非糖尿病肥胖者經減重後體適能的變化及其相關因子

Obesity and low aerobic fitness are both independent risk factors for obesity-related comorbidities. The aerobic fitness would be improved by adequate weight loss, but its associated factors were inadequately evaluated. To assess the changes of physical fitness after weight loss and the associated factor, a total of 110 obese non-diabetics (70 females, 40 males, body mass index: 31.3±4.6 kg/m^2), who had completed the 16-week of comprehensive weight-reduction program with either non-pharmacological intervention (21 cases), orlistat 120mg thrice daily (65 cases), or sibutramine 10/15 mg once daily (24 cases), were collected from the weight management clinic of a tertiary medical center during Dec. 2001 to July 2004. Over the 16-week follow-up, a moderate weight loss (7.7 kg, 9.1%) associated with significant improvements of body fat mass, waist circumference, blood pressure, fasting plasma glucose, total cholesterol, triglyceride, and three physical fitness tests of 3-min step test, curl-up test, and sit-and-reach test were found. Compared the changes between the subjects with non-pharmacological (21 cases) and pharmacological intervention (89 cases), only the decrement of total cholesterol was significantly found higher in the pharmacological intervention group. The change of body fat mass was negatively associated with the changes of the three physical fitness tests. Using the multiple linear regression models, the change of body fat mass was the independent factor for the all three physical fitness tests. The change of body weight was only independently associated with 3-min step test.
In conclusion, moderate weight loss, either by non-pharmacological or pharmacological interventions, could result in the improvement of physical fitness in the obese non-diabetics. The associated factors of the changes of physical fitness are the changes of body weight and, especially, the body fat mass.