TY - GEN
T1 - 22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control
AU - Lee, Shuenn Yuh
AU - Tsou, Chieh
AU - Huang, Peng Wei
AU - Cheng, Po Hao
AU - Liao, Chi Chung
AU - Liao, Zhan Xien
AU - Lee, Hao Yun
AU - Lin, Chou Ching
AU - Hsieh, Chia Hsiang
N1 - Funding Information:
The authors would like to thank the Chip Implementation Center (CIC) and the Ministry of Science and Technology (MOST), Taiwan, R.O.C. for their support of this work (under grant nos. MOST 106-2314-B-006-001, MOST 107-2218-E-006-034, MOST 107-2622-8-006-009 -TE2) and the help of CBIC Lab members, Ming-Chun Liang, and Ching-Fu Tsou.
Funding Information:
The authors would like to thank the Chip Implementation Center (CIC) and the Ministry of Science and Technology (MOST), Taiwan, R.O.C. for their support of this work (under grant nos. MOST 106-2314-B-006-001, MOST 107-2218-E-006- 034, MOST 107-2622-8-006-009 -TE2) and the help of CBIC Lab members, Ming-Chun Liang, and Ching-Fu Tsou.
Publisher Copyright:
© 2019 IEEE.
PY - 2019/3/6
Y1 - 2019/3/6
N2 - The number of studies on closed-loop detection and electrical stimulation systems [1]-[2] for efficient control of neurological disorders is increasing, because recent clinical studies have shown their efficiency and usefulness in symptom suppression. Electrical stimulation can produce enough stimulation to affect a large range of nerves. However, all nerves near the stimulus are excited and hurt, and over time, currents start to exceed acceptable limits. Therefore, optogenetic stimulation [3]-[4] has become compelling in recent years due to several advantages: (1) no artificial noise on the EEG; (2) ability to stimulate specific nerves; and (3) no injurious effects on nerves. In this study, a wireless programmable stimulating system-on-chip (WPSSoC) is reported that provides wireless open/closed-loop optogenetic and electrical stimulation to improve treatment for epilepsy suppression. The system is demonstrated on programmable stimulation parameters wirelessly controlled by a software Graphical User Interface (GUI) on a computer. Moreover, an animal experiment conducted on optogenetic tissue was successful, thereby demonstrating that the nerve injury on optogenetic stimulation is lower than that of electrical stimulation.
AB - The number of studies on closed-loop detection and electrical stimulation systems [1]-[2] for efficient control of neurological disorders is increasing, because recent clinical studies have shown their efficiency and usefulness in symptom suppression. Electrical stimulation can produce enough stimulation to affect a large range of nerves. However, all nerves near the stimulus are excited and hurt, and over time, currents start to exceed acceptable limits. Therefore, optogenetic stimulation [3]-[4] has become compelling in recent years due to several advantages: (1) no artificial noise on the EEG; (2) ability to stimulate specific nerves; and (3) no injurious effects on nerves. In this study, a wireless programmable stimulating system-on-chip (WPSSoC) is reported that provides wireless open/closed-loop optogenetic and electrical stimulation to improve treatment for epilepsy suppression. The system is demonstrated on programmable stimulation parameters wirelessly controlled by a software Graphical User Interface (GUI) on a computer. Moreover, an animal experiment conducted on optogenetic tissue was successful, thereby demonstrating that the nerve injury on optogenetic stimulation is lower than that of electrical stimulation.
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U2 - 10.1109/ISSCC.2019.8662385
DO - 10.1109/ISSCC.2019.8662385
M3 - Conference contribution
AN - SCOPUS:85063514014
T3 - Digest of Technical Papers - IEEE International Solid-State Circuits Conference
SP - 372
EP - 374
BT - 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019
Y2 - 17 February 2019 through 21 February 2019
ER -