α-Glucosidase inhibitors from the seeds of Syagrus romanzoffiana

Sio-Hong Lam, Jhong Min Chen, Chao Jou Kang, Chung Hsiung Chen, Shoei Sheng Lee

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)

Abstract

Bioassay-guided fractionation against α-glucosidase resulted in isolation and characterization of eight active compounds from the EtOH extract of the seeds of Syagrus romanzoffiana. Of these, seven are stilbenoids, and two of them, 13-hydroxykompasinol A (1) and scirpusin C (4), possess potent inhibitory activity against α-glucosidase type IV from Bacillus stearothermophilus with the IC50 value of 6.5 and 4.9 μM, respectively. The in vivo assay on normal Wistar rats using oral sucrose challenge also demonstrated that kompasinol A (2) and 3,3′,4,5,5′-pentahydroxy-trans-stilbene (5) possess significant effect in reducing the postprandial blood glucose level (10.2% and 12.1% at 10 mg/kg, respectively). These results suggest that stilbenoids might be explored for their therapeutic potential as hypoglycemic agents.

Original languageEnglish
Pages (from-to)1173-1178
Number of pages6
JournalPhytochemistry
Volume69
Issue number5
DOIs
Publication statusPublished - 2008 Mar 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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