• 9737 Citations
  • 48 h-Index
1984 …2020
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Personal profile

Education

  • 1986 PhD, Department of Microbiology and Immunology, Medical College, Temple University, USA

Experience

  • 1986/08 ~ 1987/07 Lecturer, Department of Microbiology, College of Medicine, National Cheng Kung University
  • 1987/08 ~ 1992/07 Associate Professor, Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University
  • 1992/08 ~ present Professor, Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University
  • 2002/08 ~ present Distinguished Professor, Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University

Research Interests

  • Dengue disease pathogenesis and antiviral strategies
  • Group A streptococcus infection and disease pathogenesis
  • Signaling pathway in autophagy

Fingerprint Dive into the research topics where Yee-Shin Lin is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 46 Similar Profiles
Dengue Virus Medicine & Life Sciences
Severe Dengue Medicine & Life Sciences
Virus Diseases Medicine & Life Sciences
Dengue Medicine & Life Sciences
Streptococcus Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Antibodies Medicine & Life Sciences
Endothelial Cells Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1995 2020

Research Output 1984 2019

Combination of modified NS1 and NS3 as a novel vaccine strategy against dengue virus infection

Kao, Y. S., Yu, C. Y., Huang, H. J., Tien, S. M., Wang, W. Y., Yang, M., Anderson, R., Yeh, T. M., Lin, Y. S. & Wan, S. W., 2019 Oct 1, In : Journal of Immunology. 203, 7, p. 1909-1917 9 p.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Vaccines
Severe Dengue
Cellular Immunity

Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy

Cheng, Y. L., Kuo, C. F., Lu, S. L., Hiroko, O., Wu, Y. N., Hsieh, C. L., Noda, T., Wu, S. R., Anderson, R., Lin, C. F., Chen, C. L., Wu, J. J. & Lin, Y. S., 2019 Oct 1, In : mBio. 10, 5

Research output: Contribution to journalArticle

Open Access
Streptococcus
Integrins
Reactive Oxygen Species
Endothelial Cells
Phagocytosis
1 Citation (Scopus)

Streptolysin S induces mitochondrial damage and macrophage death through inhibiting degradation of glycogen synthase kinase-3β in Streptococcus pyogenes infection

Tsao, N., Kuo, C. F., Cheng, M. H., Lin, W. C., Lin, C. F. & Lin, Y. S., 2019 Dec 1, In : Scientific reports. 9, 1, 5371.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Streptococcus pyogenes
Streptococcus
Macrophages
Infection
1 Citation (Scopus)

Autophagy regulates vinorelbine sensitivity due to continued Keap1-mediated ROS generation in lung adenocarcinoma cells

Wu, Y. W., Lin, C. F., Lin, Y. S., Su, W. C. & Chiu, W. H., 2018 Dec 1, In : Cell Death Discovery. 4, 1, 96.

Research output: Contribution to journalArticle

Open Access
Autophagy
Antioxidant Response Elements
Apoptosis
Drug Therapy
Physiological Stress
17 Citations (Scopus)

Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo

Lee, Y. R., Kuo, S. H., Lin, C. Y., Fu, P. J., Lin, Y. S., Yeh, T. M. & Liu, H. S., 2018 Dec 1, In : Scientific reports. 8, 1, 489.

Research output: Contribution to journalArticle

Virus Activation
Dengue Virus
Endoplasmic Reticulum Stress
Autophagy
Virus Diseases

Thesis

Autoimmunity in the pathogenesis of severe dengue

Author: 蒂, 賓., 2017 Oct 19

Supervisor: Lin, Y. (Supervisor)

Student thesis: Doctoral Thesis

Evaluation of the protective efficacy of anti-dengue virus nonstructural protein 1 monoclonal antibodies

Author: 嘉依, 洪., 2016 Aug 31

Supervisor: Lin, Y. (Supervisor)

Student thesis: Master's Thesis

Formation and transmission of novel autophagy-associated vesicle in dengue infection

Author: 彥緯, 吳., 2016 Dec 21

Supervisor: Lin, Y. (Supervisor)

Student thesis: Doctoral Thesis

IFN-γ-induced autophagy is regulated by S100A10 and required for exophagy of annexin A2

Author: 盈達, 陳., 2016 Dec 13

Supervisor: Lin, Y. (Supervisor)

Student thesis: Doctoral Thesis

Investigating the Molecular Mechanism of TNF-? Production in Dengue Virus Infection

Author: 怡琳, 鄭., 2016 Sep 22

Supervisor: Lin, Y. (Supervisor)

Student thesis: Doctoral Thesis