7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents

Jang Yang Chang, Hsing Pang Hsieh, Chi Yen Chang, Kuo Shun Hsu, Yi Fang Chiang, Chi Ming Chen, Ching Chuan Kuo, Jing Ping Liou

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61 Citations (Scopus)

Abstract

A novel series of 7-aroyl-aminoindoline-1-benzenesulfonamides showed excellent activity as inhibitors of tubulin polymerization through binding with the colchicine binding site of microtubules. Compound 15 and 16 display IC 50 values of 1.1 and 1.2 μM, respectively. Compound 15 inhibited the human cancer cell growth of KB, MKN45, H460, HT29, and TSGH, as well as one human-resistant cancer line of KB-vin 10, with an IC50 of 9.6, 8.8, 9.4, 8.6, 10.8, and 8.9 nM, respectively.

Original languageEnglish
Pages (from-to)6656-6659
Number of pages4
JournalJournal of Medicinal Chemistry
Volume49
Issue number23
DOIs
Publication statusPublished - 2006 Nov 16

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

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    Chang, J. Y., Hsieh, H. P., Chang, C. Y., Hsu, K. S., Chiang, Y. F., Chen, C. M., Kuo, C. C., & Liou, J. P. (2006). 7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents. Journal of Medicinal Chemistry, 49(23), 6656-6659. https://doi.org/10.1021/jm061076u