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1988 …2020
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Research Output 1988 2017

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16 Citations (Scopus)

2DCSi: Identification of protein secondary structure and redox state using 2D cluster analysis of NMR chemical shifts

Wang, C. C., Chen, J. H., Lai, W. C. & Chuang, W. J., 2007 May 1, In : Journal of Biomolecular NMR. 38, 1, p. 57-63 7 p.

Research output: Contribution to journalArticle

Secondary Protein Structure
Cluster analysis
Chemical shift
Oxidation-Reduction
Cluster Analysis
14 Citations (Scopus)

Abrogation of streptococcal pyrogenic exotoxin B-mediated suppression of phagocytosis in U937 cells by Cordyceps sinensis mycelium via production of cytokines

Kuo, C. F., Chen, C. C., Lin, C. F., Jan, M. S., Huang, R. Y., Luo, Y. H., Chuang, W. J., Sheu, C. C. & Lin, Y. S., 2007 Feb 1, In : Food and Chemical Toxicology. 45, 2, p. 278-285 8 p.

Research output: Contribution to journalArticle

Cordyceps
Ophiocordyceps sinensis
exotoxins
U937 Cells
Mycelium
4 Citations (Scopus)

Agaricus blazei Murill ameliorates myocardial ischemia-reperfusion injury

Huang, C. H., Tsai, H. N., Peng, R. H., Hsieh, Y. H., Chuang, W-J., Hsu, G. C., Huang, W-Y. & Chen, W. J., 2010 Dec 1, In : Acta Cardiologica Sinica. 26, 4, p. 235-241 7 p.

Research output: Contribution to journalArticle

Agaricus
Myocardial Reperfusion Injury
Reperfusion Injury
Myocardial Ischemia
Myocardial Reperfusion
32 Citations (Scopus)

An iron-binding protein, Dpr, decreases hydrogen peroxide stress and protects Streptococcus pyogenes against multiple stresses

Tsou, C. C., Chiang-Ni, C., Lin, Y. S., Chuang, W. J., Lin, M. T., Liu, C. C. & Wu, J. J., 2008 Sep 1, In : Infection and Immunity. 76, 9, p. 4038-4045 8 p.

Research output: Contribution to journalArticle

Iron-Binding Proteins
Streptococcus pyogenes
Hydrogen Peroxide
Iron
Peroxides
3 Citations (Scopus)
Clustered Regularly Interspaced Short Palindromic Repeats
Erythromycin
Streptococcus
Nucleic Acids
Streptococcus pyogenes
12 Citations (Scopus)
Streptococcus pyogenes
Taiwan
Epidemiology
Scarlet Fever
Pharyngitis
1 Citation (Scopus)

Clustered regularly interspaced short palindromic repeats are emm type-specific in highly prevalent group A streptococci

Zheng, P. X., Chan, Y. C., Chiou, C. S., Chiang-Ni, C., Wang, S. Y., Tsai, P. J., Chuang, W. J., Lin, Y. S., Liu, C. C. & Wu, J. J., 2015 Dec 1, In : PloS one. 10, 12, e0145223.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Streptococcus
molecular epidemiology
loci
nucleic acids
30 Citations (Scopus)

Coiled Coil Region of Streptokinase γ-Domain Is Essential for Plasminogen Activation

Wu, D. H., Shi, G. Y., Chuang, W. J., Hsu, J. M., Young, K. C., Chang, C. W. & Wu, H. L., 2001 May 4, In : Journal of Biological Chemistry. 276, 18, p. 15025-15033 9 p.

Research output: Contribution to journalArticle

Streptokinase
Plasminogen
Chemical activation
Amino Acids
Enzyme Induction
2 Citations (Scopus)

Comparison of the binding character of triflavin on resting and activated αIIbβ3 integrin in human platelets by electron microscopy

Chuang, W-J., Wu, C. H., Huang, H. N., Chen, S. H., Hsiao, G., Lin, C. H. & Sheu, J. R., 2003 Jan 1, In : Thrombosis Research. 109, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

Integrins
Electron Microscopy
Blood Platelets
Disintegrins
triflavin
12 Citations (Scopus)
Necrotizing Fasciitis
Streptococcus pyogenes
Pandemics
Genome
31 Citations (Scopus)

Cordyceps sinensis and its fractions stimulate MA-10 mouse leydig tumor cell steroidogenesis

Huang, B. M., Ju, S. Y., Wu, C. S., Chuang, W. J., Sheu, C. C. & Leu, S. F., 2001 Jan 1, In : Journal of Andrology. 22, 5, p. 831-837 7 p.

Research output: Contribution to journalArticle

Cordyceps
Leydig Cell Tumor
Chorionic Gonadotropin
Progesterone
Polysaccharides
30 Citations (Scopus)

Cordyceps sinensis mycelium protects mice from group A streptococcal infection

Kuo, C. F., Chen, C. C., Luo, Y. H., Huang, R. Y., Chuang, W. J., Sheu, C. C. & Lin, Y. S., 2005 Aug 1, In : Journal of Medical Microbiology. 54, 8, p. 795-802 8 p.

Research output: Contribution to journalArticle

Cordyceps
Streptococcal Infections
Mycelium
Streptococcus
Infection
45 Citations (Scopus)

Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins

Tsai, K. L., Huang, C. Y., Chang, C. H., Sun, Y. J., Chuang, W. J. & Hsiao, C. D., 2006 Jun 23, In : Journal of Biological Chemistry. 281, 25, p. 17400-17409 10 p.

Research output: Contribution to journalArticle

Forkhead Transcription Factors
Crystal structure
DNA
Deltaretrovirus
Electrophoretic mobility
30 Citations (Scopus)

Degradation of complement 3 by streptococcal pyrogenic exotoxin B inhibits complement activation and neutrophil opsonophagocytosis

Kuo, C. F., Lin, Y. S., Chuang, W. J., Wu, J. J. & Tsao, N., 2008 Mar 1, In : Infection and Immunity. 76, 3, p. 1163-1169 7 p.

Research output: Contribution to journalArticle

Complement C3
Complement Activation
Neutrophils
Serum
Zymosan
9 Citations (Scopus)

Distinct structural features of the peroxide response regulator from group A streptococcus drive DNA binding

Lin, C. S. H., Chao, S. Y., Hammel, M., Nix, J. C., Tseng, H. L., Tsou, C. C., Fei, C. H., Chiou, H. S., Jeng, U. S., Lin, Y. S., Chuang, W. J., Wu, J. J. & Wang, S., 2014 Feb 21, In : PloS one. 9, 2, e89027.

Research output: Contribution to journalArticle

Streptococcus
Peroxides
peroxides
DNA
X ray scattering
4 Citations (Scopus)

Dye-induced denaturation of DNA dissolved in water

Shieh, B., Su, I. J., Chuang, W-J. & Li, C., 1998 Mar 2, In : BioTechniques. 24, 1, p. 60-64 5 p.

Research output: Contribution to journalArticle

Denaturation
Polymerase chain reaction
Coloring Agents
Water
DNA
3 Citations (Scopus)

Dynamics and functional differences between dendroaspin and rhodostomin: Insights into protein scaffolds in integrin recognition

Cheng, C. H., Chen, Y. C., Shiu, J. H., Chang, Y. T., Chang, Y. S., Huang, C. H., Chen, C. Y. & Chuang, W. J., 2012 Dec 1, In : Protein Science. 21, 12, p. 1872-1884 13 p.

Research output: Contribution to journalArticle

Scaffolds
Integrins
Proteins
mambin
rhodostomin
8 Citations (Scopus)
Integrins
Mutation
Platelets
Platelet Aggregation
Hydrogen
9 Citations (Scopus)

Effect of p to a mutation of the n-terminal residue adjacent to the rgd motif on rhodostomin: Importance of dynamics in integrin recognition

Shiu, J. H., Chen, C. Y., Chen, Y. C., Chang, Y. T., Chang, Y. S., Huang, C. H. & Chuang, W. J., 2012 Jan 4, In : PloS one. 7, 1, e28833.

Research output: Contribution to journalArticle

integrins
Integrins
mutation
mutants
Mutation
36 Citations (Scopus)

Effects of oligopeptide permease in group A streptococcal infection

Wang, C. H., Lin, C. Y., Luo, Y. H., Tsai, P-J., Lin, Y-S., Lin, M. T., Chuang, W-J., Liu, C-C. & Wu, J. J., 2005 May 1, In : Infection and Immunity. 73, 5, p. 2881-2890 10 p.

Research output: Contribution to journalArticle

Streptococcal Infections
Streptococcus
Operon
ATP-Binding Cassette Transporters
Membrane Transport Proteins
2 Citations (Scopus)

Effects of the RGD loop and C-terminus of rhodostomin on regulating integrin αIIbβ3 recognition

Chang, Y. T., Shiu, J. H., Huang, C. H., Chen, Y. C., Chen, C. Y., Chang, Y. S. & Chuang, W. J., 2017 Apr, In : PloS one. 12, 4, e0175321.

Research output: Contribution to journalArticle

integrins
Integrins
Platelets
Disintegrins
mutants
14 Citations (Scopus)

Emergence of uncommon emm types of Streptococcus pyogenes among adult patients in southern Taiwan

Chiang-Ni, C., Wu, A. B., Liu, C. C., Chen, K. T., Lin, Y. S., Chuang, W. J., Fang, H. Y. & Wu, J. J., 2011 Dec 1, In : Journal of Microbiology, Immunology and Infection. 44, 6, p. 424-429 6 p.

Research output: Contribution to journalArticle

Streptococcus pyogenes
Taiwan
Cellulitis
Infection
Population
14 Citations (Scopus)

emm1/sequence type 28 strains of group A streptococci that express covR at early stationary phase are associated with increased growth and earlier speB secretion

Chiang-Ni, C., Zheng, P. X., Ho, Y. R., Wu, H. M., Chuang, W. J., Lin, Y. S., Lin, M. T., Liu, C. C. & Wu, J. J., 2009 Oct 1, In : Journal of Clinical Microbiology. 47, 10, p. 3161-3169 9 p.

Research output: Contribution to journalArticle

Streptococcus
Growth
Necrotizing Fasciitis
Multilocus Sequence Typing
Streptococcus pyogenes
9 Citations (Scopus)

Environmental pH changes, but not the LuxS signalling pathway, regulate SpeB expression in M1 group A streptococci

Chiang-Ni, C., Zheng, P. X., Tsai, P-J., Chuang, W-J., Lin, Y-S., Liu, C-C. & Wu, J. J., 2012 Jan 1, In : Journal of Medical Microbiology. 61, 1, p. 16-22 7 p.

Research output: Contribution to journalArticle

Streptococcus
Quorum Sensing
Cysteine Proteases
Virulence Factors
Mutation
2 Citations (Scopus)
Streptococcus pyogenes
Streptococcus
Taiwan
Epidemiology
Molecular Typing
7 Citations (Scopus)

Epitope mapping and structural analysis of the anti-Der p 1 monoclonal antibody: Insight into therapeutic potential

Dai, Y. C., Chuang, W-J., Chua, K. Y., Shieh, C-C. & Wang, J-Y., 2011 Jul 1, In : Journal of Molecular Medicine. 89, 7, p. 701-712 12 p.

Research output: Contribution to journalArticle

Epitope Mapping
Monoclonal Antibodies
Cysteine Proteases
Allergens
Immunoglobulin E
29 Citations (Scopus)
Cytochromes c
Escherichia coli
Horses
Hemeproteins
Oxidation-Reduction
13 Citations (Scopus)

Expression in Pichia pastoris and characterization of APETx2, a specific inhibitor of acid sensing ion channel 3

Anangi, R., Chen, C. C., Lin, Y. W., Cheng, Y. R., Cheng, C. H., Chen, Y. C., Chu, Y. P. & Chuang, W. J., 2010 Dec 1, In : Toxicon. 56, 8, p. 1388-1397 10 p.

Research output: Contribution to journalArticle

Acid Sensing Ion Channel Blockers
Pichia
Acid Sensing Ion Channels
Nuclear magnetic resonance
Neurology
6 Citations (Scopus)

Expression in Pichia pastoris and characterization of echistatin, an RGD-containing short disintegrin

Chen, Y. C., Cheng, C. H., Shiu, J. H., Chang, Y. T., Chang, Y. S., Huang, C. H., Lee, J. C. & Chuang, W. J., 2012 Dec 5, In : Toxicon. 60, 8, p. 1342-1348 7 p.

Research output: Contribution to journalArticle

Disintegrins
Pichia
Integrins
Platelets
Platelet Aggregation
5 Citations (Scopus)

Group A streptococcal infection caused by emm1 strains among children in southern Taiwan

Lin, H. C., Wang, S-M., Lin, Y. L., Lin, Y-S., Wu, J. J., Chuang, W-J., Lin, M. T. & Liu, C-C., 2008 Dec 1, In : European Journal of Clinical Microbiology and Infectious Diseases. 27, 12, p. 1253-1256 4 p.

Research output: Contribution to journalArticle

Streptococcal Infections
Streptococcus
Taiwan
Molecular Epidemiology
Erythromycin
10 Citations (Scopus)

HHR23A, a human homolog of Saccharomyces cerevisiae Rad23, regulates xeroderma pigmentosum C protein and is required for nucleotide excision repair

Hsieh, H. C., Hsieh, Y. H., Huang, Y. H., Shen, F. C., Tsai, H. N., Tsai, J. H., Lai, Y. T., Wang, Y. T., Chuang, W-J. & Huang, W-Y., 2005 Sep 16, In : Biochemical and Biophysical Research Communications. 335, 1, p. 181-187 7 p.

Research output: Contribution to journalArticle

Xeroderma Pigmentosum
Protein C
DNA Repair
Yeast
Saccharomyces cerevisiae
25 Citations (Scopus)

Histopathologic changes in kidney and liver correlate with streptococcal pyrogenic exotoxin B production in the mouse model of group A streptococcal infection

Kuo, C. F., Luo, Y. H., Lin, H. Y., Huang, K. J., Wu, J. J., Lei, H. Y., Lin, M. T., Chuang, W-J., Liu, C-C., Jin, Y. T. & Lin, Y-S., 2004 May 1, In : Microbial Pathogenesis. 36, 5, p. 273-285 13 p.

Research output: Contribution to journalArticle

Streptococcal Infections
Kidney
Bacteremia
Liver
Streptococcus pyogenes
3 Citations (Scopus)

Improved antithrombotic activity and diminished bleeding side effect of a PEGylated αiIbβ3 antagonist, disintegrin

Hsu, C. C., Chuang, W. J., Chung, C. H., Chang, C. H., Peng, H. C. & Huang, T. F., 2016 Jul 1, In : Thrombosis Research. 143, p. 3-10 8 p.

Research output: Contribution to journalArticle

Disintegrins
Hemorrhage
Half-Life
Platelet Aggregation
rhodostomin
12 Citations (Scopus)

Improvements in endotoxemic syndromes using a disintegrin, rhodostomin, through integrin αvβ3-dependent pathway

Hsu, C. C., Chuang, W-J., Chang, C. H., Tseng, Y. L., Peng, H. C. & Huang, T. F., 2011 Mar 1, In : Journal of Thrombosis and Haemostasis. 9, 3, p. 593-602 10 p.

Research output: Contribution to journalArticle

Disintegrins
Integrins
Lipopolysaccharides
Phagocytes
Monocytes
18 Citations (Scopus)

Inhibition of adipogenesis by RGD-dependent disintegrin

Lin, Y. T., Tang, C. H., Chuang, W. J., Wang, S. M., Huang, T. F. & Fu, W. M., 2005 Nov 15, In : Biochemical Pharmacology. 70, 10, p. 1469-1478 10 p.

Research output: Contribution to journalArticle

Disintegrins
Adipogenesis
Adipocytes
Focal Adhesion Protein-Tyrosine Kinases
Adhesion
54 Citations (Scopus)

Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST

Lu, T. J., Lai, W. Y., Huang, C. Y. F., Hsieh, W. J., Yu, J. S., Hsieh, Y. J., Chang, W. T., Leu, T. H., Chang, W. C., Chuang, W. J., Tang, M. J., Chen, T. Y., Lu, T. L. & Lai, M. D., 2006 Dec 15, In : Journal of Biological Chemistry. 281, 50, p. 38405-38417 13 p.

Research output: Contribution to journalArticle

Cell Migration Inhibition
Paxillin
Protein Tyrosine Phosphatases
Tyrosine
Phosphorylation
5 Citations (Scopus)

Inhibition of osteoporosis by the αvβ3 integrin antagonist of rhodostomin variants

Lin, T. H., Yang, R. S., Tu, H. J., Liou, H. C., Lin, Y. M., Chuang, W-J. & Fu, W. M., 2017 Jan 1, In : European Journal of Pharmacology. 804, p. 94-101 8 p.

Research output: Contribution to journalArticle

Osteoclasts
Integrins
Osteoporosis
Bone Resorption
Osteogenesis
59 Citations (Scopus)

Inhibition of tumor formation by snake venom disintegrin

Yang, R. S., Tang, C. H., Chuang, W-J., Huang, T-H., Peng, H. C., Huang, T. F. & Fu, W. M., 2005 Jan 1, In : Toxicon. 45, 5, p. 661-669 9 p.

Research output: Contribution to journalArticle

Disintegrins
Snake Venoms
Tumors
Cells
Bone
49 Citations (Scopus)

Interaction of streptokinase and plasminogen: Studied with truncated streptokinase peptides

Young, K-C., Shi, G. Y., Chang, Y. F., Chang, B. I., Chang, L. C., Lai, M-D., Chuang, W-J. & Wu, H-L., 1995 Jan 1, In : Journal of Biological Chemistry. 270, 49, p. 29601-29606 6 p.

Research output: Contribution to journalArticle

Streptokinase
Plasminogen
Peptides
Fibrinolysin
Enzymes
5 Citations (Scopus)

Invasive hypermucoid variant of group A Streptococcus is defective in growth and susceptible to DNA-damaging treatments

Chiang-Ni, C., Zheng, P. X., Wang, S-Y., Tsai, P-J., Kuo, C. F., Chuang, W-J., Lin, Y-S., Liu, C-C. & Wu, J. J., 2014 Jan 1, In : Pathogens and Disease. 70, 2, p. 194-201 8 p.

Research output: Contribution to journalArticle

Streptococcus
Capsules
DNA
Growth
Virulence
24 Citations (Scopus)

Kallistatin modulates immune cells and confers anti-inflammatory response to protect mice from group a streptococcal infection

Lu, S. L., Tsai, C. Y., Luo, Y. H., Kuo, C. F., Lin, W. C., Chang, Y. T., Wu, J. J., Chuang, W. J., Liu, C. C., Chao, L., Chao, J. & Lin, Y. S., 2013 Nov 1, In : Antimicrobial agents and chemotherapy. 57, 11, p. 5366-5372 7 p.

Research output: Contribution to journalArticle

Streptococcal Infections
Anti-Inflammatory Agents
Streptococcus
Infection
kallistatin
10 Citations (Scopus)

Kinetic and structural studies of N-acetyl-microperoxidase-5 and - microperoxidase-8

Chuang, W-J., Chang, Y. D. & Jeng, W-Y., 1999 Jun 15, In : Journal of Inorganic Biochemistry. 75, 2, p. 93-97 5 p.

Research output: Contribution to journalArticle

Kinetics
Porphyrins
Circular Dichroism
microperoxidase
Peroxidase
1 Citation (Scopus)

Magnetic resonance studies of the binding of oligonucleotide substrates to mutants of staphylococcal nuclease

Chuang, W-J., Gittis, A. G. & Mildvan, A. S., 1994 Jan 1, In : Proteins: Structure, Function, and Bioinformatics. 18, 1, p. 68-80 13 p.

Research output: Contribution to journalArticle

Micrococcal Nuclease
Magnetic resonance
Oligonucleotides
Magnetic Resonance Spectroscopy
Mutation
49 Citations (Scopus)

Maturation processing and characterization of streptopain

Chen, C. Y., Luo, S. C., Kuo, C. F., Lin, Y. S., Wu, J. J., Lin, M. T., Liu, C. C., Jeng, W. Y. & Chuang, W. J., 2003 May 9, In : Journal of Biological Chemistry. 278, 19, p. 17336-17343 8 p.

Research output: Contribution to journalArticle

streptopain
Exotoxins
Enzyme Precursors
Processing
Cysteine Proteases
19 Citations (Scopus)

Molecular analysis of group A streptococcal isolates associated with scarlet fever in southern Taiwan between 1993 and 2002

Yan, J. J., Liu, C. C., Ko, W. C., Hsu, S. Y., Wu, H. M., Lin, Y. S., Lin, M. T., Chuang, W. J. & Wu, J. J., 2003 Oct 1, In : Journal of Clinical Microbiology. 41, 10, p. 4858-4861 4 p.

Research output: Contribution to journalArticle

Scarlet Fever
Pulsed Field Gel Electrophoresis
Streptococcus
Taiwan
Clone Cells
15 Citations (Scopus)

Molecular mimicry between streptococcal pyrogenic exotoxin B and endothelial cells

Luo, Y. H., Chuang, W. J., Wu, J. J., Lin, M. T., Liu, C. C., Lin, P. Y., Roan, J. N., Wong, T. W., Chen, Y. L. & Lin, Y. S., 2010 Oct 1, In : Laboratory Investigation. 90, 10, p. 1492-1506 15 p.

Research output: Contribution to journalArticle

Molecular Mimicry
B-Lymphocytes
Endothelial Cells
Monoclonal Antibodies
Bovine Serum Albumin
4 Citations (Scopus)

Mutational tests of the NMR‐docked structure of the staphylococcal nuclease–metal–3′,5′‐pdTp complex

Chuang, WJ. J., Weber, D. J., Gittis, A. G. & Mildvan, A. S., 1993 Sep, In : Proteins: Structure, Function, and Bioinformatics. 17, 1, p. 36-48 13 p.

Research output: Contribution to journalArticle

X-Rays
Micrococcal Nuclease
Enzymes
Mutation
4 alpha-glucanotransferase
20 Citations (Scopus)

Oxidative stress and metal ions regulate a ferritin-like gene, dpr, in Streptococcus pyogenes

Tsou, C. C., Chiang-Ni, C., Lin, Y. S., Chuang, W. J., Lin, M. T., Liu, C. C. & Wu, J. J., 2010 Apr 1, In : International Journal of Medical Microbiology. 300, 4, p. 259-264 6 p.

Research output: Contribution to journalArticle

Streptococcus pyogenes
Peroxides
Ferritins
Hydrogen Peroxide
Oxidative Stress
11 Citations (Scopus)

Peroxide responsive regulator PerR of group A streptococcus is required for the expression of phage-associated DNase Sda1 under oxidative stress

Wang, C. H., Chiang-Ni, C., Kuo, H. T., Zheng, P. X., Tsou, C. C., Wang, S., Tsai, P. J., Chuang, W. J., Lin, Y. S., Liu, C. C. & Wu, J. J., 2013 Dec 3, In : PloS one. 8, 12, e81882.

Research output: Contribution to journalArticle

deoxyribonucleases
Bacteriophages
Oxidative stress
Deoxyribonucleases
Streptococcus
6 Citations (Scopus)

Perturbation of platelet adhesion to endothelial cells by plasminogen activation in vitro

Chen, H. I., Wu, Y. I., Hsieh, Y. L., Shi, G. Y., Jiang, M. J., Chang, W. C., Chuang, W. J., Kan, W. M., Tang, M. J. & Jen, C. J., 1997 Aug 1, In : Thrombosis and Haemostasis. 78, 2, p. 934-938 5 p.

Research output: Contribution to journalArticle

Plasminogen
Plasminogen Activators
Blood Platelets
Endothelial Cells
Extracellular Matrix