The discovery of restriction enzyme and ligase have brought about a revolution in biomedical technology industry in the 20th century. Through the completion of the Human Genome Project and whole genome decoding of more organism, a tremendous opportunity for advanced applications in food industry, biofuel and fighting human diseases has been opened. This technology developed an artificial targeted, light-activated nanoscissor (ATLANS) for advanced in-cell photonic manipulation of target gene scission and silencing through formation of targeted DNA triplex in the nucleus and double strand DNA scission at predesigned site through photonic activation in the visible wavelength photon energy. The technology has been successfully developed to remove green fluorescent gene in cancer cells. When target to cancer drug resistant gene, ATLANS may effectively decrease chemotherapeutic dosage and thus reduce systemic side effects while increase therapeutic efficacy. The technology could be applied to clinical disease management of cancer, infectious disease and genetic diseases in the future development.
|Translated title of the contribution
|Artificial, Targeted, Light-Activated Nanoscissor for Sequence Selective Gene Scission
|科儀新知 ＝ Instruments Today
|Published - 2012 Jun 1