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Author

  • Ting-Tsung Chang
Article

Aberrant serum immunoglobulin g glycosylation in chronic hepatitis b is associated with histological liver damage and reversible by antiviral therapy

Ho, C. H., Chien, R. N., Cheng, P. N., Liu, J. H., Liu, C. K., Su, C. S., Wu, I. C., Li, I. C., Tsai, H. W., Wu, S. L., Liu, W. C., Chen, S. H. & Chang, T. T., 2015 Jan 1, In : Journal of Infectious Diseases. 211, 1, p. 115-124 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Aligning to the sample-specific reference sequence to optimize the accuracy of next-generation sequencing analysis for hepatitis B virus

Liu, W. C., Lin, C. P., Cheng, C. P., Ho, C. H., Lan, K. L., Cheng, J. H., Yen, C. J., Cheng, P. N., Wu, I. C., Li, I. C., Chang, B. C. H., Tseng, V. S., Chiu, Y. C. & Chang, T. T., 2016 Jan 1, In : Hepatology International. 10, 1, p. 147-157 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

All-oral daclatasvir plus asunaprevir for chronic hepatitis C virus (HCV) genotype 1b infection: a sub-analysis in Asian patients from the HALLMARK DUAL study

Kao, J. H., Lee, Y. J., Heo, J., Ahn, S. H., Lim, Y. S., Peng, C. Y., Chang, T-T., Torbeyns, A., Hughes, E., Bhore, R. & Noviello, S., 2016 Oct 1, In : Liver International. 36, 10, p. 1433-1441 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

All-oral daclatasvir plus asunaprevir for hepatitis C virus genotype 1b: A multinational, phase 3, multicohort study

Manns, M., Pol, S., Jacobson, I. M., Marcellin, P., Gordon, S. C., Peng, C. Y., Chang, T. T., Everson, G. T., Heo, J., Gerken, G., Yoffe, B., Towner, W. J., Bourliere, M., Metivier, S., Chu, C. J., Sievert, W., Bronowicki, J. P., Thabut, D., Lee, Y. J., Kao, J. H. & 6 others, McPhee, F., Kopit, J., Mendez, P., Linaberry, M., Hughes, E. & Noviello, S., 2014 Jan 1, In : The Lancet. 384, 9954, p. 1597-1605 9 p.

Research output: Contribution to journalArticle

273 Citations (Scopus)

A locked nucleic acid clamp-mediated PCR assay for detection of a p53 codon 249 hotspot mutation in urine

Lin, S. Y., Dhillon, V., Jain, S., Chang, T. T., Hu, C. T., Lin, Y. J., Chen, S. H., Chang, K. C., Song, W., Yu, L., Block, T. M. & Su, Y. H., 2011 Sep, In : Journal of Molecular Diagnostics. 13, 5, p. 474-484 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

A phase 3b study of sofosbuvir plus ribavirin in Taiwanese patients with chronic genotype 2 hepatitis C virus infection

Kao, J. H., Chien, R. N., Chang, T. T., Peng, C. Y., Hu, T. H., Lo, G. H., Wang, H. Y., Chen, J. J., Yang, J. C., Knox, S. J., Han, L., Mo, H., Mathias, A., Brainard, D. M., Sheen, I. S., Hsu, Y. C., Chu, C. J. & Chuang, W. L., 2016 Aug 1, In : Liver International. 36, 8, p. 1101-1107 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Apolipoprotein J, a glucose-upregulated molecular chaperone, stabilizes core and NS5A to promote infectious hepatitis C virus virion production

Lin, C. C., Tsai, P., Sun, H. Y., Hsu, M. C., Lee, J. C., Wu, I. C., Tsao, C. W., Chang, T. T. & Young, K. C., 2014 Jan 1, In : Journal of Hepatology. 61, 5, p. 984-993 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Aspartate aminotransferase to platelet ratio index and sustained virologic response are associated with progression from hepatitis c associated liver cirrhosis to hepatocellular carcinoma after treatment with pegylated interferon plus ribavirin

Ng, K. J., Tseng, C. W., Chang, T. T., Tzeng, S. J., Hsieh, Y. H., Hung, T. H., Huang, H. T., Wu, S. F. & Tseng, K. C., 2016 Aug 1, In : Clinical Interventions in Aging. 11, p. 1035-1041 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
39 Citations (Scopus)

Association of serum IgG N-glycome and transforming growth factor-β1 with hepatitis B virus e antigen seroconversion during entecavir therapy

Ho, C. H., Chien, R. N., Cheng, P. N., Liu, C. K., Su, C. S., Wu, I. C., Liu, W. C., Chen, S. H. & Chang, T. T., 2014 Nov, In : Antiviral Research. 111, p. 121-128 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Association of sustained virologic response with reduced progression to liver cirrhosis in elderly patients with chronic hepatitis C

Tseng, C. W., Chang, T. T., Tzeng, S. J., Hsieh, Y. H., Hung, T. H., Huang, H. T., Wu, S. F. & Tseng, K. C., 2016 Mar 17, In : Clinical Interventions in Aging. 11, p. 327-334 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Changing hepatitis D virus epidemiology in a hepatitis B virus endemic area with a national vaccination program

Lin, H. H., Lee, S. S. J., Yu, M. L., Chang, T. T., Su, C. W., Hu, B. S., Chen, Y. S., Huang, C. K., Lai, C. H., Lin, J. N. & Wu, J. C., 2015 Jun 1, In : Hepatology. 61, 6, p. 1870-1879 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
11 Citations (Scopus)
2 Citations (Scopus)

Comprehensive DNA methylation analysis of hepatitis B virus genome in infected liver tissues

Jain, S., Chang, T. T., Chen, S., Boldbaatar, B., Clemens, A., Lin, S. Y., Yan, R., Hu, C. T., Guo, H., Block, T. M., Song, W. & Su, Y. H., 2015 May 22, In : Scientific reports. 5, 10478.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Contrast-induced acute kidney injury among patients with chronic kidney disease undergoing imaging studies: A meta-analysis

Lee, Y. C., Hsieh, C. C., Chang, T. T. & Li, C. Y., 2019 Jan 1, In : American Journal of Roentgenology. 213, 4, p. 728-735 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Covalently closed-circular hepatitis B virus DNA reduction with entecavir or lamivudine

Bowden, S., Locarnini, S., Chang, T. T., Chao, Y. C., Han, K. H., Gish, R. G., De Man, R. A., Yu, M., Llamoso, C. & Tang, H., 2015 Apr 21, In : World journal of gastroenterology. 21, 15, p. 4644-4651 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

DeF-GPU: Efficient and effective deletions finding in hepatitis B viral genomic DNA using a GPU architecture

Cheng, C. P., Lan, K. L., Liu, W. C., Chang, T. T. & Tseng, V. S., 2016 Dec 1, In : Methods. 111, p. 56-63 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
Open Access

Effect of human leukocyte antigen class I and II alleles on hepatitis C viral load among chronic hepatitis C patients in Southern Taiwan

Tseng, K. C., Tseng, C. W., Hsieh, Y. H., Chang, C. K., Lai, N. S., Hung, T. H. & Chang, T. T., 2013 Aug 1, In : Human Immunology. 74, 8, p. 978-982 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Effects of tenofovir disoproxil fumarate in hepatitis B e antigen-positive patients with normal levels of alanine aminotransferase and high levels of hepatitis B virus DNA

Chan, H. L. Y., Chan, C. K., Hui, A. J., Chan, S., Poordad, F., Chang, T. T., Mathurin, P., Flaherty, J. F., Lin, L., Corsa, A., Gaggar, A., Subramanian, G. M., McHutchison, J. G., Lee, S. & Gane, E. J., 2014 May, In : Gastroenterology. 146, 5, p. 1240-1248 9 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Efficacy of entecavir in chronic hepatitis B patients with persistently normal alanine aminotransferase: Randomized, double-blind, placebo-controlled study

Tseng, K. C., Chen, C. Y., Tsai, H. W., Chang, T. T., Chuang, W. L., Hsu, P. I., Liu, W. C. & Cheng, P. N., 2014, In : Antiviral Therapy. 19, 8, p. 755-764 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Efficacy of Ledipasvir and Sofosbuvir Treatment of HCV Infection in Patients Coinfected With HBV

Liu, C. J., Chuang, W. L., Sheen, I. S., Wang, H. Y., Chen, C. Y., Tseng, K. C., Chang, T. T., Massetto, B., Yang, J. C., Yun, C., Knox, S. J., Osinusi, A., Camus, G., Jiang, D., Brainard, D. M., McHutchison, J. G., Hu, T. H., Hsu, Y. C., Lo, G. H., Chu, C. J. & 4 others, Chen, J. J., Peng, C. Y., Chien, R. N. & Chen, P. J., 2018 Mar, In : Gastroenterology. 154, 4, p. 989-997 9 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
2 Citations (Scopus)
Open Access
Open Access
4 Citations (Scopus)

High SVR12 with 8-week and 12-week glecaprevir/pibrentasvir therapy: An integrated analysis of HCV genotype 1–6 patients without cirrhosis

Puoti, M., Foster, G. R., Wang, S., Mutimer, D., Gane, E., Moreno, C., Chang, T. T., Lee, S. S., Marinho, R., Dufour, J. F., Pol, S., Hezode, C., Gordon, S. C., Strasser, S. I., Thuluvath, P. J., Zhang, Z., Lovell, S., Pilot-Matias, T. & Mensa, F. J., 2018 Aug, In : Journal of Hepatology. 69, 2, p. 293-300 8 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein

Lee, J. W., Liao, P. C., Young, K. C., Chang, C. L., Chen, S. S. L., Chang, T. T., Lai, M. D. & Wang, S. W., 2011 Oct 7, In : Journal of Proteome Research. 10, 10, p. 4522-4534 13 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Ledipasvir/sofosbuvir fixed-dose combination tablet in Taiwanese patients with chronic genotype 1 hepatitis C virus

Chuang, W. L., Chien, R. N., Peng, C. Y., Chang, T. T., Lo, G. H., Sheen, I. S., Wang, H. Y., Chen, J. J., Yang, J. C., Knox, S. J., Gao, B., Garrison, K. L., Mo, H., Pang, P. S., Hsu, Y. C., Hu, T. H., Chu, C. J. & Kao, J. H., 2016 Jul 1, In : Journal of Gastroenterology and Hepatology (Australia). 31, 7, p. 1323-1329 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Lin28B is an oncofetal circulating cancer stem cell-like marker associated with recurrence of hepatocellular carcinoma

Cheng, S. W., Tsai, H. W., Lin, Y. J., Cheng, P. N., Chang, Y. C., Yen, C. J., Huang, H. P., Chuang, Y. P., Chang, T. T., Lee, C. T., Chao, A., Chou, C. Y., Chan, S. H., Chow, N. H. & Ho, C. L., 2013 Nov 14, In : PloS one. 8, 11, e80053.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Methylation of the CpG sites only on the sense strand of the APC gene is specific for hepatocellular carcinoma

Jain, S., Chang, T. T., Hamilton, J. P., Lin, S. Y., Lin, Y. J., Evans, A. A., Selaru, F. M., Lin, P. W., Chen, S. H., Block, T. M., Hu, C. T., Song, W., Meltzer, S. J. & Su, Y. H., 2011 Nov 2, In : PloS one. 6, 11, e26799.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Novel nucleotide and amino acid covariation between the 5′UTR and the NS2/NS3 proteins of hepatitis C virus: Bioinformatic and functional analyses

Sun, H. Y., Ou, N. Y., Wang, S. W., Liu, W. C., Cheng, T. F., Shr, S. J., Sun, K. T., Chang, T. T. & Young, K. C., 2011 Sep 28, In : PloS one. 6, 9, e25530.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Peginterferon alfa-2a is associated with elevations in alanine aminotransferase at the end of treatment in chronic hepatitis C patients with sustained virologic response

Tseng, C. W., Chen, C. Y., Chang, T. T., Tzeng, S. J., Hsieh, Y. H., Hung, T. H., Lee, C. C., Wu, S. F. & Tseng, K. C., 2014 Jun 17, In : PloS one. 9, 6, e100207.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Peginterferon lambda for the treatment of HBeAg-positive chronic hepatitis B: A randomized phase 2b study (LIRA-B)

LIRA-B Study Team, 2016 May 1, In : Journal of Hepatology. 64, 5, p. 1011-1019 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Plasma proteome atlas for differentiating tumor stage and post-surgical prognosis of hepatocellular carcinoma and cholangiocarcinoma

Chang, T. T. & Ho, C. H., 2020 Aug, In : PloS one. 15, 8 August, e0238251.

Research output: Contribution to journalArticle

Open Access

Plasma proteome plus site-specific N-glycoprofiling for hepatobiliary carcinomas

Chang, T. T., Cheng, J. H., Tsai, H. W., Young, K. C., Hsieh, S. Y. & Ho, C. H., 2019 Jul, In : Journal of Pathology: Clinical Research. 5, 3, p. 199-212 14 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase

Ho, C. H., Chuang, H. C., Wu, I. C., Tsai, H. W., Lin, Y. J., Sun, H. Y., Young, K. C., Chiu, Y. C., Cheng, P. N., Liu, W. C., Tan, T. H. & Chang, T. T., 2016, In : Oncotarget. 7, 31, p. 49765-49776 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
4 Citations (Scopus)

Quantitative hepatitis B surface antigen analysis in hepatitis B e antigen-positive nucleoside-naive patients treated with entecavir

Gish, R. G., Chang, T. T., Lai, C. L., De Man, R. A., Gadano, A., Llamoso, C. & Tang, H., 2013 Nov 28, In : Antiviral Therapy. 18, 5, p. 691-698 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
11 Citations (Scopus)

Telbivudine on IgG-associated hypergammaglobulinemia and TGF-β1 hyperactivity in hepatitis B virus-related liver cirrhosis

Ho, C. H., Chang, T. T. & Chien, R. N., 2019 Nov 1, In : PloS one. 14, 11, e0225482.

Research output: Contribution to journalArticle

Open Access

Tenofovir disoproxil fumarate (TDF), emtricitabine/TDF, and entecavir in patients with decompensated chronic hepatitis B liver disease

Liaw, Y. F., Sheen, I. S., Lee, C. M., Akarca, U. S., Papatheodoridis, G. V., Suet-Hing Wong, F., Chang, T. T., Horban, A., Wang, C., Kwan, P., Buti, M., Prieto, M., Berg, T., Kitrinos, K., Peschell, K., Mondou, E., Frederick, D., Rousseau, F. & Schiff, E. R., 2011 Jan 1, In : Hepatology. 53, 1, p. 62-72 11 p.

Research output: Contribution to journalArticle

248 Citations (Scopus)
26 Citations (Scopus)

Viral dynamics of persistent hepatitis C virus infection in high-sensitive reporter cells resemble patient's viremia

Tsai, P., Lin, C. C., Sun, H. Y., Lee, J. C., Chang, T. T. & Young, K. C., 2018 Aug, In : Journal of Microbiology, Immunology and Infection. 51, 4, p. 446-455 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
Comment/debate

Erratum: Effects of tenofovir disoproxil fumarate in hepatitis B e antigen-positive patients with normal levels of alanine aminotransferase and high levels of hepatitis B virus DNA (Gastroenterology (2014) 146 (1240-1248))

Chan, H. L. Y., Chan, C. K., Hui, A. J., Chan, S., Poordad, F., Chang, T. T., Mathurin, P., Flaherty, J. F., Lin, L., Corsa, A., Gaggar, A., Subramanian, G. M., McHutchison, J. G., Lau, G., Lee, S. & Gane, E. J., 2015 Jan 1, In : Gastroenterology. 148, 1, 1 p.

Research output: Contribution to journalComment/debate

Conference contribution

Discovering clinical biomarkers of chronic hepatitis B by mining mutation hotspots

Cheng, C. P., Lee, P. F., Chin, C. Y., Liu, W. C., Wu, I. C., Chang, T. T. & Tseng, V. S., 2011 Dec 1, Proceedings - 2011 Conference on Technologies and Applications of Artificial Intelligence, TAAI 2011. p. 51-56 6 p. 6120719. (Proceedings - 2011 Conference on Technologies and Applications of Artificial Intelligence, TAAI 2011).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)
Letter

Improvement in liver histology among Asian patients with chronic hepatitis B after long-term treatment with entecavir

Tong, M. J., Kowdley, K. V., Pan, C., Hu, K. Q., Chang, T. T., Han, K. H., Yoon, S. K., Goodman, Z. D., Beebe, S., Iloeje, U. & Tang, H., 2013 Apr 1, In : Liver International. 33, 4, p. 650-651 2 p.

Research output: Contribution to journalLetter

5 Citations (Scopus)