Wen-Yih Jeng

Associate Research Fellow

  • 1141 Citations
  • 18 h-Index
19992019
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Research Output 1999 2019

  • 1141 Citations
  • 18 h-Index
  • 33 Article
  • 2 Letter
  • 1 Review article
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Article
1999
10 Citations (Scopus)

Kinetic and structural studies of N-acetyl-microperoxidase-5 and - microperoxidase-8

Chuang, W-J., Chang, Y. D. & Jeng, W-Y., 1999 Jun 15, In : Journal of Inorganic Biochemistry. 75, 2, p. 93-97 5 p.

Research output: Contribution to journalArticle

Kinetics
Porphyrins
Circular Dichroism
microperoxidase
Peroxidase
2002
29 Citations (Scopus)
Cytochromes c
Escherichia coli
Horses
Hemeproteins
Oxidation-Reduction
18 Citations (Scopus)

Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a)

Liu, P. P., Chen, Y. C., Li, C., Hsieh, Y. H., Chen, S. W., Chen, S. H., Jeng, W. Y. & Chuang, W. J., 2002 Dec 1, In : Proteins: Structure, Function and Genetics. 49, 4, p. 543-553 11 p.

Research output: Contribution to journalArticle

Interleukins
DNA
Interleukin-2
Forkhead Transcription Factors
Gene expression
2003
49 Citations (Scopus)

Maturation processing and characterization of streptopain

Chen, C. Y., Luo, S. C., Kuo, C. F., Lin, Y. S., Wu, J. J., Lin, M. T., Liu, C. C., Jeng, W. Y. & Chuang, W. J., 2003 May 9, In : Journal of Biological Chemistry. 278, 19, p. 17336-17343 8 p.

Research output: Contribution to journalArticle

streptopain
Exotoxins
Enzyme Precursors
Processing
Cysteine Proteases
2004
12 Citations (Scopus)

The catalase activity of Nα-acetyl-microperoxidase-8

Jeng, W-Y., Tsai, Y. H. & Chuang, W-J., 2004 Sep 1, In : Journal of Peptide Research. 64, 3, p. 104-109 6 p.

Research output: Contribution to journalArticle

Catalase
Cytochrome P-450 Enzyme System
Peroxidase
Oxygen
Ligands
2005
16 Citations (Scopus)

Zinc ion acts as a cofactor for serine/threonine kinase MST3 and has a distinct role in autophosphorylation of MST3

Lu, T. J., Huang, C. Y. F., Yuan, C. J., Lee, Y. C., Leu, T-H., Chang, W. C., Lu, T. L., Jeng, W-Y. & Lai, M-D., 2005 Jun 1, In : Journal of Inorganic Biochemistry. 99, 6, p. 1306-1313 8 p.

Research output: Contribution to journalArticle

Protein-Serine-Threonine Kinases
Zinc
Phosphotransferases
Ions
Metal ions
2007
120 Citations (Scopus)

Bisphosphonates target multiple sites in both cis- and trans- prenyltransferases

Guo, R. T., Cao, R., Liang, P. H., Ko, T. P., Chang, T. H., Hudock, M. P., Jeng, W-Y., Chen, C. K. M., Zhang, Y., Song, Y., Kuo, C. J., Yin, F., Oldfield, E. & Wang, A. H. J., 2007 Jun 12, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 24, p. 10022-10027 6 p.

Research output: Contribution to journalArticle

undecaprenyl pyrophosphate synthetase
Diphosphonates
Farnesyltranstransferase
Geranyltranstransferase
Binding Sites
2008
264 Citations (Scopus)

A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence

Liu, C. I., Liu, G. Y., Song, Y., Yin, F., Hensler, M. E., Jeng, W-Y., Nizet, V., Wang, A. H. J. & Oldfield, E., 2008 Mar 7, In : Science. 319, 5868, p. 1391-1394 4 p.

Research output: Contribution to journalArticle

Anticholesteremic Agents
Virulence
Staphylococcus aureus
Farnesyl-Diphosphate Farnesyltransferase
Cholesterol
36 Citations (Scopus)

Crystal structure of IcaR, a repressor of the TetR family implicated in biofilm formation in staphylococcus epidermidis

Jeng, W-Y., Ko, T. P., Liu, C. I., Guo, R. T., Liu, C. L., Shr, H. L. & Wang, A. H. J., 2008 Mar 1, In : Nucleic acids research. 36, 5, p. 1567-1577 11 p.

Research output: Contribution to journalArticle

Iron-Dextran Complex
Staphylococcus epidermidis
Biofilms
DNA
Repressor Proteins
2009
8 Citations (Scopus)
Integrins
Mutation
Platelets
Platelet Aggregation
Hydrogen
55 Citations (Scopus)

Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: In vitro, in vivo, and crystallographic results

Song, Y., Liu, C. I., Lin, F. Y., Joo, H. N., Hensler, M., Liu, Y. L., Jeng, W-Y., Low, J., Liu, G. Y., Nizet, V., Wang, A. H. J. & Oldfield, E., 2009 Jul 9, In : Journal of Medicinal Chemistry. 52, 13, p. 3869-3880 12 p.

Research output: Contribution to journalArticle

Virulence Factors
Staphylococcus aureus
Carotenoids
Gold
Inhibitory Concentration 50
2010
46 Citations (Scopus)

Glycan array on aluminum oxide-coated glass slides through phosphonate chemistry

Chang, S. H., Han, J. L., Tseng, S. Y., Lee, H. Y., Lin, C. W., Lin, Y. C., Jeng, W-Y., Wang, A. H. J., Wu, C. Y. & Wong, C. H., 2010 Sep 29, In : Journal of the American Chemical Society. 132, 38, p. 13371-13380 10 p.

Research output: Contribution to journalArticle

Organophosphonates
Aluminum Oxide
Glass
Polysaccharides
Aluminum
42 Citations (Scopus)

Mechanism of action and inhibition of dehydrosqualene synthase

Lin, F. Y., Liu, C. I., Liu, Y. L., Zhang, Y., Wang, K., Jeng, W-Y., Ko, T. P., Cao, R., Wang, A. H. J. & Oldfield, E., 2010 Dec 14, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21337-21342 6 p.

Research output: Contribution to journalArticle

Diphosphates
Terpenes
Alkenes
Sterols
Carotenoids
50 Citations (Scopus)

Structural study of TcaR and its complexes with multiple antibiotics from Staphylococcus epidermidis

Chang, Y. M., Jeng, W-Y., Ko, T. P., Yeh, Y. J., Chen, C. K. M. & Wang, A. H. J., 2010 May 11, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 19, p. 8617-8622 6 p.

Research output: Contribution to journalArticle

Staphylococcus epidermidis
Iron-Dextran Complex
Biofilms
Salicylates
Anti-Bacterial Agents
16 Citations (Scopus)

Structures of human MST3 kinase in complex with adenine, ADP and Mn 2+

Ko, T. P., Jeng, W-Y., Liu, C. I., Lai, M-D., Wu, C. L., Chang, W. J., Shr, H. L., Lu, T. J. & Wang, A. H. J., 2010 Feb 17, In : Acta Crystallographica Section D: Biological Crystallography. 66, 2, p. 145-154 10 p.

Research output: Contribution to journalArticle

Adenine
Adenosine Diphosphate
Catalytic Domain
Phosphotransferases
Ligands
2011
20 Citations (Scopus)

Crystal structures of the laminarinase catalytic domain from Thermotoga maritima MSB8 in complex with inhibitors: Essential residues for β-1,3- and β-1,4-glucan selection

Jeng, W-Y., Wang, N. C., Lin, C. T., Shyur, L. F. & Wang, A. H. J., 2011 Dec 30, In : Journal of Biological Chemistry. 286, 52, p. 45030-45040 11 p.

Research output: Contribution to journalArticle

Thermotoga maritima
Cellulases
Catalytic Domain
Crystal structure
Glucans
106 Citations (Scopus)

Structural and functional analysis of three β-glucosidases from bacterium Clostridium cellulovorans, fungus Trichoderma reesei and termite Neotermes koshunensis

Jeng, W. Y., Wang, N. C., Lin, M. H., Lin, C. T., Liaw, Y. C., Chang, W. J., Liu, C. I., Liang, P. H. & Wang, A. H. J., 2011 Jan 1, In : Journal of Structural Biology. 173, 1, p. 46-56 11 p.

Research output: Contribution to journalArticle

Clostridium cellulovorans
Glucosidases
Isoptera
Trichoderma
Fungi
2012
24 Citations (Scopus)

Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase

Liu, C. I., Jeng, W. Y., Chang, W. J., Ko, T. P. & Wang, A. H. J., 2012 May 25, In : Journal of Biological Chemistry. 287, 22, p. 18750-18757 8 p.

Research output: Contribution to journalArticle

Farnesyl-Diphosphate Farnesyltransferase
Oxidative stress
Sterols
Enzymes
Metabolites
5 Citations (Scopus)

Engineering of dual-functional hybrid glucanases

Liu, W. C., Lin, Y. S., Jeng, W. Y., Chen, J. H., Wang, A. H. J. & Shyur, L. F., 2012 Nov 1, In : Protein Engineering, Design and Selection. 25, 11, p. 771-780 10 p.

Research output: Contribution to journalArticle

Enzymes
Industrial applications
Fibrobacter
Genes
Thermotoga maritima
4 Citations (Scopus)

Functional Studies of ssDNA Binding Ability of MarR Family Protein TcaR from Staphylococcus epidermidis

Chang, Y. M., Chen, C. K. M., Chang, Y. C., Jeng, W-Y., Hou, M. H. & Wang, A. H. J., 2012 Sep 21, In : PloS one. 7, 9, e45665.

Research output: Contribution to journalArticle

single-stranded DNA
Staphylococcus epidermidis
Single-Stranded DNA
binding capacity
Microbial Drug Resistance
21 Citations (Scopus)

High-resolution structures of Neotermes koshunensis β-glucosidase mutants provide insights into the catalytic mechanism and the synthesis of glucoconjugates

Jeng, W-Y., Wang, N. C., Lin, C. T., Chang, W. J., Liu, C. I. & Wang, A. H. J., 2012 Jul 1, In : Acta Crystallographica Section D: Biological Crystallography. 68, 7, p. 829-838 10 p.

Research output: Contribution to journalArticle

Glucosidases
HEPES
Opipramol
Glucose
Oligosaccharides
48 Citations (Scopus)

Mutations in the substrate entrance region of β-glucosidase from Trichoderma reesei improve enzyme activity and thermostability

Lee, H. L., Chang, C. K., Jeng, W-Y., Wang, A. H. J. & Liang, P. H., 2012 Nov 1, In : Protein Engineering, Design and Selection. 25, 11, p. 733-740 8 p.

Research output: Contribution to journalArticle

Glucosidases
Trichoderma
Enzyme activity
Cellobiose
Mutation
2014
29 Citations (Scopus)

Crowning proteins: Modulating the protein surface properties using crown ethers

Lee, C. C., Maestre-Reyna, M., Hsu, K. C., Wang, H. C., Liu, C. I., Jeng, W-Y., Lin, L. L., Wood, R., Chou, C. C., Yang, J. M. & Wang, A. H. J., 2014 Nov 24, In : Angewandte Chemie - International Edition. 53, 48, p. 13054-13058 5 p.

Research output: Contribution to journalArticle

Crown Ethers
Crown ethers
Surface properties
Proteins
Membrane Proteins
9 Citations (Scopus)

ManA is regulated by RssAB signaling and promotes motility in Serratia marcescens

Soo, P. C., Horng, Y. T., Chang, Y. L., Tsai, W. W., Jeng, W-Y., Lu, C. C. & Lai, H. C., 2014 Jan 1, In : Research in Microbiology. 165, 1, p. 21-29 9 p.

Research output: Contribution to journalArticle

Serratia marcescens
Serratia
Mannose-6-Phosphate Isomerase
Surface Tension
Electrophoretic Mobility Shift Assay
9 Citations (Scopus)

Pin1-mediated Sp1 phosphorylation by CDK1 increases Sp1 stability and decreases its DNA-binding activity during mitosis

Yang, H. C., Chuang, J. Y., Jeng, W-Y., Liu, C. I., Wang, A. H. J., Lu, P-J., Chang, W. C. & Hung, J-J., 2014 Dec 16, In : Nucleic acids research. 42, 22, p. 13573-13587 15 p.

Research output: Contribution to journalArticle

Mitosis
Phosphorylation
DNA
Peptides
Cell Cycle
23 Citations (Scopus)

Structural insights into the catalytic mechanism of human squalene synthase

Liu, C. I., Jeng, W-Y., Chang, W. J., Shih, M. F., Ko, T. P. & Wang, A. H. J., 2014 Feb 1, In : Acta Crystallographica Section D: Biological Crystallography. 70, 2, p. 231-241 11 p.

Research output: Contribution to journalArticle

Farnesyl-Diphosphate Farnesyltransferase
Niacinamide
Biosynthetic Pathways
Phosphates
Squalene
2015
8 Citations (Scopus)

Molecular analysis of codon 548 in the rpoB gene involved in Mycobacterium tuberculosis resistance to rifampin

Horng, Y. T., Jeng, W-Y., Chen, Y. Y., Liu, C. H., Dou, H. Y., Lee, J. J., Chang, K. C., Chien, C. C. & Soo, P. C., 2015 Mar 1, In : Antimicrobial agents and chemotherapy. 59, 3, p. 1542-1548 7 p.

Research output: Contribution to journalArticle

Rifampin
Mycobacterium tuberculosis
Codon
Genes
Mutation
29 Citations (Scopus)

Structural and functional roles of glycosylation in fungal laccase from lentinus sp.

Maestre-Reyna, M., Liu, W. C., Jeng, W-Y., Lee, C. C., Hsu, C. A., Wen, T. N., Wang, A. H. J. & Shyur, L. F., 2015 Apr 7, In : PLoS ONE. 10, 4, e0120601.

Research output: Contribution to journalArticle

Lentinula
Lentinus
Glycosylation
Laccase
laccase
2016

Pervanadate induces Mammalian Ste20 Kinase 3 (MST3) tyrosine phosphorylation but not activation

Kan, W. C., Lu, T. L., Ling, P., Lee, T. H., Cho, C. Y., Huang, C. Y. F., Jeng, W-Y., Weng, Y. P., Chiang, C. Y., Wu, J. B. & Lu, T. J., 2016 Jul 1, In : Journal of Inorganic Biochemistry. 160, p. 33-39 7 p.

Research output: Contribution to journalArticle

Phosphorylation
Phosphotransferases
Chemical activation
Yeast
Tyrosine
10 Citations (Scopus)

Single amino acid substitution Gly186Val in AdeS restores tigecycline susceptibility of Acinetobacter baumannii

Sun, J. R., Jeng, W-Y., Perng, C. L., Yang, Y. S., Soo, P. C., Chiang, Y. S. & Chiueh, T. S., 2016 Jun 13, In : Journal of Antimicrobial Chemotherapy. 71, 6, p. 1488-1492 5 p.

Research output: Contribution to journalArticle

Acinetobacter baumannii
Amino Acid Substitution
Operon
Microbial Drug Resistance
Site-Directed Mutagenesis
2017
3 Citations (Scopus)

Overexpression of exogenous kidney-specific Ngal attenuates progressive cyst development and prolongs lifespan in a murine model of polycystic kidney disease

Wang, E., Chiou, Y. Y., Jeng, W. Y., Lin, H. K., Lin, H. H., Chin, H. J., Leo Wang, C. K., Yu, S. S., Tsai, S. C., Chiang, C. Y., Cheng, P. H., Lin, H. J., Jiang, S. T., Chiu, S. T. & Hsieh-Li, H. M., 2017 Feb 1, In : Kidney international. 91, 2, p. 412-422 11 p.

Research output: Contribution to journalArticle

Polycystic Kidney Diseases
Cysts
Kidney
Caspase 3
Transgenic Mice
2 Citations (Scopus)

The negative effects of KPN00353 on glycerol kinase and microaerobic 1,3-propanediol production in klebsiella pneumoniae

Jeng, W-Y., Panjaitan, N. S. D., Horng, Y. T., Chung, W. T., Chien, C. C. & Soo, P. C., 2017 Dec 7, In : Frontiers in Microbiology. 8, DEC, 2441.

Research output: Contribution to journalArticle

Glycerol Kinase
Klebsiella pneumoniae
arginine glutamate
Glycerol
Phosphoenolpyruvate
2019

Crystal Structures of the C-Terminally Truncated Endoglucanase Cel9Q from Clostridium thermocellum Complexed with Cellodextrins and Tris

Jeng, W. Y., Liu, C. I., Lu, T. J., Lin, H. J., Wang, N. C. & Wang, A. H. J., 2019 Jan 18, In : ChemBioChem. 20, 2, p. 295-307 13 p.

Research output: Contribution to journalArticle

Clostridium thermocellum
Cellobiose
Clostridium
Cellulase
Crystal structure