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• 2011

  ACSL3 and GSK-3β are essential for lipid upregulation induced by endoplasmic reticulum stress in liver cells

  Chang, Y. S., Tsai, C. T., Huangfu, C. A., Huang, W. Y., Lei, H. Y., Lin, C. F., Su, I. J., Chang, W. T., Wu, P. H., Chen, Y. T., Hung, J. H., Young, K. C. & Lai, M. D., 2011 Mar 1, In: Journal of Cellular Biochemistry. 112, 3, p. 881-893 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycogen Synthase Kinase 3
  • Liver
  • Endoplasmic Reticulum Stress
  • Up-Regulation
  • Lipids
  30 Citations (Scopus)

• Amelioration of rat collagen-induced arthritis through CD4⁺ T cells apoptosis and synovial interleukin-17 reduction by indoleamine 2,3-dioxygenase gene therapy

  Chen, S. Y., Wu, C. L., Lai, M. D., Lin, C. C., Yo, Y. T., Jou, I. M., Lee, C. H., Weng, C. T., Shiau, A. L. & Wang, C. R., 2011 Feb 1, In: Human Gene Therapy. 22, 2, p. 145-154 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Experimental Arthritis
  • Interleukin-17
  • Genetic Therapy
  • Kynurenine
  26 Citations (Scopus)

• Establishment of an orthotopic transplantable gastric cancer animal model for studying the immunological effects of new cancer therapeutic modules

  Shan, Y-S., Fang, J. H., Lai, M-D., Yen, M. C., Lin, P. W., Hsu, H-P., Lin, C. Y. & Chen, Y. L., 2011 Oct 1, In: Molecular Carcinogenesis. 50, 10, p. 739-750 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Stomach Neoplasms
  • Animal Models
  • Stomach
  • Carcinoma
  • Butyric Acid
  12 Citations (Scopus)

• Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein

  Lee, J. W., Liao, P. C., Young, K. C., Chang, C. L., Chen, S. S. L., Chang, T. T., Lai, M. D. & Wang, S. W., 2011 Oct 7, In: Journal of Proteome Research. 10, 10, p. 4522-4534 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Hepatitis C virus nucleocapsid protein
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Cytoplasm
  • Nuclear Factor 45 Protein
  • Proteins
  30 Citations (Scopus)

• RNAi compound targeted to thrombospondin-1 and applications thereof

  Lai, M-D., 2011 Jul 7, Patent No. 8377902

  Research output: Patent

  • Thrombospondin 1
  • Patents and inventions
  • Genes
  • Plasmids
  • Chemical analysis

• Skin delivery of short hairpin RNA of indoleamine 2,3 dioxygenase induces antitumor immunity against orthotopic and metastatic liver cancer

  Huang, T. T., Yen, M. C., Lin, C. C., Weng, T. Y., Chen, Y. L., Lin, C. M. & Lai, M. D., 2011 Dec, In: Cancer Science. 102, 12, p. 2214-2220 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Liver Neoplasms
  • Small Interfering RNA
  • Immunity
  • Skin
  25 Citations (Scopus)
• 2012

  Aberrant cyclin a expression and centrosome overduplication induced by hepatitis B virus pre-S2 mutants and its implication in hepatocarcinogenesis

  Wang, L. H. C., Huang, W., Lai, M. D. & Su, I. J., 2012 Feb 1, In: Carcinogenesis. 33, 2, p. 466-472 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Cyclin A
  • Centrosome
  • Cyclins
  • Hepatitis B virus
  • Endoplasmic Reticulum Stress
  41 Citations (Scopus)

• Endoplasmic reticulum stress stimulates p53 expression through NF-κB activation

  Lin, W. C., Chuang, Y. C., Chang, Y. S., Lai, M. D., Teng, Y. N., Su, I. J., Wang, C. C. C., Lee, K. H. & Hung, J. H., 2012 Jul 30, In: PloS one. 7, 7, e39120.

  Research output: Contribution to journal › Article › peer-review

  • endoplasmic reticulum stress
  • Endoplasmic Reticulum Stress
  • Chemical activation
  • Brefeldin A
  • brefeldin A
  75 Citations (Scopus)
• 2013

  An HDAC inhibitor enhances cancer therapeutic efficiency of RNA polymerase III promoter-driven IDO shRNA

  Yen, M. C., Weng, T. Y., Chen, Y. L., Lin, C. C., Chen, C. Y., Wang, C. Y., Chao, H. L., Chen, C. S. & Lai, M. D., 2013 Jun, In: Cancer Gene Therapy. 20, 6, p. 351-357 7 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Polymerase III
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Histone Deacetylase Inhibitors
  • Small Interfering RNA
  • Neoplasms
  5 Citations (Scopus)

• Attenuation of argininosuccinate lyase inhibits cancer growth via cyclin A2 and nitric oxide

  Huang, H. L., Hsu, H. P., Shieh, S. C., Chang, Y. S., Chen, W. C., Cho, C. Y., Teng, C. F., Su, I. J., Hung, W. C. & Lai, M. D., 2013 Nov, In: Molecular cancer therapeutics. 12, 11, p. 2505-2516 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Argininosuccinate Lyase
  • Cyclin A2
  • Nitric Oxide
  • Growth
  • Small Interfering RNA
  17 Citations (Scopus)

• Biolistic DNA delivery to mice with the low pressure gene gun

  Yen, M. C. & Lai, M. D., 2013 Jan 1, Biolistic DNA Delivery: Methods and Protocols. Sudowe, S. & Reske-Kunz, A. (eds.). p. 169-174 6 p. (Methods in Molecular Biology; vol. 940).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Biolistics
  • Firearms
  • Pressure
  • Plasmids
  • DNA
  2 Citations (Scopus)

• Redox-sensitive endoplasmic reticulum stress and autophagy at rostral ventrolateral medulla contribute to hypertension in spontaneously hypertensive rats

  Chao, Y. M., Lai, M. D. & Chan, J. Y. H., 2013, In: Hypertension. 61, 6, p. 1270-1280 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Endoplasmic Reticulum Stress
  • Inbred SHR Rats
  • Autophagy
  • Oxidation-Reduction
  • Hypertension
  38 Citations (Scopus)

• Very low-density lipoprotein/lipo-viro particles reverse lipoprotein lipase-mediated inhibition of hepatitis C virus infection via apolipoprotein C-III

  Sun, H. Y., Lin, C. C., Lee, J. C., Wang, S-W., Cheng, P-N., Wu, I-C., Chang, T-T., Lai, M-D., Shieh, D-B. & Young, K-C., 2013 Aug 1, In: Gut. 62, 8, p. 1193-1203 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein C-III
  • VLDL Lipoproteins
  • Lipoprotein Lipase
  • Lipoproteins
  • Hepacivirus
  27 Citations (Scopus)
• 2014

  A novel cancer therapeutic using thrombospondin 1 in dendritic cells

  Weng, T. Y., Huang, S. S., Yen, M. C., Lin, C. C., Chen, Y. L., Lin, C. M., Chen, W. C., Wang, C. Y., Chang, J. Y. & Lai, M. D., 2014 Feb, In: Molecular Therapy. 22, 2, p. 292-302 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Thrombospondin 1
  • Dendritic Cells
  • Small Interfering RNA
  • Neoplasms
  • Therapeutics
  16 Citations (Scopus)

• DNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model

  Weng, T. Y., Yen, M. C., Huang, C. T., Hung, J. J., Chen, Y. L., Chen, W. C., Wang, C. Y., Chang, J. Y. & Lai, M. D., 2014 Jan 1, In: Gene Therapy. 21, 10, p. 888-896 9 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Vaccines
  • Transgenic Mice
  • Lung Neoplasms
  • Therapeutic Uses
  • Neoplasms
  11 Citations (Scopus)

• Fatty acid metabolic enzyme acyl-CoA thioesterase 8 promotes the development of hepatocellular carcinoma

  Hung, Y. U. H., Chan, Y. I. S., Chang, Y. S., Lee, K. T., Hsu, H. P., Yen, M. C., Chen, W. C., Wang, C. Y. & Lai, M. D., 2014 Jun, In: Oncology Reports. 31, 6, p. 2797-2803 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Acyl Coenzyme A
  • Fatty Acids
  • Hepatocellular Carcinoma
  • Enzymes
  • Nonesterified Fatty Acids
  16 Citations (Scopus)

• Hypoxia promotes nuclear translocation and transcriptional function in the oncogenic tyrosine kinase RON

  Chang, H. Y., Liu, H. S., Lai, M. D., Tsai, Y. S., Tzai, T. S., Cheng, H. L. & Chow, N. H., 2014 Aug 15, In: Cancer Research. 74, 16, p. 4549-4562 14 p.

  Research output: Contribution to journal › Article › peer-review

  • rice bran saccharide
  • Protein-Tyrosine Kinases
  • Hypoxia
  • Cell Survival
  • Tumor Hypoxia
  24 Citations (Scopus)

• Increase of Zinc Finger Protein 179 in Response to CCAAT/Enhancer Binding Protein Delta Conferring an Antiapoptotic Effect in Astrocytes of Alzheimer’s Disease

  Wang, S. M., Lee, Y. C., Ko, C. Y., Lai, M. D., Lin, D. Y., Pao, P. C., Chi, J. Y., Hsiao, Y. W., Liu, T. L. & Wang, J. M., 2014 Feb, In: Molecular Neurobiology. 51, 1, p. 370-382 13 p.

  Research output: Contribution to journal › Article › peer-review

  • CCAAT-Enhancer-Binding Protein-delta
  • Zinc Fingers
  • Astrocytes
  • Alzheimer Disease
  • Promyelocytic Leukemia Zinc Finger Protein
  27 Citations (Scopus)

• Induction of indoleamine 2,3-dioxygenase (IDO) enzymatic activity contributes to interferon-gamma induced apoptosis and death receptor 5 expression in human non-small cell lung cancer cells

  Chung, T. W., Tan, K. T., Chan, H. L., Lai, M. D., Yen, M. C., Li, Y. R., Lin, S. H. & Lin, C. C., 2014, In: Asian Pacific Journal of Cancer Prevention. 15, 18, p. 7995-8001 7 p.

  Research output: Contribution to journal › Article › peer-review

  • TNF-Related Apoptosis-Inducing Ligand Receptors
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Non-Small Cell Lung Carcinoma
  • Interferon-gamma
  • Apoptosis
  10 Citations (Scopus)

• Optimization protein productivity of human interleukin-2 through codon usage, gene copy number and intracellular tRNA concentration in CHO cells

  Ou, K. C., Wang, C. Y., Liu, K. T., Chen, Y. L., Chen, Y. C., Lai, M. D. & Yen, M. C., 2014 Nov 14, In: Biochemical and Biophysical Research Communications. 454, 2, p. 347-352 6 p.

  Research output: Contribution to journal › Article › peer-review

  • human IL2 protein
  • CHO Cells
  • Gene Dosage
  • Transfer RNA
  • Codon
  11 Citations (Scopus)

• Potential significance of EMP3 in patients with upper urinary tract urothelial carcinoma: Crosstalk with ErbB2-PI3K-Akt pathway

  Wang, Y. W., Li, W. M., Wu, W. J., Chai, C. Y., Liu, H. S., Lai, M. D. & Chow, N. H., 2014 Jul, In: Journal of Urology. 192, 1, p. 242-251 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Phosphatidylinositol 3-Kinases
  • Urinary Tract
  • Carcinoma
  • In Vitro Techniques
  • Cell Adhesion
  16 Citations (Scopus)

• Suppression of mucin 2 promotes interleukin-6 secretion and tumor growth in an orthotopic immune-competent colon cancer animal model

  Shan, Y. S., Hsu, H. P., Lai, M. D., Yen, M. C., Fang, J. H., Weng, T. Y. & Chen, Y. L., 2014 Dec 1, In: Oncology Reports. 32, 6, p. 2335-2342 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Mucin-2
  • Colonic Neoplasms
  • Interleukin-6
  • Animal Models
  • Growth
  15 Citations (Scopus)
• 2018

  Astrocytic CCAAT/Enhancer-binding protein delta contributes to reactive oxygen species formation in neuroinflammation

  Wang, S. M., Lim, S. W., Wang, Y. H., Lin, H. Y., Lai, M. D., Ko, C. Y. & Wang, Y-M., 2018 Jun, In: Redox Biology. 16, p. 104-112 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative stress
  • CCAAT-Enhancer-Binding Protein-delta
  • Astrocytes
  • Reactive Oxygen Species
  • Oxidative Stress
  9 Citations (Scopus)

• Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation

  Weng, T. Y., Wu, H. F., Li, C. Y., Hung, Y. H., Chang, Y. W., Chen, Y. L., Hsu, H. P., Chen, Y. H., Wang, C. Y., Chang, J. Y. & Lai, M. D., 2018 Dec 1, In: Scientific reports. 8, 1, 8216.

  Research output: Contribution to journal › Article › peer-review

  • Homoharringtonine
  • Adenocarcinoma of Lung
  • Mutation
  • B-Lymphocytes
  • Neoplasms
  6 Citations (Scopus)

• Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells

  Sun, Z., Wang, C. Y., Lawson, D. A., Kwek, S., Velozo, H. G., Owyong, M., Lai, M. D., Fong, L., Wilson, M., Su, H., Werb, Z. & Cooke, D. L., 2018, In: Oncotarget. 9, 13, p. 10945-10961 17 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Sequence Analysis
  • Transcriptome
  • Endothelial Cells
  • Breast Neoplasms
  • Genes
  15 Citations (Scopus)
• 2019

  Cancer immunotherapy: Silencing intracellular negative immune regulators of dendritic cells

  Liu, Y. H., Yeh, I. J., Lai, M. D., Liu, K. T., Kuo, P. L. & Yen, M. C., 2019 Jan 1, In: Cancers. 11, 1, 108.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Dendritic Cells
  • Immunotherapy
  • Small Interfering RNA
  • Neoplasms
  • DNA Vaccines
  2 Citations (Scopus)

• Erratum: A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy (Oncotarget (2015) 6 (13671–13687) DOI: 10.18632/oncotarget.3701)

  Hsu, T. I., Chen, Y. J., Hung, C. Y., Wang, Y. C., Lin, S. J., Su, W. C., Lai, M. D., Kim, S. Y., Wang, Q., Qian, K., Goto, M., Zhao, Y., Kashiwada, Y., Lee, K. H., Chang, W. C. & Hung, J. J., 2019, In: Oncotarget. 10, 60, p. 6536-6537 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • betulinic acid
  • Lung Neoplasms
  • Growth
  • Neoplasms
• 2020

  Cancer-derived transforming growth factor-β modulates tumor-associated macrophages in ampullary cancer

  Cheng, L. C., Chao, Y. J., Wang, C. Y., Phan, N. N., Chen, Y. L., Wang, T. W., Hsu, H. P., Lin, Y. J., Shan, Y. S. & Lai, M. D., 2020, In: OncoTargets and Therapy. 13, p. 7503-7516 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transforming Growth Factors
  • Macrophages
  • Transforming Growth Factor beta
  • Neoplasms
  • Oligonucleotide Array Sequence Analysis
  2 Citations (Scopus)

• Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short- and long-term models

  Liu, H. L., Yeh, I. J., Phan, N. N., Wu, Y. H., Yen, M. C., Hung, J. H., Chiao, C. C., Chen, C. F., Sun, Z., Jiang, J. Z., Hsu, H. P., Wang, C. Y. & Lai, M. D., 2020 Nov, In: Infection, Genetics and Evolution. 85, 104438.

  Research output: Contribution to journal › Article › peer-review

  • Severe acute respiratory syndrome coronavirus
  • severe acute respiratory syndrome
  • Severe Acute Respiratory Syndrome
  • Ferrets
  • ferrets
  4 Citations (Scopus)

• Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence

  Cheng, L. C., Chao, Y. J., Overman, M. J., Wang, C. Y., Phan, N. N., Chen, Y. L., Wang, T. W., Hsu, H. P., Shan, Y. S. & Lai, M. D., 2020 Dec 1, In: Scientific reports. 10, 1, 13255.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • WD repeat containing planar cell polarity effector
  • Adenocarcinoma
  • Recurrence
  • Peritoneal Neoplasms
  • Bone Morphogenetic Proteins
  4 Citations (Scopus)

• PODXL2 maintains cellular stemness and promotes breast cancer development through the Rac1/Akt pathway

  Lin, Y. Y., Wang, C. Y., Phan, N. N., Chiao, C. C., Li, C. Y., Sun, Z., Hung, J. H., Chen, Y. L., Yen, M. C., Weng, T. Y., Hsu, H. P. & Lai, M. D., 2020, In: International Journal of Medical Sciences. 17, 11, p. 1639-1651 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • podocalyxin
  • Breast Neoplasms
  • Computational Biology
  • Neoplastic Stem Cells
  • Proteins
  2 Citations (Scopus)