6-Pentadecylsalicylic acid; An antithrombin component isolated from the stem of Rhus semialata var. roxburghii

S. C. Kuo, C. M. Teng, L. G. Lee, T. H. Chiu, T. S. Wu, S. C. Huang, J. B. Wu, T. Y. Shieh, R. J. Chang, T. C. Chou

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Abstract

Bioassay-directed fractionation of the n-hexane extract of the stem of Rhus semialata Murr. var. roxburghii DC (Anacardiaceae) has led to the isolation of 6-pentadecylsalicylic acid. It showed antithrombin activity at 50 μg/ml in the amidolytic method. It also prolonged the clotting time in a dose-dependent manner in the clotting assay of thrombin-fibrinogen interaction.

Original languageEnglish
Pages (from-to)247-249
Number of pages3
JournalPlanta Medica
Volume57
Issue number3
DOIs
Publication statusPublished - 1991

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Kuo, S. C., Teng, C. M., Lee, L. G., Chiu, T. H., Wu, T. S., Huang, S. C., Wu, J. B., Shieh, T. Y., Chang, R. J., & Chou, T. C. (1991). 6-Pentadecylsalicylic acid; An antithrombin component isolated from the stem of Rhus semialata var. roxburghii. Planta Medica, 57(3), 247-249. https://doi.org/10.1055/s-2006-960083