Validation of the Fracture Risk Assessment Tool (Frax) Calculator in Taiwan-Two Cohorts Study

Project: Research project

Project Details


In 2030, the aging population will reach to 20% in Taiwan. According to the reports of HPA, osteoporosis is the 4th ranking common disease in old people. The incidence of osteoporotic fracture in Taiwan was 9th ranking in Worldwide and top one ranking in Asia-pacific regions. Therefore, as the 3rd common cause of disability and bedridden, the osteoporotic fracture is the major health impact in elderly in Taiwan. In 2008, the fracture risk assessment tool (FRAX) was launched by WHO to screen out high fracture risk adult aged 40 and over in prevent osteoporotic fracture. The Taiwan FRAX was developed by our study group in NCKUH and endorsed by WHO in 2010. Due to the feasibility and based-on Taiwan local data, the Taiwan FRAX was welcomed by medical societies and applied in clinical practice. In view of the country-specific FRAX in worldwide, most of the country have been validated by its corresponding cohort data or confirmed by clinical application. In contrast, only limited studies had been shown the appropriateness of 2010 Taiwan FRAX, but had never been validated by long-term follow-up cohort at same time. Therefore, the evidence -based cohort data in strengthens of Taiwan FRAX is warranted. The long-term care version 2.0 was announced in 2016 in Taiwan. The shortage of medical reimbursement for long-term care version 2.0 depends on the slow-down the unmet need of aging and rapid dependence of long-term care. Using FRAX in screening high risk osteoporotic fracture and provide on-time intervention is the key stone of turning the vicious cycle. In this two-year project, the two cohort subjects including 776( M/F= 408/468) subjects aged 65 from Tianliao district in 2009-2010 and 1200 (M/F=524/676) subjects aged 40 and over from Douliou district in 2009-2010 will be follow-up surveyed. Using mails and phone call, along the connection with NHI data bank including fracture, osteoporotic medications, hospitalization, disability and mortality, the predictability of Taiwan FRAX will be validated. The newer FRAX version 2.0 will be developed in helping the public strategy of osteoporotic prevention and alleviating the demand of long-term care in middle-aged and old people.
Effective start/end date18-08-0119-07-31


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