長期使用雙磷酸鹽藥物與下顎骨壞死─病例報告

Translated title of the contribution: Long-Term Usage of Bisphosphonate and Osteonecrosis of Jaw: Case Report

Chih-Hsing Wu, Dung-Yau Wang

Research output: Contribution to journalArticlepeer-review

Abstract

With the increasing aging population, osteoporosis is now a very common
disease in clinical practice. Long-acting bisphosphonates, the mainstay of
osteoporosis treatment, work by inhibiting osteoclast activity and suppressing bone resorption to significantly decrease osteoporotic fracture rates. While
bisphosphonate has been thought to generate minimal adverse side effects,
increasing evidence has suggested that long-term bisphosphonate use may be
associated with an uncommon problem – jaw osteonecrosis. An 82-year-old
osteoporotic female taking long term bisphosphonate was found to suffer from poor healing of extraction socket and exposed maxillary bone after removal of painful teeth. Bisphosphonate-related osteonecrosis of the jaw (BRONJ) was diagnosed based on her long-term use of bisphosphonate and absence of any other significant chronic conditions. Her symptom was much improved by discontinuing bisphosphonate and administrating antibiotics. The case of BRONJ is rare but impressive. We briefly review the clinical manifestations of BRONJ and
summarize the current strategies of treatment and prevention to remind general
practitioners of the early prevention of BRONJ.
Translated title of the contributionLong-Term Usage of Bisphosphonate and Osteonecrosis of Jaw: Case Report
Original languageChinese (Traditional)
Pages (from-to)201-208
Journal臺灣老年醫學暨老年學雜誌 = Taiwan Geriatrics & Gerontology
Volume2
Issue number3
Publication statusPublished - 2007 Feb

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