Yang-Gao Wang

2019

Simple in-house fabrication of microwells for generating uniform hepatic multicellular cancer aggregates and discovering novel therapeutics

Chiu, C. Y., Chen, Y. C., Wu, K. W., Hsu, W. C., Lin, H. P., Chang, H. C., Lee, Y. C., Wang, Y. K. & Tu, T. Y., 2019 Oct 1, In : Materials. 12, 20, 3308.

Research output: Contribution to journal › Article

Open Access

Fabrication

Cells

Cell culture

Liver

Oncology

2018

10 Citations (Scopus)

Caveolin-1 Controls Hyperresponsiveness to Mechanical Stimuli and Fibrogenesis-Associated RUNX2 Activation in Keloid Fibroblasts

Hsu, C. K., Lin, H. H., Harn, H. I., Ogawa, R., Wang, Y. K., Ho, Y. T., Chen, W. R., Lee, Y. C., Lee, J. Y. Y., Shieh, S. J., Cheng, C. M., McGrath, J. A. & Tang, M. J., 2018 Jan, In : Journal of Investigative Dermatology. 138, 1, p. 208-218 11 p.

Research output: Contribution to journal › Article

Caveolin 1

Keloid

Fibroblasts

Chemical activation

trichostatin A

5 Citations (Scopus)

Coincidence Detection of Membrane Stretch and Extracellular pH by the Proton-Sensing Receptor OGR1 (GPR68)

Wei, W. C., Bianchi, F., Wang, Y. K., Tang, M. J., Ye, H. & Glitsch, M. D., 2018 Dec 3, In : Current Biology. 28, 23, p. 3815-3823.e4

Research output: Contribution to journal › Article

protons

Protons

Membranes

receptors

Acidification

6 Citations (Scopus)

Lis1 dysfunction leads to traction force reduction and cytoskeletal disorganization during cell migration

Jheng, G. W., Hur, S. S., Chang, C. M., Wu, C. C., Cheng, J. S., Lee, H. H., Chung, B. C., Wang, Y. K., Lin, K. H., del Álamo, J. C., Chien, S. & Tsai, J. W., 2018 Mar 11, In : Biochemical and Biophysical Research Communications. 497, 3, p. 869-875 7 p.

Research output: Contribution to journal › Article

Traction

Cell Movement

Adhesion

Cell adhesion

Fibroblasts

Midazolam inhibits chondrogenesis via peripheral benzodiazepine receptor in human mesenchymal stem cells

Chen, Y. C., Wu, K. C., Huang, B. M., So, E. C. & Wang, Y. K., 2018 May, In : Journal of Cellular and Molecular Medicine. 22, 5, p. 2896-2907 12 p.

Research output: Contribution to journal › Article

Chondrogenesis

Midazolam

GABA-A Receptors

Mesenchymal Stromal Cells

Osteogenesis

2017

3 Citations (Scopus)

An Effective Cell Coculture Platform Based on the Electrospun Microtube Array Membrane for Nerve Regeneration

Tseng, V. C. H., Chew, C. H., Huang, W. T., Wang, Y. K., Chen, K. S., Chou, S. Y. & Chen, C. C., 2017 Oct 1, In : Cells Tissues Organs. 204, 3-4, p. 179-190 12 p.

Research output: Contribution to journal › Article

Nerve Regeneration

Coculture Techniques

Membranes

Neural Stem Cells

Astrocytes

10 Citations (Scopus)

Fibronectin in cell adhesion and migration via N-glycosylation

Hsiao, C. T., Cheng, H. W., Huang, C. M., Li, H. R., Ou, M. H., Huang, J. R., Khoo, K. H., Yu, H. W., Chen, Y. Q., Wang, Y. K., Chiou, A. & Kuo, J. C., 2017 Jan 1, In : Oncotarget. 8, 41, p. 70653-70668 16 p.

Research output: Contribution to journal › Article

Glycosylation

Fibronectins

Cell Adhesion

Cell Movement

Swine

2016

10 Citations (Scopus)

CCL5/RANTES contributes to hypothalamic insulin signaling for systemic insulin responsiveness through CCR5

Chou, S. Y., Ajoy, R., Changou, C. A., Hsieh, Y. T., Wang, Y. K. & Hoffer, B., 2016 Nov 29, In : Scientific reports. 6, 37659.

Research output: Contribution to journal › Article

Chemokine CCL5

Insulin

Hypothalamus

Phosphorylation

CCR5 Receptors

7 Citations (Scopus)

DDR1 promotes E-cadherin stability via inhibition of integrin-β1-Src activation-mediated E-cadherin endocytosis

Chen, H. R., Yeh, Y. C., Liu, C. Y., Wu, Y. T., Lo, F. Y., Tang, M. J. & Wang, Y. K., 2016 Nov 8, In : Scientific reports. 6, 36336.

Research output: Contribution to journal › Article

Cadherins

Endocytosis

Integrins

Clathrin

Discoidin Domain Receptor 1

2 Citations (Scopus)

Spatial distribution of filament elasticity determines the migratory behaviors of a cell

Harn, H. I. C., Hsu, C. K., Wang, Y. K., Huang, Y. W., Chiu, W. T., Lin, H. H., Cheng, C. M. & Tang, M. J., 2016 Jul 3, In : Cell Adhesion and Migration. 10, 4, p. 368-377 10 p.

Research output: Contribution to journal › Article

Elasticity

Actin Cytoskeleton

Focal Adhesions

Atomic Force Microscopy

Research

2015

36 Citations (Scopus)

Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K/AKT signaling pathways

Pan, B. S., Wang, Y. K., Lai, M. S., Mu, Y. F. & Huang, B. M., 2015 Aug 25, In : Scientific reports. 5, 13372.

Research output: Contribution to journal › Article

Leydig Cell Tumor

p38 Mitogen-Activated Protein Kinases

Phosphatidylinositol 3-Kinases

Apoptosis

Cell Death

14 Citations (Scopus)

Mechanical coupling of cytoskeletal elasticity and force generation is crucial for understanding the migrating nature of keloid fibroblasts

Harn, H. I. C., Wang, Y. K., Hsu, C. K., Ho, Y. T., Huang, Y. W., Chiu, W. T., Lin, H. H., Cheng, C. M. & Tang, M. J., 2015 Aug 1, In : Experimental Dermatology. 24, 8, p. 579-584 6 p.

Research output: Contribution to journal › Article

Keloid

Elasticity

Fibroblasts

Spatial distribution

Actins

54 Citations (Scopus)

Mechanical phenotype of cancer cells: Cell softening and loss of stiffness sensing

Lin, H. H., Lin, H. K., Lin, I. H., Chiou, Y. W., Chen, H. W., Liu, C. Y., Harn, H. I. C., Chiu, W. T., Wang, Y. K., Shen, M. R. & Tang, M. J., 2015 Jan 1, In : Oncotarget. 6, 25, p. 20946-20958 13 p.

Research output: Contribution to journal › Article

Phenotype

Caveolin 1

Neoplasms

Fibroblasts

Elasticity

4 Citations (Scopus)

Probing neural cell behaviors through micro-/nano-patterned chitosan substrates

Sung, C. Y., Yang, C. Y., Chen, W. S., Wang, Y-G., Yeh, J. A. & Cheng, C. M., 2015 Dec 18, In : Biofabrication. 7, 4, 045007.

Research output: Contribution to journal › Article

Chitosan

Substrates

Biomedical Engineering

Diamond

Biomedical engineering

134 Citations (Scopus)

Vimentin contributes to epithelial-mesenchymal transition ancer cell mechanics by mediating cytoskeletal organization and focal adhesion maturation

Liu, C. Y., Lin, H. H., Tang, M. J. & Wang, Y. K., 2015 Jan 1, In : Oncotarget. 6, 18, p. 15966-15983 18 p.

Research output: Contribution to journal › Article

Focal Adhesions

Epithelial-Mesenchymal Transition

Vimentin

Mechanics

Cytoskeleton

11 Citations (Scopus)

β-PIX controls intracellular viscoelasticity to regulate lung cancer cell migration

Yu, H. W., Chen, Y. Q., Huang, C. M., Liu, C. Y., Chiou, A., Wang, Y-G., Tang, M-J. & Kuo, J. C., 2015 May 1, In : Journal of Cellular and Molecular Medicine. 19, 5, p. 934-947 14 p.

Research output: Contribution to journal › Article

Focal Adhesions

Cell Movement

Lung Neoplasms

Actins

Actin Cytoskeleton

2014

Contrast enhancement of iohexol-cisplatin-gelatin complex under computed tomography imaging

Liu, W. H., Wang, Y. K., Wu, C. C., Deng, W. P., Lin, K. H., Lo, W. C. & Tseng, C. L., 2014 May 1, In : Journal of Polymer Engineering. 34, 3, p. 267-271 5 p.

Research output: Contribution to journal › Article

Iohexol

Gelatin

Cisplatin

Tomography

Imaging techniques

Corrigendum to ''detecting interleukin-1β genes using a n₂o plasma modified silicon nanowire biosensor'' [j exp clin med 2013;5(1):12-16]

Wu, C. Y., Tseng, C. L., Wang, Y-G., Yu, Y., Ou, K. L. & Wu, C. C., 2014 Jan 1, In : Journal of Experimental and Clinical Medicine (Taiwan). 6, 3, 1 p.

Research output: Contribution to journal › Comment/debate

Nanowires

Biosensing Techniques

Silicon

Interleukin-1beta

Genes

16 Citations (Scopus)

GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment

Huang, I. H., Hsiao, C. T., Wu, J. C., Shen, R. F., Liu, C. Y., Wang, Y. K., Chen, Y. C., Huang, C. M., del Álamo, J. C., Chang, Z. F., Tang, M. J., Khoo, K. H. & Kuo, J. C., 2014 Jan 1, In : Journal of Cell Science. 127, 19, p. 4186-4200 15 p.

Research output: Contribution to journal › Article

Focal Adhesions

Cell Lineage

Mesenchymal Stromal Cells

Stress Fibers

Osteogenesis

11 Citations (Scopus)

Ionizing radiation induces autophagy in human oral squamous cell carcinoma

Wu, S. Y., Liu, Y. W., Wang, Y. K., Lin, T. H., Li, Y. Z., Chen, S. H. & Lee, Y. R., 2014 Jan 1, In : Journal of B.U.ON.. 19, 1, p. 137-144 8 p.

Research output: Contribution to journal › Article

Autophagy

Ionizing Radiation

Squamous Cell Carcinoma

Cell Survival

Western Blotting

6 Citations (Scopus)

Midazolam induces apoptosis in MA-10 mouse leydig tumor cells through caspase activation and the involvement of MAPK signaling pathway

So, E. C., Lin, Y. X., Tseng, C. H., Pan, B. S., Cheng, K. S., Wong, K. L., Hao, L. J., Wang, Y. K. & Huang, B. M., 2014 Feb 13, In : OncoTargets and Therapy. 7, p. 211-221 11 p.

Research output: Contribution to journal › Article

Leydig Cell Tumor

Midazolam

Caspases

Apoptosis

JNK Mitogen-Activated Protein Kinases

2 Citations (Scopus)

Rabbit mesenchymal stem cells cultured in a dynamic culture system displayed superior cell proliferation and osteogenetic induction

Tseng, C. L., Chang, K. M., Wu, C. C., Wang, Y. K. & Wang, I. K., 2014 Feb 1, In : Journal of Experimental and Clinical Medicine(Taiwan). 6, 1, p. 10-15 6 p.

Research output: Contribution to journal › Article

Mesenchymal Stromal Cells

Cell Proliferation

Rabbits

Bone Regeneration

Bone and Bones

2013

98 Citations (Scopus)

Cell adhesion and mechanical stimulation in the regulation of mesenchymal stem cell differentiation

Wang, Y. K. & Chen, C. S., 2013 Jul 1, In : Journal of Cellular and Molecular Medicine. 17, 7, p. 823-832 10 p.

Research output: Contribution to journal › Review article

Mesenchymal Stromal Cells

Cell Adhesion

Cell Differentiation

Stem Cells

Cues

8 Citations (Scopus)

Detecting Interleukin-1β Genes Using a N₂O Plasma Modified Silicon Nanowire Biosensor

Wu, J. Y., Tseng, C. L., Wang, Y. K., Yu, Y., Ou, K. L. & Wu, C. C., 2013 Feb 20, In : Journal of Experimental and Clinical Medicine(Taiwan). 5, 1, p. 12-16 5 p.

Research output: Contribution to journal › Article

Nanowires

Biosensing Techniques

Silicon

Interleukin-1

Genes

14 Citations (Scopus)

Nanotechnology in the regulation of stem cell behavior

Wu, K. C., Tseng, C. L., Wu, C. C., Kao, F. C., Tu, Y. K., C So, E. & Wang, Y. K., 2013 Oct 1, In : Science and Technology of Advanced Materials. 14, 5, 054401.

Research output: Contribution to journal › Review article

Stem cells

Nanotechnology

Cytology

Cell adhesion

Scaffolds (biology)

39 Citations (Scopus)

The ER Ca²⁺ sensor STIM1 regulates actomyosin contractility of migratory cells

Chen, Y. T., Chen, Y. F., Chiu, W. T., Wang, Y. K., Chang, H. C. & Shen, M. R., 2013 Mar 1, In : Journal of Cell Science. 126, 5, p. 1260-1267 8 p.

Research output: Contribution to journal › Article

Actomyosin

Endoplasmic Reticulum

Cell Movement

Uterine Cervical Neoplasms

Myosin Type II

22 Citations (Scopus)

Three-dimensional fibroblast morphology on compliant substrates of controlled negative curvature

Lee, Y. H., Huang, J. R., Wang, Y. K. & Lin, K. H., 2013 Dec 1, In : Integrative Biology (United Kingdom). 5, 12, p. 1447-1455 9 p.

Research output: Contribution to journal › Article

Fibroblasts

Adhesion

Scaffolds

Substrates

Cellular Microenvironment

2012

131 Citations (Scopus)

Bone morphogenetic protein-2-induced signaling and osteogenesis is regulated by cell shape, RhoA/ROCK, and cytoskeletal tension

Wang, Y. K., Yu, X., Cohen, D. M., Wozniak, M. A., Yang, M. T., Gao, L., Eyckmans, J. & Chen, C. S., 2012 May 1, In : Stem Cells and Development. 21, 7, p. 1176-1186 11 p.

Research output: Contribution to journal › Article

Bone Morphogenetic Protein 2

Bone Morphogenetic Proteins

Cell Shape

Osteogenesis

Mesenchymal Stromal Cells

21 Citations (Scopus)

Effect of Lavender essential oil on LPS-stimulated inflammation

Huang, M. Y., Liao, M. H., Wang, Y. K., Huang, Y. S. & Wen, H. C., 2012 Jul 30, In : American Journal of Chinese Medicine. 40, 4, p. 845-859 15 p.

Research output: Contribution to journal › Article

Volatile Oils

Lipopolysaccharides

Inflammation

HSP70 Heat-Shock Proteins

Aromatherapy

2011

167 Citations (Scopus)

Assaying stem cell mechanobiology on microfabricated elastomeric substrates with geometrically modulated rigidity

Yang, M. T., Fu, J., Wang, Y. K., Desai, R. A. & Chen, C. S., 2011 Feb 1, In : Nature Protocols. 6, 2, p. 187-213 27 p.

Research output: Contribution to journal › Article

Biophysics

Stem cells

Rigidity

Stem Cells

Traction

48 Citations (Scopus)

DDR1 triggers epithelial cell differentiation by promoting cell adhesion through stabilization of E-cadherin

Yeh, Y. C., Wu, C-C., Wang, Y-G. & Tang, M-J., 2011 Apr 1, In : Molecular Biology of the Cell. 22, 7, p. 940-953 14 p.

Research output: Contribution to journal › Article

Cadherins

Cell Adhesion

Cell Differentiation

Epithelial Cells

Discoidin Domain Receptor 1

7 Citations (Scopus)

Erratum: Mechanical regulation of cell function with geometrically modulated elastomeric substrates (Nature Methods (2010) 7 (733-736))

Fu, J., Wang, Y. K., Yang, M. T., Desai, R. A., Yu, X., Liu, Z. & Chen, C. S., 2011 Feb 1, In : Nature Methods. 8, 2, 1 p.

Research output: Contribution to journal › Comment/debate

elastomeric

2010

653 Citations (Scopus)

Mechanical regulation of cell function with geometrically modulated elastomeric substrates

Fu, J., Wang, Y. K., Yang, M. T., Desai, R. A., Yu, X., Liu, Z. & Chen, C. S., 2010 Sep 1, In : Nature Methods. 7, 9, p. 733-736 4 p.

Research output: Contribution to journal › Article

Stem cells

Rigidity

Stem Cells

Cells

Focal Adhesions

82 Citations (Scopus)

Transforming growth factor-β1 induces Smad3-dependent β₁ integrin gene expression in epithelial-to-mesenchymal transition during chronic tubulointerstitial fibrosis

Yeh, Y. C., Wei, W. C., Wang, Y. K., Lin, S. C., Sung, J. M. & Tang, M. J., 2010 Oct, In : American Journal of Pathology. 177, 4, p. 1743-1754 12 p.

Research output: Contribution to journal › Article

Epithelial-Mesenchymal Transition

Transforming Growth Factors

Integrins

Fibrosis

Gene Expression

2008

7 Citations (Scopus)

Low substratum rigidity of collagen gel promotes ERK phosphorylation via lipid raft to augment cell migration

Wei, W. C., Hsu, Y. C., Chiu, W-T., Wang, C. Z., Wu, C. M., Wang, Y-G., Shen, M-R. & Tang, M-J., 2008 Mar 1, In : Journal of Cellular Biochemistry. 103, 4, p. 1111-1124 14 p.

Research output: Contribution to journal › Article

Phosphorylation

Rigidity

Cell Movement

Collagen

Gels

Mechanical control of stem cell differentiation using microengineered matrix

Fu, J., Wang, Y-G., Yang, M. T., Lee, T. T. & Chen, C. S., 2008 Jan 1, p. 1229-1231. 3 p.

Research output: Contribution to conference › Paper

Stem cells

Rigidity

Cell adhesion

Substrates

Mechanical properties

2007

7 Citations (Scopus)

Activation of caspase-8 and Erk-1/2 in domes regulates cell death induced by confluence in MDCK cells

Chang, Y. H., Lin, H. H., Wang, Y. K., Chiu, W. T., Su, H. W. & Tang, M. J., 2007 Apr 1, In : Journal of Cellular Physiology. 211, 1, p. 174-182 9 p.

Research output: Contribution to journal › Article

Madin Darby Canine Kidney Cells

Caspase 8

Domes

Cell death

Cell Death

23 Citations (Scopus)

Deregulation of AP-1 proteins in collagen gel-induced epithelial cell apoptosis mediated by low substratum rigidity

Wang, Y. H., Chiu, W. T., Wang, Y. K., Wu, C. C., Chen, T. L., Teng, C. F., Chang, W. T., Chang, H. C. & Tang, M. J., 2007 Jan 5, In : Journal of Biological Chemistry. 282, 1, p. 752-763 12 p.

Research output: Contribution to journal › Article

Deregulation

Transcription Factor AP-1

Rigidity

Collagen

Gels

2006

19 Citations (Scopus)

Cordyceps sinensis mycelium induces MA-10 mouse leydig tumor cell apoptosis by activating the caspase-8 pathway and suppressing the NF-κB pathway

Yang, H. Y., Leu, S. F., Wang, Y-G., Wu, C. S. & Huang, B-M., 2006 Mar 1, In : Archives of Andrology. 52, 2, p. 103-110 8 p.

Research output: Contribution to journal › Article

Cordyceps

Leydig Cell Tumor

Caspase 8

Mycelium

Apoptosis

2005

Mechanoregulation of cell function

Wang, Y. K., McBeath, R., Sniadecki, N. J., Tan, J. L., Pirone, D. M. & Chen, C. S., 2005 Dec 1, Proceedings of the 2005 Summer Bioengineering Conference, 2005 SBC. p. 904-905 2 p. (Proceedings of the 2005 Summer Bioengineering Conference; vol. 2005).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Adhesives

Microfabrication

Endothelial cells

Cell proliferation

Cell death

2004

Engineered dermal scaffold for improved skin regeneration

Huang, L. L-H., Lin, H. C., Tai, M. H., Wang, Y-G. & Liu, G. M., 2004 Dec 1, Transactions - 7th World Biomaterials Congress. 1 p. (Transactions - 7th World Biomaterials Congress).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Scaffolds (biology)

Skin

Collagen

Animals

2003

60 Citations (Scopus)

Rigidity of collagen fibrils controls collagen gel-induced down-regulation of focal adhesion complex proteins mediated by α₂β₁ integrin

Wang, Y-G., Wang, Y. H., Wang, C. Z., Sung, J-M., Chiu, W-T., Lin, S. H., Chang, Y. H. & Tang, M-J., 2003 Jun 13, In : Journal of Biological Chemistry. 278, 24, p. 21886-21892 7 p.

Research output: Contribution to journal › Article

Focal Adhesions

Integrins

Rigidity

Collagen

Down-Regulation

2002

16 Citations (Scopus)

Hepatocyte growth factor upregulates α2β1 integrin in Madin-Darby canine kidney cells: Implications in tubulogenesis

Chiu, S. J., Jiang, S. T., Wang, Y-G. & Tang, M-J., 2002 Jun 26, In : Journal of biomedical science. 9, 3, p. 261-272 12 p.

Research output: Contribution to journal › Article

Madin Darby Canine Kidney Cells

Hepatocyte Growth Factor

Integrins

Up-Regulation

Cell Communication

106 Citations (Scopus)

Ureteric bud outgrowth in response to RET activation is mediated by phosphatidylinositol 3-kinase

Tang, M. J., Cai, Y., Tsai, S. J., Wang, Y. K. & Dressler, G. R., 2002 Mar 1, In : Developmental Biology. 243, 1, p. 128-136 9 p.

Research output: Contribution to journal › Article

Phosphatidylinositol 3-Kinase

Receptor Protein-Tyrosine Kinases

Glial Cell Line-Derived Neurotrophic Factor

Morphogenesis

Kidney

2001

13 Citations (Scopus)

Collagen gel overlay induces two phases of apoptosis in MDCK cells

Wang, Y. K., Lin, H. H. & Tang, M. J., 2001, In : American Journal of Physiology - Cell Physiology. 280, 6 49-6

Research output: Contribution to journal › Article

Madin Darby Canine Kidney Cells

Collagen

Gels

Apoptosis

Focal Adhesion Protein-Tyrosine Kinases

1995

14 Citations (Scopus)

Butyrate and TGF-β Downregulate Na,K-ATPase Expression in Cultured Proximal Tubule Cells

Tang, M. J., Wang, Y. K. & Lin, H. H., 1995 Oct 4, In : Biochemical and Biophysical Research Communications. 215, 1, p. 57-66 10 p.

Research output: Contribution to journal › Article

Butyrates

Adenosine Triphosphatases

Down-Regulation

Messenger RNA

Growth Inhibitors

1994

3 Citations (Scopus)

Expression and regulation of Na,K-ATPase in primary culture of proximal tubule cells

Tang, M. J., Lin, H. H. & Wang, Y. K., 1994 Jan 1, In : Chinese Journal of Physiology. 37, 1, p. 21-29 9 p.

Research output: Contribution to journal › Article

Butyrates

Cell Proliferation

sodium-translocating ATPase

Volatile Fatty Acids

Differentiation Antigens