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• Article

  Aligning to the sample-specific reference sequence to optimize the accuracy of next-generation sequencing analysis for hepatitis B virus

  Liu, W. C., Lin, C. P., Cheng, C. P., Ho, C. H., Lan, K. L., Cheng, J. H., Yen, C. J., Cheng, P. N., Wu, I. C., Li, I. C., Chang, B. C. H., Tseng, V. S., Chiu, Y. C. & Chang, T. T., 2016 Jan 1, In: Hepatology International. 10, 1, p. 147-157 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Hepatitis B virus
  • Quasispecies
  • Datasets
  • Nucleotides
  • Genotype
  7 Citations (Scopus)

• All-oral daclatasvir plus asunaprevir for chronic hepatitis C virus (HCV) genotype 1b infection: a sub-analysis in Asian patients from the HALLMARK DUAL study

  Kao, J. H., Lee, Y. J., Heo, J., Ahn, S. H., Lim, Y. S., Peng, C. Y., Chang, T. T., Torbeyns, A., Hughes, E., Bhore, R. & Noviello, S., 2016 Oct 1, In: Liver International. 36, 10, p. 1433-1441 9 p.

  Research output: Contribution to journal › Article › peer-review

  • asunaprevir
  • BMS-790052
  • Chronic Hepatitis C
  • Hepacivirus
  • Genotype
  20 Citations (Scopus)

• A locked nucleic acid clamp-mediated PCR assay for detection of a p53 codon 249 hotspot mutation in urine

  Lin, S. Y., Dhillon, V., Jain, S., Chang, T. T., Hu, C. T., Lin, Y. J., Chen, S. H., Chang, K. C., Song, W., Yu, L., Block, T. M. & Su, Y. H., 2011 Sep, In: Journal of Molecular Diagnostics. 13, 5, p. 474-484 11 p.

  Research output: Contribution to journal › Article › peer-review

  • locked nucleic acid
  • Codon
  • Hepatocellular Carcinoma
  • Urine
  • Polymerase Chain Reaction
  21 Citations (Scopus)

• Analysis of precore/core covariances associated with viral kinetics and genotypes in hepatitis B e antigen-positive chronic hepatitis B patients

  Cheng, C. P., Lee, P. F., Liu, W. C., Wu, I. C., Chin, C. Y., Chang, T. T. & Tseng, V. S., 2012 Feb 27, In: PloS one. 7, 2, e32553.

  Research output: Contribution to journal › Article › peer-review

  • chronic hepatitis B
  • hepatitis B antigens
  • Hepatitis B e Antigens
  • Viruses
  • Chronic Hepatitis B
  4 Citations (Scopus)

• A phase 3b study of sofosbuvir plus ribavirin in Taiwanese patients with chronic genotype 2 hepatitis C virus infection

  Kao, J. H., Chien, R. N., Chang, T. T., Peng, C. Y., Hu, T. H., Lo, G. H., Wang, H. Y., Chen, J. J., Yang, J. C., Knox, S. J., Han, L., Mo, H., Mathias, A., Brainard, D. M., Sheen, I. S., Hsu, Y. C., Chu, C. J. & Chuang, W. L., 2016 Aug 1, In: Liver International. 36, 8, p. 1101-1107 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Sofosbuvir
  • Ribavirin
  • Hepacivirus
  • Virus Diseases
  • Genotype
  20 Citations (Scopus)

• Aspartate aminotransferase to platelet ratio index and sustained virologic response are associated with progression from hepatitis c associated liver cirrhosis to hepatocellular carcinoma after treatment with pegylated interferon plus ribavirin

  Ng, K. J., Tseng, C. W., Chang, T. T., Tzeng, S. J., Hsieh, Y. H., Hung, T. H., Huang, H. T., Wu, S. F. & Tseng, K. C., 2016 Aug 1, In: Clinical Interventions in Aging. 11, p. 1035-1041 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Sustained Virologic Response
  • Ribavirin
  • Aspartate Aminotransferases
  • Hepatitis
  • Liver Cirrhosis
  6 Citations (Scopus)

• Association of intrahepatic cccDNA reduction with the improvement of liver histology in chronic hepatitis B patients receiving oral antiviral agents

  Cheng, P. N., Liu, W. C., Tsai, H. W., Wu, I. C., Chang, T. T. & Young, K. C., 2011 Apr 1, In: Journal of Medical Virology. 83, 4, p. 602-607 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Circular DNA
  • Chronic Hepatitis B
  • Antiviral Agents
  • Histology
  • Hepatitis B virus
  41 Citations (Scopus)

• Association of sustained virologic response with reduced progression to liver cirrhosis in elderly patients with chronic hepatitis C

  Tseng, C. W., Chang, T. T., Tzeng, S. J., Hsieh, Y. H., Hung, T. H., Huang, H. T., Wu, S. F. & Tseng, K. C., 2016 Mar 17, In: Clinical Interventions in Aging. 11, p. 327-334 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Sustained Virologic Response
  • Chronic Hepatitis C
  • Liver Cirrhosis
  • Elderly
  • Interferons
  3 Citations (Scopus)

• Clinical significance of serum HBsAg levels and association with liver histology in HBeAg positive chronic hepatitis B

  Cheng, P. N., Tsai, H. W., Chiu, Y. C., Ho, C. H., Wu, I. C. & Chang, T. T., 2013 Aug, In: Journal of Clinical Virology. 57, 4, p. 323-330 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Hepatitis B e Antigens
  • Chronic Hepatitis B
  • Hepatitis B Surface Antigens
  • Histology
  • Liver
  11 Citations (Scopus)

• Combined transarterial embolization/ chemoembolization-based locoregional treatment with sorafenib prolongs the survival in patients with advanced hepatocellular carcinoma and preserved liver function: A propensity score matching study

  Chien, S. C., Chen, C. Y., Cheng, P. N., Liu, Y. S., Cheng, H. C., Chuang, C. H., Chang, T. T., Chiu, H. C., Lin, Y. J. & Chiu, Y. C., 2019, In: Liver Cancer. 8, 3, p. 186-202 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Sorafenib
  • Propensity Score
  • Hepatocellular Carcinoma
  • Survival
  • Liver
  4 Citations (Scopus)

• Contrast-induced acute kidney injury among patients with chronic kidney disease undergoing imaging studies: A meta-analysis

  Lee, Y. C., Hsieh, C. C., Chang, T. T. & Li, C. Y., 2019 Jan 1, In: American Journal of Roentgenology. 213, 4, p. 728-735 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Acute Kidney Injury
  • Chronic Renal Insufficiency
  • Meta-Analysis
  • Contrast Media
  • Glomerular Filtration Rate
  4 Citations (Scopus)

• DeF-GPU: Efficient and effective deletions finding in hepatitis B viral genomic DNA using a GPU architecture

  Cheng, C. P., Lan, K. L., Liu, W. C., Chang, T. T. & Tseng, V. S., 2016 Dec 1, In: Methods. 111, p. 56-63 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Viral DNA
  • Hepatitis B
  • Graphics processing unit
  • DNA
  • Immune system
  4 Citations (Scopus)

• Effect of human leukocyte antigen class I and II alleles on hepatitis C viral load among chronic hepatitis C patients in Southern Taiwan

  Tseng, K. C., Tseng, C. W., Hsieh, Y. H., Chang, C. K., Lai, N. S., Hung, T. H. & Chang, T. T., 2013 Aug 1, In: Human Immunology. 74, 8, p. 978-982 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Chronic Hepatitis C
  • Hepatitis C
  • HLA Antigens
  • Taiwan
  • Viral Load
  2 Citations (Scopus)

• Efficacy of telbivudine in Taiwanese chronic hepatitis B patients compared with GLOBE extension study and predicting treatment outcome by HBV DNA kinetics at Week 24

  Hsu, C. W., Chao, Y. C., Lee, C. M., Chang, T. T. & Chen, Y. C., 2012 Dec 13, In: BMC Gastroenterology. 12, 178.

  Research output: Contribution to journal › Article › peer-review

  • Telbivudine
  • Chronic Hepatitis B
  • Kinetics
  • DNA
  • Hepatitis B e Antigens
  7 Citations (Scopus)

• Fully galactosyl-fucosyl-bisected IgG ₁ reduces anti-HBV efficacy and liver histological improvement

  Ho, C. H., Chen, S. H., Tsai, H. W., Wu, I. C. & Chang, T. T., 2019 Mar, In: Antiviral Research. 163, p. 1-10 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Hepatitis B virus
  • Immunoglobulin G
  • Liver
  • Hepatitis B e Antigens
  • Acetylglucosamine
  1 Citation (Scopus)

• Hepatitis B virus X protein upregulates mTOR signaling through IKKβ to increase cell proliferation and VEGF production in hepatocellular carcinoma

  Yen, C. J., Lin, Y. J., Yen, C. S., Tsai, H. W., Tsai, T. F., Chang, K. Y., Huang, W. C., Lin, P. W., Chiang, C. W. & Chang, T. T., 2012 Jul 27, In: PloS one. 7, 7, e41931.

  Research output: Contribution to journal › Article › peer-review

  • IKappaB kinase
  • hepatitis B virus X protein
  • Cell proliferation
  • Hepatitis B virus
  • vascular endothelial growth factors
  46 Citations (Scopus)

• High Rates of Viral Suppression After Long-term Entecavir Treatment of Asian Patients With Hepatitis B e Antigen-Positive Chronic Hepatitis B

  Pan, C. Q., Tong, M., Kowdley, K. V., Hu, K. Q., Chang, T. T., Lai, C. L., Yoon, S. K., Lee, S. S., Cohen, D., Tang, H. & Tsai, N., 2012 Sep, In: Clinical Gastroenterology and Hepatology. 10, 9, p. 1047-1050.e1

  Research output: Contribution to journal › Article › peer-review

  • entecavir
  • Hepatitis B e Antigens
  • Chronic Hepatitis B
  • Safety
  • Seroconversion
  13 Citations (Scopus)

• Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein

  Lee, J. W., Liao, P. C., Young, K. C., Chang, C. L., Chen, S. S. L., Chang, T. T., Lai, M. D. & Wang, S. W., 2011 Oct 7, In: Journal of Proteome Research. 10, 10, p. 4522-4534 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Hepatitis C virus nucleocapsid protein
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Cytoplasm
  • Nuclear Factor 45 Protein
  • Proteins
  30 Citations (Scopus)

• Impact of increasing alanine aminotransferase levels within normal range on incident diabetes

  Wang, C. S., Chang, T. T., Yao, W. J., Wang, S. T. & Chou, P., 2012 Apr, In: Journal of the Formosan Medical Association. 111, 4, p. 201-208 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Alanine Transaminase
  • Reference Values
  • Type 2 Diabetes Mellitus
  • Body Mass Index
  • Hepatitis C
  30 Citations (Scopus)

• Impact of the location of CpG methylation within the GSTP1 gene on its specificity as a DNA marker for hepatocellular carcinoma

  Jain, S., Chen, S., Chang, K. C., Lin, Y. J., Hu, C. T., Boldbaatar, B., Hamilton, J. P., Lin, S. Y., Chang, T. T., Chen, S. H., Song, W., Meltzer, S. J., Block, T. M. & Su, Y. H., 2012 Apr 20, In: PloS one. 7, 4, e35789.

  Research output: Contribution to journal › Article › peer-review

  • Methylation
  • Liver
  • hepatoma
  • Genetic Markers
  • methylation
  33 Citations (Scopus)

• Ledipasvir/sofosbuvir fixed-dose combination tablet in Taiwanese patients with chronic genotype 1 hepatitis C virus

  Chuang, W. L., Chien, R. N., Peng, C. Y., Chang, T. T., Lo, G. H., Sheen, I. S., Wang, H. Y., Chen, J. J., Yang, J. C., Knox, S. J., Gao, B., Garrison, K. L., Mo, H., Pang, P. S., Hsu, Y. C., Hu, T. H., Chu, C. J. & Kao, J. H., 2016 Jul 1, In: Journal of Gastroenterology and Hepatology (Australia). 31, 7, p. 1323-1329 7 p.

  Research output: Contribution to journal › Article › peer-review

  • sofosbuvir drug combination ledipasvir
  • Hepacivirus
  • Tablets
  • Genotype
  • Virus Diseases
  22 Citations (Scopus)

• Lin28B is an oncofetal circulating cancer stem cell-like marker associated with recurrence of hepatocellular carcinoma

  Cheng, S. W., Tsai, H. W., Lin, Y. J., Cheng, P. N., Chang, Y. C., Yen, C. J., Huang, H. P., Chuang, Y. P., Chang, T. T., Lee, C. T., Chao, A., Chou, C. Y., Chan, S. H., Chow, N. H. & Ho, C. L., 2013 Nov 14, In: PloS one. 8, 11, e80053.

  Research output: Contribution to journal › Article › peer-review

  • Stem cells
  • hepatoma
  • Neoplastic Stem Cells
  • Tumors
  • stem cells
  38 Citations (Scopus)

• Long-term safety and tolerability of entecavir in patients with chronic hepatitis B in the rollover study ETV-901

  Manns, M. P., Akarca, U. S., Chang, T. T., Sievert, W., Yoon, S. K., Tsai, N., Min, A., Pangerl, A., Beebe, S., Yu, M. & Wongcharatrawee, S., 2012 May, In: Expert Opinion on Drug Safety. 11, 3, p. 361-368 8 p.

  Research output: Contribution to journal › Article › peer-review

  • entecavir
  • Chronic Hepatitis B
  • Safety
  • Alanine Transaminase
  • Nasopharyngitis
  43 Citations (Scopus)

• Methylation of the CpG sites only on the sense strand of the APC gene is specific for hepatocellular carcinoma

  Jain, S., Chang, T. T., Hamilton, J. P., Lin, S. Y., Lin, Y. J., Evans, A. A., Selaru, F. M., Lin, P. W., Chen, S. H., Block, T. M., Hu, C. T., Song, W., Meltzer, S. J. & Su, Y. H., 2011 Nov 2, In: PloS one. 6, 11, e26799.

  Research output: Contribution to journal › Article › peer-review

  • Methylation
  • APC Genes
  • hepatoma
  • methylation
  • Genes
  25 Citations (Scopus)

• Novel nucleotide and amino acid covariation between the 5′UTR and the NS2/NS3 proteins of hepatitis C virus: Bioinformatic and functional analyses

  Sun, H. Y., Ou, N. Y., Wang, S. W., Liu, W. C., Cheng, T. F., Shr, S. J., Sun, K. T., Chang, T. T. & Young, K. C., 2011 Sep 28, In: PloS one. 6, 9, e25530.

  Research output: Contribution to journal › Article › peer-review

  • Hepatitis C virus NS2 protein
  • hepatitis C virus NS3 protein
  • Hepatitis C virus
  • Viruses
  • Bioinformatics
  5 Citations (Scopus)

• Peginterferon lambda for the treatment of HBeAg-positive chronic hepatitis B: A randomized phase 2b study (LIRA-B)

  LIRA-B Study Team, 2016 May 1, In: Journal of Hepatology. 64, 5, p. 1011-1019 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Hepatitis B e Antigens
  • Chronic Hepatitis B
  • Hepatitis B virus
  • Seroconversion
  • DNA
  34 Citations (Scopus)

• Plasma proteome plus site-specific N-glycoprofiling for hepatobiliary carcinomas

  Chang, T. T., Cheng, J. H., Tsai, H. W., Young, K. C., Hsieh, S. Y. & Ho, C. H., 2019 Jul, In: Journal of Pathology: Clinical Research. 5, 3, p. 199-212 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proteome
  • Complement C3
  • Carcinoma
  • Hepatocellular Carcinoma
  • Mannose
  2 Citations (Scopus)

• Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase

  Ho, C. H., Chuang, H. C., Wu, I. C., Tsai, H. W., Lin, Y. J., Sun, H. Y., Young, K. C., Chiu, Y. C., Cheng, P. N., Liu, W. C., Tan, T. H. & Chang, T. T., 2016, In: Oncotarget. 7, 31, p. 49765-49776 12 p.

  Research output: Contribution to journal › Article › peer-review

  • germinal center kinases
  • Hepatocellular Carcinoma
  • Phosphotransferases
  • Recurrence
  • GCK-like kinase
  3 Citations (Scopus)

• Quantitative hepatitis B surface antigen analysis in hepatitis B e antigen-positive nucleoside-naive patients treated with entecavir

  Gish, R. G., Chang, T. T., Lai, C. L., De Man, R. A., Gadano, A., Llamoso, C. & Tang, H., 2013 Nov 28, In: Antiviral Therapy. 18, 5, p. 691-698 8 p.

  Research output: Contribution to journal › Article › peer-review

  • entecavir
  • Hepatitis B e Antigens
  • Nucleosides
  • Hepatitis B Surface Antigens
  • Chronic Hepatitis B
  16 Citations (Scopus)

• Resistance of ground glass hepatocytes to oral antivirals in chronic hepatitis B patients and implication for the development of hepatocellular carcinoma

  Tsai, H. W., Lin, Y. J., Wu, H. C., Chang, T. T., Wu, I. C., Cheng, P. N., Yen, C. J., Chan, S. H., Huang, W. & Su, I. J., 2016 May 10, In: Oncotarget. 7, 19, p. 27724-27734 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Chronic Hepatitis B
  • Glass
  • Antiviral Agents
  • Hepatocytes
  • Hepatocellular Carcinoma
  13 Citations (Scopus)

• Telbivudine on IgG-associated hypergammaglobulinemia and TGF-β1 hyperactivity in hepatitis B virus-related liver cirrhosis

  Ho, C. H., Chang, T. T. & Chien, R. N., 2019 Nov 1, In: PloS one. 14, 11, e0225482.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • hypergammaglobulinemia
  • Telbivudine
  • liver cirrhosis
  • Hepatitis B virus
  • Hypergammaglobulinemia

• Tenofovir disoproxil fumarate (TDF), emtricitabine/TDF, and entecavir in patients with decompensated chronic hepatitis B liver disease

  Liaw, Y. F., Sheen, I. S., Lee, C. M., Akarca, U. S., Papatheodoridis, G. V., Suet-Hing Wong, F., Chang, T. T., Horban, A., Wang, C., Kwan, P., Buti, M., Prieto, M., Berg, T., Kitrinos, K., Peschell, K., Mondou, E., Frederick, D., Rousseau, F. & Schiff, E. R., 2011 Jan, In: Hepatology. 53, 1, p. 62-72 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Emtricitabine
  • entecavir
  • Tenofovir
  • Chronic Hepatitis B
  • Liver Diseases
  256 Citations (Scopus)

• Very low-density lipoprotein/lipo-viro particles reverse lipoprotein lipase-mediated inhibition of hepatitis C virus infection via apolipoprotein C-III

  Sun, H. Y., Lin, C. C., Lee, J. C., Wang, S-W., Cheng, P-N., Wu, I-C., Chang, T-T., Lai, M-D., Shieh, D-B. & Young, K-C., 2013 Aug 1, In: Gut. 62, 8, p. 1193-1203 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein C-III
  • VLDL Lipoproteins
  • Lipoprotein Lipase
  • Lipoproteins
  • Hepacivirus
  27 Citations (Scopus)
• Conference contribution

  Discovering clinical biomarkers of chronic hepatitis B by mining mutation hotspots

  Cheng, C. P., Lee, P. F., Chin, C. Y., Liu, W. C., Wu, I. C., Chang, T. T. & Tseng, V. S., 2011 Dec 1, Proceedings - 2011 Conference on Technologies and Applications of Artificial Intelligence, TAAI 2011. p. 51-56 6 p. 6120719. (Proceedings - 2011 Conference on Technologies and Applications of Artificial Intelligence, TAAI 2011).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Biomarkers
  • Viruses
  • Proteins
  • Amino acids
  • DNA
  3 Citations (Scopus)
• Letter

  Improvement in liver histology among Asian patients with chronic hepatitis B after long-term treatment with entecavir

  Tong, M. J., Kowdley, K. V., Pan, C., Hu, K. Q., Chang, T. T., Han, K. H., Yoon, S. K., Goodman, Z. D., Beebe, S., Iloeje, U. & Tang, H., 2013 Apr, In: Liver International. 33, 4, p. 650-651 2 p.

  Research output: Contribution to journal › Letter › peer-review
  7 Citations (Scopus)