Abstract
Eight new clausenamides, including three γ-lactams (1-3), four γ-lactams (4-7), and an amide (8), and seven known lactams, including compounds 9-11, which were purified from natural sources for the first time, were characterized from the leaves of Clausena lansium. Their structures were elucidated using spectroscopic methods, and the absolute configurations were determined using electronic circular dichroism and single-crystal X-ray diffraction analyses with Cu Kα radiation. Compound 2 (50 μM) protected 22.24% of cortical neurons against Aβ25-35-induced cell death.
| Original language | English |
|---|---|
| Pages (from-to) | 2521-2530 |
| Number of pages | 10 |
| Journal | Journal of Natural Products |
| Volume | 78 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2015 Nov 25 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
Cite this
}
γ- and δ-Lactams from the Leaves of Clausena lansium. / Shen, De Yang; Nguyen, Thi Ngan; Wu, Shwu Jen; Shiao, Young Ji; Hung, Hsin-Yi; Kuo, Ping-Chung; Kuo, Daih Huang; Thang, Tran Dinh; Wu, Tian-Shung.
In: Journal of Natural Products, Vol. 78, No. 11, 25.11.2015, p. 2521-2530.Research output: Contribution to journal › Article
TY - JOUR
T1 - γ- and δ-Lactams from the Leaves of Clausena lansium
AU - Shen, De Yang
AU - Nguyen, Thi Ngan
AU - Wu, Shwu Jen
AU - Shiao, Young Ji
AU - Hung, Hsin-Yi
AU - Kuo, Ping-Chung
AU - Kuo, Daih Huang
AU - Thang, Tran Dinh
AU - Wu, Tian-Shung
PY - 2015/11/25
Y1 - 2015/11/25
N2 - Eight new clausenamides, including three γ-lactams (1-3), four γ-lactams (4-7), and an amide (8), and seven known lactams, including compounds 9-11, which were purified from natural sources for the first time, were characterized from the leaves of Clausena lansium. Their structures were elucidated using spectroscopic methods, and the absolute configurations were determined using electronic circular dichroism and single-crystal X-ray diffraction analyses with Cu Kα radiation. Compound 2 (50 μM) protected 22.24% of cortical neurons against Aβ25-35-induced cell death.
AB - Eight new clausenamides, including three γ-lactams (1-3), four γ-lactams (4-7), and an amide (8), and seven known lactams, including compounds 9-11, which were purified from natural sources for the first time, were characterized from the leaves of Clausena lansium. Their structures were elucidated using spectroscopic methods, and the absolute configurations were determined using electronic circular dichroism and single-crystal X-ray diffraction analyses with Cu Kα radiation. Compound 2 (50 μM) protected 22.24% of cortical neurons against Aβ25-35-induced cell death.
UR - http://www.scopus.com/inward/record.url?scp=84948757264&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84948757264&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.5b00148
DO - 10.1021/acs.jnatprod.5b00148
M3 - Article
C2 - 26523463
AN - SCOPUS:84948757264
VL - 78
SP - 2521
EP - 2530
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 11
ER -