• 1553 Citations
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1989 …2019
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Research Output 1989 2019

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Article
2019

A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish

Lee, G. H., Chang, C. L., Chiu, W. T., Hsiao, T. H., Chen, P. Y., Wang, K. C., Kuo, C. H., Chen, B. H., Shi, G. Y., Wu, H. L. & Fu, T. F., 2019 Aug 26, In : Journal of biomedical science. 26, 1, 60.

Research output: Contribution to journalArticle

Open Access
Thrombomodulin
Germ Layers
Blastomeres
Organogenesis
Zebrafish

Cystic Fibrosis Transmembrane Conductance Regulator: A Possible New Target for Photodynamic Therapy Enhances Wound Healing

Chiu, W. T., Tran, T. T. V., Pan, S. C., Huang, H. K., Chen, Y. C. & Wong, T. W., 2019 Oct, In : Advances in Wound Care. 8, 10, p. 476-486 11 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Photochemotherapy
Wound Healing
Indocyanine Green
Cell Movement

Etifoxine, a TSPO Ligand, Worsens Hepatitis C-Related Insulin Resistance but Relieves Lipid Accumulation

Lin, Y. M., Sun, H. Y., Chiu, W-T., Su, H. C., Chien, Y. C., Chang, H. A., Chong, L. W., Chang, H. C., Young, K-C., Bai, C. H. & Tsao, C. W., 2019 Jan 1, In : BioMed research international. 2019, 3102414.

Research output: Contribution to journalArticle

Open Access
Hepatitis C
Viruses
Hepacivirus
Insulin Resistance
Insulin
1 Citation (Scopus)

Src and SHP2 coordinately regulate the dynamics and organization of vimentin filaments during cell migration

Yang, C. Y., Chang, P. W., Hsu, W. H., Chang, H. C., Chen, C. L., Lai, C. C., Chiu, W. T. & Chen, H. C., 2019 May 23, In : Oncogene. 38, 21, p. 4075-4094 20 p.

Research output: Contribution to journalArticle

Vimentin
Cell Movement
Intermediate Filaments
Pseudopodia
Intercellular Signaling Peptides and Proteins
2018
10 Citations (Scopus)

Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis

Chiu, W. T., Chang, H. A., Lin, Y. H., Lin, Y. S., Chang, H. T., Lin, H. H., Huang, S. C., Tang, M. J. & Shen, M. R., 2018 Dec 1, In : Cell Death Discovery. 4, 1, 37.

Research output: Contribution to journalArticle

Open Access
Apoptosis
Tunicamycin
Thapsigargin
Mitochondria
Death Domain Receptors

Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis

Chiu, W., Chang, H., Lin, Y., Lin, Y., Chang, H., Lin, H., Huang, S., Tang, M. & Shen, M., 2018 Dec 1, In : Cell Death Discovery. 4, 1

Research output: Contribution to journalArticle

5 Citations (Scopus)

Biogenesis of podosome rosettes through fission

Kuo, S. L., Chen, C. L., Pan, Y. R., Chiu, W-T. & Chen, H. C., 2018 Dec 1, In : Scientific reports. 8, 1, 524.

Research output: Contribution to journalArticle

Fibroblasts
Myosin Type II
Myosin-Light-Chain Kinase
rho-Associated Kinases
Podosomes
3 Citations (Scopus)

Calcitriol inhibits HCV infection via blockade of activation of PPAR and interference with endoplasmic reticulum-associated degradation

Lin, Y. M., Sun, H. Y., Chiu, W-T., Su, H. C., Chien, Y. C., Chong, L. W., Chang, H. C., Bai, C. H., Young, K-C. & Tsao, C. W., 2018 Feb 1, In : Viruses. 10, 2, 57.

Research output: Contribution to journalArticle

Endoplasmic Reticulum-Associated Degradation
Peroxisome Proliferator-Activated Receptors
Calcitriol
Virus Diseases
Hepacivirus

Caveolin-1 down-regulation is required for Wnt5a-Frizzled 2 signalling in Ha-RasV12-induced cell transformation

Lin, H. K., Lin, H. H., Chiou, Y. W., Wu, C. L., Chiu, W. T. & Tang, M. J., 2018 May 1, In : Journal of Cellular and Molecular Medicine. 22, 5, p. 2631-2643 13 p.

Research output: Contribution to journalArticle

Caveolin 1
Down-Regulation
Madin Darby Canine Kidney Cells
Exosomes
Conditioned Culture Medium
1 Citation (Scopus)

Chemo-photothermal effects of doxorubicin/silica-carbon hollow spheres on liver cancer

Chen, Y. C., Chiu, W. T., Chang, C., Wu, P. C., Tu, T. Y., Lin, H. P. & Chang, H. C., 2018 Jan 1, In : RSC Advances. 8, 64, p. 36775-36784 10 p.

Research output: Contribution to journalArticle

Silicon Dioxide
Liver
Doxorubicin
Carbon
Silica
1 Citation (Scopus)

Modulation of motor excitability by cortical optogenetic theta burst stimulation

Wu, C., Chiu, W., Hsieh, T., Hsieh, C., Chen, J. J. & Yuan, T. (ed.), 2018 Aug, In : PLoS One. 13, 8, p. e0203333

Research output: Contribution to journalArticle

1 Citation (Scopus)

Scanned laser pico projection and stokes-mueller matrix imaging polarimetry for detecting cancer cells with different cytoskeletal organizations and metastatic potencies

Chang, Y. J., Lo, Y-L., Chiu, W-T., Huang, C. L., Chang, H. A. & Phan, Q. H., 2018 Dec 1, In : IEEE Photonics Journal. 10, 6, 8556511.

Research output: Contribution to journalArticle

Polarimeters
polarimetry
projection
cancer
Cells
1 Citation (Scopus)

STIM1 knockout enhances PDGF-mediated Ca2+ signaling through upregulation of the PDGFR–PLCγ–STIM2 cascade

Huang, T. Y., Lin, Y. H., Chang, H. A., Yeh, T. Y., Chang, Y. H., Chen, Y. F., Chen, Y. C., Li, C-C. & Chiu, W. T., 2018 Jun 18, In : International journal of molecular sciences. 19, 6, 1799.

Research output: Contribution to journalArticle

Platelet-Derived Growth Factor
Platelets
platelets
cascades
Up-Regulation
2017
3 Citations (Scopus)

Chronic treatment with cisplatin induces chemoresistance through the TIP60-mediated Fanconi anemia and homologous recombination repair pathways

Su, W-P., Ho, Y. C., Wu, C. K., Hsu, S. H., Shiu, J. L., Huang, J. C., Chang, S-B., Chiu, W-T., Hung, J-J., Liu, T., Wu, W-S., Wu, P. Y., Su, W-C., Chang, J-Y. & Liaw, H-J., 2017 Dec 1, In : Scientific reports. 7, 1, 3879.

Research output: Contribution to journalArticle

Fanconi Anemia
Recombinational DNA Repair
Cisplatin
Fanconi Anemia Complementation Group D2 Protein
Genes
11 Citations (Scopus)

CO 2 Delivery to Accelerate Incisional Wound Healing Following Single Irradiation of Near-Infrared Lamp on the Coordinated Colloids

Li, W. P., Su, C. H., Wang, S. J., Tsai, F. J., Chang, C. T., Liao, M. C., Yu, C. C., Vi Tran, T. T., Lee, C-N., Chiu, W-T., Wong, T-W. & Yeh, C-S., 2017 Jun 27, In : ACS Nano. 11, 6, p. 5826-5835 10 p.

Research output: Contribution to journalArticle

Infrared lamps
wound healing
Colloids
Carbon Monoxide
luminaires
2 Citations (Scopus)

Differential Ca2+ mobilization and mast cell degranulation by FcεRI- and GPCR-mediated signaling

Chen, Y. C., Chang, Y. C., Chang, H. A., Lin, Y. S., Tsao, C. W., Shen, M-R. & Chiu, W-T., 2017 Nov 1, In : Cell Calcium. 67, p. 31-39 9 p.

Research output: Contribution to journalArticle

Cell Degranulation
Mast Cells
Histamine
Histamine Release
G-Protein-Coupled Receptors
3 Citations (Scopus)
Amino Acid Transport System X-AG
PPAR alpha
Peroxisome Proliferator-Activated Receptors
Endocytosis
Astrocytes
3 Citations (Scopus)

Revealing the three dimensional architecture of focal adhesion components to explain Ca2 +-mediated turnover of focal adhesions

Chang, S. J., Chen, Y. C., Yang, C. H., Huang, S. C., Huang, H. K., Li, C. C., Harn, H. I. C. & Chiu, W. T., 2017 Mar 1, In : Biochimica et Biophysica Acta - General Subjects. 1861, 3, p. 624-635 12 p.

Research output: Contribution to journalArticle

Focal Adhesions
Adhesion
Calpain
Molecules
Talin
5 Citations (Scopus)

STIM1-dependent Ca2+ signaling regulates podosome formation to facilitate cancer cell invasion

Chen, Y-W., Chen, Y. F., Chiu, W. T., Chen, H. C. & Shen, M. R., 2017 Dec 1, In : Scientific reports. 7, 1, 11523.

Research output: Contribution to journalArticle

Neoplasms
Cell Surface Extensions
Rosette Formation
Podosomes
Extracellular Matrix
2016
2 Citations (Scopus)

Fluoxetine regulates cell growth inhibition of interferon-α

Lin, Y. M., Yu, B. C., Chiu, W. T., Sun, H. Y., Chien, Y. C., Su, H. C., Yen, S. Y., Lai, H. W., Bai, C. H., Young, K. C. & Tsao, C. W., 2016 Oct, In : International Journal of Oncology. 49, 4, p. 1746-1754 9 p.

Research output: Contribution to journalArticle

Fluoxetine
Interferon-alpha
Interferons
Peroxisome Proliferator-Activated Receptors
Trans-Activators
10 Citations (Scopus)

Hepatitis B virus preS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability

Yen, T. T. C., Yang, A., Chiu, W-T., Li, T. N., Wang, L. H., Wu, Y. H., Wang, H. C., Chen, L., Wang, W. C., Huang, W-Y., Chang, C. W., Chang, M. D. T., Shen, M-R., Su, I. J. & Wang, L. H. C., 2016 Apr 26, In : Oncotarget. 7, 17, p. 23346-23360 15 p.

Research output: Contribution to journalArticle

Chromosomal Instability
Surface Antigens
Hepatitis B virus
Calcium
Endoplasmic Reticulum
2 Citations (Scopus)

Spatial distribution of filament elasticity determines the migratory behaviors of a cell

Harn, H. I. C., Hsu, C. K., Wang, Y. K., Huang, Y. W., Chiu, W. T., Lin, H. H., Cheng, C. M. & Tang, M. J., 2016 Jul 3, In : Cell Adhesion and Migration. 10, 4, p. 368-377 10 p.

Research output: Contribution to journalArticle

Elasticity
Actin Cytoskeleton
Focal Adhesions
Atomic Force Microscopy
Research
25 Citations (Scopus)

The STIM1-Orai1 pathway of store-operated Ca2+ entry controls the checkpoint in cell cycle G1/S transition

Chen, Y. W., Chen, Y. F., Chen, Y. T., Chiu, W. T. & Shen, M. R., 2016 Feb 26, In : Scientific reports. 26, 6, 22142.

Research output: Contribution to journalArticle

G1 Phase Cell Cycle Checkpoints
Cell Cycle
Down-Regulation
Cell Membrane Structures
Phosphorylation
2015
75 Citations (Scopus)

FOXM1 confers to epithelial-mesenchymal transition, stemness and chemoresistance in epithelial ovarian carcinoma cells

Chiu, W-T., Huang, Y-F., Tsai, H. Y., Chen, C. C., Chang, C. H., Huang, S. C., Hsu, K-F. & Chou, C-Y., 2015 Jan 1, In : Oncotarget. 6, 4, p. 2349-2365 17 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Cisplatin
Ovarian Neoplasms
Carcinoma
Neoplasms
36 Citations (Scopus)

FoxM1 promotes breast tumorigenesis by activating PDGF-A and forming a positive feedback loop with the PDGF/AKT signaling pathway

Yu, G., Zhou, A., Xue, J., Huang, C., Zhang, X., Kang, S. H., Chiu, W. T., Tan, C., Xie, K., Wang, J. & Huang, S., 2015 Jan 1, In : Oncotarget. 6, 13, p. 11281-11294 14 p.

Research output: Contribution to journalArticle

Platelet-Derived Growth Factor
Carcinogenesis
Breast
Breast Neoplasms
Up-Regulation
9 Citations (Scopus)

Loss of Egr-1 sensitizes pancreatic β-cells to palmitate-induced ER stress and apoptosis

Cheong, M. W., Kuo, L. H., Cheng, Y. N., Tsai, P-J., Ho, L. C., Tai, H. C., Chiu, W-T., Chen, S., Lu, P-J., Shan, Y-S., Chuang, L. M. & Tsai, Y-S., 2015 Jul 22, In : Journal of Molecular Medicine. 93, 7, p. 807-818 12 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Palmitates
Palmitic Acid
Apoptosis
Growth
14 Citations (Scopus)
Keloid
Elasticity
Fibroblasts
Spatial distribution
Actins
50 Citations (Scopus)

Mechanical phenotype of cancer cells: Cell softening and loss of stiffness sensing

Lin, H. H., Lin, H. K., Lin, I. H., Chiou, Y. W., Chen, H. W., Liu, C. Y., Harn, H. I. C., Chiu, W. T., Wang, Y. K., Shen, M. R. & Tang, M. J., 2015 Jan 1, In : Oncotarget. 6, 25, p. 20946-20958 13 p.

Research output: Contribution to journalArticle

Phenotype
Caveolin 1
Neoplasms
Fibroblasts
Elasticity
17 Citations (Scopus)

Mechanosensitive store-operated calcium entry regulates the formation of cell polarity

Huang, Y. W., Chang, S. J., I-Chen Harn, H., Huang, H. T., Lin, H. H., Shen, M. R., Tang, M. J. & Chiu, W. T., 2015 Sep 1, In : Journal of Cellular Physiology. 230, 9, p. 2086-2097 12 p.

Research output: Contribution to journalArticle

Cell Polarity
Caveolin 1
Cells
Calcium
Polarization
4 Citations (Scopus)

Optical detection of metastatic cancer cells using a scanned laser pico-projection system

Huang, C. L., Chiu, W. T., Lo, Y. L., Chuang, C. H., Chen, Y. B., Chang, S. J., Ke, T. T., Cheng, H. C. & Wu, H. L., 2015 Mar 1, In : Laser Physics Letters. 12, 3, 035602.

Research output: Contribution to journalArticle

Projection systems
projection
cancer
Cells
Lasers
7 Citations (Scopus)

Solanum incanum extract downregulates aldehyde dehydrogenase 1-mediated stemness and inhibits tumor formation in ovarian cancer cells

Wu, Y. H., Chiu, W. T., Young, M. J., Chang, T. H., Huang, Y. F. & Chou, C. Y., 2015 Jan 1, In : Journal of Cancer. 6, 10, p. 1011-1019 9 p.

Research output: Contribution to journalArticle

Solanum
Ovarian Neoplasms
Down-Regulation
Neoplasms
Inhibitory Concentration 50
6 Citations (Scopus)

The photothermal effect of silica-carbon hollow sphere-concanavalin A on liver cancer cells

Chen, Y. C., Chiu, W-T., Chen, J. C., Chang, C. S., Hui-Ching Wang, L., Lin, H-P. & Chang, H-C., 2015 Mar 28, In : Journal of Materials Chemistry B. 3, 12, p. 2447-2454 8 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Concanavalin A
Silicon Dioxide
Liver
Hepatocellular Carcinoma
2014
30 Citations (Scopus)

All-trans retinoic acid downregulates ALDH1-mediated stemness and inhibits tumour formation in ovarian cancer cells

Young, M. J., Wu, Y. H., Chiu, W. T., Weng, T. Y., Huang, Y. F. & Chou, C. Y., 2014 Jul 10, In : Carcinogenesis. 36, 4, p. 498-507 10 p.

Research output: Contribution to journalArticle

Tretinoin
Ovarian Neoplasms
Down-Regulation
Neoplasms
Neoplastic Stem Cells
9 Citations (Scopus)
Chromatids
Cisplatin
Genetic Recombination
Homologous Recombination
Fanconi Anemia
5 Citations (Scopus)

Real-time electrochemical recording of dopamine release under optogenetic stimulation

Chiu, W. T., Lin, C. M., Tsai, T. C., Wu, C. W., Tsai, C. L., Lin, S. H. & Chen, J. J. J., 2014 Feb 20, In : PloS one. 9, 2, e89293.

Research output: Contribution to journalArticle

Optogenetics
dopamine
Dopamine
PC12 Cells
cells
90 Citations (Scopus)

Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis

Xue, J., Lin, X., Chiu, W. T., Chen, Y. H., Yu, G., Liu, M., Feng, X. H., Sawaya, R., Medema, R. H., Hung, M. C. & Huang, S., 2014 Feb 3, In : Journal of Clinical Investigation. 124, 2, p. 564-579 16 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Ubiquitin-Protein Ligases
Oncogenes
12 Citations (Scopus)
Epithelial-Mesenchymal Transition
Transforming Growth Factors
Actins
Adhesion
Epithelial Cells
2013
29 Citations (Scopus)
Shiga Toxin 1
Shiga Toxins
Enterohemorrhagic Escherichia coli
Escherichia coli O157
Caenorhabditis elegans
17 Citations (Scopus)

Glycosylation regulates the function and membrane localization of KCC4

Weng, T. Y., Chiu, W-T., Liu, H-S., Cheng, H-C., Shen, M-R., Mount, D. B. & Chou, C-Y., 2013 May 1, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 5, p. 1133-1146 14 p.

Research output: Contribution to journalArticle

Glycosylation
Membranes
Polysaccharides
Mutation
Protein Folding
10 Citations (Scopus)

Immobilization of the nematode caenorhabditis elegans with addressable light-induced heat knockdown (ALINK)

Chuang, H-S., Chen, H. Y., Chen, C-S. & Chiu, W-T., 2013 Aug 7, In : Lab on a Chip. 13, 15, p. 2980-2989 10 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Immobilization
Hot Temperature
Light
ITO glass
31 Citations (Scopus)

Microtubule-associated histone deacetylase 6 supports the calcium store sensor STIM1 in mediating malignant cell behaviors

Chen, Y. T., Chen, Y. F., Chiu, W-T., Liu, K. Y., Liu, Y. L., Chang, J-Y., Chang, H-C. & Shen, M-R., 2013 Jul 15, In : Cancer Research. 73, 14, p. 4500-4509 10 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Microtubules
Calcium
Uterine Cervical Neoplasms
Epithelial Cells
39 Citations (Scopus)

The ER Ca2+ sensor STIM1 regulates actomyosin contractility of migratory cells

Chen, Y. T., Chen, Y. F., Chiu, W. T., Wang, Y. K., Chang, H. C. & Shen, M. R., 2013 Mar 1, In : Journal of Cell Science. 126, 5, p. 1260-1267 8 p.

Research output: Contribution to journalArticle

Actomyosin
Endoplasmic Reticulum
Cell Movement
Uterine Cervical Neoplasms
Myosin Type II
2011
203 Citations (Scopus)
Uterine Cervical Neoplasms
Calcium
Growth
Neoplasms
Epidermal Growth Factor
47 Citations (Scopus)

Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by Stat3 inhibition

Chiu, W. T., Lee, H. T., Huang, F. J., Aldape, K. D., Yao, J., Steeg, P. S., Chou, C. Y., Lu, Z., Xie, K. & Huang, S., 2011 Jul 15, In : Cancer Research. 71, 14, p. 4932-4943 12 p.

Research output: Contribution to journalArticle

Caveolin 1
Up-Regulation
Breast Neoplasms
Neoplasm Metastasis
Brain
293 Citations (Scopus)

FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis

Zhang, N., Wei, P., Gong, A., Chiu, W-T., Lee, H. T., Colman, H., Huang, H., Xue, J., Liu, M., Wang, Y., Sawaya, R., Xie, K., Yung, W. K. A., Medema, R. H., He, X. & Huang, S., 2011 Oct 18, In : Cancer Cell. 20, 4, p. 427-442 16 p.

Research output: Contribution to journalArticle

Catenins
Glioma
Carcinogenesis
Gene Expression
Cell Nucleus Active Transport
2008
7 Citations (Scopus)

Low substratum rigidity of collagen gel promotes ERK phosphorylation via lipid raft to augment cell migration

Wei, W. C., Hsu, Y. C., Chiu, W-T., Wang, C. Z., Wu, C. M., Wang, Y-G., Shen, M-R. & Tang, M-J., 2008 Mar 1, In : Journal of Cellular Biochemistry. 103, 4, p. 1111-1124 14 p.

Research output: Contribution to journalArticle

Phosphorylation
Rigidity
Cell Movement
Collagen
Gels
58 Citations (Scopus)

Molecular basis for the critical role of suppressor of cytokine signaling-1 in melanoma brain metastasis

Huang, F. J., Steeg, P. S., Price, J. E., Chiu, W-T., Chou, P. C., Xie, K., Sawaya, R. & Huang, S., 2008 Dec 1, In : Cancer Research. 68, 23, p. 9634-9642 9 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Melanoma
Cytokines
Neoplasm Metastasis
Brain
30 Citations (Scopus)
Calpain
Up-Regulation
Epithelial Cells
Apoptosis
Homeostasis
2007
7 Citations (Scopus)

Activation of caspase-8 and Erk-1/2 in domes regulates cell death induced by confluence in MDCK cells

Chang, Y. H., Lin, H. H., Wang, Y. K., Chiu, W. T., Su, H. W. & Tang, M. J., 2007 Apr 1, In : Journal of Cellular Physiology. 211, 1, p. 174-182 9 p.

Research output: Contribution to journalArticle

Madin Darby Canine Kidney Cells
Caspase 8
Domes
Cell death
Cell Death
23 Citations (Scopus)

Deregulation of AP-1 proteins in collagen gel-induced epithelial cell apoptosis mediated by low substratum rigidity

Wang, Y. H., Chiu, W-T., Wang, Y-G., Wu, C. C., Chen, T. L., Teng, C. F., Chang, W-T., Chang, H-C. & Tang, M-J., 2007 Jan 5, In : Journal of Biological Chemistry. 282, 1, p. 752-763 12 p.

Research output: Contribution to journalArticle

Deregulation
Transcription Factor AP-1
Rigidity
Collagen
Gels