• 9317 Citations
  • 47 h-Index
1984 …2020
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Personal profile

Education

  • 1986 PhD, Department of Microbiology and Immunology, Medical College, Temple University, USA

Experience

  • 1986/08 ~ 1987/07 Lecturer, Department of Microbiology, College of Medicine, National Cheng Kung University
  • 1987/08 ~ 1992/07 Associate Professor, Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University
  • 1992/08 ~ present Professor, Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University
  • 2002/08 ~ present Distinguished Professor, Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University

Research Interests

  • Dengue disease pathogenesis and antiviral strategies
  • Group A streptococcus infection and disease pathogenesis
  • Signaling pathway in autophagy

Fingerprint Dive into the research topics where Yee-Shin Lin is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 48 Similar Profiles
Dengue Virus Medicine & Life Sciences
Severe Dengue Medicine & Life Sciences
Virus Diseases Medicine & Life Sciences
Dengue Medicine & Life Sciences
Streptococcus Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Antibodies Medicine & Life Sciences
Endothelial Cells Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1995 2020

Research Output 1984 2019

Streptolysin S induces mitochondrial damage and macrophage death through inhibiting degradation of glycogen synthase kinase-3β in Streptococcus pyogenes infection

Tsao, N., Kuo, C. F., Cheng, M. H., Lin, W. C., Lin, C. F. & Lin, Y-S., 2019 Dec 1, In : Scientific reports. 9, 1, 5371.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Streptococcus pyogenes
Streptococcus
Macrophages
Infection
11 Citations (Scopus)

Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo

Lee, Y. R., Kuo, S. H., Lin, C. Y., Fu, P. J., Lin, Y-S., Yeh, T-M. & Liu, H-S., 2018 Dec 1, In : Scientific reports. 8, 1, 489.

Research output: Contribution to journalArticle

Virus Activation
Dengue Virus
Endoplasmic Reticulum Stress
Autophagy
Virus Diseases
3 Citations (Scopus)

Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability

Chen, H. R., Chao, C. H., Liu, C-C., Ho, T-S., Tsai, H. P., Perng, G-C., Lin, Y-S., Wang, J-R. & Yeh, T-M., 2018 Apr 1, In : PLoS pathogens. 14, 4, e1007033.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Glycocalyx
Dengue
Metalloproteases
Proteins
3 Citations (Scopus)

Minocycline suppresses dengue virus replication by down-regulation of macrophage migration inhibitory factor-induced autophagy

Lai, Y. C., Chuang, Y. C., Chang, C-P., Lin, Y-S., Perng, G-C., Wu, H. C., Hsieh, S. L. & Yeh, T-M., 2018 Jul 1, In : Antiviral Research. 155, p. 28-38 11 p.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Dengue Virus
Minocycline
Autophagy
Virus Replication

NAD-glycohydrolase depletes intracellular NAD+ and inhibits acidification of autophagosomes to enhance multiplication of group A Streptococcus in endothelial cells

Hsieh, C. L., Huang, H. M., Hsieh, S. Y., Zheng, P. X., Lin, Y-S., Chiang-Ni, C., Tsai, P-J., Wang, S-Y., Liu, C-C. & Wu, J. J., 2018 Aug 3, In : Frontiers in Microbiology. 9, AUG, 1733.

Research output: Contribution to journalArticle

NAD+ Nucleosidase
Streptococcus
NAD
Endothelial Cells
Vacuoles

Thesis

Autoimmunity in the pathogenesis of severe dengue

Author: 蒂, 賓., 2017 Oct 19

Supervisor: Lin, Y. (Supervisor)

Student thesis: Doctoral Thesis

Evaluation of the protective efficacy of anti-dengue virus nonstructural protein 1 monoclonal antibodies

Author: 嘉依, 洪., 2016 Aug 31

Supervisor: Lin, Y. (Supervisor)

Student thesis: Master's Thesis

Formation and transmission of novel autophagy-associated vesicle in dengue infection

Author: 彥緯, 吳., 2016 Dec 21

Supervisor: Lin, Y. (Supervisor)

Student thesis: Doctoral Thesis

IFN-γ-induced autophagy is regulated by S100A10 and required for exophagy of annexin A2

Author: 盈達, 陳., 2016 Dec 13

Supervisor: Lin, Y. (Supervisor)

Student thesis: Doctoral Thesis

Investigating the Molecular Mechanism of TNF-? Production in Dengue Virus Infection

Author: 怡琳, 鄭., 2016 Sep 22

Supervisor: Lin, Y. (Supervisor)

Student thesis: Doctoral Thesis