• 2513 Citations
  • 27 h-Index
1991 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 2513 Citations
  • 27 h-Index
  • 56 Article
  • 1 Conference contribution
  • 1 Review article
2020

Development of microfluidic concentrator using ion concentration polarization mechanism to assist trapping magnetic nanoparticle-bound miRNA to detect with Raman tags

Chen, W. Y., Wang, C. H., Wang, K. H., Chen, Y. L., Chau, L. K. & Wang, S. C., 2020 Jan 1, In : Biomicrofluidics. 14, 1, 014102.

Research output: Contribution to journalArticle

MicroRNA-150-5p promotes cell motility by inhibiting c-Myb-mediated Slug suppression and is a prognostic biomarker for recurrent ovarian cancer

Tung, C. H., Kuo, L. W., Huang, M. F., Wu, Y. Y., Tsai, Y. T., Wu, J. E., Hsu, K. F., Chen, Y. L. & Hong, T. M., 2020 Jan 23, In : Oncogene. 39, 4, p. 862-876 15 p.

Research output: Contribution to journalArticle

2019

A DNA Aptamer Targeting Galectin-1 as a Novel Immunotherapeutic Strategy for Lung Cancer

Tsai, Y. T., Liang, C. H., Yu, J. H., Huang, K. C., Tung, C. H., Wu, J. E., Wu, Y. Y., Chang, C. H., Hong, T. M. & Chen, Y. L., 2019 Dec 6, In : Molecular Therapy - Nucleic Acids. 18, p. 991-998 8 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Effects of Restorative Materials on Dental Pulp Stem Cell Properties

Chen, C. A., Chen, Y-L., Huang, J-S., Huang, G. T. J. & Chuang, S-F., 2019 Apr 1, In : Journal of Endodontics. 45, 4, p. 420-426 7 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2018
2017

Glycosylation-dependent galectin-1/neuropilin-1 interactions promote liver fibrosis through activation of TGF-β-and PDGF-like signals in hepatic stellate cells

Wu, M. H., Chen, Y. L., Lee, K. H., Chang, C. C., Cheng, T. M., Wu, S. Y., Tu, C. C. & Tsui, W. L., 2017 Dec 1, In : Scientific reports. 7, 1, 11006.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2016

CASZ1 is a novel promoter of metastasis in ovarian cancer

Wu, Y. Y., Chang, C. L., Chuang, Y. J., Wu, J. E., Tung, C. H., Chen, Y. C., Chen, Y. L., Hong, T. M. & Hsu, K. F., 2016 Jan 1, In : American Journal of Cancer Research. 6, 6, p. 1253-1270 18 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Targeting FXYD2 by cardiac glycosides potently blocks tumor growth in ovarian clear cell carcinoma

Hsu, I. L., Chou, C. Y., Wu, Y. Y., Wu, J. E., Liang, C. H., Tsai, Y. T., Ke, J. Y., Chen, Y. L., Hsu, K. F. & Hong, T. M., 2016 Jan 1, In : Oncotarget. 7, 39, p. 62925-62938 14 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2015

Enterovirus 71 virion-associated galectin-1 facilitates viral replication and stability

Lee, P. H., Liu, C. M., Ho, T. S., Tsai, Y. C., Lin, C. C., Wang, Y. F., Chen, Y. L., Yu, C. K., Wang, S. M., Liu, C. C., Shiau, A. L., Lei, H. Y. & Chang, C. P., 2015 Feb 23, In : PloS one. 10, 2, e0116278.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Galectin-1 accelerates wound healing by regulating the neuropilin-1/Smad3/NOX4 pathway and ROS production in myofibroblasts

Lin, Y. T., Chen, J. S., Wu, M. H., Hsieh, I. S., Liang, C. H., Hsu, C. L., Hong, T. M. & Chen, Y. L., 2015 Jan 1, In : Journal of Investigative Dermatology. 135, 1, p. 258-268 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
5 Citations (Scopus)

Synergy of endothelial and neural progenitor cells from adipose-derived stem cells to preserve neurovascular structures in rat hypoxic-ischemic brain injury

Hsueh, Y. Y., Chang, Y. J., Huang, C. W., Handayani, F., Chiang, Y. L., Fan, S. C., Ho, C. J., Kuo, Y. M., Yang, S. H., Chen, Y. L., Lin, S. C., Huang, C. C. & Wu, C. C., 2015 Oct 8, In : Scientific reports. 5, 14985.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2014

Galectin-1 induces vascular permeability through the neuropilin-1/vascular endothelial growth factor receptor-1 complex

Wu, M. H., Ying, N. W., Hong, T. M., Chiang, W. F., Lin, Y. T. & Chen, Y. L., 2014 Oct 1, In : Angiogenesis. 17, 4, p. 839-849 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

High-level β1-integrin expression in a subpopulation of highly tumorigenic oral cancer cells

Lin, H. C., Wu, C. L., Chen, Y. L., Huang, J. S., Wong, T. Y. & Yuan, K., 2014 Jan 1, In : Clinical Oral Investigations. 18, 4, p. 1277-1284 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis

Hsu, C. L., Liu, J. S., Wu, P. L., Guan, H. H., Chen, Y. L., Lin, A. C., Ting, H. J., Pang, S. T., Yeh, S. D., Ma, W. L., Chen, C. J., Wu, W. G. & Chang, C., 2014 Dec 1, In : Molecular Oncology. 8, 8, p. 1575-1587 13 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

MiR-320 regulates tumor angiogenesis driven by vascular endothelial cells in oral cancer by silencing neuropilin 1

Wu, Y. Y., Chen, Y. L., Jao, Y. C., Hsieh, I. S., Chang, K. C. & Hong, T. M., 2014 Jan 1, In : Angiogenesis. 17, 1, p. 247-260 14 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

MiR-99a exerts anti-metastasis through inhibiting myotubularin-related protein 3 expression in oral cancer

Kuo, Y. Z., Tai, Y. H., Lo, H. I., Chen, Y. L., Cheng, H. C., Fang, W. Y., Lin, S. H., Yang, C. L., Tsai, S. T. & Wu, L. W., 2014 Apr, In : Oral Diseases. 20, 3, p. e65-e75

Research output: Contribution to journalArticle

31 Citations (Scopus)
2013

An automatic microfluidic system for rapid screening of cancer stem-like cell-specific aptamers

Weng, C. H., Hsieh, I. S., Hung, L. Y., Lin, H. I., Shiesh, S. C., Chen, Y. L. & Lee, G. B., 2013 Jan 1, In : Microfluidics and Nanofluidics. 14, 3-4, p. 753-765 13 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Anterior gradient 2: A novel sensitive tumor marker for metastatic oral cancer

Chen, Y. T., Ho, C. L., Chen, P. K., Chen, Y. L. & Chang, C. F., 2013 Oct 10, In : Cancer Letters. 339, 2, p. 270-278 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

MicroRNA-320 suppresses the stem cell-like characteristics of prostate cancer cells by downregulating the Wnt/beta-catenin signaling pathway

Hsieh, I. S., Chang, K. C., Tsai, Y. T., Ke, J. Y., Lu, P. J., Lee, K. H., Yeh, S. D., Hong, T. M. & Chen, Y. L., 2013 Mar 1, In : Carcinogenesis. 34, 3, p. 530-538 9 p.

Research output: Contribution to journalArticle

152 Citations (Scopus)

Riboflavin-ultraviolet-A-induced collagen cross-linking treatments in improving dentin bonding

Chiang, Y. S., Chen, Y. L., Chuang, S. F., Wu, C. M., Wei, P. J., Han, C. F., Lin, J. C. & Chang, H. T., 2013 Jun 1, In : Dental Materials. 29, 6, p. 682-692 11 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

α-catulin drives metastasis by activating ILK and driving an αvβ3 integrin signaling axis

Liang, C. H., Chiu, S. Y., Hsu, I. L., Wu, Y. Y., Tsai, Y. T., Ke, J. Y., Pan, S. H., Hsu, Y. C., Li, K. C., Yang, P. C., Chen, Y. L. & Hong, T. M., 2013 Jan 1, In : Cancer Research. 73, 1, p. 428-438 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2012

Multivalent structure of galectin-1-nanogold complex serves as potential therapeutics for rheumatoid arthritis by enhancing receptor clustering

Huang, Y. J., Shiau, A. L., Chen, S. Y., Chen, Y. L., Wang, C. R., Tsai, C. Y., Chang, M. Y., Li, Y. T., Leu, C. H. & Wu, C. L., 2012 Jan, In : European Cells and Materials. 23, p. 170-181 12 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2011

An integrated microfluidic system for automating on-chip selex process to screen tumor cell-specific aptamers

Weng, C. H., Hung, L. Y., Lin, H. I., Hsieh, I. S., Shiesh, S. C., Chen, Y. L. & Lee, G. B., 2011, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 3. p. 2086-2088 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Galectin-1 binds to influenza virus and ameliorates influenza virus pathogenesis

Yang, M. L., Chen, Y. H., Wang, S. W., Huang, Y. J., Leu, C. H., Yeh, N. C., Chu, C. Y., Lin, C. C., Shieh, G. S., Chen, Y. L., Wang, J. R., Wang, C. H., Wu, C. L. & Shiau, A. L., 2011 Oct 1, In : Journal of Virology. 85, 19, p. 10010-10020 11 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Increased galectin-3 facilitates leukemia cell survival from apoptotic stimuli

Cheng, Y. L., Huang, W. C., Chen, C. L., Tsai, C. C., Wang, C. Y., Chiu, W. H., Chen, Y. L., Lin, Y. S., Chang, C. F. & Lin, C. F., 2011 Aug 26, In : Biochemical and Biophysical Research Communications. 412, 2, p. 334-340 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Overexpression of Rho GDP-dissociation inhibitor alpha predicts poor survival in oral squamous cell carcinoma

Chiang, W. F., Ho, H. C., Chang, H. Y., Chiu, C. C., Chen, Y. L., Hour, T. C., Chuang, S. J., Wu, Y. J., Chen, H. R., Chen, J. H., Liu, S. Y., Lu, C. L. & Chen, J. Y. F., 2011 Jun 1, In : Oral Oncology. 47, 6, p. 452-458 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Targeting galectin-1 in carcinoma-associated fibroblasts inhibits oral squamous cell carcinoma metastasis by downregulating MCP-1/CCL2 expression

Wu, M. H., Hong, H. C., Hong, T-M., Chiang, W. F., Jin, Y. T. & Chen, Y-L., 2011 Mar 15, In : Clinical Cancer Research. 17, 6, p. 1306-1316 11 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

α-Catulin knockdown induces senescence in cancer cells

Fan, L. C., Chiang, W. F., Liang, C. H., Tsai, Y. T., Wong, T. Y., Chen, K. C., Hong, T. M. & Chen, Y. L., 2011 Jun 9, In : Oncogene. 30, 23, p. 2610-2621 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2010

Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription

Wu, M. H., Ma, W. L., Hsu, C. L., Chen, Y-L., Ou, J. H. J., Ryan, C. K., Hung, Y. C., Yeh, S. & Chang, C., 2010 Jun 7, In : Science Translational Medicine. 2, 32

Research output: Contribution to journalArticle

118 Citations (Scopus)

Cyclic αvβ6-targeting peptide selected from biopanning with clinical potential for head and neck squamous cell carcinoma

Hsiao, J-R., Chang, Y., Chen, Y-L., Hsieh, S. H., Hsu, K-F., Wang, C. F., Tsai, S-T. & Jin, Y. T., 2010 Feb 1, In : Head and Neck. 32, 2, p. 160-172 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Fatty-acid-binding protein 5 promotes cell proliferation and invasion in oral squamous cell carcinoma

Fang, L. Y., Wong, T. Y., Chiang, W. F. & Chen, Y. L., 2010 Apr 1, In : Journal of Oral Pathology and Medicine. 39, 4, p. 342-348 7 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Intra-articular lentivirus-mediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis

Wang, C. R., Shiau, A. L., Chen, S. Y., Cheng, Z. S., Li, Y. T., Lee, C. H., Yo, Y. T., Lo, C. W., Lin, Y. S., Juan, H. Y., Chen, Y. L. & Wu, C. L., 2010 Oct 1, In : Gene Therapy. 17, 10, p. 1225-1233 9 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Molecular mimicry between streptococcal pyrogenic exotoxin B and endothelial cells

Luo, Y. H., Chuang, W. J., Wu, J. J., Lin, M. T., Liu, C. C., Lin, P. Y., Roan, J. N., Wong, T. W., Chen, Y. L. & Lin, Y. S., 2010 Oct 1, In : Laboratory Investigation. 90, 10, p. 1492-1506 15 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2009

Galectin-1-Mediated tumor invasion and metastasis, Up-Regulated matrix metalloproteinase expression, and reorganized actin cytoskeletons

Wu, M. H., Hong, T. M., Cheng, H. W., Pan, S. H., Liang, Y. R., Hong, H. C., Chiang, W. F., Wong, T. Y., Shieh, D. B., Shiau, A. L., Jin, Y. T. & Chen, Y. L., 2009 Mar 1, In : Molecular Cancer Research. 7, 3, p. 311-318 8 p.

Research output: Contribution to journalArticle

108 Citations (Scopus)

MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation

Lee, K. H., Chen, Y. L., Yeh, S. D., Hsiao, M., Lin, J. T., Goan, Y. G. & Lu, P. J., 2009 Sep 24, In : Oncogene. 28, 38, p. 3360-3370 11 p.

Research output: Contribution to journalArticle

147 Citations (Scopus)

MicroRNA-373 (miR-373) post-transcriptionally regulates large tumor suppressor, homolog 2 (LATS2) and stimulates proliferation in human esophageal cancer

Lee, K. H., Goan, Y. G., Hsiao, M., Lee, C. H., Jian, S. H., Lin, J. T., Chen, Y. L. & Lu, P. J., 2009 Sep 10, In : Experimental Cell Research. 315, 15, p. 2529-2538 10 p.

Research output: Contribution to journalArticle

148 Citations (Scopus)
2008

Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells

Hsieh, S. H., Ying, N. W., Wu, M. H., Chiang, W. F., Hsu, C. L., Wong, T. Y., Jin, Y. T., Hong, T. M. & Chen, Y. L., 2008 Jun 12, In : Oncogene. 27, 26, p. 3746-3753 8 p.

Research output: Contribution to journalArticle

143 Citations (Scopus)

Overexpression of galectin-1 at the tumor invasion front is associated with poor prognosis in early-stage oral squamous cell carcinoma

Chiang, W. F., Liu, S. Y., Fang, L. Y., Lin, C. N., Wu, M. H., Chen, Y. C., Chen, Y. L. & Jin, Y. T., 2008 Apr 1, In : Oral Oncology. 44, 4, p. 325-334 10 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Periodontal regeneration using ex vivo autologous stem cells engineered to express the BMP-2 gene: An alternative to alveolaplasty

Chen, Y. L., Chen, P. K. T., Jeng, L. B., Huang, C. S., Yang, L. C., Chung, H. Y. & Chang, S. C. N., 2008 Aug 15, In : Gene Therapy. 15, 22, p. 1469-1477 9 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
2007

Targeting neuropilin 1 as an antitumor strategy in lung cancer

Hong, T. M., Chen, Y. L., Wu, Y. Y., Yuan, A., Chao, Y. C., Chung, Y. C., Wu, M. H., Yang, S. C., Pan, S. H., Shih, J. Y., Chan, W. K. & Yang, P. C., 2007 Aug 15, In : Clinical Cancer Research. 13, 16, p. 4759-4768 10 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)

TR4 orphan nuclear receptor functions as an apoptosis modulator via regulation of Bcl-2 gene expression

Kim, E., Ma, W. L., Lin, D. L., Inui, S., Chen, Y. L. & Chang, C., 2007 Sep 21, In : Biochemical and Biophysical Research Communications. 361, 2, p. 323-328 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth

Yang, Z., Chang, Y. J., Miyamoto, H., Ni, J., Niu, Y., Chen, Z., Chen, Y. L., Yao, J. L., Di Sant'Agnese, P. A. & Chang, C., 2007 Feb 1, In : Molecular Endocrinology. 21, 2, p. 343-358 16 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)
2005

Androgen receptor (AR) NH2- and COOH-terminal interactions result in the differential influences on the AR-mediated transactivation and cell growth

Hsu, C. L., Chen, Y-L., Ting, H. J., Lin, W. J., Yang, Z., Zhang, Y., Wang, L., Wu, C. T., Chang, H. C., Yeh, S., Pimplikar, S. W. & Chang, C., 2005 Feb 1, In : Molecular Endocrinology. 19, 2, p. 350-361 12 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Crotalid venom vascular endothelial growth factors has preferential affinity for VEGFR-I

Chen, Y. L., Tsai, I. H., Hong, T. M. & Tsai, S. H., 2005 Feb 1, In : Thrombosis and Haemostasis. 93, 2, p. 331-338 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2003

The use of phage display technique for the isolation of androgen receptor interacting peptides with (F/W)XXL(F/W) and FXXLY new signature motifs

Hsu, C. L., Chen, Y. L., Yeh, S., Ting, H. J., Hu, Y. C., Lin, H., Wang, X. & Chang, C., 2003 Jul 27, In : Journal of Biological Chemistry. 278, 26, p. 23691-23698 8 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)
2002

Polymorphic CAG/CAA repeat length in the AIB1/SRC-3 gene and prostate cancer risk: A population-based case-control study

Hsing, A. W., Chokkalingam, A. P., Gao, Y. T., Wu, G., Wang, X., Deng, J., Cheng, J., Sesterhenn, I. A., Mostofi, F. K., Chiang, T., Chen, Y. L., Stanczyk, F. Z. & Chang, C., 2002 Jan 1, In : Cancer Epidemiology Biomarkers and Prevention. 11, 4, p. 337-341 5 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
2000

Functional analysis of androgen receptor N-terminal and ligand binding domain interacting coregulators in prostate cancer

Yeh, S., Sampson, E. R., Dong Kun Lee, K. L., Kim, E., Hsu, C. L., Chen, Y. L., Chang, H. C., Altuwaijri, S., Huang, K. E. & Chang, C., 2000 Dec 1, In : Journal of the Formosan Medical Association. 99, 12, p. 885-894 10 p.

Research output: Contribution to journalReview article

17 Citations (Scopus)

Glycoprotein Ib-binding protein from the venom of Deinagkistrodon acutus - cDNA sequence, functional characterization, and three-dimensional modeling

Chen, Y. L., Tsai, K. W., Chang, T., Hong, T. M. & Tsai, I. H., 2000 Jan 25, In : Thrombosis and Haemostasis. 83, 1, p. 119-126 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)