• 1690 Citations
  • 24 h-Index
1988 …2020
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Research Output 1988 2017

2017
2 Citations (Scopus)

Effects of the RGD loop and C-terminus of rhodostomin on regulating integrin αIIbβ3 recognition

Chang, Y. T., Shiu, J. H., Huang, C. H., Chen, Y. C., Chen, C. Y., Chang, Y. S. & Chuang, W. J., 2017 Apr, In : PloS one. 12, 4, e0175321.

Research output: Contribution to journalArticle

integrins
Integrins
Platelets
Disintegrins
mutants
5 Citations (Scopus)

Inhibition of osteoporosis by the αvβ3 integrin antagonist of rhodostomin variants

Lin, T. H., Yang, R. S., Tu, H. J., Liou, H. C., Lin, Y. M., Chuang, W-J. & Fu, W. M., 2017 Jan 1, In : European Journal of Pharmacology. 804, p. 94-101 8 p.

Research output: Contribution to journalArticle

Osteoclasts
Integrins
Osteoporosis
Bone Resorption
Osteogenesis
2016
2 Citations (Scopus)

Epidemiology analysis of streptococcus pyogenes in a hospital in Southern Taiwan by use of the updated emm cluster typing system

Chiang-Ni, C., Zheng, P. X., Wang, S-Y., Tsai, P-J., Chuang, W-J., Lin, Y-S., Liu, C-C. & Wu, J. J., 2016 Jan 1, In : Journal of Clinical Microbiology. 54, 1, p. 157-162 6 p.

Research output: Contribution to journalArticle

Streptococcus pyogenes
Streptococcus
Taiwan
Epidemiology
Molecular Typing
3 Citations (Scopus)

Improved antithrombotic activity and diminished bleeding side effect of a PEGylated αiIbβ3 antagonist, disintegrin

Hsu, C. C., Chuang, W-J., Chung, C. H., Chang, C. H., Peng, H. C. & Huang, T. F., 2016 Jul 1, In : Thrombosis Research. 143, p. 3-10 8 p.

Research output: Contribution to journalArticle

Disintegrins
Hemorrhage
Half-Life
Platelet Aggregation
rhodostomin
Chemical shift
Oxidation-Reduction
Cysteine
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
5 Citations (Scopus)

Snake Venom Disintegrin Inhibits the Activation of Toll-Like Receptors and Alleviates Sepsis through Integrin alphaVbeta3 Blockade

Hsu, C. C., Chuang, W-J., Chung, C. H., Chang, C. H., Peng, H. C. & Huang, T. F., 2016 Mar 18, In : Scientific reports. 6, 23387.

Research output: Contribution to journalArticle

Integrin alphaVbeta3
Disintegrins
Snake Venoms
Toll-Like Receptors
Sepsis
1 Citation (Scopus)

Streptococcal pyrogenic exotoxin B inhibits apoptotic cell clearance by macrophages through protein S cleavage

Chen, C. L., Wu, Y. Y., Lin, C. F., Kuo, C. F., Han, C. L., Wang, S., Chuang, W. J., Chen, C. Y., Wu, J. J., Tsai, P. J., Liu, C. C. & Lin, Y. S., 2016 May 16, In : Scientific reports. 6, 26026.

Research output: Contribution to journalArticle

Protein S
Macrophages
streptopain
Streptococcus
Phagocytosis
2015
1 Citation (Scopus)

Clustered regularly interspaced short palindromic repeats are emm type-specific in highly prevalent group A streptococci

Zheng, P. X., Chan, Y. C., Chiou, C. S., Chiang-Ni, C., Wang, S. Y., Tsai, P. J., Chuang, W. J., Lin, Y. S., Liu, C. C. & Wu, J. J., 2015 Dec 1, In : PloS one. 10, 12, e0145223.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Streptococcus
molecular epidemiology
loci
nucleic acids
15 Citations (Scopus)

Role of spinal CXCL1 (GROα) in opioid tolerance a human-to-rodent translational study

Lin, C. P., Kang, K. H., Lin, T. H., Wu, M. Y., Liou, H. C., Chuang, W-J., Sun, W. Z. & Fu, W. M., 2015 Mar 4, In : Anesthesiology. 122, 3, p. 666-676 11 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Rodentia
Morphine
Cerebrospinal Fluid
Chemokines
2014
3 Citations (Scopus)
Clustered Regularly Interspaced Short Palindromic Repeats
Erythromycin
Streptococcus
Nucleic Acids
Streptococcus pyogenes
9 Citations (Scopus)

Distinct structural features of the peroxide response regulator from group A streptococcus drive DNA binding

Lin, C. S. H., Chao, S. Y., Hammel, M., Nix, J. C., Tseng, H. L., Tsou, C. C., Fei, C. H., Chiou, H. S., Jeng, U. S., Lin, Y. S., Chuang, W. J., Wu, J. J. & Wang, S., 2014 Feb 21, In : PloS one. 9, 2, e89027.

Research output: Contribution to journalArticle

Streptococcus
Peroxides
peroxides
DNA
X ray scattering
5 Citations (Scopus)

Invasive hypermucoid variant of group A Streptococcus is defective in growth and susceptible to DNA-damaging treatments

Chiang-Ni, C., Zheng, P. X., Wang, S-Y., Tsai, P-J., Kuo, C. F., Chuang, W-J., Lin, Y-S., Liu, C-C. & Wu, J. J., 2014 Jan 1, In : Pathogens and Disease. 70, 2, p. 194-201 8 p.

Research output: Contribution to journalArticle

Streptococcus
Capsules
DNA
Growth
Virulence
2 Citations (Scopus)

Type i and II β-turns prediction using NMR chemical shifts

Wang, C. C., Lai, W. C. & Chuang, W-J., 2014 Jan 1, In : Journal of Biomolecular NMR. 59, 3, p. 175-184 10 p.

Research output: Contribution to journalArticle

Chemical shift
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Secondary Protein Structure
Cluster Analysis

人類纖維黏蛋白變異體及其醫藥用途

Chuang, W-J., 2014 Apr 1, Patent No. I580692

Research output: Patent

2013
12 Citations (Scopus)
Necrotizing Fasciitis
Streptococcus pyogenes
Pandemics
Genome

DISINTEGRIN VARIANTS AND PHARMACEUTICAL USES THEREOF

Chuang, W-J., 2013 Mar 28, Patent No. HK1136160

Research output: Patent

Disintegrins
Integrins
Pharmaceutical Preparations
Peptides
24 Citations (Scopus)

Kallistatin modulates immune cells and confers anti-inflammatory response to protect mice from group a streptococcal infection

Lu, S. L., Tsai, C. Y., Luo, Y. H., Kuo, C. F., Lin, W. C., Chang, Y. T., Wu, J. J., Chuang, W. J., Liu, C. C., Chao, L., Chao, J. & Lin, Y. S., 2013 Nov 1, In : Antimicrobial agents and chemotherapy. 57, 11, p. 5366-5372 7 p.

Research output: Contribution to journalArticle

Streptococcal Infections
Anti-Inflammatory Agents
Streptococcus
Infection
kallistatin
11 Citations (Scopus)

Peroxide responsive regulator PerR of group A streptococcus is required for the expression of phage-associated DNase Sda1 under oxidative stress

Wang, C. H., Chiang-Ni, C., Kuo, H. T., Zheng, P. X., Tsou, C. C., Wang, S., Tsai, P. J., Chuang, W. J., Lin, Y. S., Liu, C. C. & Wu, J. J., 2013 Dec 3, In : PloS one. 8, 12, e81882.

Research output: Contribution to journalArticle

deoxyribonucleases
Bacteriophages
Oxidative stress
Deoxyribonucleases
Streptococcus

Streptopain

Chuang, W-J., Lin, Y-S., Wu, J. J., Liu, C-C. & Lin, M. T., 2013 Aug 29, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 2. p. 2142-2150 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

streptopain
25 Citations (Scopus)

Upregulation of drug transporter expression by osteopontin in prostate cancer cellss

Hsieh, I. S., Huang, W. H., Liou, H. C., Chuang, W-J., Yang, R. S. & Fu, W. M., 2013 May 1, In : Molecular Pharmacology. 83, 5, p. 968-977 10 p.

Research output: Contribution to journalArticle

Osteopontin
Prostatic Neoplasms
Up-Regulation
Daunorubicin
Pharmaceutical Preparations
2 Citations (Scopus)

Zinc-dependent interaction between JAB1 and Pre-S2 mutant large surface antigen of hepatitis B virus and its implications for viral hepatocarcinogenesis

Hsu, J. L., Chuang, W. J., Su, I. J., Gui, W. J., Chang, Y. Y., Lee, Y. P., Ai, Y. L., Chuang, D. T. & Huang, W., 2013 Dec 1, In : Journal of Virology. 87, 23, p. 12675-12684 10 p.

Research output: Contribution to journalArticle

Hepatitis B virus
surface antigens
Surface Antigens
binding proteins
Zinc
2012

Disintegrin variants and pharmaceutical uses thereof

Chuang, W-J., 2012 Mar 30, Patent No. 577998

Research output: Patent

Disintegrins
Integrins
Pharmaceutical Preparations
Peptides

Disintegrin variants and pharmaceutical uses thereof

Chuang, W-J., 2012 Mar 30, Patent No. 598176

Research output: Patent

Disintegrins
Integrins
Pharmaceutical Preparations
Peptides
3 Citations (Scopus)

Dynamics and functional differences between dendroaspin and rhodostomin: Insights into protein scaffolds in integrin recognition

Cheng, C. H., Chen, Y. C., Shiu, J. H., Chang, Y. T., Chang, Y. S., Huang, C. H., Chen, C. Y. & Chuang, W. J., 2012 Dec 1, In : Protein Science. 21, 12, p. 1872-1884 13 p.

Research output: Contribution to journalArticle

Scaffolds
Integrins
Proteins
mambin
rhodostomin
9 Citations (Scopus)

Effect of p to a mutation of the n-terminal residue adjacent to the rgd motif on rhodostomin: Importance of dynamics in integrin recognition

Shiu, J. H., Chen, C. Y., Chen, Y. C., Chang, Y. T., Chang, Y. S., Huang, C. H. & Chuang, W. J., 2012 Jan 4, In : PLoS ONE. 7, 1, e28833.

Research output: Contribution to journalArticle

integrins
Integrins
mutation
mutants
Mutation
9 Citations (Scopus)

Environmental pH changes, but not the LuxS signalling pathway, regulate SpeB expression in M1 group A streptococci

Chiang-Ni, C., Zheng, P. X., Tsai, P-J., Chuang, W-J., Lin, Y-S., Liu, C-C. & Wu, J. J., 2012 Jan 1, In : Journal of Medical Microbiology. 61, 1, p. 16-22 7 p.

Research output: Contribution to journalArticle

Streptococcus
Quorum Sensing
Cysteine Proteases
Virulence Factors
Mutation
6 Citations (Scopus)

Expression in Pichia pastoris and characterization of echistatin, an RGD-containing short disintegrin

Chen, Y. C., Cheng, C. H., Shiu, J. H., Chang, Y. T., Chang, Y. S., Huang, C. H., Lee, J. C. & Chuang, W. J., 2012 Dec 5, In : Toxicon. 60, 8, p. 1342-1348 7 p.

Research output: Contribution to journalArticle

Disintegrins
Pichia
Integrins
Platelets
Platelet Aggregation
8 Citations (Scopus)

Recombinant Expression of Margatoxin and Agitoxin-2 in Pichia pastoris: An Efficient Method for Production of KV1.3 Channel Blockers

Anangi, R., Koshy, S., Huq, R., Beeton, C., Chuang, W. J. & King, G. F., 2012 Dec 29, In : PloS one. 7, 12, e52965.

Research output: Contribution to journalArticle

Pichia pastoris
Pichia
T-cells
toxins
Disulfides
2011

Disintegrin variants and pharmaceutical uses thereof

Chuang, W-J., 2011 Feb 10, Patent No. 2477727

Research output: Patent

Disintegrins
Integrins
Pharmaceutical Preparations
Peptides
14 Citations (Scopus)

Emergence of uncommon emm types of Streptococcus pyogenes among adult patients in southern Taiwan

Chiang-Ni, C., Wu, A-B., Liu, C-C., Chen, K. T., Lin, Y-S., Chuang, W-J., Fang, H. Y. & Wu, J. J., 2011 Dec 1, In : Journal of Microbiology, Immunology and Infection. 44, 6, p. 424-429 6 p.

Research output: Contribution to journalArticle

Streptococcus pyogenes
Taiwan
Cellulitis
Infection
Population
7 Citations (Scopus)

Epitope mapping and structural analysis of the anti-Der p 1 monoclonal antibody: Insight into therapeutic potential

Dai, Y. C., Chuang, W-J., Chua, K. Y., Shieh, C-C. & Wang, J-Y., 2011 Jul 1, In : Journal of Molecular Medicine. 89, 7, p. 701-712 12 p.

Research output: Contribution to journalArticle

Epitope Mapping
Monoclonal Antibodies
Cysteine Proteases
Allergens
Immunoglobulin E
12 Citations (Scopus)

Improvements in endotoxemic syndromes using a disintegrin, rhodostomin, through integrin αvβ3-dependent pathway

Hsu, C. C., Chuang, W-J., Chang, C. H., Tseng, Y. L., Peng, H. C. & Huang, T. F., 2011 Mar 1, In : Journal of Thrombosis and Haemostasis. 9, 3, p. 593-602 10 p.

Research output: Contribution to journalArticle

Disintegrins
Integrins
Lipopolysaccharides
Phagocytes
Monocytes
17 Citations (Scopus)

Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: Insight into its domain swapping and DNA binding

Chu, Y. P., Chang, C. H., Shiu, J. H., Chang, Y. T., Chen, C. Y. & Chuang, W. J., 2011 May 1, In : Protein Science. 20, 5, p. 908-924 17 p.

Research output: Contribution to journalArticle

Monomers
Dimers
DNA
Hinges
Forkhead Transcription Factors
7 Citations (Scopus)

The deficient cleavage of M protein-bound IgG by IdeS: Insight into the escape of Streptococcus pyogenes from antibody-mediated immunity

Su, Y. F., Chuang, W. J., Wang, S. M., Chen, W. Y., Chiang-Ni, C., Lin, Y. S., Wu, J. J. & Liu, C. C., 2011 Oct 1, In : Molecular Immunology. 49, 1-2, p. 134-142 9 p.

Research output: Contribution to journalArticle

Streptococcus pyogenes
Immunity
Immunoglobulin G
Antibodies
Enzymes
2010
4 Citations (Scopus)

Agaricus blazei Murill ameliorates myocardial ischemia-reperfusion injury

Huang, C. H., Tsai, H. N., Peng, R. H., Hsieh, Y. H., Chuang, W-J., Hsu, G. C., Huang, W-Y. & Chen, W. J., 2010 Dec 1, In : Acta Cardiologica Sinica. 26, 4, p. 235-241 7 p.

Research output: Contribution to journalArticle

Agaricus
Myocardial Reperfusion Injury
Reperfusion Injury
Myocardial Ischemia
Myocardial Reperfusion
13 Citations (Scopus)

Expression in Pichia pastoris and characterization of APETx2, a specific inhibitor of acid sensing ion channel 3

Anangi, R., Chen, C. C., Lin, Y. W., Cheng, Y. R., Cheng, C. H., Chen, Y. C., Chu, Y. P. & Chuang, W. J., 2010 Dec 1, In : Toxicon. 56, 8, p. 1388-1397 10 p.

Research output: Contribution to journalArticle

Acid Sensing Ion Channel Blockers
Pichia
Acid Sensing Ion Channels
Nuclear magnetic resonance
Neurology
15 Citations (Scopus)

Molecular mimicry between streptococcal pyrogenic exotoxin B and endothelial cells

Luo, Y. H., Chuang, W-J., Wu, J. J., Lin, M. T., Liu, C-C., Lin, P-Y., Roan, J-N., Wong, T-W., Chen, Y-L. & Lin, Y-S., 2010 Oct 1, In : Laboratory Investigation. 90, 10, p. 1492-1506 15 p.

Research output: Contribution to journalArticle

Molecular Mimicry
B-Lymphocytes
Endothelial Cells
Monoclonal Antibodies
Bovine Serum Albumin
20 Citations (Scopus)

Oxidative stress and metal ions regulate a ferritin-like gene, dpr, in Streptococcus pyogenes

Tsou, C. C., Chiang-Ni, C., Lin, Y. S., Chuang, W. J., Lin, M. T., Liu, C. C. & Wu, J. J., 2010 Apr 1, In : International Journal of Medical Microbiology. 300, 4, p. 259-264 6 p.

Research output: Contribution to journalArticle

Streptococcus pyogenes
Peroxides
Ferritins
Hydrogen Peroxide
Oxidative Stress
2009
12 Citations (Scopus)
Streptococcus pyogenes
Taiwan
Epidemiology
Scarlet Fever
Pharyngitis

Disintegrin variants and pharmaceutical uses thereof

Chuang, W-J., 2009 Jul 29, Patent No. 153383

Research output: Patent

Disintegrins
Integrins
Pharmaceutical Preparations
Peptides

Disintegrin variants and pharmaceutical uses thereof

Chuang, W-J., 2009 Oct 13, Patent No. 291711

Research output: Patent

Disintegrins
Integrins
Pharmaceutical Preparations
Peptides

DISINTEGRIN VARIANTS AND PHARMACEUTICAL USES THEREOF

Chuang, W-J., 2009 Dec 2, Patent No. EP 2124548

Research output: Patent

Disintegrins
Integrins
Pharmaceutical Preparations
Peptides

DISINTEGRIN VARIANTS AND PHARMACEUTICAL USES THEREOF

Chuang, W-J., 2009 Jul 23, Patent No. 60/871,854

Research output: Patent

Disintegrins
Integrins
Pharmaceutical Preparations
Peptides
8 Citations (Scopus)
Integrins
Mutation
Platelets
Platelet Aggregation
Hydrogen
12 Citations (Scopus)

emm1/sequence type 28 strains of group A streptococci that express covR at early stationary phase are associated with increased growth and earlier speB secretion

Chiang-Ni, C., Zheng, P. X., Ho, Y. R., Wu, H. M., Chuang, W. J., Lin, Y. S., Lin, M. T., Liu, C. C. & Wu, J. J., 2009 Oct 1, In : Journal of Clinical Microbiology. 47, 10, p. 3161-3169 9 p.

Research output: Contribution to journalArticle

Streptococcus
Growth
Necrotizing Fasciitis
Multilocus Sequence Typing
Streptococcus pyogenes
17 Citations (Scopus)

Procaspase 8 and bax are up-regulated by distinct pathways in streptococcal pyrogenic exotoxin B-induced apoptosis

Chang, C. W., Tsai, W. H., Chuang, W-J., Lin, Y-S., Wu, J. J., Liu, C-C., Tsai, P-J. & Lin, M. T., 2009 Nov 27, In : Journal of Biological Chemistry. 284, 48, p. 33195-33205 11 p.

Research output: Contribution to journalArticle

Caspase 8
Small Interfering RNA
Phosphorylation
Apoptosis
Tyrosine
13 Citations (Scopus)

Solution structure and backbone dynamics of streptopain: Insight into diverse substrate specificity

Wang, C. C., Houng, H. C., Chen, C. L., Wang, P. J., Kuo, C. F., Lin, Y-S., Wu, J. J., Lin, M. T., Liu, C-C., Huang, W-Y. & Chuang, W-J., 2009 Apr 17, In : Journal of Biological Chemistry. 284, 16, p. 10957-10967 11 p.

Research output: Contribution to journalArticle

streptopain
Substrate Specificity
Substrates
X-Rays
X rays
4 Citations (Scopus)

The IL-8 production by streptococcal pyrogenic exotoxin B

Chang, C. W., Wu, S. Y., Chuang, W-J., Lin, Y-S., Wu, S. Y., Liu, C-C., Tsai, P-J. & Lin, M. T., 2009 Nov 1, In : Experimental Biology and Medicine. 234, 11, p. 1316-1326 11 p.

Research output: Contribution to journalArticle

Caspase 8
Interleukin-8
Chemical activation
CD95 Antigens
Phosphorylation