β-carboline alkaloids from Stellaria dichotoma var. lanceolata and their anti-inflammatory activity

Yuh Fung Chen, Ping Chung Kuo, Hsiu Hui Chan, I. Je Kuo, Fu Wen Lin, Chung Ren Su, Mei Lin Yang, Ding Tzai Li, Tian Shung Wu

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The present investigation on the chemical constituents of the roots of Stellaria dichotoma var. lanceolata has resulted in the isolation of 21 β-carboline alkaloids, including 13 new compounds, dichotomides III-XIV (1-12) and dichotomine E (13), and eight known compounds. The structures of the new compounds were established on the basis of spectroscopic data analysis. Among these isolated alkaloids, five compounds were examined for their anti-inflammatory potential for the inhibition of NO production in LPS-treated RAW 264.7 cells. All compounds tested exhibited significant inhibition of NO production, with IC50 values in the range of 11.3 to 19.3 μM.

Original languageEnglish
Pages (from-to)1993-1998
Number of pages6
JournalJournal of Natural Products
Volume73
Issue number12
DOIs
Publication statusPublished - 2010 Dec 27

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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