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Research Output 1984 2019

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2019

Streptolysin S induces mitochondrial damage and macrophage death through inhibiting degradation of glycogen synthase kinase-3β in Streptococcus pyogenes infection

Tsao, N., Kuo, C. F., Cheng, M. H., Lin, W. C., Lin, C. F. & Lin, Y-S., 2019 Dec 1, In : Scientific reports. 9, 1, 5371.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Streptococcus pyogenes
Streptococcus
Macrophages
Infection
2018

Autophagy regulates vinorelbine sensitivity due to continued Keap1-mediated ROS generation in lung adenocarcinoma cells

Wu, Y. W., Lin, C. F., Lin, Y-S., Su, W. C. & Chiu, W-H., 2018 Dec 1, In : Cell Death Discovery. 4, 1, 96.

Research output: Contribution to journalArticle

Open Access
Autophagy
Antioxidant Response Elements
Apoptosis
Drug Therapy
Physiological Stress
12 Citations (Scopus)

Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo

Lee, Y. R., Kuo, S. H., Lin, C. Y., Fu, P. J., Lin, Y-S., Yeh, T-M. & Liu, H-S., 2018 Dec 1, In : Scientific reports. 8, 1, 489.

Research output: Contribution to journalArticle

Virus Activation
Dengue Virus
Endoplasmic Reticulum Stress
Autophagy
Virus Diseases
3 Citations (Scopus)

Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability

Chen, H. R., Chao, C. H., Liu, C-C., Ho, T-S., Tsai, H. P., Perng, G-C., Lin, Y-S., Wang, J-R. & Yeh, T-M., 2018 Apr 1, In : PLoS pathogens. 14, 4, e1007033.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Glycocalyx
Dengue
Metalloproteases
Proteins
3 Citations (Scopus)

Minocycline suppresses dengue virus replication by down-regulation of macrophage migration inhibitory factor-induced autophagy

Lai, Y. C., Chuang, Y. C., Chang, C-P., Lin, Y-S., Perng, G-C., Wu, H. C., Hsieh, S. L. & Yeh, T-M., 2018 Jul 1, In : Antiviral Research. 155, p. 28-38 11 p.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Dengue Virus
Minocycline
Autophagy
Virus Replication

NAD-glycohydrolase depletes intracellular NAD+ and inhibits acidification of autophagosomes to enhance multiplication of group A Streptococcus in endothelial cells

Hsieh, C. L., Huang, H. M., Hsieh, S. Y., Zheng, P. X., Lin, Y-S., Chiang-Ni, C., Tsai, P-J., Wang, S-Y., Liu, C-C. & Wu, J. J., 2018 Aug 3, In : Frontiers in Microbiology. 9, AUG, 1733.

Research output: Contribution to journalArticle

NAD+ Nucleosidase
Streptococcus
NAD
Endothelial Cells
Vacuoles

Sera of patients with systemic lupus erythematosus cross-neutralizes dengue viruses

Zainal, N., Tan, K. K., Johari, J., Hussein, H., Wan Musa, W. R., Hassan, J., Lin, Y-S. & AbuBakar, S., 2018 Oct 1, In : Microbiology and Immunology. 62, 10, p. 659-672 14 p.

Research output: Contribution to journalArticle

Dengue Virus
Systemic Lupus Erythematosus
Serum
Dengue
Immunoglobulin G
2017
7 Citations (Scopus)

Antibodies Against Modified NS1 Wing Domain Peptide Protect Against Dengue Virus Infection

Lai, Y. C., Chuang, Y. C., Liu, C-C., Ho, T-S., Lin, Y-S., Anderson, R. & Yeh, T-M., 2017 Dec 1, In : Scientific reports. 7, 1, 6975.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Antibodies
Proteins
Dengue
6 Citations (Scopus)

Antibodies against nonstructural protein 1 protect mice from dengue virus-induced mast cell activation

Chu, Y. T., Wan, S. W., Chang, Y. C., Lee, C. K., Wu-Hsieh, B. A., Anderson, R. & Lin, Y-S., 2017 May 1, In : Laboratory Investigation. 97, 5, p. 602-614 13 p.

Research output: Contribution to journalArticle

Dengue Virus
Mast Cells
Severe Dengue
Antibodies
Proteins
12 Citations (Scopus)

AR-12 suppresses dengue virus replication by down-regulation of PI3K/AKT and GRP78

Chen, H. H., Chen, C. C., Lin, Y-S., Chang, P. C., Lu, Z. Y., Lin, C. F., Chen, C. L. & Chang, C-P., 2017 Jun 1, In : Antiviral Research. 142, p. 158-168 11 p.

Research output: Contribution to journalArticle

Dengue Virus
Virus Replication
Phosphatidylinositol 3-Kinases
Down-Regulation
Virus Diseases
7 Citations (Scopus)

Dengue virus infection increases microglial cell migration

Jhan, M. K., Tsai, T. T., Chen, C. L., Tsai, C. C., Cheng, Y. L., Lee, Y. C., Ko, C. Y., Lin, Y-S., Chang, C-P., Lin, L. T. & Lin, C. F., 2017 Jan 1, In : Scientific reports. 7, 1, 91.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Cell Movement
Clathrin
Viral RNA
3 Citations (Scopus)

Endothelial cells are intrinsically defective in xenophagy of Streptococcus pyogenes

Lu, S. L., Kawabata, T., Cheng, Y. L., Omori, H., Hamasaki, M., Kusaba, T., Iwamoto, R., Arimoto, H., Noda, T., Lin, Y-S. & Yoshimori, T., 2017 Jul 1, In : PLoS pathogens. 13, 7, e1006444.

Research output: Contribution to journalArticle

Streptococcus pyogenes
Streptococcus
Endothelial Cells
Ubiquitin
Autophagy
14 Citations (Scopus)

Exophagy of annexin A2 via RAB11, RAB8A and RAB27A in IFN-γ-stimulated lung epithelial cells

Chen, Y. D., Fang, Y. T., Cheng, Y. L., Lin, C. F., Hsu, L-J., Wang, S-Y., Anderson, R., Chang, C-P. & Lin, Y-S., 2017 Dec 1, In : Scientific reports. 7, 1, 5676.

Research output: Contribution to journalArticle

Annexin A2
Annexins
Epithelial Cells
Lung
Multivesicular Bodies
4 Citations (Scopus)

Galectin-3 inhibits galectin-8/parkin- mediated ubiquitination of group A streptococcus

Cheng, Y. L., Wu, Y. W., Kuo, C. F., Lu, S. L., Liu, F. T., Anderson, R., Lin, C. F., Liu, Y. L., Wang, W. Y., Chen, Y. D., Zheng, P. X., Wu, J. J. & Lin, Y-S., 2017 Jul 1, In : mBio. 8, 4, e00899-17.

Research output: Contribution to journalArticle

Galectins
Galectin 3
Ubiquitination
Streptococcus
Endothelial Cells
4 Citations (Scopus)

Honeysuckle aqueous extract and induced let-7a suppress dengue virus type 2 replication and pathogenesis

Lee, Y. R., Yeh, S. F., Ruan, X. M., Zhang, H., Hsu, S. D., Huang, H. D., Hsieh, C. C., Lin, Y-S., Yeh, T-M., Liu, H-S. & Gan, D. D., 2017 Feb 23, In : Journal of Ethnopharmacology. 198, p. 109-121 13 p.

Research output: Contribution to journalArticle

Lonicera
Dengue Virus
Virus Replication
MicroRNAs
High-Throughput Nucleotide Sequencing
2 Citations (Scopus)

Immunization with a streptococcal multipleepitope recombinant protein protects mice against invasive group A streptococcal infection

Kuo, C. F., Tsao, N., Hsieh, I. C., Lin, Y-S., Wu, J. J. & Hung, Y. T., 2017 Mar 1, In : PloS one. 12, 3, 0174464.

Research output: Contribution to journalArticle

Immunization
Streptococcal Infections
Recombinant Proteins
recombinant proteins
immunization
6 Citations (Scopus)

Plasma kallistatin in critically ill patients with severe sepsis and septic shock

Lin, W-C., Chen, C-W., Chao, L., Chao, J. & Lin, Y-S., 2017 May 1, In : PloS one. 12, 5, e0178387.

Research output: Contribution to journalArticle

septic shock
sepsis (infection)
Septic Shock
Critical Illness
Sepsis
9 Citations (Scopus)

Resveratrol treatment reveals a novel role for HMGB1 in regulation of the type 1 interferon response in dengue virus infection

Zainal, N., Chang, C-P., Cheng, Y. L., Wu, Y. W., Anderson, R., Wan, S. W., Chen, C. L., Ho, T-S., Abubakar, S. & Lin, Y-S., 2017 Feb 20, In : Scientific reports. 7, 42998.

Research output: Contribution to journalArticle

Interferon Type I
Dengue Virus
Virus Diseases
Interferons
Genes
3 Citations (Scopus)

S100A10 Regulates ULK1 Localization to ER–Mitochondria Contact Sites in IFN-γ-Triggered Autophagy

Chen, Y. D., Fang, Y. T., Chang, C-P., Lin, C. F., Hsu, L-J., Wu, S-R., Chiu, Y. C., Anderson, R. & Lin, Y-S., 2017 Jan 6, In : Journal of Molecular Biology. 429, 1, p. 142-157 16 p.

Research output: Contribution to journalArticle

Autophagy
Annexin A2
High Mobility Group Proteins
Annexins
Autophagosomes
8 Citations (Scopus)

Therapeutic effects of monoclonal antibody against dengue virus NS1 in a STAT1 knockout mouse model of dengue infection

Wan, S. W., Chen, P. W., Chen, C. Y., Lai, Y. C., Chu, Y. T., Hung, C. Y., Lee, H., Wu, H. F., Chuang, Y. C., Lin, J., Chang, C-P., Wang, S-Y., Liu, C-C., Ho, T-S., Lin, C. F., Lee, C. K., Wu-Hsieh, B. A., Anderson, R., Yeh, T-M. & Lin, Y-S., 2017 Oct 15, In : Journal of Immunology. 199, 8, p. 2834-2844 11 p.

Research output: Contribution to journalArticle

Dengue Virus
Dengue
Therapeutic Uses
Knockout Mice
Monoclonal Antibodies
2016
16 Citations (Scopus)

Activation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF-α production by mononuclear phagocytes

Cheng, Y. L., Lin, Y-S., Chen, C. L., Tsai, T. T., Tsai, C. C., Wu, Y. W., Ou, Y. D., Chu, Y. Y., Wang, J-M., Yu, C. Y. & Lin, C. F., 2016 Aug 26, In : Scientific reports. 6, 32000.

Research output: Contribution to journalArticle

Dengue Virus
Phagocytes
Tumor Necrosis Factor-alpha
Virus Diseases
Toll-Like Receptor 3
8 Citations (Scopus)

Anti-dengue virus nonstructural protein 1 antibodies contribute to platelet phagocytosis by macrophages

Wan, S. W., Yang, Y. W., Chu, Y. T., Lin, C. F., Chang, C-P., Yeh, T-M., Anderson, R. & Lin, Y-S., 2016 Jan 1, In : Thrombosis and Haemostasis. 115, 3, p. 646-656 11 p.

Research output: Contribution to journalArticle

Dengue Virus
Phagocytosis
Blood Platelets
Macrophages
Antibodies
12 Citations (Scopus)

Autophagy-associated dengue vesicles promote viral transmission avoiding antibody neutralization

Wu, Y. W., Mettling, C., Wu, S-R., Yu, C. Y., Perng, G-C., Lin, Y-S. & Lin, Y. L., 2016 Aug 25, In : Scientific reports. 6, 32243.

Research output: Contribution to journalArticle

Dengue
Autophagy
Neutralizing Antibodies
Viral RNA
Antibodies
15 Citations (Scopus)

Dengue virus nonstructural protein 1-induced antibodies cross-react with human plasminogen and enhance its activation

Chuang, Y. C., Lin, J., Lin, Y-S., Wang, S-Y. & Yeh, T-M., 2016 Feb 1, In : Journal of Immunology. 196, 3, p. 1218-1226 9 p.

Research output: Contribution to journalArticle

Severe Dengue
Dengue Virus
Plasminogen
Antibodies
Proteins
28 Citations (Scopus)
Macrophage Migration-Inhibitory Factors
Dengue Virus
Severe Dengue
Autophagy
Blood Vessels
2 Citations (Scopus)

Epidemiology analysis of streptococcus pyogenes in a hospital in Southern Taiwan by use of the updated emm cluster typing system

Chiang-Ni, C., Zheng, P. X., Wang, S-Y., Tsai, P-J., Chuang, W-J., Lin, Y-S., Liu, C-C. & Wu, J. J., 2016 Jan 1, In : Journal of Clinical Microbiology. 54, 1, p. 157-162 6 p.

Research output: Contribution to journalArticle

Streptococcus pyogenes
Streptococcus
Taiwan
Epidemiology
Molecular Typing
25 Citations (Scopus)

Galectin-1-induced autophagy facilitates cisplatin resistance of hepatocellular carcinoma

Su, Y. C., Davuluri, G. V. N., Chen, C. H., Shiau, D. C., Chen, C. C., Chen, C. L., Lin, Y-S. & Chang, C-P., 2016 Feb 1, In : PLoS ONE. 11, 2, e0148408.

Research output: Contribution to journalArticle

Galectin 1
cisplatin
autophagy
Autophagy
hepatoma
24 Citations (Scopus)

Microglia retard dengue virus-induced acute viral encephalitis

Tsai, T. T., Chen, C. L., Lin, Y-S., Chang, C-P., Tsai, C. C., Cheng, Y. L., Huang, C-C., Ho, C. J., Lee, Y. C., Lin, L. T., Jhan, M. K. & Lin, C. F., 2016 Jun 9, In : Scientific reports. 6, 27670.

Research output: Contribution to journalArticle

Viral Encephalitis
Dengue Virus
Microglia
Virus Diseases
Cytotoxic T-Lymphocytes

Streptococcal pyrogenic exotoxin B inhibits apoptotic cell clearance by macrophages through protein S cleavage

Chen, C. L., Wu, Y. Y., Lin, C. F., Kuo, C. F., Han, C. L., Wang, S-Y., Chuang, W-J., Chen, C. Y., Wu, J. J., Tsai, P-J., Liu, C-C. & Lin, Y-S., 2016 May 16, In : Scientific reports. 6, 26026.

Research output: Contribution to journalArticle

Protein S
Macrophages
streptopain
Streptococcus
Phagocytosis
2015
1 Citation (Scopus)

Clustered regularly interspaced short palindromic repeats are emm type-specific in highly prevalent group A streptococci

Zheng, P. X., Chan, Y. C., Chiou, C. S., Chiang-Ni, C., Wang, S-Y., Tsai, P-J., Chuang, W-J., Lin, Y-S., Liu, C-C. & Wu, J. J., 2015 Dec 1, In : PLoS ONE. 10, 12, e0145223.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Streptococcus
molecular epidemiology
loci
nucleic acids
6 Citations (Scopus)

Correlation between serum levels of anti-endothelial cell autoantigen and anti-dengue virus nonstructural protein 1 antibodies in dengue patients

Cheng, H. J., Luo, Y. H., Wan, S. W., Lin, C. F., Wang, S-T., Hung, N. T., Liu, C-C., Ho, T-S., Liu, H-S., Yeh, T-M. & Lin, Y-S., 2015 May 1, In : American Journal of Tropical Medicine and Hygiene. 92, 5, p. 989-995 7 p.

Research output: Contribution to journalArticle

Dengue Virus
Dengue
Autoantigens
Protein Disulfide-Isomerases
Immunoglobulin M
6 Citations (Scopus)

Dengue Virus Infection Causes the Activation of Distinct NF- κ B Pathways for Inducible Nitric Oxide Synthase and TNF- Expression in RAW264.7 Cells

Cheng, Y. L., Lin, Y-S., Chen, C. L., Wan, S. W., Ou, Y. D., Yu, C. Y., Tsai, T. T., Tseng, P. C. & Lin, C. F., 2015 Jan 1, In : Mediators of Inflammation. 2015, 274025.

Research output: Contribution to journalArticle

Dengue Virus
Nitric Oxide Synthase Type II
Virus Diseases
Nitric Oxide
Viral Proteins
15 Citations (Scopus)

Insufficient acidification of autophagosomes facilitates group a streptococcus survival and growth in endothelial cells

Lu, S. L., Kuo, C. F., Chen, H. W., Yang, Y. S., Liu, C-C., Anderson, R., Wu, J. J. & Lin, Y-S., 2015 Jan 1, In : mBio. 6, 5, e01435-15.

Research output: Contribution to journalArticle

Streptococcus
Endothelial Cells
Survival
Growth
Autophagy
40 Citations (Scopus)

Kallistatin protects against sepsis-related acute lung injury via inhibiting inflammation and apoptosis

Lin, W-C., Chen, C-W., Huang, Y. W., Chao, L., Chao, J., Lin, Y-S. & Lin, C. F., 2015 Jul 22, In : Scientific reports. 5, 12463.

Research output: Contribution to journalArticle

Acute Lung Injury
Sepsis
Apoptosis
Inflammation
Bronchoalveolar Lavage Fluid
11 Citations (Scopus)

Mast cell-macrophage dynamics in modulation of dengue virus infection in skin

Chu, Y. T., Wan, S. W., Anderson, R. & Lin, Y-S., 2015 Sep 1, In : Immunology. 146, 1, p. 163-172 10 p.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Mast Cells
Macrophages
Skin
13 Citations (Scopus)

Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain

Chang, J. Y., Lee, M. H., Lin, S. R., Yang, L. Y., Sun, H-F., Sze, C-I., Hong, Q., Lin, Y-S., Chou, Y. T., Hsu, L-J., Jan, M. S., Gong, C. X. & Chang, N-S., 2015 Jan 1, In : Oncotarget. 6, 6, p. 3578-3589 12 p.

Research output: Contribution to journalArticle

Protein Transport
Hippocampus
Down-Regulation
Brain
Alternative Splicing
2014
21 Citations (Scopus)

Antibody-Dependent Enhancement Infection Facilitates Dengue Virus-Regulated Signaling of IL-10 Production in Monocytes

Tsai, T. T., Chuang, Y. J., Lin, Y-S., Chang, C-P., Wan, S. W., Lin, S-H., Chen, C. L. & Lin, C. F., 2014 Jan 1, In : PLoS neglected tropical diseases. 8, 11

Research output: Contribution to journalArticle

Antibody-Dependent Enhancement
Dengue Virus
Interleukin-10
Monocytes
1-Phosphatidylinositol 4-Kinase
3 Citations (Scopus)
Clustered Regularly Interspaced Short Palindromic Repeats
Erythromycin
Streptococcus
Nucleic Acids
Streptococcus pyogenes
14 Citations (Scopus)

Autophagy facilitates antibody-enhanced dengue virus infection in human pre-basophil/mast cells

Fang, Y. T., Wan, S. W., Lu, Y. T., Yao, J. H., Lin, C. F., Hsu, L-J., Brown, M. G., Marshall, J. S., Anderson, R. & Lin, Y-S., 2014 Oct 16, In : PLoS ONE. 9, 10, 110655.

Research output: Contribution to journalArticle

Dengue virus
Dengue Virus
basophils
Basophils
autophagy
9 Citations (Scopus)

Distinct structural features of the peroxide response regulator from group A streptococcus drive DNA binding

Lin, C. S. H., Chao, S. Y., Hammel, M., Nix, J. C., Tseng, H. L., Tsou, C. C., Fei, C. H., Chiou, H. S., Jeng, U. S., Lin, Y-S., Chuang, W-J., Wu, J. J. & Wang, S-Y., 2014 Feb 21, In : PloS one. 9, 2, e89027.

Research output: Contribution to journalArticle

Streptococcus
Peroxides
peroxides
DNA
X ray scattering
3 Citations (Scopus)
H1N1 Subtype Influenza A Virus
Pediatrics
Influenza A virus
Virus Diseases
Viruses
5 Citations (Scopus)

Invasive hypermucoid variant of group A Streptococcus is defective in growth and susceptible to DNA-damaging treatments

Chiang-Ni, C., Zheng, P. X., Wang, S-Y., Tsai, P-J., Kuo, C. F., Chuang, W-J., Lin, Y-S., Liu, C-C. & Wu, J. J., 2014 Jan 1, In : Pathogens and Disease. 70, 2, p. 194-201 8 p.

Research output: Contribution to journalArticle

Streptococcus
Capsules
DNA
Growth
Virulence
13 Citations (Scopus)

Macrophage migration inhibitory factor triggers chemotaxis of CD74+CXCR2+NKT cells in chemically induced IFN-γ-Mediated skin inflammation

Hsieh, C. Y., Chen, C. L., Lin, Y-S., Yeh, T-M., Tsai, T. T., Hong, M-Y. & Lin, C. F., 2014 Oct 1, In : Journal of Immunology. 193, 7, p. 3693-3703 11 p.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Natural Killer T-Cells
Chemotaxis
Inflammation
Skin
14 Citations (Scopus)
molecular mimicry
Molecular Mimicry
fibrinolysis
Dengue virus
Dengue Virus
23 Citations (Scopus)

Protection against dengue virus infection in mice by administration of antibodies against modified nonstructural protein 1

Wan, S. W., Lu, Y. T., Huang, C. H., Lin, C. F., Anderson, R., Liu, H-S., Yeh, T-M., Yen, Y. T., Wu-Hsieh, B. A. & Lin, Y-S., 2014 Mar 21, In : PloS one. 9, 3, e92495.

Research output: Contribution to journalArticle

Dengue virus
Dengue Virus
Virus Diseases
Viruses
antibodies
2013
12 Citations (Scopus)

Antibodies against thrombin in dengue patients contain both anti-thrombotic and pro-fibrinolytic activities

Chuang, Y. C., Lin, Y-S., Liu, H-S., Wang, J-R. & Yeh, T-M., 2013 Aug 2, In : Thrombosis and Haemostasis. 110, 2, p. 358-365 8 p.

Research output: Contribution to journalArticle

Dengue
Thrombin
Antibodies
Severe Dengue
Dengue Virus
21 Citations (Scopus)

Anti-dengue virus nonstructural protein 1 antibodies cause NO-mediated endothelial cell apoptosis via ceramide-regulated glycogen synthase kinase-3β and NF-κB activation

Chen, C. L., Lin, C. F., Wan, S. W., Wei, L. S., Chen, M. C., Yeh, T-M., Liu, H-S., Anderson, R. & Lin, Y-S., 2013 Aug 15, In : Journal of Immunology. 191, 4, p. 1744-1752 9 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Dengue Virus
Ceramides
Endothelial Cells
Apoptosis
32 Citations (Scopus)

Clinical and laboratory predictive markers for acute dengue infection

Ho, T-S., Wang, S-M., Lin, Y-S. & Liu, C-C., 2013 Oct 22, In : Journal of biomedical science. 20, 1, 75.

Research output: Contribution to journalArticle

Dengue
Biomarkers
Severe Dengue
Infection
Viruses
11 Citations (Scopus)
Necrotizing Fasciitis
Streptococcus pyogenes
Pandemics
Genome
46 Citations (Scopus)

Dengue virus infection induces autophagy: An in vivo study

Lee, Y. R., Hu, H. Y., Kuo, S. H., Lei, H. Y., Lin, Y-S., Yeh, T-M., Liu, C-C. & Liu, H-S., 2013 Sep 11, In : Journal of biomedical science. 20, 1, 65.

Research output: Contribution to journalArticle

Dengue Virus
Autophagy
Virus Diseases
Viruses
Virus Replication