22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control

Shuenn Yuh Lee, Chieh Tsou, Peng Wei Huang, Po Hao Cheng, Chi Chung Liao, Zhan Xien Liao, Hao Yun Lee, Chou Ching Lin, Chia Hsiang Hsieh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The number of studies on closed-loop detection and electrical stimulation systems [1]-[2] for efficient control of neurological disorders is increasing, because recent clinical studies have shown their efficiency and usefulness in symptom suppression. Electrical stimulation can produce enough stimulation to affect a large range of nerves. However, all nerves near the stimulus are excited and hurt, and over time, currents start to exceed acceptable limits. Therefore, optogenetic stimulation [3]-[4] has become compelling in recent years due to several advantages: (1) no artificial noise on the EEG; (2) ability to stimulate specific nerves; and (3) no injurious effects on nerves. In this study, a wireless programmable stimulating system-on-chip (WPSSoC) is reported that provides wireless open/closed-loop optogenetic and electrical stimulation to improve treatment for epilepsy suppression. The system is demonstrated on programmable stimulation parameters wirelessly controlled by a software Graphical User Interface (GUI) on a computer. Moreover, an animal experiment conducted on optogenetic tissue was successful, thereby demonstrating that the nerve injury on optogenetic stimulation is lower than that of electrical stimulation.

Original languageEnglish
Title of host publication2019 IEEE International Solid-State Circuits Conference, ISSCC 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages372-374
Number of pages3
ISBN (Electronic)9781538685310
DOIs
Publication statusPublished - 2019 Mar 6
Event2019 IEEE International Solid-State Circuits Conference, ISSCC 2019 - San Francisco, United States
Duration: 2019 Feb 172019 Feb 21

Publication series

NameDigest of Technical Papers - IEEE International Solid-State Circuits Conference
Volume2019-February
ISSN (Print)0193-6530

Conference

Conference2019 IEEE International Solid-State Circuits Conference, ISSCC 2019
CountryUnited States
CitySan Francisco
Period19-02-1719-02-21

Fingerprint

Electroencephalography
Monitoring
Graphical user interfaces
Animals
Tissue
Experiments
System-on-chip

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

Cite this

Lee, S. Y., Tsou, C., Huang, P. W., Cheng, P. H., Liao, C. C., Liao, Z. X., ... Hsieh, C. H. (2019). 22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control. In 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019 (pp. 372-374). [8662385] (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 2019-February). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ISSCC.2019.8662385
Lee, Shuenn Yuh ; Tsou, Chieh ; Huang, Peng Wei ; Cheng, Po Hao ; Liao, Chi Chung ; Liao, Zhan Xien ; Lee, Hao Yun ; Lin, Chou Ching ; Hsieh, Chia Hsiang. / 22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control. 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 372-374 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference).
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abstract = "The number of studies on closed-loop detection and electrical stimulation systems [1]-[2] for efficient control of neurological disorders is increasing, because recent clinical studies have shown their efficiency and usefulness in symptom suppression. Electrical stimulation can produce enough stimulation to affect a large range of nerves. However, all nerves near the stimulus are excited and hurt, and over time, currents start to exceed acceptable limits. Therefore, optogenetic stimulation [3]-[4] has become compelling in recent years due to several advantages: (1) no artificial noise on the EEG; (2) ability to stimulate specific nerves; and (3) no injurious effects on nerves. In this study, a wireless programmable stimulating system-on-chip (WPSSoC) is reported that provides wireless open/closed-loop optogenetic and electrical stimulation to improve treatment for epilepsy suppression. The system is demonstrated on programmable stimulation parameters wirelessly controlled by a software Graphical User Interface (GUI) on a computer. Moreover, an animal experiment conducted on optogenetic tissue was successful, thereby demonstrating that the nerve injury on optogenetic stimulation is lower than that of electrical stimulation.",
author = "Lee, {Shuenn Yuh} and Chieh Tsou and Huang, {Peng Wei} and Cheng, {Po Hao} and Liao, {Chi Chung} and Liao, {Zhan Xien} and Lee, {Hao Yun} and Lin, {Chou Ching} and Hsieh, {Chia Hsiang}",
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Lee, SY, Tsou, C, Huang, PW, Cheng, PH, Liao, CC, Liao, ZX, Lee, HY, Lin, CC & Hsieh, CH 2019, 22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control. in 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019., 8662385, Digest of Technical Papers - IEEE International Solid-State Circuits Conference, vol. 2019-February, Institute of Electrical and Electronics Engineers Inc., pp. 372-374, 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019, San Francisco, United States, 19-02-17. https://doi.org/10.1109/ISSCC.2019.8662385

22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control. / Lee, Shuenn Yuh; Tsou, Chieh; Huang, Peng Wei; Cheng, Po Hao; Liao, Chi Chung; Liao, Zhan Xien; Lee, Hao Yun; Lin, Chou Ching; Hsieh, Chia Hsiang.

2019 IEEE International Solid-State Circuits Conference, ISSCC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. p. 372-374 8662385 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 2019-February).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Lee SY, Tsou C, Huang PW, Cheng PH, Liao CC, Liao ZX et al. 22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control. In 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019. Institute of Electrical and Electronics Engineers Inc. 2019. p. 372-374. 8662385. (Digest of Technical Papers - IEEE International Solid-State Circuits Conference). https://doi.org/10.1109/ISSCC.2019.8662385