4(R)- And 4(S)-(5-phenylpentyl)-glutamic Acids Attenuate Excitatory Postsynaptic Potential on Hippocampus without Inhibiting Postsynaptic NMDA and AMPA Receptors

Sheue Houy Tyan, Hsiuming Chang, Po Wu Gean, Yung Son Hon, Yen Chung Chang

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Abstract

The electrophysiological effects of 4(R)- and 4(S)-(5-phenylpentyl)-glutamic acids (C 5R and C 5S analogues) were investigated. In the presence of 5 μM C 5R or C 5S , excitatory postsynaptic potentials (EPSPs), elicited by stimulating the Schaffer collateral-commissural pathway, recorded in the hippocampal CA1 region on rat brain slices were reduced by more than 50% of the control. Both the NMDA receptor-and the non-MNDA receptor-mediated components of the EPSP were attenuated to the similar extent. The blockade of the presynaptic input, by 0.5 μM tetrodotoxin (TTX), resulted in that C 5 analogues no longer inhibited the depolarization induced by AMPA or NMDA on brain slices. On the other hand, the AMPA- and NMDA-induced whole cell inward current of the dissociated hippocampal neurons was not affected by the presence of C 5 analogues, investigated with the whole cell patch-clamping technique. These results suggest that the site of the inhibitory action of C 5R and C 5S may be at the presynaptic termini and that the release of the excitatory neurotransmitter, most likely the glutamate, may be tampered.

Original languageEnglish
Pages (from-to)131-137
Number of pages7
JournalChinese Journal of Physiology
Volume39
Issue number2
Publication statusPublished - 1996 Jan 1

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

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