• 4202 Citations
  • 39 h-Index
1991 …2020

Research output per year

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Research Output

2020

Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer

Ding, L. Y., Hou, Y. C., Kuo, I. Y., Hsu, T. Y., Tsai, T. C., Chang, H. W., Hsu, W. Y., Tsao, C. C., Tian, C. C., Wang, P. S., Wang, H. C., Lee, C. T., Wang, Y. C., Lin, S. H., Hughes, M. W., Chuang, W. J., Lu, P. J., Shan, Y. S. & Huang, P. H., 2020 Jun 17, In : Clinical Epigenetics. 12, 1, 87.

Research output: Contribution to journalArticle

Open Access

ST2 Signaling in the Tumor Microenvironment

Chang, C. P., Hu, M. H., Hsiao, Y. P. & Wang, Y. C., 2020 Jan 1, Advances in Experimental Medicine and Biology. Springer, p. 83-93 11 p. (Advances in Experimental Medicine and Biology; vol. 1240).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)
2019

AKT-mediated phosphorylation enhances protein stability and transcription activity of ZNF322A to promote lung cancer progression

Liao, S. Y., Kuo, I. Y., Chen, Y. T., Liao, P. C., Liu, Y. F., Wu, H. Y., Lai, W. W. & Wang, Y. C., 2019 Oct 10, In : Oncogene. 38, 41, p. 6723-6736 14 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

High-CLDN4 ESCC cells harbor stem-like properties and indicate for poor concurrent chemoradiation therapy response in esophageal squamous cell carcinoma

Lin, C. H., Li, H. Y., Liu, Y. P., Kuo, P. F., Wang, W. C., Lin, F. C., Chang, W. L., Sheu, B. S., Wang, Y. C., Hung, W. C., Cheng, H. C., Yao, Y. C., Calkins, M. J., Hsiao, M. & Lu, P. J., 2019, In : Therapeutic Advances in Medical Oncology. 11

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

LncRNA NORAD is repressed by the YAP pathway and suppresses lung and breast cancer metastasis by sequestering S100P

Tan, B. S., Yang, M. C., Singh, S., Chou, Y. C., Chen, H. Y., Wang, M. Y., Wang, Y. C. & Chen, R. H., 2019 Jul 11, In : Oncogene. 38, 28, p. 5612-5626 15 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
Open Access
3 Citations (Scopus)
2018

Medical Applications of Collagen and Hyaluronan in Regenerative Medicine

Huang, L. L. H., Chen, Y. H. A., Zhuo, Z. Y., Hsieh, Y. T., Yang, C. L., Chen, W. T., Lin, J. Y., Lin, Y. X., Jiang, J. T., Zhuang, C. H., Wang, Y. C., Nguyendac, H., Lin, K. W. & Liu, W. L., 2018 Jan 1, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 285-306 22 p. (Advances in Experimental Medicine and Biology; vol. 1077).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)
6 Citations (Scopus)

Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype

Tzeng, H. T., Su, C. C., Chang, C. P., Lai, W. W., Su, W. C. & Wang, Y-C., 2018 Oct 1, In : International Journal of Cancer. 143, 7, p. 1753-1763 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
4 Citations (Scopus)

VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function

Wang, Y., Tzeng, H., Tsai, C., Cheng, H., Lai, W., Liu, H. & Wang, Y., 2018 Nov 1, In : Cancer Letters. 437, p. 79-88

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer

Shieh, J. M., Tang, Y. A., Hu, F. H., Huang, W. J., Wang, Y. J., Jen, J., Liao, S. Y., Lu, Y. H., Yeh, Y. L., Wang, T. W., Lin, P. & Wang, Y. C., 2017 May 15, In : International Journal of Cancer. 140, 10, p. 2375-2386 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer

Wu, Y. H., Hong, C. W., Wang, Y. C., Huang, W. J., Yeh, Y. L., Wang, B. J., Wang, Y. J. & Chiu, H. W., 2017 Aug 1, In : Cancer Letters. 400, p. 79-88 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
9 Citations (Scopus)

CK1δ/GSK3β/FBXW7α axis promotes degradation of the ZNF322A oncoprotein to suppress lung cancer progression

Liao, S. Y., Chiang, C-W., Hsu, C. H., Chen, Y. T., Jen, J., Juan, H. F., Lai, W-W. & Wang, Y-C., 2017 Oct 12, In : Oncogene. 36, 41, p. 5722-5733 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Dysregulation of Rab37-mediated cross-talk between cancer cells and endothelial cells via thrombospondin-1 promotes tumor neovasculature and metastasis

Tzeng, H. T., Tsai, C. H., Yen, Y. T., Cheng, H. C., Chen, Y. C., Pu, S. W., Wang, Y. S., Shan, Y. S., Tseng, Y. L., Su, W. C., Lai, W. W., Wu, L. W. & Wang, Y. C., 2017 May 1, In : Clinical Cancer Research. 23, 9, p. 2335-2345 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Hyaluronan synthase 3 mediated oncogenic action through forming inter-regulation loop with tumor necrosis factor alpha in oral cancer

Kuo, Y. Z., Fang, W. Y., Huang, C. C., Tsai, S. T., Wang, Y. C., Yang, C. L. & Wu, L. W., 2017 Jan 1, In : Oncotarget. 8, 9, p. 15563-15583 21 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
86 Citations (Scopus)

Oncogenic MCT-1 activation promotes YY1-EGFR-MnSOD signaling and tumor progression

Tseng, H., Chen, Y., Jen, J., Shen, P., Chen, L., Lin, T., Wang, Y-C. & Hsu, H., 2017 Apr 1, In : Oncogenesis. 6, 4, p. e313-e313

Research output: Contribution to journalArticle

14 Citations (Scopus)

Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37

Tzeng, H. T., Li, T. H., Tang, Y. A., Tsai, C. H., Lu, P. J. F., Lai, W. W., Chiang, C. W. & Wang, Y. C., 2017, In : Oncotarget. 8, 65, p. 108556-108570 15 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment

Wang, Y. T., Chen, J., Chang, C. W., Jen, J., Huang, T. Y., Chen, C. M., Shen, R., Liang, S. Y., Cheng, I. C., Yang, S. C., Lai, W. W., Cheng, K. H., Hsieh, T. S., Lai, M. Z., Cheng, H. C., Wang, Y. C. & Chen, R. H., 2017 Aug 1, In : Journal of Clinical Investigation. 127, 8, p. 2982-2997 16 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2016
4 Citations (Scopus)
21 Citations (Scopus)

Inhibition of HDAC3- and HDAC6-promoted survivin expression plays an important role in SAHA-induced autophagy and viability reduction in breast cancer cells

Lee, J. Y. C., Kuo, C. W., Tsai, S. L., Cheng, S. M., Chen, S. H., Chan, H. H., Lin, C. H., Lin, K. Y., Li, C. F., Kanwar, J. R., Leung, E. Y., Cheung, C. C. H., Huang, W. J., Wang, Y. C. & Cheung, C. H. A., 2016 Mar 31, In : Frontiers in Pharmacology. 7, MAR, 81.

Research output: Contribution to journalArticle

26 Citations (Scopus)

MiR-193a-5p/ERBB2 act as concurrent chemoradiation therapy response indicator of esophageal squamous cell carcinoma

Lin, C. H., Tsai, C. H., Yeh, C. T., Liang, J. L., Hung, W. C., Lin, F. C., Chang, W. L., Li, H. Y., Yao, Y. C., Hsu, T. I., Lee, Y. C., Wang, Y. C., Sheu, B. S., Lai, W. W., Calkins, M. J., Hsiao, M. & Lu, P. J., 2016, In : Oncotarget. 7, 26, p. 39680-39693 14 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer

Jen, J., Lin, L. L., Chen, H. T., Liao, S. Y., Lo, F. Y., Tang, Y. A., Su, W. C., Salgia, R., Hsu, C. L., Huang, H. C., Juan, H. F. & Wang, Y. C., 2016 May 5, In : Oncogene. 35, 18, p. 2357-2369 13 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Rab-mediated vesicle trafficking in cancer

Tzeng, H. T. & Wang, Y. C., 2016 Jan 1, In : Journal of biomedical science. 23, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Refined-mapping of the novel TSG within the 17q24.3 chromosomal region in non-small cell lung cancer samples

Huang, W., Wang, Y., Chu, W. & Tseng, R., 2016 Sep, In : Oncology Letters. 12, 3, p. 1975-1980 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Zinc finger proteins in cancer progression

Jen, J. & Wang, Y. C., 2016 Jul 13, In : Journal of biomedical science. 23, 1, 53.

Research output: Contribution to journalReview article

81 Citations (Scopus)
2015

Deregulation of SLIT2-mediated Cdc42 activity is associated with esophageal cancer metastasis and poor prognosis

Tseng, R. C., Chang, J. M., Chen, J. H., Huang, W. R., Tang, Y. A., Kuo, I. Y., Yan, J. J., Lai, W. W. & Wang, Y. C., 2015 Jan 1, In : Journal of Thoracic Oncology. 10, 1, p. 189-198 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
15 Citations (Scopus)

Global Oct4 target gene analysis reveals novel downstream PTEN and TNC genes required for drug-resistance and metastasis in lung cancer

Tang, Y. A., Chen, C. H., Sun, H. S., Cheng, C. P., Tseng, V. S., Hsu, H. S., Su, W. C., Lai, W. W. & Wang, Y. C., 2015, In : Nucleic acids research. 43, 3, p. 1593-1608 16 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/β-TrCP/β-catenin pathways in lung cancer

Tseng, R. C., Chang, J. W., Mao, J. S., Tsai, C. D., Wu, P. C., Lin, C. J., Lu, Y. L., Liao, S. Y., Cheng, H. C., Hsu, H. S. & Wang, Y. C., 2015, In : Oncotarget. 6, 42, p. 44207-44221 15 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2014

A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies

Huang, W. J., Tang, Y. A., Chen, M. Y., Wang, Y. J., Hu, F. H., Wang, T. W., Chao, S. W., Chiu, H. W., Yeh, Y. L., Chang, H. Y., Juan, H. F., Lin, P. & Wang, Y. C., 2014 Apr 28, In : Cancer Letters. 346, 1, p. 84-93 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential

Wang, S. C., Lee, T. H., Hsu, C. H., Chang, Y. J., Chang, M. S., Wang, Y-C., Ho, Y. S., Wen, W. C. & Lin, R. K., 2014 Jun 18, In : Journal of Agricultural and Food Chemistry. 62, 24, p. 5625-5635 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer

Yang, Y. C., Tang, Y. A., Shieh, J. M., Lin, R. K., Hsu, H. S. & Wang, Y. C., 2014 Sep, In : Journal of Thoracic Oncology. 9, 9, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer

Lin, R. K. & Wang, Y. C., 2014 Aug 19, In : Cell and Bioscience. 4, 1, 46.

Research output: Contribution to journalArticle

43 Citations (Scopus)

HBP1 promoter methylation augments the oncogenic β-catenin to correlate with prognosis in NSCLC

Tseng, R. C., Huang, W. R., Lin, S. F., Wu, P. C., Hsu, H. S. & Wang, Y. C., 2014 Sep 1, In : Journal of Cellular and Molecular Medicine. 18, 9, p. 1752-1761 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Low SOX17 expression is a prognostic factor and drives transcriptional dysregulation and esophageal cancer progression

Kuo, I. Y., Wu, C. C., Chang, J. M., Huang, Y. L., Lin, C. H., Yan, J. J., Sheu, B. S., Lu, P. J., Chang, W. L., Lai, W. W. & Wang, Y. C., 2014 Aug 1, In : International Journal of Cancer. 135, 3, p. 563-573 11 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Network-based analysis identifies epigenetic biomarkers of esophageal squamous cell carcinoma progression

Cheng, C. P., Kuo, I. Y., Alakus, H., Frazer, K. A., Harismendy, O., Wang, Y. C. & Tseng, V. S., 2014 May 28, In : Bioinformatics. 30, 21, p. 3054-3061 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Pin1 positively affects tumorigenesis of esophageal squamous cell carcinoma and correlates with poor survival of patients

Lin, F. C., Lee, Y. C., Goan, Y. G., Tsai, C. H., Yao, Y. C., Cheng, H. C., Lai, W. W., Wang, Y. C., Sheu, B. S. & Lu, P. J., 2014 Aug 27, In : Journal of biomedical science. 21, 1, 21.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Prognostic CpG methylation biomarkers identified by methylation array in esophageal squamous cell carcinoma patients

Kuo, I. Y., Chang, J. M., Jiang, S. S., Chen, C. H., Chang, I. S., Sheu, B. S., Lu, P. J., Chang, W. L., Lai, W. W. & Wang, Y. C., 2014 May 30, In : International Journal of Medical Sciences. 11, 8, p. 779-787 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis

Tsai, C. H., Cheng, H. C., Wang, Y. S., Lin, P., Jen, J., Kuo, I. Y., Chang, Y. H., Liao, P. C., Chen, R. H., Yuan, W. C., Hsu, H. S., Yang, M. H., Hsu, M. T., Wu, C. Y. & Wang, Y. C., 2014 Sep 3, In : Nature communications. 5, 4804.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Thematic series: Transcriptional regulation and disease

Wang, Y. C., 2014 Jun 20, In : Cell and Bioscience. 4, 1, 42.

Research output: Contribution to journalEditorial

2013

A Synthetic Podophyllotoxin Derivative Exerts Anti-Cancer Effects by Inducing Mitotic Arrest and Pro-Apoptotic ER Stress in Lung Cancer Preclinical Models

Chen, J. Y., Tang, Y. A., Li, W. S., Chiou, Y. C., Shieh, J. M. & Wang, Y. C., 2013 Apr 30, In : PloS one. 8, 4, e62082.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Lack of association of C-Met-N375S sequence variant with lung cancer susceptibility and prognosis

Shieh, J. M., Tang, Y. A., Yang, T. H., Chen, C. Y., Hsu, H. S., Tan, Y. H. C., Salgia, R. & Wang, Y. C., 2013, In : International Journal of Medical Sciences. 10, 8, p. 988-994 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Suberoylanilide Hydroxamic Acid, an Inhibitor of Histone Deacetylase, Enhances Radiosensitivity and Suppresses Lung Metastasis in Breast Cancer In Vitro and In Vivo

Chiu, H. W., Yeh, Y. L., Wang, Y. C., Huang, W. J., Chen, Y. A., Chiou, Y. S., Ho, S. Y., Lin, P. & Wang, Y. J., 2013 Oct 10, In : PloS one. 8, 10, e76340.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2012

Annexin A2 silencing induces G2 arrest of non-small cell lung cancer cells through p53-dependent and -independent mechanisms

Wang, C. Y., Chen, C. L., Tseng, Y. L., Fang, Y. T., Lin, Y. S., Su, W. C., Chen, C. C., Chang, K. C., Wang, Y. C. & Lin, C. F., 2012 Sep 21, In : Journal of Biological Chemistry. 287, 39, p. 32512-32524 13 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Cancer epigenomics

Chang, J. W. & Wang, Y-C., 2012 Jan 1, Systems Biology: Applications in Cancer-Related Research. World Scientific Publishing Co., p. 129-159 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Ectopic ATP synthase blockade suppresses lung adenocarcinoma growth by activating the unfolded protein response

Chang, H. Y., Huang, H. C., Huang, T. C., Yang, P. C., Wang, Y. C. & Juan, H. F., 2012 Sep 15, In : Cancer Research. 72, 18, p. 4696-4706 11 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)