17β-Estradiol protects against acetaminophen-overdose-induced acute oxidative hepatic damage and increases the survival rate in mice

Victor Raj Mohan Chandrasekaran, Srinivasan Periasamy, Li Lian Liu, Ming-Yi Liu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Acetaminophen overdose causes acute liver injury or even death in both humans and experimental animals. We investigated the effect of 17β-estradiol against acetaminophen-induced acute liver injury and mortality in mice. Male mice were given acetaminophen (p-acetamidophenol; 300 mg/kg; orally) to induce acute liver injury. Acetaminophen significantly increased the levels of aspartate transaminase, alanine transaminase, myeloperoxidase, lipid peroxidation, and glutathione reductase, but it decreased superoxide dismutase, catalase, and glutathione. In addition, acetaminophen-induced mortality began 4 h post-treatment, and all mice died within 9 h. 17β-Estradiol (200 μg/kg; i.p.) protected against acetaminophen-induced oxidative hepatic damage by inhibiting neutrophil infiltration and stimulating the antioxidant defense system. However, 17β-estradiol did not affect acetaminophen-induced glutathione depletion or increased glutathione reductase activity. We conclude that 17β-estradiol specifically attenuates acute hepatic damage and decreases mortality in acetaminophen-overdosed male mice.

Original languageEnglish
Pages (from-to)118-124
Number of pages7
JournalSteroids
Volume76
Issue number1-2
DOIs
Publication statusPublished - 2011 Jan 1

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Acetaminophen
Estradiol
Survival Rate
Liver
Glutathione Reductase
Mortality
Wounds and Injuries
Glutathione
Neutrophil Infiltration
Aspartate Aminotransferases
Alanine Transaminase
Catalase
Lipid Peroxidation
Peroxidase
Superoxide Dismutase
Infiltration
Antioxidants
Animals
Lipids

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Chandrasekaran, Victor Raj Mohan ; Periasamy, Srinivasan ; Liu, Li Lian ; Liu, Ming-Yi. / 17β-Estradiol protects against acetaminophen-overdose-induced acute oxidative hepatic damage and increases the survival rate in mice. In: Steroids. 2011 ; Vol. 76, No. 1-2. pp. 118-124.
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17β-Estradiol protects against acetaminophen-overdose-induced acute oxidative hepatic damage and increases the survival rate in mice. / Chandrasekaran, Victor Raj Mohan; Periasamy, Srinivasan; Liu, Li Lian; Liu, Ming-Yi.

In: Steroids, Vol. 76, No. 1-2, 01.01.2011, p. 118-124.

Research output: Contribution to journalArticle

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