13-Methyl-3,4-seco-ent-podocarpanes, rare C18-diterpenoids from the roots of Flueggea virosa

Chih Hua Chao, Ju Chien Cheng, De Yang Shen, Hui Chi Huang, Yang Chang Wu, Tian Shung Wu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

As a part of our continuing search for anti-HCV agents from a medicinal plant, Flueggea virosa, we identified fourteen new ingredients, including 13-methyl-3,4-seco-ent-podocarpanes (1-13) and a new naphthalene derivative (14). Their structures were determined by analysis of 2D NMR spectroscopic data, while their absolute configurations were determined by comparison of specific optical rotations with related analogues in the literature. The therapeutic potential against hepatitis C virus (HCV) infection was evaluated for the isolates. Compound 8 showed the most potent anti-HCV activity with a therapeutic index (TI = IC50/EC50) of 100.5.

Original languageEnglish
Pages (from-to)34708-34714
Number of pages7
JournalRSC Advances
Volume6
Issue number41
DOIs
Publication statusPublished - 2016 Jan 1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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    Chao, C. H., Cheng, J. C., Shen, D. Y., Huang, H. C., Wu, Y. C., & Wu, T. S. (2016). 13-Methyl-3,4-seco-ent-podocarpanes, rare C18-diterpenoids from the roots of Flueggea virosa. RSC Advances, 6(41), 34708-34714. https://doi.org/10.1039/c6ra00843g