Abstract
Obesity appears to be the central component of the metabolic syndrome (MetS). The weight loss, along with increasing physical activity, is recommended as the first-line treatment for metabolic syndrome. To assess the influences of different degrees of weight loss on MetS in obese non-diabetics, subjects who had completed the 28-week of comprehensive dieting program with orlistat 120mg thrice daily in the weight management clinic of a tertiary medical center in southern Taiwan were collated from Dec. 2001 to May 2004. A total of 63 obese non-diabetics (36 female, 27 male) with initial mean body mass index 32.7±5.0 kg/m^2 were included. On 28-week follow-up examination, a moderate weight loss (9.8 kg, 11.1%) and significant improvement of main factors of MetS, such as waist circumference, systolic/diastolic blood pressure, fasting plasma glucose, triglyceride and high density lipoprotein (HDL) cholesterol, were noted. The prevalence of MetS was also reduced from 54% to 37%. According to the degree of weight loss, subjects were dichotomized into less than 10% (29 cases) and≧10% (34 cases) groups. Concerned about the effects of different degree of weight loss, the≧10% group showed a better improvement than < 10% group in terms of the body mass index, waist circumference, total cholesterol and triglyceride level. Furthermore, the subjects with MetS (n=34) had higher initial BMI and metabolic parameters, but lower HDL cholesterol than those without MetS (n=29). However, after 28-week of diet and orlistat intervention, the changes of body weight and metabolic parameters were similar in both groups with or without MetS, except that the better improvement of HDL cholesterol was noted in the group with MetS than that without MetS.
In conclusion, for the obese non-diabetics, the 28-week of comprehensive dieting program with orlistat 120mg thrice daily could bring about an acceptable weight reduction effect and improvement of MetS. A modest weight reduction of more than 10% body weight was associated with greater improvement of MetS. The effects of weight loss on the improvement of metabolic parameters were not significantly different between the subjects with or without MetS.
In conclusion, for the obese non-diabetics, the 28-week of comprehensive dieting program with orlistat 120mg thrice daily could bring about an acceptable weight reduction effect and improvement of MetS. A modest weight reduction of more than 10% body weight was associated with greater improvement of MetS. The effects of weight loss on the improvement of metabolic parameters were not significantly different between the subjects with or without MetS.
Translated title of the contribution | Effects of Different Degrees of Weight Loss on Metabolic Syndrome in Obese Non-Diabetics |
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Original language | Chinese (Traditional) |
Pages (from-to) | 220-231 |
Number of pages | 12 |
Journal | 臺灣家庭醫學雜誌 = Taiwan Journal of Family Medicine |
Volume | 15 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2005 |