TY - JOUR
T1 - 40 GHz RF biosensor based on microwave coplanar waveguide transmission line for cancer cells (HepG2) dielectric characterization
AU - Chen, Yu Fu
AU - Wu, Hung Wei
AU - Hong, Yong Han
AU - Lee, Hsin Ying
N1 - Funding Information:
The authors especially acknowledge the funding support from Nation Science Council of Taiwan , under Grants NSC 100-2628-E-168-001-MY2 , NSC102-2633-E168-001 and NSC 102-2511-S-168-003 .
PY - 2014/11/15
Y1 - 2014/11/15
N2 - This paper presents a 40-GHz RF biosensor that involves using a microwave coplanar waveguide (CPW) transmission line for the dielectric characterization of cancer cells (Hepatoma G2, HepG2). In the past, conventional resonator-based biosensors were designed to operate at a specific resonant peak; however, the dielectric sensitivity of the cells was restricted to a narrow bandwidth. To provide a very wide bandwidth (1-40 GHz), biosensors were based on a microwave CPW transmission line. The proposed biosensor can rapidly measure two frequency-dependent cell-based dielectric parameters of HepG2 cells, microwave attenuation (α(f)cell) and the dielectric constant (εr(f)cell), while removing the microwave parasitic effects (including the cultured medium and substrate materials). The proposed biosensor can be applied in postoperative cancer diagnosis.
AB - This paper presents a 40-GHz RF biosensor that involves using a microwave coplanar waveguide (CPW) transmission line for the dielectric characterization of cancer cells (Hepatoma G2, HepG2). In the past, conventional resonator-based biosensors were designed to operate at a specific resonant peak; however, the dielectric sensitivity of the cells was restricted to a narrow bandwidth. To provide a very wide bandwidth (1-40 GHz), biosensors were based on a microwave CPW transmission line. The proposed biosensor can rapidly measure two frequency-dependent cell-based dielectric parameters of HepG2 cells, microwave attenuation (α(f)cell) and the dielectric constant (εr(f)cell), while removing the microwave parasitic effects (including the cultured medium and substrate materials). The proposed biosensor can be applied in postoperative cancer diagnosis.
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U2 - 10.1016/j.bios.2014.05.060
DO - 10.1016/j.bios.2014.05.060
M3 - Article
C2 - 24934741
AN - SCOPUS:84902242949
SN - 0956-5663
VL - 61
SP - 417
EP - 421
JO - Biosensors and Bioelectronics
JF - Biosensors and Bioelectronics
ER -
