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• 2019

  Cancer immunotherapy: Silencing intracellular negative immune regulators of dendritic cells

  Liu, Y. H., Yeh, I. J., Lai, M. D., Liu, K. T., Kuo, P. L. & Yen, M. C., 2019 Jan 1, In: Cancers. 11, 1, 108.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Dendritic Cells
  • Immunotherapy
  • Small Interfering RNA
  • Neoplasms
  • DNA Vaccines
  2 Citations (Scopus)

• Erratum: A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy (Oncotarget (2015) 6 (13671–13687) DOI: 10.18632/oncotarget.3701)

  Hsu, T. I., Chen, Y. J., Hung, C. Y., Wang, Y. C., Lin, S. J., Su, W. C., Lai, M. D., Kim, S. Y., Wang, Q., Qian, K., Goto, M., Zhao, Y., Kashiwada, Y., Lee, K. H., Chang, W. C. & Hung, J. J., 2019, In: Oncotarget. 10, 60, p. 6536-6537 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • betulinic acid
  • Lung Neoplasms
  • Growth
  • Neoplasms
• 2018

  Astrocytic CCAAT/Enhancer-binding protein delta contributes to reactive oxygen species formation in neuroinflammation

  Wang, S. M., Lim, S. W., Wang, Y. H., Lin, H. Y., Lai, M. D., Ko, C. Y. & Wang, Y-M., 2018 Jun, In: Redox Biology. 16, p. 104-112 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative stress
  • CCAAT-Enhancer-Binding Protein-delta
  • Astrocytes
  • Reactive Oxygen Species
  • Oxidative Stress
  7 Citations (Scopus)

• Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation

  Weng, T. Y., Wu, H. F., Li, C. Y., Hung, Y. H., Chang, Y. W., Chen, Y. L., Hsu, H. P., Chen, Y. H., Wang, C. Y., Chang, J. Y. & Lai, M. D., 2018 Dec 1, In: Scientific reports. 8, 1, 8216.

  Research output: Contribution to journal › Article › peer-review

  • Homoharringtonine
  • Adenocarcinoma of Lung
  • Mutation
  • B-Lymphocytes
  • Neoplasms
  5 Citations (Scopus)

• Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells

  Sun, Z., Wang, C. Y., Lawson, D. A., Kwek, S., Velozo, H. G., Owyong, M., Lai, M. D., Fong, L., Wilson, M., Su, H., Werb, Z. & Cooke, D. L., 2018, In: Oncotarget. 9, 13, p. 10945-10961 17 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Sequence Analysis
  • Transcriptome
  • Endothelial Cells
  • Breast Neoplasms
  • Genes
  12 Citations (Scopus)
• 2017

  Argininosuccinate lyase interacts with cyclin A2 in cytoplasm and modulates growth of liver tumor cells

  Hung, Y. H., Huang, H. L., Chen, W. C., Yen, M. C., Cho, C. Y., Weng, T. Y., Wang, C. Y., Chen, Y. L., Chen, L. T. & Lai, M. D., 2017 Feb, In: Oncology Reports. 37, 2, p. 969-978 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Argininosuccinate Lyase
  • Cyclin A2
  • Cytoplasm
  • Liver
  • Growth
  8 Citations (Scopus)

• Cyclin D1 overexpression correlates with poor tumor differentiation and prognosis in gastric cancer

  Shan, Y. S., Hsu, H. P., Lai, M. D., Hung, Y. H., Wang, C. Y., Yen, M. C. & Chen, Y. L., 2017, In: Oncology Letters. 14, 4, p. 4517-4526 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Cyclin D1
  • Stomach Neoplasms
  • Cyclin D2
  • Cyclin D
  • Adenocarcinoma
  22 Citations (Scopus)

• GATA3 targets semaphorin 3B in mammary epithelial cells to suppress breast cancer progression and metastasis

  Shahi, P., Wang, C. Y., Chou, J., Hagerling, C., Gonzalez Velozo, H., Ruderisch, A., Yu, Y., Lai, M. D. & Werb, Z., 2017 Oct 5, In: Oncogene. 36, 40, p. 5567-5575 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Semaphorins
  • Breast
  • Epithelial Cells
  • Breast Neoplasms
  • Neoplasm Metastasis
  19 Citations (Scopus)

• Mucin 2 silencing promotes colon cancer metastasis through interleukin-6 signaling

  Hsu, H. P., Lai, M. D., Lee, J. C., Yen, M. C., Weng, T. Y., Chen, W. C., Fang, J. H. & Chen, Y. L., 2017 Dec 1, In: Scientific reports. 7, 1, 5823.

  Research output: Contribution to journal › Article › peer-review

  • Mucin-2
  • Colonic Neoplasms
  • Interleukin-6
  • Neoplasm Metastasis
  • Down-Regulation
  18 Citations (Scopus)

• PSMB5 plays a dual role in cancer development and immunosuppression

  Wang, C. Y., Li, C. Y., Hsu, H. P., Cho, C. Y., Yen, M. C., Weng, T. Y., Chen, W. C., Hung, Y. H., Lee, K. T., Hung, J. H., Chen, Y. L. & Lai, M. D., 2017, In: American Journal of Cancer Research. 7, 11, p. 2103-2120 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Immunosuppression
  • Proteasome Endopeptidase Complex
  • Computational Biology
  • Macrophages
  • Neoplasms
  10 Citations (Scopus)

• Silencing of argininosuccinate lyase inhibits colorectal cancer formation

  Huang, H. L., Chen, W. C., Hsu, H. P., Cho, C. Y., Hung, Y. H., Wang, C. Y. & Lai, M. D., 2017 Jan, In: Oncology Reports. 37, 1, p. 163-170 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Argininosuccinate Lyase
  • Colorectal Neoplasms
  • Colonic Neoplasms
  • Nitric Oxide
  • Small Interfering RNA
  8 Citations (Scopus)

• Skin Delivery of Clec4a Small Hairpin RNA Elicited an Effective Antitumor Response by Enhancing CD8⁺ Immunity In Vivo

  Weng, T. Y., Li, C. J., Li, C. Y., Hung, Y. H., Yen, M. C., Chang, Y. W., Chen, Y. H., Chen, Y. L., Hsu, H. P., Chang, J. Y. & Lai, M. D., 2017 Dec, In: Molecular Therapy - Nucleic Acids. 9, p. 419-427 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Small Interfering RNA
  • Immunity
  • Skin
  • Neoplasms
  • DNA Vaccines
  4 Citations (Scopus)

• Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients

  Wang, C. Y., Shahi, P., Huang, J. T. W., Phan, N. N., Sun, Z., Lin, Y. C., Lai, M. D. & Werb, Z., 2017 Jan 1, In: Molecular and Clinical Oncology. 6, 1, p. 7-18 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Achaete-Scute Complex Genome Region
  • Neoplasms
  • Colonic Neoplasms
  • Kidney Neoplasms
  • Urinary Bladder Neoplasms

• Voltage-gated calcium channels: Novel targets for cancer therapy

  Phan, N. N., Wang, C. Y., Chen, C. F., Sun, Z., Lai, M. D. & Lin, Y. C., 2017, In: Oncology Letters. 14, 2, p. 2059-2074 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcium Channels
  • Genes
  • Brain Neoplasms
  • Neoplasms
  • Kidney Neoplasms
  38 Citations (Scopus)

• ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression

  Shahi, P., Wang, C. Y., Lawson, D. A., Slorach, E. M., Lu, A., Yu, Y., Lai, M. D., Velozo, H. G. & Werb, Z., 2017 Mar 21, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 12, p. 3169-3174 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Down-Regulation
  • Breast Neoplasms
  • GATA3 Transcription Factor
  • Breast
  • Epithelial Cells
  9 Citations (Scopus)
• 2016

  Astrocytic CCAAT/Enhancer-Binding Protein Delta Contributes to Glial Scar Formation and Impairs Functional Recovery After Spinal Cord Injury

  Wang, S. M., Hsu, J. Y. C., Ko, C. Y., Chiu, N. E., Kan, W. M., Lai, M. D. & Wang, J. M., 2016 Nov 1, In: Molecular Neurobiology. 53, 9, p. 5912-5927 16 p.

  Research output: Contribution to journal › Article › peer-review

  • CCAAT-Enhancer-Binding Protein-delta
  • Spinal Cord Injuries
  • Astrocytes
  • Neuroglia
  • Cicatrix
  9 Citations (Scopus)

• Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin

  Chen, W. C., Hsu, H. P., Li, C. Y., Yang, Y. J., Hung, Y. H., Cho, C. Y., Wang, C. Y., Weng, T. Y. & Lai, M. D., 2016 Nov, In: International Journal of Oncology. 49, 5, p. 1881-1889 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Neoplastic Stem Cells
  • Integrins
  • Ovarian Neoplasms
  • Growth
  • Anoikis
  16 Citations (Scopus)

• Differential expression pattern of THBS1 and THBS2 in lung cancer: Clinical outcome and a systematic-analysis of microarray databases

  Weng, T. Y., Wang, C. Y., Hung, Y. H., Chen, W. C., Chen, Y. L. & Lai, M. D., 2016 Aug, In: PloS one. 11, 8, e0161007.

  Research output: Contribution to journal › Article › peer-review

  • thrombospondin 2
  • Thrombospondin 1
  • lung neoplasms
  • Microarrays
  • microarray technology
  24 Citations (Scopus)

• Membrane bile acid receptor TGR5 predicts good prognosis in ampullary adenocarcinoma patients with hyperbilirubinemia

  Chen, M. C., Chen, Y. L., Wang, T. W., Hsu, H. P. & Lai, M. D., 2016 Oct, In: Oncology Reports. 36, 4, p. 1997-2008 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Hyperbilirubinemia
  • Bile Acids and Salts
  • Adenocarcinoma
  • Membranes
  • GTP-Binding Proteins
  10 Citations (Scopus)

• MST3 promotes proliferation and tumorigenicity through the VAV2/Rac1 signal axis in breast cancer

  Cho, C. Y., Lee, K. T., Chen, W. C., Wang, C. Y., Chang, Y. S., Huang, H. L., Hsu, H. P., Yen, M. C., Lai, M. Z. & Lai, M. D., 2016 Mar 22, In: Oncotarget. 7, 12, p. 14586-14604 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Phosphotransferases
  • Breast Neoplasms
  • Proline
  • Growth
  • Breast Cancer 3
  16 Citations (Scopus)

• Regulation of oncogenic KRAS signaling via a novel KRAS-integrin-linked kinase-hnRNPA1 regulatory loop in human pancreatic cancer cells

  Chu, P. C., Yang, M. C., Kulp, S. K., Salunke, S. B., Himmel, L. E., Fang, C. S., Jadhav, A. M., Shan, Y. S., Lee, C. T., Lai, M. D., Shirley, L. A., Bekaii-Saab, T. & Chen, C. S., 2016 Jul 28, In: Oncogene. 35, 30, p. 3897-3908 12 p.

  Research output: Contribution to journal › Article › peer-review

  • integrin-linked kinase
  • Pancreatic Neoplasms
  • Small Interfering RNA
  • G-Quadruplexes
  • Heterogeneous-Nuclear Ribonucleoproteins
  19 Citations (Scopus)

• Systematic analysis of gene expression alterations and clinical outcomes for long-chain acyl-coenzyme A synthetase family in cancer

  Chen, W. C., Wang, C. Y., Hung, Y. H., Weng, T. Y., Yen, M. C. & Lai, M. D., 2016 May 1, In: PloS one. 11, 5, e0155660.

  Research output: Contribution to journal › Article › peer-review

  • Coenzyme A Ligases
  • acyl coenzyme A
  • prognosis
  • Gene expression
  • lung neoplasms
  45 Citations (Scopus)
• 2015

  A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy

  Hsu, T. I., Chen, Y. J., Hung, C. Y., Wang, Y-C., Lin, S. J., Su, W-C., Lai, M-D., Kim, S. Y., Wang, Q., Qian, K., Goto, M., Zhao, Y., Kashiwada, Y., Lee, K. H., Chang, W. C. & Hung, J-J., 2015, In: Oncotarget. 6, 15, p. 13671-13687 17 p.

  Research output: Contribution to journal › Article › peer-review

  • betulinic acid
  • Lung Neoplasms
  • Endoplasmic Reticulum Stress
  • Cyclin A2
  • Growth
  14 Citations (Scopus)

• Argininosuccinate lyase is a potential therapeutic target in breast cancer

  Huang, H. L., Chen, W. C., Hsu, H. P., Cho, C. Y., Hung, Y. H., Wang, C. Y. & Lai, M. D., 2015 Dec 1, In: Oncology Reports. 34, 6, p. 3131-3139 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Argininosuccinate Lyase
  • Breast Neoplasms
  • Cyclin A2
  • Small Interfering RNA
  • Autophagy
  13 Citations (Scopus)

• Argininosuccinate synthetase 1 suppression and arginine restriction inhibit cell migration in gastric cancer cell lines

  Shan, Y. S., Hsu, H. P., Lai, M. D., Yen, M. C., Chen, W. C., Fang, J. H., Weng, T. Y. & Chen, Y. L., 2015 Apr 30, In: Scientific reports. 5, 9783.

  Research output: Contribution to journal › Article › peer-review

  • Argininosuccinate Synthase
  • Arginine
  • Stomach Neoplasms
  • Cell Movement
  • Cell Line
  20 Citations (Scopus)

• Cell surface nucleolin facilitates enterovirus 71 binding and infection

  Su, P. Y., Wang, Y. F., Huang, S. W., Lo, Y. C., Wang, Y. H., Wu, S. R., Shieh, D. B., Chen, S. H., Wang, J. R., Lai, M. D. & Chang, C. F., 2015, In: Journal of Virology. 89, 8, p. 4527-4538 12 p.

  Research output: Contribution to journal › Article › peer-review

  • nucleolin
  • Enterovirus
  • infection
  • Infection
  • glycoproteomics
  49 Citations (Scopus)

• Dual role of CD44 isoforms in ampullary adenocarcinoma: CD44s predicts poor prognosis in early cancer and CD44v is an indicator for recurrence in advanced cancer

  Wu, C. L., Chao, Y. J., Yang, T. M., Chen, Y. L., Chang, K. C., Hsu, H. P., Shan, Y. S. & Lai, M. D., 2015 Nov 16, In: BMC cancer. 15, 1, 903.

  Research output: Contribution to journal › Article › peer-review

  • Protein Isoforms
  • Adenocarcinoma
  • Recurrence
  • Neoplasms
  • Reverse Transcription
  11 Citations (Scopus)

• Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels

  Sun, Z., Lawson, D. A., Sinclair, E., Wang, C. Y., Lai, M. D., Hetts, S. W., Higashida, R. T., Dowd, C. F., Halbach, V. V., Werb, Z., Su, H. & Cooke, D. L., 2015 Sep 1, In: Biotechnology Reports. 7, p. 157-165 9 p., 106.

  Research output: Contribution to journal › Article › peer-review

  • Transcriptome
  • Endothelial Cells
  • Biopsy
  • Flow Cytometry
  • Leukocytes
  4 Citations (Scopus)

• Increased expression of argininosuccinate synthetase protein predicts poor prognosis in human gastric cancer

  Shan, Y. S., Hsu, H. P., Lai, M. D., Yen, M. C., Luo, Y. P. & Chen, Y. L., 2015 Jan 1, In: Oncology Reports. 33, 1, p. 49-57 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Argininosuccinate Synthase
  • Stomach Neoplasms
  • Proteins
  • Neoplasms
  • Neoplasm Staging
  15 Citations (Scopus)

• Meta-analysis of public microarray datasets reveals voltage-gated calcium gene signatures in clinical cancer patients

  Wang, C. Y., Lai, M. D., Phan, N. N., Sun, Z. & Lin, Y. C., 2015 Jul 6, In: PloS one. 10, 7, e0125766.

  Research output: Contribution to journal › Article › peer-review

  • meta-analysis
  • Microarrays
  • Calcium Channels
  • calcium channels
  • electric potential difference
  37 Citations (Scopus)

• Nestin predicts a favorable prognosis in early ampullary adenocarcinoma and functions as a promoter of metastasis in advanced cancer

  Shan, Y. S., Chen, Y. L., Lai, M. D. & Hsu, H. P., 2015 Jan 1, In: Oncology Reports. 33, 1, p. 40-48 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Nestin
  • Adenocarcinoma
  • Neoplasm Metastasis
  • Cyclin-Dependent Kinase 5
  • Neoplasms
  7 Citations (Scopus)

• SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor

  Chiang, C. Y., Pan, C. C., Chang, H. Y., Lai, M. D., Tzai, T. S., Tsai, Y. S., Ling, P., Liu, H. S., Lee, B. F., Cheng, H. L., Ho, C. L., Chen, S. H. & Chow, N. H., 2015 Dec 15, In: Clinical Cancer Research. 21, 24, p. 5601-5611 11 p.

  Research output: Contribution to journal › Article › peer-review

  • src Homology Domains
  • ErbB Receptors
  • Glutamic Acid
  • Biomarkers
  • Carcinoma
  17 Citations (Scopus)

• The iNOS/Src/FAK axis contributes to lithium chloride-mediated macrophage migration

  Chen, H. C., Chien, W. C., Chang, M. Y., Hsieh, M. Y., Lai, M. D., Maa, M. C. & Leu, T. H., 2015 May 1, In: Nitric Oxide - Biology and Chemistry. 47, p. 58-64 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Macrophages
  • Lithium Chloride
  • Peritoneal Macrophages
  • kenpaullone
  • AG 1879
  6 Citations (Scopus)

• Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer

  Chen, W. C., Chang, Y. S., Hsu, H. P., Yen, M. C., Huang, H. L., Cho, C. Y., Wang, C. Y., Weng, T. Y., Lai, P. T., Chen, C. S., Lin, Y. J. & Lai, M. D., 2015, In: Oncotarget. 6, 40, p. 42923-42937 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Liver Neoplasms
  • OSU-CG5
  • Integrins
  • Ectopic Gene Expression
  • Neoplastic Stem Cells
  29 Citations (Scopus)

• The significance of the co-existence of osteopontin and tumor-associated macrophages in gastric cancer progression

  Lin, C. N., Wang, C. J., Chao, Y. J., Lai, M. D. & Shan, Y. S., 2015 Mar 15, In: BMC cancer. 15, 1, 128.

  Research output: Contribution to journal › Article › peer-review

  • Osteopontin
  • Stomach Neoplasms
  • Macrophages
  • Neoplasms
  • U937 Cells
  37 Citations (Scopus)
• 2014

  A novel cancer therapeutic using thrombospondin 1 in dendritic cells

  Weng, T. Y., Huang, S. S., Yen, M. C., Lin, C. C., Chen, Y. L., Lin, C. M., Chen, W. C., Wang, C. Y., Chang, J. Y. & Lai, M. D., 2014 Feb, In: Molecular Therapy. 22, 2, p. 292-302 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Thrombospondin 1
  • Dendritic Cells
  • Small Interfering RNA
  • Neoplasms
  • Therapeutics
  15 Citations (Scopus)

• DNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model

  Weng, T. Y., Yen, M. C., Huang, C. T., Hung, J. J., Chen, Y. L., Chen, W. C., Wang, C. Y., Chang, J. Y. & Lai, M. D., 2014 Jan 1, In: Gene Therapy. 21, 10, p. 888-896 9 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Vaccines
  • Transgenic Mice
  • Lung Neoplasms
  • Therapeutic Uses
  • Neoplasms
  10 Citations (Scopus)

• Fatty acid metabolic enzyme acyl-CoA thioesterase 8 promotes the development of hepatocellular carcinoma

  Hung, Y. U. H., Chan, Y. I. S., Chang, Y. S., Lee, K. T., Hsu, H. P., Yen, M. C., Chen, W. C., Wang, C. Y. & Lai, M. D., 2014 Jun, In: Oncology Reports. 31, 6, p. 2797-2803 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Acyl Coenzyme A
  • Fatty Acids
  • Hepatocellular Carcinoma
  • Enzymes
  • Nonesterified Fatty Acids
  14 Citations (Scopus)

• Hypoxia promotes nuclear translocation and transcriptional function in the oncogenic tyrosine kinase RON

  Chang, H. Y., Liu, H. S., Lai, M. D., Tsai, Y. S., Tzai, T. S., Cheng, H. L. & Chow, N. H., 2014 Aug 15, In: Cancer Research. 74, 16, p. 4549-4562 14 p.

  Research output: Contribution to journal › Article › peer-review

  • rice bran saccharide
  • Protein-Tyrosine Kinases
  • Hypoxia
  • Cell Survival
  • Tumor Hypoxia
  22 Citations (Scopus)

• Increase of Zinc Finger Protein 179 in Response to CCAAT/Enhancer Binding Protein Delta Conferring an Antiapoptotic Effect in Astrocytes of Alzheimer’s Disease

  Wang, S. M., Lee, Y. C., Ko, C. Y., Lai, M. D., Lin, D. Y., Pao, P. C., Chi, J. Y., Hsiao, Y. W., Liu, T. L. & Wang, J. M., 2014, In: Molecular Neurobiology. 51, 1, p. 370-382 13 p.

  Research output: Contribution to journal › Article › peer-review

  • CCAAT-Enhancer-Binding Protein-delta
  • Zinc Fingers
  • Astrocytes
  • Alzheimer Disease
  • Promyelocytic Leukemia Zinc Finger Protein
  26 Citations (Scopus)

• Induction of indoleamine 2,3-dioxygenase (IDO) enzymatic activity contributes to interferon-gamma induced apoptosis and death receptor 5 expression in human non-small cell lung cancer cells

  Chung, T. W., Tan, K. T., Chan, H. L., Lai, M. D., Yen, M. C., Li, Y. R., Lin, S. H. & Lin, C. C., 2014 Jan 1, In: Asian Pacific Journal of Cancer Prevention. 15, 18, p. 7995-8001 7 p.

  Research output: Contribution to journal › Article › peer-review

  • TNF-Related Apoptosis-Inducing Ligand Receptors
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Non-Small Cell Lung Carcinoma
  • Interferon-gamma
  • Apoptosis
  10 Citations (Scopus)

• Optimization protein productivity of human interleukin-2 through codon usage, gene copy number and intracellular tRNA concentration in CHO cells

  Ou, K. C., Wang, C. Y., Liu, K. T., Chen, Y. L., Chen, Y. C., Lai, M. D. & Yen, M. C., 2014 Nov 14, In: Biochemical and Biophysical Research Communications. 454, 2, p. 347-352 6 p.

  Research output: Contribution to journal › Article › peer-review

  • human IL2 protein
  • CHO Cells
  • Gene Dosage
  • Transfer RNA
  • Codon
  9 Citations (Scopus)

• Potential significance of EMP3 in patients with upper urinary tract urothelial carcinoma: Crosstalk with ErbB2-PI3K-Akt pathway

  Wang, Y. W., Li, W. M., Wu, W. J., Chai, C. Y., Liu, H. S., Lai, M. D. & Chow, N. H., 2014 Jul, In: Journal of Urology. 192, 1, p. 242-251 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Phosphatidylinositol 3-Kinases
  • Urinary Tract
  • Carcinoma
  • In Vitro Techniques
  • Cell Adhesion
  16 Citations (Scopus)

• Suppression of mucin 2 promotes interleukin-6 secretion and tumor growth in an orthotopic immune-competent colon cancer animal model

  Shan, Y. S., Hsu, H. P., Lai, M. D., Yen, M. C., Fang, J. H., Weng, T. Y. & Chen, Y. L., 2014 Dec 1, In: Oncology Reports. 32, 6, p. 2335-2342 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Mucin-2
  • Colonic Neoplasms
  • Interleukin-6
  • Animal Models
  • Growth
  15 Citations (Scopus)
• 2013

  An HDAC inhibitor enhances cancer therapeutic efficiency of RNA polymerase III promoter-driven IDO shRNA

  Yen, M. C., Weng, T. Y., Chen, Y. L., Lin, C. C., Chen, C. Y., Wang, C. Y., Chao, H. L., Chen, C. S. & Lai, M. D., 2013 Jun 1, In: Cancer Gene Therapy. 20, 6, p. 351-357 7 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Polymerase III
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Histone Deacetylase Inhibitors
  • Small Interfering RNA
  • Neoplasms
  5 Citations (Scopus)

• Attenuation of argininosuccinate lyase inhibits cancer growth via cyclin A2 and nitric oxide

  Huang, H. L., Hsu, H. P., Shieh, S. C., Chang, Y. S., Chen, W. C., Cho, C. Y., Teng, C. F., Su, I. J., Hung, W. C. & Lai, M. D., 2013 Nov, In: Molecular Cancer Therapeutics. 12, 11, p. 2505-2516 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Argininosuccinate Lyase
  • Cyclin A2
  • Nitric Oxide
  • Growth
  • Small Interfering RNA
  16 Citations (Scopus)

• Biolistic DNA delivery to mice with the low pressure gene gun

  Yen, M. C. & Lai, M. D., 2013 Jan 1, Biolistic DNA Delivery: Methods and Protocols. Sudowe, S. & Reske-Kunz, A. (eds.). p. 169-174 6 p. (Methods in Molecular Biology; vol. 940).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Biolistics
  • Firearms
  • Pressure
  • Plasmids
  • DNA
  2 Citations (Scopus)

• Redox-sensitive endoplasmic reticulum stress and autophagy at rostral ventrolateral medulla contribute to hypertension in spontaneously hypertensive rats

  Chao, Y. M., Lai, M. D. & Chan, J. Y. H., 2013, In: Hypertension. 61, 6, p. 1270-1280 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Endoplasmic Reticulum Stress
  • Inbred SHR Rats
  • Autophagy
  • Oxidation-Reduction
  • Hypertension
  38 Citations (Scopus)

• Very low-density lipoprotein/lipo-viro particles reverse lipoprotein lipase-mediated inhibition of hepatitis C virus infection via apolipoprotein C-III

  Sun, H. Y., Lin, C. C., Lee, J. C., Wang, S-W., Cheng, P-N., Wu, I-C., Chang, T-T., Lai, M-D., Shieh, D-B. & Young, K-C., 2013 Aug 1, In: Gut. 62, 8, p. 1193-1203 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein C-III
  • VLDL Lipoproteins
  • Lipoprotein Lipase
  • Lipoproteins
  • Hepacivirus
  26 Citations (Scopus)
• 2012

  Aberrant cyclin a expression and centrosome overduplication induced by hepatitis B virus pre-S2 mutants and its implication in hepatocarcinogenesis

  Wang, L. H. C., Huang, W., Lai, M. D. & Su, I. J., 2012, In: Carcinogenesis. 33, 2, p. 466-472 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Cyclin A
  • Centrosome
  • Cyclins
  • Hepatitis B virus
  • Endoplasmic Reticulum Stress
  40 Citations (Scopus)