γ- and δ-Lactams from the Leaves of Clausena lansium

De Yang Shen, Thi Ngan Nguyen, Shwu Jen Wu, Young Ji Shiao, Hsin-Yi Hung, Ping-Chung Kuo, Daih Huang Kuo, Tran Dinh Thang, Tian-Shung Wu

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Eight new clausenamides, including three γ-lactams (1-3), four γ-lactams (4-7), and an amide (8), and seven known lactams, including compounds 9-11, which were purified from natural sources for the first time, were characterized from the leaves of Clausena lansium. Their structures were elucidated using spectroscopic methods, and the absolute configurations were determined using electronic circular dichroism and single-crystal X-ray diffraction analyses with Cu Kα radiation. Compound 2 (50 μM) protected 22.24% of cortical neurons against Aβ25-35-induced cell death.

Original languageEnglish
Pages (from-to)2521-2530
Number of pages10
JournalJournal of Natural Products
Volume78
Issue number11
DOIs
Publication statusPublished - 2015 Nov 25

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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