TY - JOUR
T1 - 3-T proton magnetic resonance spectroscopy of central neurocytoma
T2 - 3 Case reports and review of the literature
AU - Chuang, Ming Tsung
AU - Lin, Wei Chen
AU - Tsai, Huei Yi
AU - Liu, Gin Chung
AU - Hu, Shih Wen
AU - Chiang, I. Chan
PY - 2005/9
Y1 - 2005/9
N2 - Central neurocytoma (CNC), first described by Hassoun et al in 1982, is a rare neuronal tumor of the central nervous system, accounting for 0.25% to 0.5% of all central nervous system tumors. To our knowledge, there are only 5 published articles reporting the magnetic resonance spectroscopy (MRS) findings of neurocytomas. The 3-T proton MRS findings of 3 cases with CNC confirmed by immunohistochemical stains are reported here. Increased choline (Cho)/creatine (Cr) ratios with decreased N-acetylaspartate (NAA)/Cr ratios were observed in all 3 cases, but only 1 case had an increased peak at 3.55 ppm known as glycine (Gly). The other case with an increased alanine peak at 1.5 ppm had a poor prognosis. Therefore, we conclude that the presence of a Gly peak may suggest the diagnosis of CNC but that the absence of Gly does not exclude the diagnosis of CNC.
AB - Central neurocytoma (CNC), first described by Hassoun et al in 1982, is a rare neuronal tumor of the central nervous system, accounting for 0.25% to 0.5% of all central nervous system tumors. To our knowledge, there are only 5 published articles reporting the magnetic resonance spectroscopy (MRS) findings of neurocytomas. The 3-T proton MRS findings of 3 cases with CNC confirmed by immunohistochemical stains are reported here. Increased choline (Cho)/creatine (Cr) ratios with decreased N-acetylaspartate (NAA)/Cr ratios were observed in all 3 cases, but only 1 case had an increased peak at 3.55 ppm known as glycine (Gly). The other case with an increased alanine peak at 1.5 ppm had a poor prognosis. Therefore, we conclude that the presence of a Gly peak may suggest the diagnosis of CNC but that the absence of Gly does not exclude the diagnosis of CNC.
UR - http://www.scopus.com/inward/record.url?scp=25844526357&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=25844526357&partnerID=8YFLogxK
U2 - 10.1097/01.rct.0000171240.95430.29
DO - 10.1097/01.rct.0000171240.95430.29
M3 - Article
C2 - 16163043
AN - SCOPUS:25844526357
VL - 29
SP - 683
EP - 688
JO - Journal of Computer Assisted Tomography
JF - Journal of Computer Assisted Tomography
SN - 0363-8715
IS - 5
ER -