• 1728 Citations
  • 25 h-Index
1988 …2020

Research output per year

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Research Output

2019

A novel αiIbβ3 antagonist from snake venom prevents thrombosis without causing bleeding

Kuo, Y. J., Chung, C. H., Pan, T. Y., Chuang, W. J. & Huang, T. F., 2019 Dec 21, In : Toxins. 12, 1, 11.

Research output: Contribution to journalArticle

Open Access
2017

Effects of the RGD loop and C-terminus of rhodostomin on regulating integrin αIIbβ3 recognition

Chang, Y. T., Shiu, J. H., Huang, C. H., Chen, Y. C., Chen, C. Y., Chang, Y. S. & Chuang, W. J., 2017 Apr, In : PloS one. 12, 4, e0175321.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Inhibition of osteoporosis by the αvβ3 integrin antagonist of rhodostomin variants

Lin, T. H., Yang, R. S., Tu, H. J., Liou, H. C., Lin, Y. M., Chuang, W-J. & Fu, W. M., 2017 Jan 1, In : European Journal of Pharmacology. 804, p. 94-101 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016
3 Citations (Scopus)

Improved antithrombotic activity and diminished bleeding side effect of a PEGylated αiIbβ3 antagonist, disintegrin

Hsu, C. C., Chuang, W. J., Chung, C. H., Chang, C. H., Peng, H. C. & Huang, T. F., 2016 Jul 1, In : Thrombosis Research. 143, p. 3-10 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Snake Venom Disintegrin Inhibits the Activation of Toll-Like Receptors and Alleviates Sepsis through Integrin alphaVbeta3 Blockade

Hsu, C. C., Chuang, W. J., Chung, C. H., Chang, C. H., Peng, H. C. & Huang, T. F., 2016 Mar 18, In : Scientific reports. 6, 23387.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Streptococcal pyrogenic exotoxin B inhibits apoptotic cell clearance by macrophages through protein S cleavage

Chen, C. L., Wu, Y. Y., Lin, C. F., Kuo, C. F., Han, C. L., Wang, S., Chuang, W. J., Chen, C. Y., Wu, J. J., Tsai, P. J., Liu, C. C. & Lin, Y. S., 2016 May 16, In : Scientific reports. 6, 26026.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2015

Clustered regularly interspaced short palindromic repeats are emm type-specific in highly prevalent group A streptococci

Zheng, P. X., Chan, Y. C., Chiou, C. S., Chiang-Ni, C., Wang, S. Y., Tsai, P. J., Chuang, W. J., Lin, Y. S., Liu, C. C. & Wu, J. J., 2015 Dec 1, In : PloS one. 10, 12, e0145223.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Role of spinal CXCL1 (GROα) in opioid tolerance a human-to-rodent translational study

Lin, C. P., Kang, K. H., Lin, T. H., Wu, M. Y., Liou, H. C., Chuang, W. J., Sun, W. Z. & Fu, W. M., 2015 Mar 4, In : Anesthesiology. 122, 3, p. 666-676 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2014
4 Citations (Scopus)

Distinct structural features of the peroxide response regulator from group A streptococcus drive DNA binding

Lin, C. S. H., Chao, S. Y., Hammel, M., Nix, J. C., Tseng, H. L., Tsou, C. C., Fei, C. H., Chiou, H. S., Jeng, U. S., Lin, Y. S., Chuang, W. J., Wu, J. J. & Wang, S., 2014 Feb 21, In : PloS one. 9, 2, e89027.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Invasive hypermucoid variant of group A Streptococcus is defective in growth and susceptible to DNA-damaging treatments

Chiang-Ni, C., Zheng, P. X., Wang, S-Y., Tsai, P-J., Kuo, C. F., Chuang, W-J., Lin, Y-S., Liu, C-C. & Wu, J. J., 2014 Jan 1, In : Pathogens and Disease. 70, 2, p. 194-201 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Type i and II β-turns prediction using NMR chemical shifts

Wang, C. C., Lai, W. C. & Chuang, W. J., 2014 Jul, In : Journal of Biomolecular NMR. 59, 3, p. 175-184 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

人類纖維黏蛋白變異體及其醫藥用途

Chuang, W-J., 2014 Apr 1, Patent No. I580692

Research output: Patent

2013
13 Citations (Scopus)

DISINTEGRIN VARIANTS AND PHARMACEUTICAL USES THEREOF

Chuang, W-J., 2013 Mar 28, Patent No. HK1136160

Research output: Patent

Kallistatin modulates immune cells and confers anti-inflammatory response to protect mice from group a streptococcal infection

Lu, S. L., Tsai, C. Y., Luo, Y. H., Kuo, C. F., Lin, W. C., Chang, Y. T., Wu, J. J., Chuang, W. J., Liu, C. C., Chao, L., Chao, J. & Lin, Y. S., 2013 Nov 1, In : Antimicrobial agents and chemotherapy. 57, 11, p. 5366-5372 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Peroxide responsive regulator PerR of group A streptococcus is required for the expression of phage-associated DNase Sda1 under oxidative stress

Wang, C. H., Chiang-Ni, C., Kuo, H. T., Zheng, P. X., Tsou, C. C., Wang, S., Tsai, P. J., Chuang, W. J., Lin, Y. S., Liu, C. C. & Wu, J. J., 2013 Dec 3, In : PloS one. 8, 12, e81882.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Streptopain

Chuang, W. J., Lin, Y. S., Wu, J. J., Liu, C. C. & Lin, M. T., 2013 Aug 29, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 2. p. 2142-2150 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Upregulation of drug transporter expression by osteopontin in prostate cancer cellss

Hsieh, I. S., Huang, W. H., Liou, H. C., Chuang, W-J., Yang, R. S. & Fu, W. M., 2013 May 1, In : Molecular Pharmacology. 83, 5, p. 968-977 10 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Zinc-dependent interaction between JAB1 and Pre-S2 mutant large surface antigen of hepatitis B virus and its implications for viral hepatocarcinogenesis

Hsu, J. L., Chuang, W. J., Su, I. J., Gui, W. J., Chang, Y. Y., Lee, Y. P., Ai, Y. L., Chuang, D. T. & Huang, W., 2013 Dec 1, In : Journal of Virology. 87, 23, p. 12675-12684 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2012

Disintegrin variants and pharmaceutical uses thereof

Chuang, W-J., 2012 Mar 30, Patent No. 577998

Research output: Patent

Disintegrin variants and pharmaceutical uses thereof

Chuang, W-J., 2012 Mar 30, Patent No. 598176

Research output: Patent

Dynamics and functional differences between dendroaspin and rhodostomin: Insights into protein scaffolds in integrin recognition

Cheng, C. H., Chen, Y. C., Shiu, J. H., Chang, Y. T., Chang, Y. S., Huang, C. H., Chen, C. Y. & Chuang, W. J., 2012 Dec 1, In : Protein Science. 21, 12, p. 1872-1884 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Effect of p to a mutation of the n-terminal residue adjacent to the rgd motif on rhodostomin: Importance of dynamics in integrin recognition

Shiu, J. H., Chen, C. Y., Chen, Y. C., Chang, Y. T., Chang, Y. S., Huang, C. H. & Chuang, W. J., 2012 Jan 4, In : PloS one. 7, 1, e28833.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Environmental pH changes, but not the LuxS signalling pathway, regulate SpeB expression in M1 group A streptococci

Chiang-Ni, C., Zheng, P. X., Tsai, P. J., Chuang, W. J., Lin, Y. S., Liu, C. C. & Wu, J. J., 2012 Jan 1, In : Journal of Medical Microbiology. 61, 1, p. 16-22 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Expression in Pichia pastoris and characterization of echistatin, an RGD-containing short disintegrin

Chen, Y. C., Cheng, C. H., Shiu, J. H., Chang, Y. T., Chang, Y. S., Huang, C. H., Lee, J. C. & Chuang, W. J., 2012 Dec 5, In : Toxicon. 60, 8, p. 1342-1348 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Recombinant Expression of Margatoxin and Agitoxin-2 in Pichia pastoris: An Efficient Method for Production of KV1.3 Channel Blockers

Anangi, R., Koshy, S., Huq, R., Beeton, C., Chuang, W. J. & King, G. F., 2012 Dec 29, In : PloS one. 7, 12, e52965.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2011

Disintegrin variants and pharmaceutical uses thereof

Chuang, W-J., 2011 Feb 10, Patent No. 2477727

Research output: Patent

Emergence of uncommon emm types of Streptococcus pyogenes among adult patients in southern Taiwan

Chiang-Ni, C., Wu, A. B., Liu, C. C., Chen, K. T., Lin, Y. S., Chuang, W. J., Fang, H. Y. & Wu, J. J., 2011 Dec 1, In : Journal of Microbiology, Immunology and Infection. 44, 6, p. 424-429 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Epitope mapping and structural analysis of the anti-Der p 1 monoclonal antibody: Insight into therapeutic potential

Dai, Y. C., Chuang, W-J., Chua, K. Y., Shieh, C-C. & Wang, J-Y., 2011 Jul 1, In : Journal of Molecular Medicine. 89, 7, p. 701-712 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Improvements in endotoxemic syndromes using a disintegrin, rhodostomin, through integrin αvβ3-dependent pathway

Hsu, C. C., Chuang, W-J., Chang, C. H., Tseng, Y. L., Peng, H. C. & Huang, T. F., 2011 Mar 1, In : Journal of Thrombosis and Haemostasis. 9, 3, p. 593-602 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: Insight into its domain swapping and DNA binding

Chu, Y. P., Chang, C. H., Shiu, J. H., Chang, Y. T., Chen, C. Y. & Chuang, W. J., 2011 May 1, In : Protein Science. 20, 5, p. 908-924 17 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The deficient cleavage of M protein-bound IgG by IdeS: Insight into the escape of Streptococcus pyogenes from antibody-mediated immunity

Su, Y. F., Chuang, W. J., Wang, S. M., Chen, W. Y., Chiang-Ni, C., Lin, Y. S., Wu, J. J. & Liu, C. C., 2011 Oct 1, In : Molecular Immunology. 49, 1-2, p. 134-142 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2010

Agaricus blazei Murill ameliorates myocardial ischemia-reperfusion injury

Huang, C. H., Tsai, H. N., Peng, R. H., Hsieh, Y. H., Chuang, W-J., Hsu, G. C., Huang, W-Y. & Chen, W. J., 2010 Dec 1, In : Acta Cardiologica Sinica. 26, 4, p. 235-241 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Expression in Pichia pastoris and characterization of APETx2, a specific inhibitor of acid sensing ion channel 3

Anangi, R., Chen, C. C., Lin, Y. W., Cheng, Y. R., Cheng, C. H., Chen, Y. C., Chu, Y. P. & Chuang, W. J., 2010 Dec 1, In : Toxicon. 56, 8, p. 1388-1397 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Molecular mimicry between streptococcal pyrogenic exotoxin B and endothelial cells

Luo, Y. H., Chuang, W. J., Wu, J. J., Lin, M. T., Liu, C. C., Lin, P. Y., Roan, J. N., Wong, T. W., Chen, Y. L. & Lin, Y. S., 2010 Oct 1, In : Laboratory Investigation. 90, 10, p. 1492-1506 15 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Oxidative stress and metal ions regulate a ferritin-like gene, dpr, in Streptococcus pyogenes

Tsou, C. C., Chiang-Ni, C., Lin, Y. S., Chuang, W. J., Lin, M. T., Liu, C. C. & Wu, J. J., 2010 Apr 1, In : International Journal of Medical Microbiology. 300, 4, p. 259-264 6 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2009
12 Citations (Scopus)

Disintegrin variants and pharmaceutical uses thereof

Chuang, W-J., 2009 Jul 29, Patent No. 153383

Research output: Patent

Disintegrin variants and pharmaceutical uses thereof

Chuang, W-J., 2009 Oct 13, Patent No. 291711

Research output: Patent

DISINTEGRIN VARIANTS AND PHARMACEUTICAL USES THEREOF

Chuang, W-J., 2009 Jul 23, Patent No. 60/871,854

Research output: Patent

DISINTEGRIN VARIANTS AND PHARMACEUTICAL USES THEREOF

Chuang, W-J., 2009 Dec 2, Patent No. EP 2124548

Research output: Patent

8 Citations (Scopus)

emm1/sequence type 28 strains of group A streptococci that express covR at early stationary phase are associated with increased growth and earlier speB secretion

Chiang-Ni, C., Zheng, P. X., Ho, Y. R., Wu, H. M., Chuang, W. J., Lin, Y. S., Lin, M. T., Liu, C. C. & Wu, J. J., 2009 Oct 1, In : Journal of Clinical Microbiology. 47, 10, p. 3161-3169 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Procaspase 8 and bax are up-regulated by distinct pathways in streptococcal pyrogenic exotoxin B-induced apoptosis

Chang, C. W., Tsai, W. H., Chuang, W. J., Lin, Y. S., Wu, J. J., Liu, C. C., Tsai, P. J. & Lin, M. T., 2009 Nov 27, In : Journal of Biological Chemistry. 284, 48, p. 33195-33205 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Solution structure and backbone dynamics of streptopain: Insight into diverse substrate specificity

Wang, C. C., Houng, H. C., Chen, C. L., Wang, P. J., Kuo, C. F., Lin, Y. S., Wu, J. J., Lin, M. T., Liu, C. C., Huang, W. & Chuang, W. J., 2009 Apr 17, In : Journal of Biological Chemistry. 284, 16, p. 10957-10967 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)