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Author

  • Ming-Derg Lai
2019

Cancer immunotherapy: Silencing intracellular negative immune regulators of dendritic cells

Liu, Y. H., Yeh, I. J., Lai, M. D., Liu, K. T., Kuo, P. L. & Yen, M. C., 2019 Jan 1, In : Cancers. 11, 1, 108.

Research output: Contribution to journalReview article

Open Access
2 Citations (Scopus)

Erratum: A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy (Oncotarget (2015) 6 (13671–13687) DOI: 10.18632/oncotarget.3701)

Hsu, T. I., Chen, Y. J., Hung, C. Y., Wang, Y. C., Lin, S. J., Su, W. C., Lai, M. D., Kim, S. Y., Wang, Q., Qian, K., Goto, M., Zhao, Y., Kashiwada, Y., Lee, K. H., Chang, W. C. & Hung, J. J., 2019 Jan 1, In : Oncotarget. 10, 60, p. 6536-6537 2 p.

Research output: Contribution to journalComment/debate

2018

Astrocytic CCAAT/Enhancer-binding protein delta contributes to reactive oxygen species formation in neuroinflammation

Wang, S. M., Lim, S. W., Wang, Y. H., Lin, H. Y., Lai, M. D., Ko, C. Y. & Wang, Y-M., 2018 Jun, In : Redox Biology. 16, p. 104-112 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation

Weng, T. Y., Wu, H. F., Li, C. Y., Hung, Y. H., Chang, Y. W., Chen, Y. L., Hsu, H. P., Chen, Y. H., Wang, C. Y., Chang, J. Y. & Lai, M. D., 2018 Dec 1, In : Scientific reports. 8, 1, 8216.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells

Sun, Z., Wang, C. Y., Lawson, D. A., Kwek, S., Velozo, H. G., Owyong, M., Lai, M. D., Fong, L., Wilson, M., Su, H., Werb, Z. & Cooke, D. L., 2018, In : Oncotarget. 9, 13, p. 10945-10961 17 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2017

Argininosuccinate lyase interacts with cyclin A2 in cytoplasm and modulates growth of liver tumor cells

Hung, Y. H., Huang, H. L., Chen, W. C., Yen, M. C., Cho, C. Y., Weng, T. Y., Wang, C. Y., Chen, Y. L., Chen, L. T. & Lai, M. D., 2017 Feb, In : Oncology Reports. 37, 2, p. 969-978 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Cyclin D1 overexpression correlates with poor tumor differentiation and prognosis in gastric cancer

Shan, Y. S., Hsu, H. P., Lai, M. D., Hung, Y. H., Wang, C. Y., Yen, M. C. & Chen, Y. L., 2017, In : Oncology Letters. 14, 4, p. 4517-4526 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

GATA3 targets semaphorin 3B in mammary epithelial cells to suppress breast cancer progression and metastasis

Shahi, P., Wang, C. Y., Chou, J., Hagerling, C., Gonzalez Velozo, H., Ruderisch, A., Yu, Y., Lai, M. D. & Werb, Z., 2017 Oct 5, In : Oncogene. 36, 40, p. 5567-5575 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Mucin 2 silencing promotes colon cancer metastasis through interleukin-6 signaling

Hsu, H. P., Lai, M. D., Lee, J. C., Yen, M. C., Weng, T. Y., Chen, W. C., Fang, J. H. & Chen, Y. L., 2017 Dec 1, In : Scientific reports. 7, 1, 5823.

Research output: Contribution to journalArticle

16 Citations (Scopus)

PSMB5 plays a dual role in cancer development and immunosuppression

Wang, C. Y., Li, C. Y., Hsu, H. P., Cho, C. Y., Yen, M. C., Weng, T. Y., Chen, W. C., Hung, Y. H., Lee, K. T., Hung, J. H., Chen, Y. L. & Lai, M. D., 2017 Jan 1, In : American Journal of Cancer Research. 7, 11, p. 2103-2120 18 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Silencing of argininosuccinate lyase inhibits colorectal cancer formation

Huang, H. L., Chen, W. C., Hsu, H. P., Cho, C. Y., Hung, Y. H., Wang, C. Y. & Lai, M. D., 2017 Jan, In : Oncology Reports. 37, 1, p. 163-170 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Skin Delivery of Clec4a Small Hairpin RNA Elicited an Effective Antitumor Response by Enhancing CD8+ Immunity In Vivo

Weng, T. Y., Li, C. J., Li, C. Y., Hung, Y. H., Yen, M. C., Chang, Y. W., Chen, Y. H., Chen, Y. L., Hsu, H. P., Chang, J. Y. & Lai, M. D., 2017 Dec, In : Molecular Therapy - Nucleic Acids. 9, p. 419-427 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients

Wang, C. Y., Shahi, P., Huang, J. T. W., Phan, N. N., Sun, Z., Lin, Y. C., Lai, M. D. & Werb, Z., 2017 Jan 1, In : Molecular and Clinical Oncology. 6, 1, p. 7-18 12 p.

Research output: Contribution to journalArticle

Voltage-gated calcium channels: Novel targets for cancer therapy

Phan, N. N., Wang, C. Y., Chen, C. F., Sun, Z., Lai, M. D. & Lin, Y. C., 2017, In : Oncology Letters. 14, 2, p. 2059-2074 16 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression

Shahi, P., Wang, C. Y., Lawson, D. A., Slorach, E. M., Lu, A., Yu, Y., Lai, M. D., Velozo, H. G. & Werb, Z., 2017 Mar 21, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 12, p. 3169-3174 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2016

Astrocytic CCAAT/Enhancer-Binding Protein Delta Contributes to Glial Scar Formation and Impairs Functional Recovery After Spinal Cord Injury

Wang, S. M., Hsu, J. Y. C., Ko, C. Y., Chiu, N. E., Kan, W. M., Lai, M. D. & Wang, J. M., 2016 Nov 1, In : Molecular Neurobiology. 53, 9, p. 5912-5927 16 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin

Chen, W. C., Hsu, H. P., Li, C. Y., Yang, Y. J., Hung, Y. H., Cho, C. Y., Wang, C. Y., Weng, T. Y. & Lai, M. D., 2016 Nov, In : International Journal of Oncology. 49, 5, p. 1881-1889 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Differential expression pattern of THBS1 and THBS2 in lung cancer: Clinical outcome and a systematic-analysis of microarray databases

Weng, T. Y., Wang, C. Y., Hung, Y. H., Chen, W. C., Chen, Y. L. & Lai, M. D., 2016 Aug, In : PloS one. 11, 8, e0161007.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Membrane bile acid receptor TGR5 predicts good prognosis in ampullary adenocarcinoma patients with hyperbilirubinemia

Chen, M. C., Chen, Y. L., Wang, T. W., Hsu, H. P. & Lai, M. D., 2016 Oct, In : Oncology Reports. 36, 4, p. 1997-2008 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

MST3 promotes proliferation and tumorigenicity through the VAV2/Rac1 signal axis in breast cancer

Cho, C. Y., Lee, K. T., Chen, W. C., Wang, C. Y., Chang, Y. S., Huang, H. L., Hsu, H. P., Yen, M. C., Lai, M. Z. & Lai, M. D., 2016 Mar 22, In : Oncotarget. 7, 12, p. 14586-14604 19 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Regulation of oncogenic KRAS signaling via a novel KRAS-integrin-linked kinase-hnRNPA1 regulatory loop in human pancreatic cancer cells

Chu, P. C., Yang, M. C., Kulp, S. K., Salunke, S. B., Himmel, L. E., Fang, C. S., Jadhav, A. M., Shan, Y. S., Lee, C. T., Lai, M. D., Shirley, L. A., Bekaii-Saab, T. & Chen, C. S., 2016 Jul 28, In : Oncogene. 35, 30, p. 3897-3908 12 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Systematic analysis of gene expression alterations and clinical outcomes for long-chain acyl-coenzyme A synthetase family in cancer

Chen, W. C., Wang, C. Y., Hung, Y. H., Weng, T. Y., Yen, M. C. & Lai, M. D., 2016 May 1, In : PloS one. 11, 5, e0155660.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2015

A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy

Hsu, T. I., Chen, Y. J., Hung, C. Y., Wang, Y-C., Lin, S. J., Su, W-C., Lai, M-D., Kim, S. Y., Wang, Q., Qian, K., Goto, M., Zhao, Y., Kashiwada, Y., Lee, K. H., Chang, W. C. & Hung, J-J., 2015, In : Oncotarget. 6, 15, p. 13671-13687 17 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Argininosuccinate lyase is a potential therapeutic target in breast cancer

Huang, H. L., Chen, W. C., Hsu, H. P., Cho, C. Y., Hung, Y. H., Wang, C. Y. & Lai, M. D., 2015 Dec 1, In : Oncology Reports. 34, 6, p. 3131-3139 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Argininosuccinate synthetase 1 suppression and arginine restriction inhibit cell migration in gastric cancer cell lines

Shan, Y. S., Hsu, H. P., Lai, M. D., Yen, M. C., Chen, W. C., Fang, J. H., Weng, T. Y. & Chen, Y. L., 2015 Apr 30, In : Scientific reports. 5, 9783.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Cell surface nucleolin facilitates enterovirus 71 binding and infection

Su, P. Y., Wang, Y. F., Huang, S. W., Lo, Y. C., Wang, Y. H., Wu, S. R., Shieh, D. B., Chen, S. H., Wang, J. R., Lai, M. D. & Chang, C. F., 2015, In : Journal of Virology. 89, 8, p. 4527-4538 12 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
9 Citations (Scopus)

Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels

Sun, Z., Lawson, D. A., Sinclair, E., Wang, C. Y., Lai, M. D., Hetts, S. W., Higashida, R. T., Dowd, C. F., Halbach, V. V., Werb, Z., Su, H. & Cooke, D. L., 2015 Sep 1, In : Biotechnology Reports. 7, p. 157-165 9 p., 106.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Increased expression of argininosuccinate synthetase protein predicts poor prognosis in human gastric cancer

Shan, Y. S., Hsu, H. P., Lai, M. D., Yen, M. C., Luo, Y. P. & Chen, Y. L., 2015 Jan 1, In : Oncology Reports. 33, 1, p. 49-57 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Meta-analysis of public microarray datasets reveals voltage-gated calcium gene signatures in clinical cancer patients

Wang, C. Y., Lai, M. D., Phan, N. N., Sun, Z. & Lin, Y. C., 2015 Jul 6, In : PloS one. 10, 7, e0125766.

Research output: Contribution to journalArticle

32 Citations (Scopus)
7 Citations (Scopus)

SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor

Chiang, C. Y., Pan, C. C., Chang, H. Y., Lai, M-D., Tzai, T. S., Tsai, Y-S., Ling, P., Liu, H-S., Lee, B-F., Cheng, H-L., Ho, C-L., Chen, S-H. & Chow, N-H., 2015 Dec 15, In : Clinical Cancer Research. 21, 24, p. 5601-5611 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The iNOS/Src/FAK axis contributes to lithium chloride-mediated macrophage migration

Chen, H. C., Chien, W. C., Chang, M. Y., Hsieh, M. Y., Lai, M. D., Maa, M. C. & Leu, T. H., 2015 May 1, In : Nitric Oxide - Biology and Chemistry. 47, p. 58-64 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer

Chen, W. C., Chang, Y. S., Hsu, H. P., Yen, M. C., Huang, H. L., Cho, C. Y., Wang, C. Y., Weng, T. Y., Lai, P. T., Chen, C. S., Lin, Y. J. & Lai, M. D., 2015, In : Oncotarget. 6, 40, p. 42923-42937 15 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
33 Citations (Scopus)
2014

A novel cancer therapeutic using thrombospondin 1 in dendritic cells

Weng, T. Y., Huang, S. S., Yen, M. C., Lin, C. C., Chen, Y. L., Lin, C. M., Chen, W. C., Wang, C. Y., Chang, J. Y. & Lai, M. D., 2014 Feb, In : Molecular Therapy. 22, 2, p. 292-302 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

DNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model

Weng, T. Y., Yen, M. C., Huang, C. T., Hung, J. J., Chen, Y. L., Chen, W. C., Wang, C. Y., Chang, J. Y. & Lai, M. D., 2014 Jan 1, In : Gene Therapy. 21, 10, p. 888-896 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Fatty acid metabolic enzyme acyl-CoA thioesterase 8 promotes the development of hepatocellular carcinoma

Hung, Y. U. H., Chan, Y. I. S., Chang, Y. S., Lee, K. T., Hsu, H. P., Yen, M. C., Chen, W. C., Wang, C. Y. & Lai, M. D., 2014 Jan 1, In : Oncology Reports. 31, 6, p. 2797-2803 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Hypoxia promotes nuclear translocation and transcriptional function in the oncogenic tyrosine kinase RON

Chang, H. Y., Liu, H. S., Lai, M. D., Tsai, Y. S., Tzai, T. S., Cheng, H. L. & Chow, N. H., 2014 Aug 15, In : Cancer Research. 74, 16, p. 4549-4562 14 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
25 Citations (Scopus)

Induction of indoleamine 2,3-dioxygenase (IDO) enzymatic activity contributes to interferon-gamma induced apoptosis and death receptor 5 expression in human non-small cell lung cancer cells

Chung, T. W., Tan, K. T., Chan, H. L., Lai, M. D., Yen, M. C., Li, Y. R., Lin, S. H. & Lin, C. C., 2014 Jan 1, In : Asian Pacific Journal of Cancer Prevention. 15, 18, p. 7995-8001 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Optimization protein productivity of human interleukin-2 through codon usage, gene copy number and intracellular tRNA concentration in CHO cells

Ou, K. C., Wang, C. Y., Liu, K. T., Chen, Y. L., Chen, Y. C., Lai, M. D. & Yen, M. C., 2014 Nov 14, In : Biochemical and Biophysical Research Communications. 454, 2, p. 347-352 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Potential significance of EMP3 in patients with upper urinary tract urothelial carcinoma: Crosstalk with ErbB2-PI3K-Akt pathway

Wang, Y. W., Li, W. M., Wu, W. J., Chai, C. Y., Liu, H. S., Lai, M. D. & Chow, N. H., 2014 Jul, In : Journal of Urology. 192, 1, p. 242-251 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Suppression of mucin 2 promotes interleukin-6 secretion and tumor growth in an orthotopic immune-competent colon cancer animal model

Shan, Y. S., Hsu, H. P., Lai, M. D., Yen, M. C., Fang, J. H., Weng, T. Y. & Chen, Y. L., 2014 Dec 1, In : Oncology Reports. 32, 6, p. 2335-2342 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2013

An HDAC inhibitor enhances cancer therapeutic efficiency of RNA polymerase III promoter-driven IDO shRNA

Yen, M. C., Weng, T. Y., Chen, Y. L., Lin, C. C., Chen, C. Y., Wang, C. Y., Chao, H. L., Chen, C. S. & Lai, M. D., 2013 Jun 1, In : Cancer Gene Therapy. 20, 6, p. 351-357 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Attenuation of argininosuccinate lyase inhibits cancer growth via cyclin A2 and nitric oxide

Huang, H. L., Hsu, H. P., Shieh, S. C., Chang, Y. S., Chen, W. C., Cho, C. Y., Teng, C. F., Su, I. J., Hung, W. C. & Lai, M. D., 2013 Nov, In : Molecular Cancer Therapeutics. 12, 11, p. 2505-2516 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Biolistic DNA delivery to mice with the low pressure gene gun

Yen, M. C. & Lai, M. D., 2013 Jan 1, Biolistic DNA Delivery: Methods and Protocols. Sudowe, S. & Reske-Kunz, A. (eds.). p. 169-174 6 p. (Methods in Molecular Biology; vol. 940).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Redox-sensitive endoplasmic reticulum stress and autophagy at rostral ventrolateral medulla contribute to hypertension in spontaneously hypertensive rats

Chao, Y. M., Lai, M. D. & Chan, J. Y. H., 2013, In : Hypertension. 61, 6, p. 1270-1280 11 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
26 Citations (Scopus)
2012

Aberrant cyclin a expression and centrosome overduplication induced by hepatitis B virus pre-S2 mutants and its implication in hepatocarcinogenesis

Wang, L. H. C., Huang, W., Lai, M. D. & Su, I. J., 2012 Feb 8, In : Carcinogenesis. 33, 2, p. 466-472 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)