• 13573 Citations
  • 49 h-Index
19942019

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Article
2006

Mechanisms of apoptosis induction and cell cycle regulation in irradiated leukemia U937 cells and enhancement by arsenic trioxide

Ho, S. Y., Huang, P. C., Guo, H-R., Chang, W. H., Chen, R-J., Wei, B. L., Wu, W. J., Tai, C. & Wang, Y-J., 2006 Apr 1, In : Radiation Research. 165, 4, p. 390-399 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Prolonged exposure to arecoline arrested human KB epithelial cell growth: Regulatory mechanisms of cell cycle and apoptosis

Lee, P. H., Chang, M. C., Chang, W. H., Wang, T. M., Wang, Y. J., Hahn, L. J., Ho, Y. S., Lin, C. Y. & Jeng, J. H., 2006 Mar 15, In : Toxicology. 220, 2-3, p. 81-89 9 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Protective effects of N-acetylcysteine treatment post acute paraquat intoxication in rats and in human lung epithelial cells

Yeh, S. T. Y., Guo, H-R., Su, Y. S., Lin, H. J., Hou, C. C., Chen, H. M., Chang, M. C. & Wang, Y-J., 2006 Jun 15, In : Toxicology. 223, 3, p. 181-190 10 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Signaling mechanism of thrombin-induced gingival fibroblast-populated collagen gel contraction

Jeng, J. H., Lan, W. H., Wang, J. S., Chan, C. P., Ho, Y. S., Lee, P. H., Wang, Y-J., Wang, T. M., Chen, Y. J. & Chang, M. C., 2006 Jan 1, In : British Journal of Pharmacology. 147, 2, p. 188-198 11 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Staurosporine modulates radiosensitivity and radiation-induced apoptosis in U937 cells

Guo, H-R., Chen, C-H., Ho, S. Y., Ho, Y. S., Chen, R-J. & Wang, Y-J., 2006 Feb 1, In : International Journal of Radiation Biology. 82, 2, p. 97-109 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Toxic and metabolic effect of sodium butyrate on SAS tongue cancer cells: Role of cell cycle deregulation and redox changes

Jeng, J. H., Kuo, M. Y. P., Lee, P. H., Wang, Y. J., Lee, M. Y., Lee, J. J., Lin, B. R., Tai, T. F. & Chang, M. C., 2006 Jun 15, In : Toxicology. 223, 3, p. 235-247 13 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2005
50 Citations (Scopus)
28 Citations (Scopus)
16 Citations (Scopus)

Inhibition of cyclooxygenase activity, platelet aggregation and thromboxane B 2 production by two environmental toxicants: m- and o-cresol

Chan, C. P., Yuan-Soon, H., Wang, Y-J., Lan, W. H., Chen, L. I., Chen, Y. J., Lin, B. R., Chang, M. C. & Jeng, J. H., 2005 Mar 1, In : Toxicology. 208, 1, p. 95-104 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: Roles of cyclic AMP and p38 mitogen-activated protein kinase

Liang, Y. C., Wu, C. H., Chu, J. S., Wang, C. K., Hung, L. F., Wang, Y. J., Ho, Y. S., Chang, J. G. & Lin, S. Y., 2005 May 7, In : World journal of gastroenterology. 11, 17, p. 2557-2563 7 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Molecular mechanisms of denbinobin-induced anti-tumorigenesis effect in colon cancer cells

Yang, K. C., Uen, Y. H., Suk, F. M., Liang, Y. C., Wang, Y. J., Ho, Y. S., Li, I. H. & Lin, S. Y., 2005 May 28, In : World journal of gastroenterology. 11, 20, p. 3040-3045 6 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Molecular mechanisms of econazole-induced toxicity on human colon cancer cells: G0/G1 cell cycle arrest and caspase 8-independent apoptotic signaling pathways

Ho, Y. S., Wu, C. H., Chou, H. M., Wang, Y. J., Tseng, H., Chen, C. H., Chen, L. C., Lee, C. H. & Lin, S. Y., 2005 Oct 1, In : Food and Chemical Toxicology. 43, 10, p. 1483-1495 13 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFκB activation and cyclin D1 up-regulation

Ho, Y. S., Chen, C. H., Wang, Y. J., Pestell, R. G., Albanese, C., Chen, R. J., Chang, M. C., Jeng, J. H., Lin, S. Y., Liang, Y. C., Tseng, H., Lee, W. S., Lin, J. K., Chu, J. S., Chen, L. C., Lee, C. H., Tso, W. L., Lai, Y. C. & Wu, C. H., 2005 Jun 1, In : Toxicology and Applied Pharmacology. 205, 2, p. 133-148 16 p.

Research output: Contribution to journalArticle

89 Citations (Scopus)
2004

Bcl-2 Overexpression Inhibits Tetrachlorohydroquinone-Induced Apoptosis in NIH3T3 Cells: A Possible Mechanism for Tumor Promotion

Lin, Y. P., Zhu, B. Z., Yang, M. C., Frei, B., Pan, M. H., Lin, J. K. & Wang, Y. J., 2004 May 1, In : Molecular Carcinogenesis. 40, 1, p. 24-33 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Increased risk of developing hepatocellular carcinoma associated with carriage of the TNF2 allele of the -308 tumor necrosis factor-α promoter gene

Ho, S. Y., Wang, Y. J., Chen, H. L., Chen, C. H., Chang, C. J., Wang, P. J., Chen, H. H. W. & Guo, H. R., 2004 Sep 1, In : Cancer Causes and Control. 15, 7, p. 657-663 7 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)
92 Citations (Scopus)

Reactive oxygen species are crucial for hydroxychavicol toxicity toward KB epithelial cells

Jeng, J. H., Wang, Y. J., Chang, W. H., Wu, H. L., Li, C. H., Uang, B. J., Kang, J. J., Lee, J. J., Hahn, L. J., Lin, B. R. & Chang, M. C., 2004 Jan 1, In : Cellular and Molecular Life Sciences. 61, 1, p. 83-96 14 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

The topical application of 2,3,7,8-tetrachlorodibenzo-p-dioxin lacks skin tumor-promoting potency but induces hepatic injury and tumor necrosis factor-α expression in ICR male mice

Wu, C. H., Chen, H. L., Su, H-J., Lee, C-C., Shen, K. T., Ho, W. L., Ho, S. Y., Ho, Y. S. & Wang, Y-J., 2004 Aug 1, In : Food and Chemical Toxicology. 42, 8, p. 1217-1225 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2003

Antioxidative and antiplatelet effects of aqueous inflorescence Piper betle extract

Lei, D., Chan, C. P., Wang, Y-J., Wang, T. M., Lin, B. R., Huang, C. H., Lee, J. J., Chen, H. M., Jeng, J. H. & Chang, M. C., 2003 Mar 26, In : Journal of Agricultural and Food Chemistry. 51, 7, p. 2083-2088 6 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
24 Citations (Scopus)

In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrest

Lee, W. S., Chen, R-J., Wang, Y-J., Tseng, H., Jeng, J. H., Lin, S. Y., Liang, Y. C., Chen, C. H., Lin, C. H., Lin, J. K., Ho, P. Y., Chu, J. S., Ho, W. L., Chen, L. C. & Ho, Y. S., 2003 Aug 10, In : International Journal of Cancer. 106, 1, p. 125-137 13 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Lipid peroxidation and cell death mechanisms in rats and human cells induced by chloral hydrate

Ho, Y. S., Ma, H. Y., Chang, H. Y., Wei, B. L., Lee, C-C., Ho, S. Y., Guo, H-R., Wu, T. P., Chang, W. H. & Wang, Y-J., 2003 May 1, In : Food and Chemical Toxicology. 41, 5, p. 621-629 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Mediation of enhanced transcription of the IL-10 gene in T cells, upon contact with human glioma cells, by Fas signaling through a protein kinase A-independent pathway

Yang, B. C., Lin, H. K., Hor, W. S., Hwang, J. Y., Lin, Y. P., Liu, M. Y. & Wang, Y. J., 2003 Oct 15, In : Journal of Immunology. 171, 8, p. 3947-3954 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Molecular mechanisms of G0/G1 cell-cycle arrest and apoptosis induced by terfenadine in human cancer cells

Liu, J. D., Wang, Y. J., Chen, C. H., Yu, C. F., Chen, L. C., Lin, J. K., Liang, Y. C., Lin, S. Y. & Ho, Y. S., 2003 May 1, In : Molecular Carcinogenesis. 37, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Skin tumor-promoting potential and systemic effects of pentachlorophenol and its major metabolite tetrachlorohydroquinone in CD-1 mice

Chang, W. C., Jeng, J. H., Shieh, C. C., Tsai, Y. C., Ho, Y. S., Guo, H. R., Liu, H. I., Lee, C. C., Ho, S. Y. & Wang, Y. J., 2003 Apr 1, In : Molecular Carcinogenesis. 36, 4, p. 161-170 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2002

Antitumor effects of miconazole on human colon carcinoma xenografts in nude mice through induction of apoptosis and G0/G1 cell cycle arrest

Wu, C. H., Jeng, J. H., Wang, Y. J., Tseng, C. J., Liang, Y. C., Chen, C. H., Lee, H. M., Lin, J. K., Lin, C. H., Lin, S. Y., Li, C. P. & Ho, Y. S., 2002 Apr 1, In : Toxicology and Applied Pharmacology. 180, 1, p. 22-35 14 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity

Wang, Y. J., Yu, C. F., Chen, L. C., Chen, C. H., Lin, J. K., Liang, Y. C., Lin, C. H., Lin, S. Y., Chen, C. F. & Ho, Y. S., 2002 Oct 16, In : Journal of Cellular Biochemistry. 87, 2, p. 147-159 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Ketoconazole potentiates the antitumor effects of nocodazole: In vivo therapy for human tumor xenografts in nude mice

Wang, Y. J., Jeng, J. H., Chen, R. J., Tseng, H., Chen, L. C., Liang, Y. C., Lin, C. H., Chen, C. H., Chu, J. S., Ho, W. L. & Ho, Y. S., 2002 Aug 14, In : Molecular Carcinogenesis. 34, 4, p. 199-210 12 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Lipid peroxidation and cell death mechanisms in pulmonary epithelial cells induced by peroxynitrite and nitric oxide

Ho, Y. S., Liou, H. B., Lin, J. K., Jeng, J. H., Pan, M. H., Lin, Y. P., Guo, H. R., Ho, S. Y., Lee, C. C. & Wang, Y. J., 2002 Sep 17, In : Archives of Toxicology. 76, 8, p. 484-493 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Microtubule damaging agents induce apoptosis in HL 60 cells and G2/M cell cycle arrest in HT 29 cells

Tseng, C. J., Wang, Y. J., Liang, Y. C., Jeng, J. H., Lee, W. S., Lin, J. K., Chen, C. H., Liu, I. C. & Ho, Y. S., 2002 Jun 14, In : Toxicology. 175, 1-3, p. 123-142 20 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)
2001

Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: Association of glutathione, reactive oxygen species and mitochondrial membrane potential

Chang, M. C., Ho, Y. S., Lee, P. H., Chan, C. P., Lee, J. J., Hahn, L. J., Wang, Y-J. & Jeng, J. H., 2001 Oct 8, In : Carcinogenesis. 22, 9, p. 1527-1535 9 p.

Research output: Contribution to journalArticle

107 Citations (Scopus)

Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells

Ho, Y. S., Duh, J. S., Jeng, J. H., Wang, Y-J., Liang, Y. C., Lin, C. H., Tseng, C. J., Yu, C. F., Chen, R-J. & Lin, J. K., 2001 Feb 1, In : International Journal of Cancer. 91, 3, p. 393-401 9 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)

Oxidative stress and liver toxicity in rats and human hepatoma cell line induced by pentachlorophenol and its major metabolite tetrachlorohydroquinone

Wang, Y. J., Lee, C. C., Chang, W. C., Liou, H. B. & Ho, Y. S., 2001 Jun 20, In : Toxicology Letters. 122, 2, p. 157-169 13 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions

Chen, A. L., Hsu, C. H., Lin, J. K., Hsu, M. M., Ho, Y. F., She, T. S., Ko, J. Y., Lin, J. T., Lin, B. R., Wu, M. S., Yu, H. S., Jee, S. H., Chen, G. S., Chen, T. M., Chen, C. A., Lai, M. K., Pu, Y. S., Pan, M. H., Wang, Y-J., Tsai, C. C. & 1 others, Hsieh, C. Y., 2001 Nov 22, In : Anticancer research. 21, 4 B, p. 2895-2900 6 p.

Research output: Contribution to journalArticle

1557 Citations (Scopus)
2000

Areca nut extract up-regulates prostaglandin production, cyclooxygenase-2 mRNA and protein expression of human oral keratinocytes

Jeng, J. H., Ho, Y. S., Chan, C. P., Wang, Y. J., Hahn, L. J., Lei, D., Hsu, C. C. & Chang, M. C., 2000 Jan 1, In : Carcinogenesis. 21, 7, p. 1365-1370 6 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)
42 Citations (Scopus)

Ketoconazole induces G0/G1 arrest in human colorectal and hepatocellular carcinoma cell lines

Chen, R. J., Lee, W. S., Liang, Y. C., Lin, J. K., Wang, Y. J., Lin, C. H., Hsieh, J. Y., Chaing, C. C. & Ho, Y. S., 2000 Dec 1, In : Toxicology and Applied Pharmacology. 169, 2, p. 132-141 10 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
1999

Induction of apoptosis by S-nitrosoglutathione and Cu2+ or Ni2+ ion through modulation of bax, bad, and bcl-2 proteins in human colon adenocarcinoma cells

Ho, Y. S., Liu, H. L., Duh, J. S., Chen, R-J., Ho, W. L., Jeng, J. H., Wang, Y-J. & Lin, J. K., 1999 Nov 22, In : Molecular Carcinogenesis. 26, 3, p. 201-211 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
1998

Mechanisms of cell death induced by nitric oxide and peroxynitrite in Calu-1 cells

Wang, Y. J., Ho, Y. S., Pan, M. H. & Lin, J. K., 1998 Aug 4, In : Environmental Toxicology and Pharmacology. 6, 1, p. 35-44 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
1997

Induction of glutathione depletion, p53 protein accumulation and cellular transformation by tetrachlorohydroquinone, a toxic metabolite of pentachlorophenol

Wang, Y. J., Ho, Y. S., Chu, S. W., Lien, H. J., Liu, T. H. & Lin, J. K., 1997 Jun 6, In : Chemico-Biological Interactions. 105, 1, p. 1-16 16 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Stability of curcumin in buffer solutions and characterization of its degradation products

Wang, Y. J., Pan, M. H., Cheng, A. L., Lin, L. I., Ho, Y. S., Hsieh, C. Y. & Lin, J. K., 1997 Aug 1, In : Journal of Pharmaceutical and Biomedical Analysis. 15, 12, p. 1867-1876 10 p.

Research output: Contribution to journalArticle

1062 Citations (Scopus)

Suppression of nitric oxide-induced apoptosis by N-acetyl-L-cysteine through modulation of glutathione, bcl-2, and bax protein levels

Ho, Y. S., Lee, H. M., Mou, T. C., Wang, Y-J. & Lin, J. K., 1997 Jul 28, In : Molecular Carcinogenesis. 19, 2, p. 101-113 13 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
1996

Induction of p53 and p21/WAF1/CIP1 expression by nitric oxide and their association with apoptosis in human cancer cells

Ho, Y. S., Wang, Y. J. & Lin, J. K., 1996 May 1, In : Molecular Carcinogenesis. 16, 1, p. 20-31 12 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)
1995
30 Citations (Scopus)

Oxidative modification of DNA bases in rat liver and lung during chemical carcinogenesis and aging

Wang, Y-J., Ho, Y. S., Lo, M. J. & Lin, J. K., 1995 Jan 1, In : Chemico-Biological Interactions. 94, 2, p. 135-145 11 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

p53 gene mutational spectra in hepatocellular carcinomas induced by 2‐acetylaminofluorene and N‐nitroso‐2‐acetylaminofluorene in rats

Ho, YS. S., Cheng, HT. T., Wang, YJ. J. & Lin, JK. K., 1995 Jul, In : Molecular Carcinogenesis. 13, 3, p. 182-190 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
1994

Eugenol Triggers Different Pathobiological Effects on Human Oral Mucosal Fibroblasts 1

Jeng, J. H., Hahn, L. J., Kuo, M. Y. P. & Wang, Y. J., 1994 May, In : Journal of Dental Research. 73, 5, p. 1050-1055 6 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)