• 13573 Citations
  • 49 h-Index
19942019

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5-Hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone induces apoptosis through reactive oxygen species production, growth arrest and DNA damage-inducible gene 153 expression, and caspase activation in human leukemia cells

Pan, M. H., Lai, Y. S., Lai, C. S., Wang, Y. J., Li, S., Lo, C. Y., Dushenkov, S. & Ho, C. T., 2007 Jun 27, In : Journal of Agricultural and Food Chemistry. 55, 13, p. 5081-5091 11 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)
50 Citations (Scopus)

Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice

Pan, M. H., Lai, C. S., Wang, Y. J. & Ho, C. T., 2006 Nov 15, In : Biochemical Pharmacology. 72, 10, p. 1293-1303 11 p.

Research output: Contribution to journalArticle

107 Citations (Scopus)
28 Citations (Scopus)

A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer

Shieh, J. M., Tang, Y. A., Hu, F. H., Huang, W. J., Wang, Y. J., Jen, J., Liao, S. Y., Lu, Y. H., Yeh, Y. L., Wang, T. W., Lin, P. & Wang, Y. C., 2017 May 15, In : International Journal of Cancer. 140, 10, p. 2375-2386 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies

Huang, W. J., Tang, Y. A., Chen, M. Y., Wang, Y. J., Hu, F. H., Wang, T. W., Chao, S. W., Chiu, H. W., Yeh, Y. L., Chang, H. Y., Juan, H. F., Lin, P. & Wang, Y. C., 2014 Apr 28, In : Cancer Letters. 346, 1, p. 84-93 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

A new histone deacetylase inhibitor enhances radiation sensitivity through the induction of misfolded protein aggregation and autophagy in triple-negative breast cancer

Chiu, H. W., Yeh, Y. L., Ho, S. Y., Wu, Y. H., Wang, B. J., Huang, W. J., Ho, Y. S., Wang, Y. J., Chen, L. C. & Tu, S. H., 2019 Nov, In : Cancers. 11, 11, 1703.

Research output: Contribution to journalArticle

Open Access

A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer

Wu, Y. H., Hong, C. W., Wang, Y. C., Huang, W. J., Yeh, Y. L., Wang, B. J., Wang, Y. J. & Chiu, H. W., 2017 Aug 1, In : Cancer Letters. 400, p. 79-88 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Anti-inflammatory and antitumor promotional effects of a novel urinary metabolite, 3′,4′-didemethylnobiletin, derived from nobiletin

Lai, C. S., Li, S., Chai, C. Y., Lo, C. Y., Dushenkov, S., Ho, C. T., Pan, M. H. & Wang, Y-J., 2008 Dec 15, In : Carcinogenesis. 29, 12, p. 2415-2424 10 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)

Antioxidative and antiplatelet effects of aqueous inflorescence Piper betle extract

Lei, D., Chan, C. P., Wang, Y-J., Wang, T. M., Lin, B. R., Huang, C. H., Lee, J. J., Chen, H. M., Jeng, J. H. & Chang, M. C., 2003 Mar 26, In : Journal of Agricultural and Food Chemistry. 51, 7, p. 2083-2088 6 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Antiplatelet effect of sanguinarine is correlated to calcium mobilization, thromboxane and cAMP production

Jeng, J. H., Wu, H. L., Lin, B. R., Lan, W. H., Chang, H. H., Ho, Y. S., Lee, P. H., Wang, Y. J., Wang, J. S., Chen, Y. J. & Chang, M. C., 2007 Apr 1, In : Atherosclerosis. 191, 2, p. 250-258 9 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Antitumor activity of 3,5,4′-trimethoxystilbene in COLO 205 cells and xenografts in SCID mice

Pan, M. H., Gao, J. H., Lai, C. S., Wang, Y. J., Chen, W. M., Lo, C. Y., Wang, M., Dushenkov, S. & Ho, C. T., 2008 Mar 1, In : Molecular Carcinogenesis. 47, 3, p. 184-196 13 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Antitumor effects of miconazole on human colon carcinoma xenografts in nude mice through induction of apoptosis and G0/G1 cell cycle arrest

Wu, C. H., Jeng, J. H., Wang, Y. J., Tseng, C. J., Liang, Y. C., Chen, C. H., Lee, H. M., Lin, J. K., Lin, C. H., Lin, S. Y., Li, C. P. & Ho, Y. S., 2002 Apr 1, In : Toxicology and Applied Pharmacology. 180, 1, p. 22-35 14 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Apple polyphenol phloretin potentiates the anticancer actions of paclitaxel through induction of apoptosis in human Hep G2 cells

Yang, K. C., Tsai, C. Y., Wang, Y. J., Wei, P. L., Lee, C. H., Chen, J. H., Wu, C. H. & Ho, Y. S., 2009 May 1, In : Molecular Carcinogenesis. 48, 5, p. 420-431 12 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: Association of glutathione, reactive oxygen species and mitochondrial membrane potential

Chang, M. C., Ho, Y. S., Lee, P. H., Chan, C. P., Lee, J. J., Hahn, L. J., Wang, Y-J. & Jeng, J. H., 2001 Oct 8, In : Carcinogenesis. 22, 9, p. 1527-1535 9 p.

Research output: Contribution to journalArticle

107 Citations (Scopus)

Areca nut extract up-regulates prostaglandin production, cyclooxygenase-2 mRNA and protein expression of human oral keratinocytes

Jeng, J. H., Ho, Y. S., Chan, C. P., Wang, Y. J., Hahn, L. J., Lei, D., Hsu, C. C. & Chang, M. C., 2000 Jan 1, In : Carcinogenesis. 21, 7, p. 1365-1370 6 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts

Washington, M. N., Suh, G., Orozco, A. F., Sutton, M. N., Yang, H., Wang, Y., Mao, W., Millward, S., Ornelas, A., Atkinson, N., Liao, W., Bast, R. C. & Lu, Z., 2015 Aug 6, In : Cell Death and Disease. 6, e1836.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: Roles of ROS, NF -kB, and MAPK pathways

Wang, L., Kou, M. C., Weng, C. Y., Hu, L. W., Wang, Y. J. & Wu, M. J., 2012 Jun 1, In : Archives of Toxicology. 86, 6, p. 879-896 18 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Arsenic trioxide and radiation enhance apoptotic effects in HL-60 cells through increased ROS generation and regulation of JNK and p38 MAPK signaling pathways

Ho, S. Y., Wu, W., Chiu, H. W., Chen, Y. A., Ho, Y. S., Guo, H. R. & Wang, Y. J., 2011 Sep 5, In : Chemico-Biological Interactions. 193, 2, p. 162-171 10 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Arsenic trioxide enhances the radiation sensitivity of androgen-dependent and -independent human prostate cancer cells

Chiu, H. W., Chen, Y. A., Ho, S. Y. & Wang, Y. J., 2012 Feb 20, In : PloS one. 7, 2, e31579.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Arsenic trioxide induces autophagy and apoptosis in human glioma cells in vitro and in vivo through downregulation of survivin

Chiu, H. W., Ho, Y. S. & Wang, Y. J., 2011 Sep 1, In : Journal of Molecular Medicine. 89, 9, p. 927-941 15 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Arsenic trioxide induces programmed cell death through stimulation of ER stress and inhibition of the ubiquitin-proteasome system in human sarcoma cells

Chiu, H. W., Tseng, Y. C., Hsu, Y. H., Lin, Y. F., Foo, N. P., Guo, H-R. & Wang, Y-J., 2015 Jan 28, In : Cancer Letters. 356, 2, p. 762-772 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Arsenic trioxide induces unfolded protein response in vascular endothelial cells

Weng, C. Y., Chiou, S. Y., Wang, L., Kou, M. C., Wang, Y. J. & Wu, M. J., 2014 Feb 1, In : Archives of Toxicology. 88, 2, p. 213-226 14 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2 Citations (Scopus)

Autophagy-inducing effect of pterostilbene: A prospective therapeutic/preventive option for skin diseases

Chen, R. J., Lee, Y. H., Yeh, Y. L., Wu, W. S., Ho, C. T., Li, C. Y., Wang, B. J. & Wang, Y. J., 2017 Jan 1, In : Journal of Food and Drug Analysis. 25, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Bcl-2 Overexpression Inhibits Tetrachlorohydroquinone-Induced Apoptosis in NIH3T3 Cells: A Possible Mechanism for Tumor Promotion

Lin, Y. P., Zhu, B. Z., Yang, M. C., Frei, B., Pan, M. H., Lin, J. K. & Wang, Y. J., 2004 May 1, In : Molecular Carcinogenesis. 40, 1, p. 24-33 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
20 Citations (Scopus)

Bortezomib enhances radiosensitivity in oral cancer through inducing autophagy-mediated TRAF6 oncoprotein degradation

Wu, Y. H., Wu, W. S., Lin, L. C., Liu, C. S., Ho, S. Y., Wang, B. J., Huang, B. M., Yeh, Y. L., Chiu, H. W., Yang, W. L. & Wang, Y. J., 2018 Apr 27, In : Journal of Experimental and Clinical Cancer Research. 37, 1, 91.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Carbonyl compounds and toxicity assessments of emissions from a diesel engine running on biodiesels

Liu, Y. Y., Lin, T. C., Wang, Y. J. & Ho, W. L., 2009 Feb, In : Journal of the Air and Waste Management Association. 59, 2, p. 163-171 9 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Cationic polystyrene nanospheres induce autophagic cell death through the induction of endoplasmic reticulum stress

Chiu, H. W., Xia, T., Lee, Y-H., Chen, C. W., Tsai, J-C. & Wang, Y-J., 2015 Jan 14, In : Nanoscale. 7, 2, p. 736-746 11 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Chemoprevention of colonic tumorigenesis by dietary hydroxylated polymethoxyflavones in azoxymethane-treated mice

Lai, C. S., Tsai, M. L., Cheng, A. C., Li, S., Lo, C. Y., Wang, Y., Xiao, H., Ho, C. T., Wang, Y. J. & Pan, M. H., 2011 Feb 1, In : Molecular Nutrition and Food Research. 55, 2, p. 278-290 13 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Chemopreventive effects of pterostilbene on urethane-induced lung carcinogenesis in mice via the inhibition of EGFR-mediated pathways and the induction of apoptosis and autophagy

Chen, R-J., Tsai, S. J., Ho, C. T., Pan, M. H., Ho, Y. S., Wu, C. H. & Wang, Y-J., 2012 Nov 21, In : Journal of Agricultural and Food Chemistry. 60, 46, p. 11533-11541 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Chitosan prevents the development of AOM-induced aberrant crypt foci in mice and suppressed the proliferation of AGS cells by inhibiting DNA synthesis

Lin, S. Y., Chan, H. Y., Shen, F. H., Chen, M. H., Wang, Y-J. & Yu, C-K., 2007 Apr 15, In : Journal of Cellular Biochemistry. 100, 6, p. 1573-1580 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Combination of inductive effect of lipopolysaccharide and in situ mechanical conditioning for forming an autologous vascular graft in vivo

Chen, C. L., Guo, H. R., Wang, Y. J., Chang, H. T., Pan, C. Y., Tuan-Mu, H. Y., Lin, H. C., Chen, C. Y. & Hu, J. J., 2019 Dec 1, In : Scientific reports. 9, 1, 10616.

Research output: Contribution to journalArticle

Open Access
20 Citations (Scopus)

Combination treatment with arsenic trioxide and irradiation enhances apoptotic effects in U937 cells through increased mitotic arrest and ROS generation

Ho, S. Y., Chen, W. C., Chiu, H. W., Lai, C. S., Guo, H. R. & Wang, Y. J., 2009 May 15, In : Chemico-Biological Interactions. 179, 2-3, p. 304-313 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
83 Citations (Scopus)

Cordycepin enhances radiosensitivity in oral squamous carcinoma cells by inducing autophagy and apoptosis through cell cycle arrest

Ho, S. Y., Wu, W. S., Lin, L. C., Wu, Y. H., Chiu, H. W., Yeh, Y. L., Huang, B. M. & Wang, Y. J., 2019 Nov 1, In : International journal of molecular sciences. 20, 21, 5366.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces α9-nicotinic acetylcholine receptor expression in human breast cancer cells

Lee, C. H., Chang, Y. C., Chen, C. S., Tu, S. H., Wang, Y. J., Chen, L. C., Chang, Y. J., Wei, P. L., Chang, H. W., Chang, C. H., Huang, C. S., Wu, C. H. & Ho, Y. S., 2011 Sep 1, In : Breast Cancer Research and Treatment. 129, 2, p. 331-345 15 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Cytotoxicity, oxidative stress, apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic fibroblasts

Lee, Y. H., Cheng, F. Y., Chiu, H. W., Tsai, J. C., Fang, C. Y., Chen, C. W. & Wang, Y. J., 2014 May, In : Biomaterials. 35, 16, p. 4706-4715 10 p.

Research output: Contribution to journalArticle

193 Citations (Scopus)

Development of taiwan’s strategies for regulating nanotechnology-based pharmaceuticals harmonized with international considerations

Guo, J. W., Lee, Y. H., Huang, H. W., Tzou, M. C., Wang, Y. J. & Tsai, J. C., 2014 Oct 15, In : International journal of nanomedicine. 9, 1, p. 4773-4783 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
42 Citations (Scopus)

Dihydrolipoic acid inhibits skin tumor promotion through anti-inflammation and anti-oxidation

Ho, Y. S., Lai, C. S., Liu, H. I., Ho, S. Y., Tai, C., Pan, M. H. & Wang, Y. J., 2007 Jun 1, In : Biochemical Pharmacology. 73, 11, p. 1786-1795 10 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Dihydrolipoic acid inhibits tetrachlorohydroquinone-induced tumor promotion through prevention of oxidative damage

Wang, Y. J., Yang, M. C. & Pan, M. H., 2008 Dec 1, In : Food and Chemical Toxicology. 46, 12, p. 3739-3748 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Directly interact with Keap1 and LPS is involved in the anti-inflammatory mechanisms of (-)-epicatechin-3-gallate in LPS-induced macrophages and endotoxemia

Chiou, Y. S., Huang, Q., Ho, C. T., Wang, Y. J. & Pan, M. H., 2016 May 1, In : Free Radical Biology and Medicine. 94, p. 1-16 16 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
18 Citations (Scopus)

Effects of fungal-derived high molecular weight chitosan on 5-fluorouracil-induced adverse reactions

Uen, Y. H., Wang, Y. J., Hsu, T. M., Chen, M. H., Chan, H. Y., Ho, Y. S. & Lin, S. Y., 2008 Sep 1, In : Journal of Bioactive and Compatible Polymers. 23, 5, p. 458-472 15 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells

Huang, C. H., Tsai, S. J., Wang, Y. J., Pan, M. H., Kao, J. Y. & Way, T. D., 2009 Oct 9, In : Molecular Nutrition and Food Research. 53, 9, p. 1156-1165 10 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Endoplasmic reticulum stress-triggered autophagy and lysosomal dysfunction contribute to the cytotoxicity of amine-modified silver nanoparticles in NIH 3T3 cells

Lee, Y-H., Fang, C. Y., Chiu, H. W., Cheng, F. Y., Tsai, J-C., Chen, C. W. & Wang, Y-J., 2017 Jul 1, In : Journal of Biomedical Nanotechnology. 13, 7, p. 778-794 17 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
30 Citations (Scopus)