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19942019

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2019

A new histone deacetylase inhibitor enhances radiation sensitivity through the induction of misfolded protein aggregation and autophagy in triple-negative breast cancer

Chiu, H. W., Yeh, Y. L., Ho, S. Y., Wu, Y. H., Wang, B. J., Huang, W. J., Ho, Y. S., Wang, Y. J., Chen, L. C. & Tu, S. H., 2019 Nov, In : Cancers. 11, 11, 1703.

Research output: Contribution to journalArticle

Open Access

Combination of inductive effect of lipopolysaccharide and in situ mechanical conditioning for forming an autologous vascular graft in vivo

Chen, C. L., Guo, H. R., Wang, Y. J., Chang, H. T., Pan, C. Y., Tuan-Mu, H. Y., Lin, H. C., Chen, C. Y. & Hu, J. J., 2019 Dec 1, In : Scientific reports. 9, 1, 10616.

Research output: Contribution to journalArticle

Open Access

Cordycepin enhances radiosensitivity in oral squamous carcinoma cells by inducing autophagy and apoptosis through cell cycle arrest

Ho, S. Y., Wu, W. S., Lin, L. C., Wu, Y. H., Chiu, H. W., Yeh, Y. L., Huang, B. M. & Wang, Y. J., 2019 Nov 1, In : International journal of molecular sciences. 20, 21, 5366.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Bortezomib enhances radiosensitivity in oral cancer through inducing autophagy-mediated TRAF6 oncoprotein degradation

Wu, Y. H., Wu, W. S., Lin, L. C., Liu, C. S., Ho, S. Y., Wang, B. J., Huang, B. M., Yeh, Y. L., Chiu, H. W., Yang, W. L. & Wang, Y. J., 2018 Apr 27, In : Journal of Experimental and Clinical Cancer Research. 37, 1, 91.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Polymethoxyflavones prevent benzo[a]pyrene/dextran sodium sulfate-induced colorectal carcinogenesis through modulating xenobiotic metabolism and ameliorate autophagic defect in ICR mice

Wu, J. C., Tsai, M. L., Lai, C. S., Lo, C. Y., Ho, C. T., Wang, Y. J. & Pan, M. H., 2018 Apr 15, In : International Journal of Cancer. 142, 8, p. 1689-1701 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
31 Citations (Scopus)
2017

A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer

Shieh, J. M., Tang, Y. A., Hu, F. H., Huang, W. J., Wang, Y. J., Jen, J., Liao, S. Y., Lu, Y. H., Yeh, Y. L., Wang, T. W., Lin, P. & Wang, Y. C., 2017 May 15, In : International Journal of Cancer. 140, 10, p. 2375-2386 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer

Wu, Y. H., Hong, C. W., Wang, Y. C., Huang, W. J., Yeh, Y. L., Wang, B. J., Wang, Y. J. & Chiu, H. W., 2017 Aug 1, In : Cancer Letters. 400, p. 79-88 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Autophagy-inducing effect of pterostilbene: A prospective therapeutic/preventive option for skin diseases

Chen, R. J., Lee, Y. H., Yeh, Y. L., Wu, W. S., Ho, C. T., Li, C. Y., Wang, B. J. & Wang, Y. J., 2017 Jan 1, In : Journal of Food and Drug Analysis. 25, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Endoplasmic reticulum stress-triggered autophagy and lysosomal dysfunction contribute to the cytotoxicity of amine-modified silver nanoparticles in NIH 3T3 cells

Lee, Y-H., Fang, C. Y., Chiu, H. W., Cheng, F. Y., Tsai, J-C., Chen, C. W. & Wang, Y-J., 2017 Jul 1, In : Journal of Biomedical Nanotechnology. 13, 7, p. 778-794 17 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Evaluating the urate-lowering effects of different microbial fermented extracts in hyperuricemic models accompanied with a safety study

Chen, R. J., Chen, M. H., Chen, Y. L., Hsiao, C. M., Chen, H. M., Chen, S. J., Wu, M. D., Yech, Y. J., Yuan, G. F. & Wang, Y. J., 2017 Jul, In : Journal of Food and Drug Analysis. 25, 3, p. 597-606 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

P53-dependent downregulation of hTERT protein expression and telomerase activity induces senescence in lung cancer cells as a result of pterostilbene treatment

Chen, R. J., Wu, P. H., Ho, C. T., Way, T. D., Pan, M. H., Chen, H. M., Ho, Y. S. & Wang, Y. J., 2017 Aug 10, In : Cell death & disease. 8, 8, p. e2985

Research output: Contribution to journalArticle

16 Citations (Scopus)
12 Citations (Scopus)
2016
2 Citations (Scopus)
19 Citations (Scopus)

Directly interact with Keap1 and LPS is involved in the anti-inflammatory mechanisms of (-)-epicatechin-3-gallate in LPS-induced macrophages and endotoxemia

Chiou, Y. S., Huang, Q., Ho, C. T., Wang, Y. J. & Pan, M. H., 2016 May 1, In : Free Radical Biology and Medicine. 94, p. 1-16 16 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The role of hypoxia-inducible factor-1α in zinc oxide nanoparticle-induced nephrotoxicity in vitro and in vivo

Lin, Y. F., Chiu, I. J., Cheng, F. Y., Lee, Y. H., Wang, Y. J., Hsu, Y. H. & Chiu, H. W., 2016 Sep 27, In : Particle and Fibre Toxicology. 13, 1, 52.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2015

ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts

Washington, M. N., Suh, G., Orozco, A. F., Sutton, M. N., Yang, H., Wang, Y., Mao, W., Millward, S., Ornelas, A., Atkinson, N., Liao, W., Bast, R. C. & Lu, Z., 2015 Aug 6, In : Cell Death and Disease. 6, e1836.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Arsenic trioxide induces programmed cell death through stimulation of ER stress and inhibition of the ubiquitin-proteasome system in human sarcoma cells

Chiu, H. W., Tseng, Y. C., Hsu, Y. H., Lin, Y. F., Foo, N. P., Guo, H-R. & Wang, Y-J., 2015 Jan 28, In : Cancer Letters. 356, 2, p. 762-772 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Cationic polystyrene nanospheres induce autophagic cell death through the induction of endoplasmic reticulum stress

Chiu, H. W., Xia, T., Lee, Y-H., Chen, C. W., Tsai, J-C. & Wang, Y-J., 2015 Jan 14, In : Nanoscale. 7, 2, p. 736-746 11 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Protective macroautophagy is involved in Vitamin E succinate effects on human gastric carcinoma cell line SGC-7901 by inhibiting mTOR axis phosphorylation

Hou, L., Li, Y., Song, H., Zhang, Z., Sun, Y., Zhang, X., Wu, K. & Wang, Y. J., 2015 Jul 13, In : PloS one. 10, 7, e0132829.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Se-Allylselenocysteine induces autophagy by modulating the AMPK/mTOR signaling pathway and epigenetic regulation of PCDH17 in human colorectal adenocarcinoma cells

Wu, J. C., Wang, F. Z., Tsai, M. L., Lo, C. Y., Badmaev, V., Ho, C. T., Wang, Y-J. & Pan, M. H., 2015 Dec 1, In : Molecular Nutrition and Food Research. 59, 12, p. 2511-2522 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Skp2-MacroH2A1-CDK8 axis orchestrates G2/M transition and tumorigenesis

Xu, D., Li, C. F., Zhang, X., Gong, Z., Chan, C. H., Lee, S. W., Jin, G., Rezaeian, A. H., Han, F., Wang, J., Yang, W. L., Feng, Z. Z., Chen, W., Wu, C. Y., Wang, Y. J., Chow, L. P., Zhu, X. F., Zeng, Y. X. & Lin, H. K., 2015 Mar, In : Nature communications. 6, 6641.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Synergistic antitumor effects of radiation and proteasome inhibitor treatment in pancreatic cancer through the induction of autophagy and the downregulation of TRAF6

Chiu, H. W., Lin, S. W., Lin, L. C., Hsu, Y. H., Lin, Y. F., Ho, S. Y., Wu, Y-H. & Wang, Y-J., 2015 Sep 1, In : Cancer Letters. 365, 2, p. 229-239 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2014

A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies

Huang, W. J., Tang, Y. A., Chen, M. Y., Wang, Y. J., Hu, F. H., Wang, T. W., Chao, S. W., Chiu, H. W., Yeh, Y. L., Chang, H. Y., Juan, H. F., Lin, P. & Wang, Y. C., 2014 Apr 28, In : Cancer Letters. 346, 1, p. 84-93 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Arsenic trioxide induces unfolded protein response in vascular endothelial cells

Weng, C. Y., Chiou, S. Y., Wang, L., Kou, M. C., Wang, Y. J. & Wu, M. J., 2014 Feb 1, In : Archives of Toxicology. 88, 2, p. 213-226 14 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Cytotoxicity, oxidative stress, apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic fibroblasts

Lee, Y. H., Cheng, F. Y., Chiu, H. W., Tsai, J. C., Fang, C. Y., Chen, C. W. & Wang, Y. J., 2014 May, In : Biomaterials. 35, 16, p. 4706-4715 10 p.

Research output: Contribution to journalArticle

186 Citations (Scopus)

Development of taiwan’s strategies for regulating nanotechnology-based pharmaceuticals harmonized with international considerations

Guo, J. W., Lee, Y. H., Huang, H. W., Tzou, M. C., Wang, Y. J. & Tsai, J. C., 2014 Oct 15, In : International journal of nanomedicine. 9, 1, p. 4773-4783 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Metabolic and colonic microbiota transformation may enhance the bioactivities of dietary polyphenols

Chiou, Y. S., Wu, J. C., Huang, Q., Shahidi, F., Wang, Y. J., Ho, C. T. & Pan, M. H., 2014 Jan 1, In : Journal of Functional Foods. 7, 1, p. 3-25 23 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

N-acetylcysteine attenuates hexavalent chromium-induced hypersensitivity through inhibition of cell death, ROS-related signaling and cytokine expression

Lee, Y. H., Su, S. B., Huang, C. C., Sheu, H. M., Tsai, J. C., Lin, C. H., Wang, Y. J. & Wang, B. J., 2014 Sep 23, In : PloS one. 9, 9, e108317.

Research output: Contribution to journalArticle

28 Citations (Scopus)

TCDD promotes lung tumors via attenuation of apoptosis through activation of the Akt and ERK1/2 signaling pathways

Chen, R. J., Siao, S. H., Hsu, C. H., Chang, C. Y., Chang, L. W., Wu, C. H., Lin, P. & Wang, Y. J., 2014 Jun 13, In : PloS one. 9, 6, e99586.

Research output: Contribution to journalArticle

11 Citations (Scopus)
9 Citations (Scopus)

The regulation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumor promotion by estradiol in female A/J mice

Chen, R. J., Chang, C. Y., Chang, L. W., Siao, S. H., Ho, Y. S., Wu, C. H., Foo, N. P., Lin, P. & Wang, Y. J., 2014 Mar 28, In : PloS one. 9, 3, e93152.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Vitamin C effect on mitoxantrone-induced cytotoxicity in human breast cancer cell lines

Guerriero, E., Sorice, A., Capone, F., Napolitano, V., Colonna, G., Storti, G., Castello, G., Costantini, S. & Wang, Y. J., 2014 Dec 22, In : PloS one. 9, 12, e115287.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2013

Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors

Chiou, Y. S., Sang, S., Cheng, K. H., Ho, C. T., Wang, Y-J. & Pan, M. H., 2013 Jun 1, In : Carcinogenesis. 34, 6, p. 1315-1322 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Preventive effects of monascus on androgen-related diseases: Androgenetic alopecia, benign prostatic hyperplasia, and prostate cancer

Chiu, H. W., Chen, M. H., Fang, W. H., Hung, C. M., Chen, Y. L., Wu, M. D., Yuan, G. F., Wu, M. J. & Wang, Y-J., 2013 May 8, In : Journal of Agricultural and Food Chemistry. 61, 18, p. 4379-4386 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Suberoylanilide Hydroxamic Acid, an Inhibitor of Histone Deacetylase, Enhances Radiosensitivity and Suppresses Lung Metastasis in Breast Cancer In Vitro and In Vivo

Chiu, H. W., Yeh, Y. L., Wang, Y. C., Huang, W. J., Chen, Y. A., Chiou, Y. S., Ho, S. Y., Lin, P. & Wang, Y. J., 2013 Oct 10, In : PloS one. 8, 10, e76340.

Research output: Contribution to journalArticle

38 Citations (Scopus)

The immunotoxic effects of dual exposure to PCP and TCDD

Chen, H. M., Lee, Y. H., Chen, R. J., Chiu, H. W., Wang, B. J. & Wang, Y. J., 2013 Oct 16, In : Chemico-Biological Interactions. 206, 2, p. 166-174 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2012

Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: Roles of ROS, NF -kB, and MAPK pathways

Wang, L., Kou, M. C., Weng, C. Y., Hu, L. W., Wang, Y. J. & Wu, M. J., 2012 Jun 1, In : Archives of Toxicology. 86, 6, p. 879-896 18 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Arsenic trioxide enhances the radiation sensitivity of androgen-dependent and -independent human prostate cancer cells

Chiu, H. W., Chen, Y. A., Ho, S. Y. & Wang, Y. J., 2012 Feb 20, In : PloS one. 7, 2, e31579.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Chemopreventive effects of pterostilbene on urethane-induced lung carcinogenesis in mice via the inhibition of EGFR-mediated pathways and the induction of apoptosis and autophagy

Chen, R-J., Tsai, S. J., Ho, C. T., Pan, M. H., Ho, Y. S., Wu, C. H. & Wang, Y-J., 2012 Nov 21, In : Journal of Agricultural and Food Chemistry. 60, 46, p. 11533-11541 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Increased serum level of epidermal growth factor receptor in liver cancer patients and its association with exposure to arsenic

Sung, T. I., Wang, Y. J., Chen, C. Y., Hung, T. L. & Guo, H. R., 2012 May 1, In : Science of the Total Environment. 424, p. 74-78 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Monascuspiloin enhances the radiation sensitivity of human prostate cancer cells by stimulating endoplasmic reticulum stress and inducing autophagy

Chiu, H. W., Fang, W. H., Chen, Y. L., Wu, M. D., Yuan, G. F., Ho, S. Y. & Wang, Y. J., 2012 Jul 3, In : PloS one. 7, 7, e40462.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Monascuspiloin induces apoptosis and autophagic cell death in human prostate cancer cells via the akt and AMPK signaling pathways

Chen, R-J., Hung, C. M., Chen, Y. L., Wu, M. D., Yuan, G. F. & Wang, Y-J., 2012 Jul 25, In : Journal of Agricultural and Food Chemistry. 60, 29, p. 7185-7193 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice

Chiou, Y. S., Ma, N. J. L., Sang, S., Ho, C. T., Wang, Y-J. & Pan, M. H., 2012 Apr 4, In : Journal of Agricultural and Food Chemistry. 60, 13, p. 3441-3451 11 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)
2011

Arsenic trioxide and radiation enhance apoptotic effects in HL-60 cells through increased ROS generation and regulation of JNK and p38 MAPK signaling pathways

Ho, S. Y., Wu, W., Chiu, H. W., Chen, Y. A., Ho, Y. S., Guo, H. R. & Wang, Y. J., 2011 Sep 5, In : Chemico-Biological Interactions. 193, 2, p. 162-171 10 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Arsenic trioxide induces autophagy and apoptosis in human glioma cells in vitro and in vivo through downregulation of survivin

Chiu, H. W., Ho, Y. S. & Wang, Y. J., 2011 Sep 1, In : Journal of Molecular Medicine. 89, 9, p. 927-941 15 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Chemoprevention of colonic tumorigenesis by dietary hydroxylated polymethoxyflavones in azoxymethane-treated mice

Lai, C. S., Tsai, M. L., Cheng, A. C., Li, S., Lo, C. Y., Wang, Y., Xiao, H., Ho, C. T., Wang, Y-J. & Pan, M. H., 2011 Feb 1, In : Molecular Nutrition and Food Research. 55, 2, p. 278-290 13 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces α9-nicotinic acetylcholine receptor expression in human breast cancer cells

Lee, C. H., Chang, Y. C., Chen, C. S., Tu, S. H., Wang, Y. J., Chen, L. C., Chang, Y. J., Wei, P. L., Chang, H. W., Chang, C. H., Huang, C. S., Wu, C. H. & Ho, Y. S., 2011 Sep 1, In : Breast Cancer Research and Treatment. 129, 2, p. 331-345 15 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
20 Citations (Scopus)