γ- and δ-Lactams from the Leaves of Clausena lansium

De Yang Shen, Thi Ngan Nguyen, Shwu Jen Wu, Young Ji Shiao, Hsin-Yi Hung, Ping-Chung Kuo, Daih Huang Kuo, Tran Dinh Thang, Tian-Shung Wu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Eight new clausenamides, including three γ-lactams (1-3), four γ-lactams (4-7), and an amide (8), and seven known lactams, including compounds 9-11, which were purified from natural sources for the first time, were characterized from the leaves of Clausena lansium. Their structures were elucidated using spectroscopic methods, and the absolute configurations were determined using electronic circular dichroism and single-crystal X-ray diffraction analyses with Cu Kα radiation. Compound 2 (50 μM) protected 22.24% of cortical neurons against Aβ25-35-induced cell death.

Original languageEnglish
Pages (from-to)2521-2530
Number of pages10
JournalJournal of Natural Products
Volume78
Issue number11
DOIs
Publication statusPublished - 2015 Nov 25

Fingerprint

Clausena
Lactams
Cell death
Circular Dichroism
Amides
X-Ray Diffraction
Neurons
Cell Death
Single crystals
Radiation
X ray diffraction

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Shen, De Yang ; Nguyen, Thi Ngan ; Wu, Shwu Jen ; Shiao, Young Ji ; Hung, Hsin-Yi ; Kuo, Ping-Chung ; Kuo, Daih Huang ; Thang, Tran Dinh ; Wu, Tian-Shung. / γ- and δ-Lactams from the Leaves of Clausena lansium. In: Journal of Natural Products. 2015 ; Vol. 78, No. 11. pp. 2521-2530.
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Shen, DY, Nguyen, TN, Wu, SJ, Shiao, YJ, Hung, H-Y, Kuo, P-C, Kuo, DH, Thang, TD & Wu, T-S 2015, 'γ- and δ-Lactams from the Leaves of Clausena lansium', Journal of Natural Products, vol. 78, no. 11, pp. 2521-2530. https://doi.org/10.1021/acs.jnatprod.5b00148

γ- and δ-Lactams from the Leaves of Clausena lansium. / Shen, De Yang; Nguyen, Thi Ngan; Wu, Shwu Jen; Shiao, Young Ji; Hung, Hsin-Yi; Kuo, Ping-Chung; Kuo, Daih Huang; Thang, Tran Dinh; Wu, Tian-Shung.

In: Journal of Natural Products, Vol. 78, No. 11, 25.11.2015, p. 2521-2530.

Research output: Contribution to journalArticle

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AU - Kuo, Ping-Chung

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