γ- and δ-Lactams from the Leaves of Clausena lansium

De Yang Shen; Thi Ngan Nguyen; Shwu Jen Wu; Young Ji Shiao; Hsin-Yi Hung; Ping-Chung Kuo; Daih Huang Kuo; Tran Dinh Thang; Tian-Shung Wu

doi:10.1021/acs.jnatprod.5b00148

γ- and δ-Lactams from the Leaves of Clausena lansium

De Yang Shen, Thi Ngan Nguyen, Shwu Jen Wu, Young Ji Shiao, Hsin-Yi Hung, Ping-Chung Kuo, Daih Huang Kuo, Tran Dinh Thang, Tian-Shung Wu

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Eight new clausenamides, including three γ-lactams (1-3), four γ-lactams (4-7), and an amide (8), and seven known lactams, including compounds 9-11, which were purified from natural sources for the first time, were characterized from the leaves of Clausena lansium. Their structures were elucidated using spectroscopic methods, and the absolute configurations were determined using electronic circular dichroism and single-crystal X-ray diffraction analyses with Cu Kα radiation. Compound 2 (50 μM) protected 22.24% of cortical neurons against Aβ_25-35-induced cell death.

Original language	English
Pages (from-to)	2521-2530
Number of pages	10
Journal	Journal of Natural Products
Volume	78
Issue number	11
DOIs	https://doi.org/10.1021/acs.jnatprod.5b00148
Publication status	Published - 2015 Nov 25

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/acs.jnatprod.5b00148

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abstract = "Eight new clausenamides, including three γ-lactams (1-3), four γ-lactams (4-7), and an amide (8), and seven known lactams, including compounds 9-11, which were purified from natural sources for the first time, were characterized from the leaves of Clausena lansium. Their structures were elucidated using spectroscopic methods, and the absolute configurations were determined using electronic circular dichroism and single-crystal X-ray diffraction analyses with Cu Kα radiation. Compound 2 (50 μM) protected 22.24% of cortical neurons against Aβ25-35-induced cell death.",

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AU - Shen, De Yang

AU - Nguyen, Thi Ngan

AU - Wu, Shwu Jen

AU - Shiao, Young Ji

AU - Hung, Hsin-Yi

AU - Kuo, Ping-Chung

AU - Kuo, Daih Huang

AU - Thang, Tran Dinh

AU - Wu, Tian-Shung

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