22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control

Shuenn Yuh Lee; Chieh Tsou; Peng Wei Huang; Po Hao Cheng; Chi Chung Liao; Zhan Xien Liao; Hao Yun Lee; Chou Ching Lin; Chia Hsiang Hsieh

doi:10.1109/ISSCC.2019.8662385

22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control

Shuenn Yuh Lee, Chieh Tsou, Peng Wei Huang, Po Hao Cheng, Chi Chung Liao, Zhan Xien Liao, Hao Yun Lee, Chou Ching Lin, Chia Hsiang Hsieh

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

5 Citations (Scopus)

Abstract

The number of studies on closed-loop detection and electrical stimulation systems [1]-[2] for efficient control of neurological disorders is increasing, because recent clinical studies have shown their efficiency and usefulness in symptom suppression. Electrical stimulation can produce enough stimulation to affect a large range of nerves. However, all nerves near the stimulus are excited and hurt, and over time, currents start to exceed acceptable limits. Therefore, optogenetic stimulation [3]-[4] has become compelling in recent years due to several advantages: (1) no artificial noise on the EEG; (2) ability to stimulate specific nerves; and (3) no injurious effects on nerves. In this study, a wireless programmable stimulating system-on-chip (WPSSoC) is reported that provides wireless open/closed-loop optogenetic and electrical stimulation to improve treatment for epilepsy suppression. The system is demonstrated on programmable stimulation parameters wirelessly controlled by a software Graphical User Interface (GUI) on a computer. Moreover, an animal experiment conducted on optogenetic tissue was successful, thereby demonstrating that the nerve injury on optogenetic stimulation is lower than that of electrical stimulation.

Original language	English
Title of host publication	2019 IEEE International Solid-State Circuits Conference, ISSCC 2019
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	372-374
Number of pages	3
ISBN (Electronic)	9781538685310
DOIs	https://doi.org/10.1109/ISSCC.2019.8662385
Publication status	Published - 2019 Mar 6
Event	2019 IEEE International Solid-State Circuits Conference, ISSCC 2019 - San Francisco, United States Duration: 2019 Feb 17 → 2019 Feb 21

Publication series

Name	Digest of Technical Papers - IEEE International Solid-State Circuits Conference
Volume	2019-February
ISSN (Print)	0193-6530

Conference

Conference	2019 IEEE International Solid-State Circuits Conference, ISSCC 2019
Country	United States
City	San Francisco
Period	19-02-17 → 19-02-21

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Electrical and Electronic Engineering

Access to Document

10.1109/ISSCC.2019.8662385

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Lee, S. Y., Tsou, C., Huang, P. W., Cheng, P. H., Liao, C. C., Liao, Z. X., Lee, H. Y., Lin, C. C., & Hsieh, C. H. (2019). 22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control. In 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019 (pp. 372-374). [8662385] (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 2019-February). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ISSCC.2019.8662385

Lee, Shuenn Yuh ; Tsou, Chieh ; Huang, Peng Wei ; Cheng, Po Hao ; Liao, Chi Chung ; Liao, Zhan Xien ; Lee, Hao Yun ; Lin, Chou Ching ; Hsieh, Chia Hsiang. / 22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control. 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 372-374 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference).

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abstract = "The number of studies on closed-loop detection and electrical stimulation systems [1]-[2] for efficient control of neurological disorders is increasing, because recent clinical studies have shown their efficiency and usefulness in symptom suppression. Electrical stimulation can produce enough stimulation to affect a large range of nerves. However, all nerves near the stimulus are excited and hurt, and over time, currents start to exceed acceptable limits. Therefore, optogenetic stimulation [3]-[4] has become compelling in recent years due to several advantages: (1) no artificial noise on the EEG; (2) ability to stimulate specific nerves; and (3) no injurious effects on nerves. In this study, a wireless programmable stimulating system-on-chip (WPSSoC) is reported that provides wireless open/closed-loop optogenetic and electrical stimulation to improve treatment for epilepsy suppression. The system is demonstrated on programmable stimulation parameters wirelessly controlled by a software Graphical User Interface (GUI) on a computer. Moreover, an animal experiment conducted on optogenetic tissue was successful, thereby demonstrating that the nerve injury on optogenetic stimulation is lower than that of electrical stimulation.",

author = "Lee, {Shuenn Yuh} and Chieh Tsou and Huang, {Peng Wei} and Cheng, {Po Hao} and Liao, {Chi Chung} and Liao, {Zhan Xien} and Lee, {Hao Yun} and Lin, {Chou Ching} and Hsieh, {Chia Hsiang}",

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Lee, SY, Tsou, C, Huang, PW, Cheng, PH, Liao, CC, Liao, ZX, Lee, HY, Lin, CC & Hsieh, CH 2019, 22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control. in 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019., 8662385, Digest of Technical Papers - IEEE International Solid-State Circuits Conference, vol. 2019-February, Institute of Electrical and Electronics Engineers Inc., pp. 372-374, 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019, San Francisco, United States, 19-02-17. https://doi.org/10.1109/ISSCC.2019.8662385

22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control. / Lee, Shuenn Yuh; Tsou, Chieh; Huang, Peng Wei; Cheng, Po Hao; Liao, Chi Chung; Liao, Zhan Xien; Lee, Hao Yun; Lin, Chou Ching; Hsieh, Chia Hsiang.

2019 IEEE International Solid-State Circuits Conference, ISSCC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. p. 372-374 8662385 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 2019-February).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Liao, Zhan Xien

AU - Lee, Hao Yun

AU - Lin, Chou Ching

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Lee SY, Tsou C, Huang PW, Cheng PH, Liao CC, Liao ZX et al. 22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control. In 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019. Institute of Electrical and Electronics Engineers Inc. 2019. p. 372-374. 8662385. (Digest of Technical Papers - IEEE International Solid-State Circuits Conference). https://doi.org/10.1109/ISSCC.2019.8662385