4(R)- And 4(S)-(5-phenylpentyl)-glutamic Acids Attenuate Excitatory Postsynaptic Potential on Hippocampus without Inhibiting Postsynaptic NMDA and AMPA Receptors

Sheue Houy Tyan, Hsiuming Chang, Po Wu Gean, Yung Son Hon, Yen Chung Chang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The electrophysiological effects of 4(R)- and 4(S)-(5-phenylpentyl)-glutamic acids (C 5R and C 5S analogues) were investigated. In the presence of 5 μM C 5R or C 5S , excitatory postsynaptic potentials (EPSPs), elicited by stimulating the Schaffer collateral-commissural pathway, recorded in the hippocampal CA1 region on rat brain slices were reduced by more than 50% of the control. Both the NMDA receptor-and the non-MNDA receptor-mediated components of the EPSP were attenuated to the similar extent. The blockade of the presynaptic input, by 0.5 μM tetrodotoxin (TTX), resulted in that C 5 analogues no longer inhibited the depolarization induced by AMPA or NMDA on brain slices. On the other hand, the AMPA- and NMDA-induced whole cell inward current of the dissociated hippocampal neurons was not affected by the presence of C 5 analogues, investigated with the whole cell patch-clamping technique. These results suggest that the site of the inhibitory action of C 5R and C 5S may be at the presynaptic termini and that the release of the excitatory neurotransmitter, most likely the glutamate, may be tampered.

Original languageEnglish
Pages (from-to)131-137
Number of pages7
JournalChinese Journal of Physiology
Volume39
Issue number2
Publication statusPublished - 1996

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Fingerprint

Dive into the research topics of '4(R)- And 4(S)-(5-phenylpentyl)-glutamic Acids Attenuate Excitatory Postsynaptic Potential on Hippocampus without Inhibiting Postsynaptic NMDA and AMPA Receptors'. Together they form a unique fingerprint.

Cite this