Abstract
The number of studies on closed-loop detection and electrical stimulation systems [1]-[2] for efficient control of neurological disorders is increasing, because recent clinical studies have shown their efficiency and usefulness in symptom suppression. Electrical stimulation can produce enough stimulation to affect a large range of nerves. However, all nerves near the stimulus are excited and hurt, and over time, currents start to exceed acceptable limits. Therefore, optogenetic stimulation [3]-[4] has become compelling in recent years due to several advantages: (1) no artificial noise on the EEG; (2) ability to stimulate specific nerves; and (3) no injurious effects on nerves. In this study, a wireless programmable stimulating system-on-chip (WPSSoC) is reported that provides wireless open/closed-loop optogenetic and electrical stimulation to improve treatment for epilepsy suppression. The system is demonstrated on programmable stimulation parameters wirelessly controlled by a software Graphical User Interface (GUI) on a computer. Moreover, an animal experiment conducted on optogenetic tissue was successful, thereby demonstrating that the nerve injury on optogenetic stimulation is lower than that of electrical stimulation.
| Original language | English |
|---|---|
| Title of host publication | 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019 |
| Publisher | Institute of Electrical and Electronics Engineers Inc. |
| Pages | 372-374 |
| Number of pages | 3 |
| ISBN (Electronic) | 9781538685310 |
| DOIs | |
| Publication status | Published - 2019 Mar 6 |
| Event | 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019 - San Francisco, United States Duration: 2019 Feb 17 → 2019 Feb 21 |
Publication series
| Name | Digest of Technical Papers - IEEE International Solid-State Circuits Conference |
|---|---|
| Volume | 2019-February |
| ISSN (Print) | 0193-6530 |
Conference
| Conference | 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019 |
|---|---|
| Country | United States |
| City | San Francisco |
| Period | 19-02-17 → 19-02-21 |
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All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Electrical and Electronic Engineering
Cite this
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22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control. / Lee, Shuenn-Yuh; Tsou, Chieh; Huang, Peng Wei; Cheng, Po Hao; Liao, Chi Chung; Liao, Zhan Xien; Lee, Hao Yun; Lin, Chou-Ching; Hsieh, Chia Hsiang.
2019 IEEE International Solid-State Circuits Conference, ISSCC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. p. 372-374 8662385 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 2019-February).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - 22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control
AU - Lee, Shuenn-Yuh
AU - Tsou, Chieh
AU - Huang, Peng Wei
AU - Cheng, Po Hao
AU - Liao, Chi Chung
AU - Liao, Zhan Xien
AU - Lee, Hao Yun
AU - Lin, Chou-Ching
AU - Hsieh, Chia Hsiang
PY - 2019/3/6
Y1 - 2019/3/6
N2 - The number of studies on closed-loop detection and electrical stimulation systems [1]-[2] for efficient control of neurological disorders is increasing, because recent clinical studies have shown their efficiency and usefulness in symptom suppression. Electrical stimulation can produce enough stimulation to affect a large range of nerves. However, all nerves near the stimulus are excited and hurt, and over time, currents start to exceed acceptable limits. Therefore, optogenetic stimulation [3]-[4] has become compelling in recent years due to several advantages: (1) no artificial noise on the EEG; (2) ability to stimulate specific nerves; and (3) no injurious effects on nerves. In this study, a wireless programmable stimulating system-on-chip (WPSSoC) is reported that provides wireless open/closed-loop optogenetic and electrical stimulation to improve treatment for epilepsy suppression. The system is demonstrated on programmable stimulation parameters wirelessly controlled by a software Graphical User Interface (GUI) on a computer. Moreover, an animal experiment conducted on optogenetic tissue was successful, thereby demonstrating that the nerve injury on optogenetic stimulation is lower than that of electrical stimulation.
AB - The number of studies on closed-loop detection and electrical stimulation systems [1]-[2] for efficient control of neurological disorders is increasing, because recent clinical studies have shown their efficiency and usefulness in symptom suppression. Electrical stimulation can produce enough stimulation to affect a large range of nerves. However, all nerves near the stimulus are excited and hurt, and over time, currents start to exceed acceptable limits. Therefore, optogenetic stimulation [3]-[4] has become compelling in recent years due to several advantages: (1) no artificial noise on the EEG; (2) ability to stimulate specific nerves; and (3) no injurious effects on nerves. In this study, a wireless programmable stimulating system-on-chip (WPSSoC) is reported that provides wireless open/closed-loop optogenetic and electrical stimulation to improve treatment for epilepsy suppression. The system is demonstrated on programmable stimulation parameters wirelessly controlled by a software Graphical User Interface (GUI) on a computer. Moreover, an animal experiment conducted on optogenetic tissue was successful, thereby demonstrating that the nerve injury on optogenetic stimulation is lower than that of electrical stimulation.
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UR - http://www.scopus.com/inward/citedby.url?scp=85063514014&partnerID=8YFLogxK
U2 - 10.1109/ISSCC.2019.8662385
DO - 10.1109/ISSCC.2019.8662385
M3 - Conference contribution
T3 - Digest of Technical Papers - IEEE International Solid-State Circuits Conference
SP - 372
EP - 374
BT - 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019
PB - Institute of Electrical and Electronics Engineers Inc.
ER -