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• 2019

  Cancer immunotherapy: Silencing intracellular negative immune regulators of dendritic cells

  Liu, Y. H., Yeh, I. J., Lai, M. D., Liu, K. T., Kuo, P. L. & Yen, M. C., 2019 Jan 1, In: Cancers. 11, 1, 108.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Dendritic Cells
  • Immunotherapy
  • Small Interfering RNA
  • Neoplasms
  • DNA Vaccines
  2 Citations (Scopus)

• Erratum: A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy (Oncotarget (2015) 6 (13671–13687) DOI: 10.18632/oncotarget.3701)

  Hsu, T. I., Chen, Y. J., Hung, C. Y., Wang, Y. C., Lin, S. J., Su, W. C., Lai, M. D., Kim, S. Y., Wang, Q., Qian, K., Goto, M., Zhao, Y., Kashiwada, Y., Lee, K. H., Chang, W. C. & Hung, J. J., 2019, In: Oncotarget. 10, 60, p. 6536-6537 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • betulinic acid
  • Lung Neoplasms
  • Growth
  • Neoplasms
• 2016

  Astrocytic CCAAT/Enhancer-Binding Protein Delta Contributes to Glial Scar Formation and Impairs Functional Recovery After Spinal Cord Injury

  Wang, S. M., Hsu, J. Y. C., Ko, C. Y., Chiu, N. E., Kan, W. M., Lai, M. D. & Wang, J. M., 2016 Nov 1, In: Molecular Neurobiology. 53, 9, p. 5912-5927 16 p.

  Research output: Contribution to journal › Article › peer-review

  • CCAAT-Enhancer-Binding Protein-delta
  • Spinal Cord Injuries
  • Astrocytes
  • Neuroglia
  • Cicatrix
  10 Citations (Scopus)

• Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin

  Chen, W. C., Hsu, H. P., Li, C. Y., Yang, Y. J., Hung, Y. H., Cho, C. Y., Wang, C. Y., Weng, T. Y. & Lai, M. D., 2016 Nov, In: International Journal of Oncology. 49, 5, p. 1881-1889 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Neoplastic Stem Cells
  • Integrins
  • Ovarian Neoplasms
  • Growth
  • Anoikis
  17 Citations (Scopus)

• Differential expression pattern of THBS1 and THBS2 in lung cancer: Clinical outcome and a systematic-analysis of microarray databases

  Weng, T. Y., Wang, C. Y., Hung, Y. H., Chen, W. C., Chen, Y. L. & Lai, M. D., 2016 Aug, In: PloS one. 11, 8, e0161007.

  Research output: Contribution to journal › Article › peer-review

  • thrombospondin 2
  • Thrombospondin 1
  • lung neoplasms
  • Microarrays
  • microarray technology
  24 Citations (Scopus)

• Membrane bile acid receptor TGR5 predicts good prognosis in ampullary adenocarcinoma patients with hyperbilirubinemia

  Chen, M. C., Chen, Y. L., Wang, T. W., Hsu, H. P. & Lai, M. D., 2016 Oct, In: Oncology Reports. 36, 4, p. 1997-2008 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Hyperbilirubinemia
  • Bile Acids and Salts
  • Adenocarcinoma
  • Membranes
  • GTP-Binding Proteins
  10 Citations (Scopus)

• MST3 promotes proliferation and tumorigenicity through the VAV2/Rac1 signal axis in breast cancer

  Cho, C. Y., Lee, K. T., Chen, W. C., Wang, C. Y., Chang, Y. S., Huang, H. L., Hsu, H. P., Yen, M. C., Lai, M. Z. & Lai, M. D., 2016 Mar 22, In: Oncotarget. 7, 12, p. 14586-14604 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Phosphotransferases
  • Breast Neoplasms
  • Proline
  • Growth
  • Breast Cancer 3
  16 Citations (Scopus)

• Regulation of oncogenic KRAS signaling via a novel KRAS-integrin-linked kinase-hnRNPA1 regulatory loop in human pancreatic cancer cells

  Chu, P. C., Yang, M. C., Kulp, S. K., Salunke, S. B., Himmel, L. E., Fang, C. S., Jadhav, A. M., Shan, Y. S., Lee, C. T., Lai, M. D., Shirley, L. A., Bekaii-Saab, T. & Chen, C. S., 2016 Jul 28, In: Oncogene. 35, 30, p. 3897-3908 12 p.

  Research output: Contribution to journal › Article › peer-review

  • integrin-linked kinase
  • Pancreatic Neoplasms
  • Small Interfering RNA
  • G-Quadruplexes
  • Heterogeneous-Nuclear Ribonucleoproteins
  19 Citations (Scopus)

• Systematic analysis of gene expression alterations and clinical outcomes for long-chain acyl-coenzyme A synthetase family in cancer

  Chen, W. C., Wang, C. Y., Hung, Y. H., Weng, T. Y., Yen, M. C. & Lai, M. D., 2016 May 1, In: PloS one. 11, 5, e0155660.

  Research output: Contribution to journal › Article › peer-review

  • Coenzyme A Ligases
  • acyl coenzyme A
  • prognosis
  • Gene expression
  • lung neoplasms
  46 Citations (Scopus)
• 2015

  A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy

  Hsu, T. I., Chen, Y. J., Hung, C. Y., Wang, Y-C., Lin, S. J., Su, W-C., Lai, M-D., Kim, S. Y., Wang, Q., Qian, K., Goto, M., Zhao, Y., Kashiwada, Y., Lee, K. H., Chang, W. C. & Hung, J-J., 2015, In: Oncotarget. 6, 15, p. 13671-13687 17 p.

  Research output: Contribution to journal › Article › peer-review

  • betulinic acid
  • Lung Neoplasms
  • Endoplasmic Reticulum Stress
  • Cyclin A2
  • Growth
  14 Citations (Scopus)

• Argininosuccinate lyase is a potential therapeutic target in breast cancer

  Huang, H. L., Chen, W. C., Hsu, H. P., Cho, C. Y., Hung, Y. H., Wang, C. Y. & Lai, M. D., 2015 Dec 1, In: Oncology Reports. 34, 6, p. 3131-3139 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Argininosuccinate Lyase
  • Breast Neoplasms
  • Cyclin A2
  • Small Interfering RNA
  • Autophagy
  13 Citations (Scopus)

• Argininosuccinate synthetase 1 suppression and arginine restriction inhibit cell migration in gastric cancer cell lines

  Shan, Y. S., Hsu, H. P., Lai, M. D., Yen, M. C., Chen, W. C., Fang, J. H., Weng, T. Y. & Chen, Y. L., 2015 Apr 30, In: Scientific reports. 5, 9783.

  Research output: Contribution to journal › Article › peer-review

  • Argininosuccinate Synthase
  • Arginine
  • Stomach Neoplasms
  • Cell Movement
  • Cell Line
  20 Citations (Scopus)

• Cell surface nucleolin facilitates enterovirus 71 binding and infection

  Su, P. Y., Wang, Y. F., Huang, S. W., Lo, Y. C., Wang, Y. H., Wu, S. R., Shieh, D. B., Chen, S. H., Wang, J. R., Lai, M. D. & Chang, C. F., 2015, In: Journal of Virology. 89, 8, p. 4527-4538 12 p.

  Research output: Contribution to journal › Article › peer-review

  • nucleolin
  • Enterovirus
  • infection
  • Infection
  • glycoproteomics
  52 Citations (Scopus)

• Dual role of CD44 isoforms in ampullary adenocarcinoma: CD44s predicts poor prognosis in early cancer and CD44v is an indicator for recurrence in advanced cancer

  Wu, C. L., Chao, Y. J., Yang, T. M., Chen, Y. L., Chang, K. C., Hsu, H. P., Shan, Y. S. & Lai, M. D., 2015 Nov 16, In: BMC cancer. 15, 1, 903.

  Research output: Contribution to journal › Article › peer-review

  • Protein Isoforms
  • Adenocarcinoma
  • Recurrence
  • Neoplasms
  • Reverse Transcription
  11 Citations (Scopus)

• Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels

  Sun, Z., Lawson, D. A., Sinclair, E., Wang, C. Y., Lai, M. D., Hetts, S. W., Higashida, R. T., Dowd, C. F., Halbach, V. V., Werb, Z., Su, H. & Cooke, D. L., 2015 Sep 1, In: Biotechnology Reports. 7, p. 157-165 9 p., 106.

  Research output: Contribution to journal › Article › peer-review

  • Transcriptome
  • Endothelial Cells
  • Biopsy
  • Flow Cytometry
  • Leukocytes
  4 Citations (Scopus)

• Increased expression of argininosuccinate synthetase protein predicts poor prognosis in human gastric cancer

  Shan, Y. S., Hsu, H. P., Lai, M. D., Yen, M. C., Luo, Y. P. & Chen, Y. L., 2015 Jan 1, In: Oncology Reports. 33, 1, p. 49-57 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Argininosuccinate Synthase
  • Stomach Neoplasms
  • Proteins
  • Neoplasms
  • Neoplasm Staging
  15 Citations (Scopus)

• Meta-analysis of public microarray datasets reveals voltage-gated calcium gene signatures in clinical cancer patients

  Wang, C. Y., Lai, M. D., Phan, N. N., Sun, Z. & Lin, Y. C., 2015 Jul 6, In: PloS one. 10, 7, e0125766.

  Research output: Contribution to journal › Article › peer-review

  • meta-analysis
  • Microarrays
  • Calcium Channels
  • calcium channels
  • electric potential difference
  39 Citations (Scopus)

• Nestin predicts a favorable prognosis in early ampullary adenocarcinoma and functions as a promoter of metastasis in advanced cancer

  Shan, Y. S., Chen, Y. L., Lai, M. D. & Hsu, H. P., 2015 Jan 1, In: Oncology Reports. 33, 1, p. 40-48 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Nestin
  • Adenocarcinoma
  • Neoplasm Metastasis
  • Cyclin-Dependent Kinase 5
  • Neoplasms
  7 Citations (Scopus)

• SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor

  Chiang, C. Y., Pan, C. C., Chang, H. Y., Lai, M. D., Tzai, T. S., Tsai, Y. S., Ling, P., Liu, H. S., Lee, B. F., Cheng, H. L., Ho, C. L., Chen, S. H. & Chow, N. H., 2015 Dec 15, In: Clinical Cancer Research. 21, 24, p. 5601-5611 11 p.

  Research output: Contribution to journal › Article › peer-review

  • src Homology Domains
  • ErbB Receptors
  • Glutamic Acid
  • Biomarkers
  • Carcinoma
  17 Citations (Scopus)

• The iNOS/Src/FAK axis contributes to lithium chloride-mediated macrophage migration

  Chen, H. C., Chien, W. C., Chang, M. Y., Hsieh, M. Y., Lai, M. D., Maa, M. C. & Leu, T. H., 2015 May 1, In: Nitric Oxide - Biology and Chemistry. 47, p. 58-64 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Macrophages
  • Lithium Chloride
  • Peritoneal Macrophages
  • kenpaullone
  • AG 1879
  7 Citations (Scopus)

• Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer

  Chen, W. C., Chang, Y. S., Hsu, H. P., Yen, M. C., Huang, H. L., Cho, C. Y., Wang, C. Y., Weng, T. Y., Lai, P. T., Chen, C. S., Lin, Y. J. & Lai, M. D., 2015, In: Oncotarget. 6, 40, p. 42923-42937 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Liver Neoplasms
  • OSU-CG5
  • Integrins
  • Ectopic Gene Expression
  • Neoplastic Stem Cells
  30 Citations (Scopus)

• The significance of the co-existence of osteopontin and tumor-associated macrophages in gastric cancer progression

  Lin, C. N., Wang, C. J., Chao, Y. J., Lai, M. D. & Shan, Y. S., 2015 Mar 15, In: BMC cancer. 15, 1, 128.

  Research output: Contribution to journal › Article › peer-review

  • Osteopontin
  • Stomach Neoplasms
  • Macrophages
  • Neoplasms
  • U937 Cells
  39 Citations (Scopus)
• 2013

  An HDAC inhibitor enhances cancer therapeutic efficiency of RNA polymerase III promoter-driven IDO shRNA

  Yen, M. C., Weng, T. Y., Chen, Y. L., Lin, C. C., Chen, C. Y., Wang, C. Y., Chao, H. L., Chen, C. S. & Lai, M. D., 2013 Jun 1, In: Cancer Gene Therapy. 20, 6, p. 351-357 7 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Polymerase III
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Histone Deacetylase Inhibitors
  • Small Interfering RNA
  • Neoplasms
  5 Citations (Scopus)

• Attenuation of argininosuccinate lyase inhibits cancer growth via cyclin A2 and nitric oxide

  Huang, H. L., Hsu, H. P., Shieh, S. C., Chang, Y. S., Chen, W. C., Cho, C. Y., Teng, C. F., Su, I. J., Hung, W. C. & Lai, M. D., 2013 Nov, In: Molecular cancer therapeutics. 12, 11, p. 2505-2516 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Argininosuccinate Lyase
  • Cyclin A2
  • Nitric Oxide
  • Growth
  • Small Interfering RNA
  17 Citations (Scopus)

• Biolistic DNA delivery to mice with the low pressure gene gun

  Yen, M. C. & Lai, M. D., 2013 Jan 1, Biolistic DNA Delivery: Methods and Protocols. Sudowe, S. & Reske-Kunz, A. (eds.). p. 169-174 6 p. (Methods in Molecular Biology; vol. 940).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Biolistics
  • Firearms
  • Pressure
  • Plasmids
  • DNA
  2 Citations (Scopus)

• Redox-sensitive endoplasmic reticulum stress and autophagy at rostral ventrolateral medulla contribute to hypertension in spontaneously hypertensive rats

  Chao, Y. M., Lai, M. D. & Chan, J. Y. H., 2013, In: Hypertension. 61, 6, p. 1270-1280 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Endoplasmic Reticulum Stress
  • Inbred SHR Rats
  • Autophagy
  • Oxidation-Reduction
  • Hypertension
  38 Citations (Scopus)

• Very low-density lipoprotein/lipo-viro particles reverse lipoprotein lipase-mediated inhibition of hepatitis C virus infection via apolipoprotein C-III

  Sun, H. Y., Lin, C. C., Lee, J. C., Wang, S-W., Cheng, P-N., Wu, I-C., Chang, T-T., Lai, M-D., Shieh, D-B. & Young, K-C., 2013 Aug 1, In: Gut. 62, 8, p. 1193-1203 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein C-III
  • VLDL Lipoproteins
  • Lipoprotein Lipase
  • Lipoproteins
  • Hepacivirus
  27 Citations (Scopus)
• 2012

  Aberrant cyclin a expression and centrosome overduplication induced by hepatitis B virus pre-S2 mutants and its implication in hepatocarcinogenesis

  Wang, L. H. C., Huang, W., Lai, M. D. & Su, I. J., 2012 Feb 1, In: Carcinogenesis. 33, 2, p. 466-472 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Cyclin A
  • Centrosome
  • Cyclins
  • Hepatitis B virus
  • Endoplasmic Reticulum Stress
  40 Citations (Scopus)

• Endoplasmic reticulum stress stimulates p53 expression through NF-κB activation

  Lin, W. C., Chuang, Y. C., Chang, Y. S., Lai, M. D., Teng, Y. N., Su, I. J., Wang, C. C. C., Lee, K. H. & Hung, J. H., 2012 Jul 30, In: PloS one. 7, 7, e39120.

  Research output: Contribution to journal › Article › peer-review

  • endoplasmic reticulum stress
  • Endoplasmic Reticulum Stress
  • Chemical activation
  • Brefeldin A
  • brefeldin A
  75 Citations (Scopus)
• 2011

  ACSL3 and GSK-3β are essential for lipid upregulation induced by endoplasmic reticulum stress in liver cells

  Chang, Y. S., Tsai, C. T., Huangfu, C. A., Huang, W. Y., Lei, H. Y., Lin, C. F., Su, I. J., Chang, W. T., Wu, P. H., Chen, Y. T., Hung, J. H., Young, K. C. & Lai, M. D., 2011 Mar 1, In: Journal of Cellular Biochemistry. 112, 3, p. 881-893 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycogen Synthase Kinase 3
  • Liver
  • Endoplasmic Reticulum Stress
  • Up-Regulation
  • Lipids
  30 Citations (Scopus)

• Amelioration of rat collagen-induced arthritis through CD4⁺ T cells apoptosis and synovial interleukin-17 reduction by indoleamine 2,3-dioxygenase gene therapy

  Chen, S. Y., Wu, C. L., Lai, M. D., Lin, C. C., Yo, Y. T., Jou, I. M., Lee, C. H., Weng, C. T., Shiau, A. L. & Wang, C. R., 2011 Feb 1, In: Human Gene Therapy. 22, 2, p. 145-154 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Experimental Arthritis
  • Interleukin-17
  • Genetic Therapy
  • Kynurenine
  26 Citations (Scopus)

• Establishment of an orthotopic transplantable gastric cancer animal model for studying the immunological effects of new cancer therapeutic modules

  Shan, Y-S., Fang, J. H., Lai, M-D., Yen, M. C., Lin, P. W., Hsu, H-P., Lin, C. Y. & Chen, Y. L., 2011 Oct 1, In: Molecular Carcinogenesis. 50, 10, p. 739-750 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Stomach Neoplasms
  • Animal Models
  • Stomach
  • Carcinoma
  • Butyric Acid
  12 Citations (Scopus)

• Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein

  Lee, J. W., Liao, P. C., Young, K. C., Chang, C. L., Chen, S. S. L., Chang, T. T., Lai, M. D. & Wang, S. W., 2011 Oct 7, In: Journal of Proteome Research. 10, 10, p. 4522-4534 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Hepatitis C virus nucleocapsid protein
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Cytoplasm
  • Nuclear Factor 45 Protein
  • Proteins
  30 Citations (Scopus)

• RNAi compound targeted to thrombospondin-1 and applications thereof

  Lai, M-D., 2011 Jul 7, Patent No. 8377902

  Research output: Patent

  • Thrombospondin 1
  • Patents and inventions
  • Genes
  • Plasmids
  • Chemical analysis

• Skin delivery of short hairpin RNA of indoleamine 2,3 dioxygenase induces antitumor immunity against orthotopic and metastatic liver cancer

  Huang, T. T., Yen, M. C., Lin, C. C., Weng, T. Y., Chen, Y. L., Lin, C. M. & Lai, M. D., 2011 Dec, In: Cancer Science. 102, 12, p. 2214-2220 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Liver Neoplasms
  • Small Interfering RNA
  • Immunity
  • Skin
  25 Citations (Scopus)