Yee-Shin Lin

Personal profile

Education

1986 PhD, Department of Microbiology and Immunology, Medical College, Temple University, USA

Experience

1986/08 ~ 1987/07 Lecturer, Department of Microbiology, College of Medicine, National Cheng Kung University
1987/08 ~ 1992/07 Associate Professor, Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University
1992/08 ~ present Professor, Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University
2002/08 ~ present Distinguished Professor, Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University

Research Interests

Dengue disease pathogenesis and antiviral strategies
Group A streptococcus infection and disease pathogenesis
Signaling pathway in autophagy

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Dengue Virus Medicine & Life Sciences

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Apoptosis Medicine & Life Sciences

Antibodies Medicine & Life Sciences

Endothelial Cells Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1995 2020

2 Active
41 Finished

發展針對登革病毒非結構性蛋白一之人源化單株抗體治療(II)

Lin, Y.

19-02-01 → 20-01-31

Project: Research project

微免及檢驗醫學學門規劃研究推動計畫

Lin, Y.

19-01-01 → 19-12-31

Project: Research project

微免及檢驗醫學學門規劃研究推動計畫

Lin, Y.

18-01-01 → 18-12-31

Project: Research project

A群鏈球菌感染內皮細胞的致病機轉-A群鏈球菌感染內皮細胞的致病機轉：細胞方面的研究(3/3)

Lin, Y.

17-08-01 → 18-07-31

Project: Research project

微免及檢驗醫學學門規劃研究推動計畫

Lin, Y.

17-01-01 → 17-12-31

Project: Research project

Research Output 1984 2019

9317 Citations
47 h-Index
216 Article
12 Review article
12 Patent
2 Comment/debate
3 More

Streptolysin S induces mitochondrial damage and macrophage death through inhibiting degradation of glycogen synthase kinase-3β in Streptococcus pyogenes infection

Tsao, N., Kuo, C. F., Cheng, M. H., Lin, W. C., Lin, C. F. & Lin, Y-S., 2019 Dec 1, In : Scientific reports. 9, 1, 5371.

Research output: Contribution to journal › Article

Glycogen Synthase Kinase 3

Streptococcus pyogenes

Streptococcus

Macrophages

Infection

11 Citations (Scopus)

Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo

Lee, Y. R., Kuo, S. H., Lin, C. Y., Fu, P. J., Lin, Y-S., Yeh, T-M. & Liu, H-S., 2018 Dec 1, In : Scientific reports. 8, 1, 489.

Research output: Contribution to journal › Article

Virus Activation

Dengue Virus

Endoplasmic Reticulum Stress

Autophagy

Virus Diseases

3 Citations (Scopus)

Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability

Chen, H. R., Chao, C. H., Liu, C-C., Ho, T-S., Tsai, H. P., Perng, G-C., Lin, Y-S., Wang, J-R. & Yeh, T-M., 2018 Apr 1, In : PLoS pathogens. 14, 4, e1007033.

Research output: Contribution to journal › Article

Macrophage Migration-Inhibitory Factors

Glycocalyx

Dengue

Metalloproteases

Proteins

3 Citations (Scopus)

Minocycline suppresses dengue virus replication by down-regulation of macrophage migration inhibitory factor-induced autophagy

Lai, Y. C., Chuang, Y. C., Chang, C-P., Lin, Y-S., Perng, G-C., Wu, H. C., Hsieh, S. L. & Yeh, T-M., 2018 Jul 1, In : Antiviral Research. 155, p. 28-38 11 p.

Research output: Contribution to journal › Article

Macrophage Migration-Inhibitory Factors

Dengue Virus

Minocycline

Autophagy

Virus Replication

NAD-glycohydrolase depletes intracellular NAD⁺ and inhibits acidification of autophagosomes to enhance multiplication of group A Streptococcus in endothelial cells

Hsieh, C. L., Huang, H. M., Hsieh, S. Y., Zheng, P. X., Lin, Y-S., Chiang-Ni, C., Tsai, P-J., Wang, S-Y., Liu, C-C. & Wu, J. J., 2018 Aug 3, In : Frontiers in Microbiology. 9, AUG, 1733.

Research output: Contribution to journal › Article

NAD+ Nucleosidase

Streptococcus

NAD

Endothelial Cells

Vacuoles