprevention of monascus-fermented product on oral cancer

Hsu, W-H. & Pan, T. M., 2011 Apr 1, Oral Cancer: Causes, Diagnosis and Treatment. Nova Science Publishers, Inc., p. 233-252 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Monascus
Mouth Neoplasms
Chemoprevention
Tumors
Cheek
46 Citations (Scopus)

Antihypertensive effects of Lactobacillus-fermented milk orally administered to spontaneously hypertensive rats

Liu, C. F., Tung, Y. T., Wu, C. L., Lee, B. H., Hsu, W-H. & Pan, T. M., 2011 May 11, In : Journal of Agricultural and Food Chemistry. 59, 9, p. 4537-4543 7 p.

Research output: Contribution to journalArticle

Fermented milk
antihypertensive effect
fermented milk
enzyme inhibitors
gamma-aminobutyric acid
24 Citations (Scopus)

Effects of red mold dioscorea on oral carcinogenesis in DMBA-induced hamster animal model

Hsu, W-H., Lee, B. H. & Pan, T. M., 2011 Jun 1, In : Food and Chemical Toxicology. 49, 6, p. 1292-1297 6 p.

Research output: Contribution to journalArticle

Dioscorea
9,10-Dimethyl-1,2-benzanthracene
hamsters
Cricetinae
carcinogenesis
108 Citations (Scopus)

Immunomodulatory and antioxidant potential of Lactobacillus exopolysaccharides

Liu, C. F., Tseng, K. C., Chiang, S. S., Lee, B. H., Hsu, W-H. & Pan, T. M., 2011 Sep 1, In : Journal of the Science of Food and Agriculture. 91, 12, p. 2284-2291 8 p.

Research output: Contribution to journalArticle

Immunomodulation
exopolysaccharides
Probiotics
Lactobacillus
immunomodulation
16 Citations (Scopus)

Inhibitory effects of dioscorea polysaccharide on TNF-α-induced insulin resistance in mouse FL83B cells

Lee, B. H., Hsu, W-H. & Pan, T. M., 2011 May 25, In : Journal of Agricultural and Food Chemistry. 59, 10, p. 5279-5285 7 p.

Research output: Contribution to journalArticle

Dioscorea
insulin resistance
Polysaccharides
Insulin Resistance
polysaccharides

The anti-inflammatory effect of the Monascus-fermented product monascin on murine macrophages

Huang, T., Hsu, W. H., Chang, Y. Y. & Pan, T. M., 2011 Jun 1, In : Taiwanese Journal of Agricultural Chemistry and Food Science. 49, 3, p. 111-117 7 p.

Research output: Contribution to journalArticle

Monascus
anti-inflammatory activity
macrophages
Anti-Inflammatory Agents
inflammation