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Aberrant cyclin a expression and centrosome overduplication induced by hepatitis B virus pre-S2 mutants and its implication in hepatocarcinogenesis
Wang, L. H. C., Huang, W., Lai, M. D. & Su, I. J., 2012 Feb 1, In: Carcinogenesis. 33, 2, p. 466-472 7 p.Research output: Contribution to journal › Article › peer-review
40 Citations (Scopus) -
ACSL3 and GSK-3β are essential for lipid upregulation induced by endoplasmic reticulum stress in liver cells
Chang, Y. S., Tsai, C. T., Huangfu, C. A., Huang, W. Y., Lei, H. Y., Lin, C. F., Su, I. J., Chang, W. T., Wu, P. H., Chen, Y. T., Hung, J. H., Young, K. C. & Lai, M. D., 2011 Mar 1, In: Journal of Cellular Biochemistry. 112, 3, p. 881-893 13 p.Research output: Contribution to journal › Article › peer-review
30 Citations (Scopus) -
Amelioration of rat collagen-induced arthritis through CD4+ T cells apoptosis and synovial interleukin-17 reduction by indoleamine 2,3-dioxygenase gene therapy
Chen, S. Y., Wu, C. L., Lai, M. D., Lin, C. C., Yo, Y. T., Jou, I. M., Lee, C. H., Weng, C. T., Shiau, A. L. & Wang, C. R., 2011 Feb 1, In: Human Gene Therapy. 22, 2, p. 145-154 10 p.Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus) -
A novel cancer therapeutic using thrombospondin 1 in dendritic cells
Weng, T. Y., Huang, S. S., Yen, M. C., Lin, C. C., Chen, Y. L., Lin, C. M., Chen, W. C., Wang, C. Y., Chang, J. Y. & Lai, M. D., 2014 Feb, In: Molecular Therapy. 22, 2, p. 292-302 11 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy
Hsu, T. I., Chen, Y. J., Hung, C. Y., Wang, Y-C., Lin, S. J., Su, W-C., Lai, M-D., Kim, S. Y., Wang, Q., Qian, K., Goto, M., Zhao, Y., Kashiwada, Y., Lee, K. H., Chang, W. C. & Hung, J-J., 2015, In: Oncotarget. 6, 15, p. 13671-13687 17 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
Argininosuccinate lyase is a potential therapeutic target in breast cancer
Huang, H. L., Chen, W. C., Hsu, H. P., Cho, C. Y., Hung, Y. H., Wang, C. Y. & Lai, M. D., 2015 Dec 1, In: Oncology Reports. 34, 6, p. 3131-3139 9 p.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
Argininosuccinate synthetase 1 suppression and arginine restriction inhibit cell migration in gastric cancer cell lines
Shan, Y. S., Hsu, H. P., Lai, M. D., Yen, M. C., Chen, W. C., Fang, J. H., Weng, T. Y. & Chen, Y. L., 2015 Apr 30, In: Scientific reports. 5, 9783.Research output: Contribution to journal › Article › peer-review
20 Citations (Scopus) -
Astrocytic CCAAT/Enhancer-Binding Protein Delta Contributes to Glial Scar Formation and Impairs Functional Recovery After Spinal Cord Injury
Wang, S. M., Hsu, J. Y. C., Ko, C. Y., Chiu, N. E., Kan, W. M., Lai, M. D. & Wang, J. M., 2016 Nov 1, In: Molecular Neurobiology. 53, 9, p. 5912-5927 16 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Astrocytic CCAAT/Enhancer-binding protein delta contributes to reactive oxygen species formation in neuroinflammation
Wang, S. M., Lim, S. W., Wang, Y. H., Lin, H. Y., Lai, M. D., Ko, C. Y. & Wang, Y-M., 2018 Jun, In: Redox Biology. 16, p. 104-112 9 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
Cancer-derived transforming growth factor-β modulates tumor-associated macrophages in ampullary cancer
Cheng, L. C., Chao, Y. J., Wang, C. Y., Phan, N. N., Chen, Y. L., Wang, T. W., Hsu, H. P., Lin, Y. J., Shan, Y. S. & Lai, M. D., 2020, In: OncoTargets and Therapy. 13, p. 7503-7516 14 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Cancer immunotherapy: Silencing intracellular negative immune regulators of dendritic cells
Liu, Y. H., Yeh, I. J., Lai, M. D., Liu, K. T., Kuo, P. L. & Yen, M. C., 2019 Jan 1, In: Cancers. 11, 1, 108.Research output: Contribution to journal › Review article › peer-review
Open Access2 Citations (Scopus) -
Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin
Chen, W. C., Hsu, H. P., Li, C. Y., Yang, Y. J., Hung, Y. H., Cho, C. Y., Wang, C. Y., Weng, T. Y. & Lai, M. D., 2016 Nov, In: International Journal of Oncology. 49, 5, p. 1881-1889 9 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
Cell surface nucleolin facilitates enterovirus 71 binding and infection
Su, P. Y., Wang, Y. F., Huang, S. W., Lo, Y. C., Wang, Y. H., Wu, S. R., Shieh, D. B., Chen, S. H., Wang, J. R., Lai, M. D. & Chang, C. F., 2015, In: Journal of Virology. 89, 8, p. 4527-4538 12 p.Research output: Contribution to journal › Article › peer-review
52 Citations (Scopus) -
Differential expression pattern of THBS1 and THBS2 in lung cancer: Clinical outcome and a systematic-analysis of microarray databases
Weng, T. Y., Wang, C. Y., Hung, Y. H., Chen, W. C., Chen, Y. L. & Lai, M. D., 2016 Aug, In: PloS one. 11, 8, e0161007.Research output: Contribution to journal › Article › peer-review
24 Citations (Scopus) -
DNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model
Weng, T. Y., Yen, M. C., Huang, C. T., Hung, J. J., Chen, Y. L., Chen, W. C., Wang, C. Y., Chang, J. Y. & Lai, M. D., 2014 Jan 1, In: Gene Therapy. 21, 10, p. 888-896 9 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Dual role of CD44 isoforms in ampullary adenocarcinoma: CD44s predicts poor prognosis in early cancer and CD44v is an indicator for recurrence in advanced cancer
Wu, C. L., Chao, Y. J., Yang, T. M., Chen, Y. L., Chang, K. C., Hsu, H. P., Shan, Y. S. & Lai, M. D., 2015 Nov 16, In: BMC cancer. 15, 1, 903.Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
Endoplasmic reticulum stress stimulates p53 expression through NF-κB activation
Lin, W. C., Chuang, Y. C., Chang, Y. S., Lai, M. D., Teng, Y. N., Su, I. J., Wang, C. C. C., Lee, K. H. & Hung, J. H., 2012 Jul 30, In: PloS one. 7, 7, e39120.Research output: Contribution to journal › Article › peer-review
75 Citations (Scopus) -
Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels
Sun, Z., Lawson, D. A., Sinclair, E., Wang, C. Y., Lai, M. D., Hetts, S. W., Higashida, R. T., Dowd, C. F., Halbach, V. V., Werb, Z., Su, H. & Cooke, D. L., 2015 Sep 1, In: Biotechnology Reports. 7, p. 157-165 9 p., 106.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
Erratum: A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy (Oncotarget (2015) 6 (13671–13687) DOI: 10.18632/oncotarget.3701)
Hsu, T. I., Chen, Y. J., Hung, C. Y., Wang, Y. C., Lin, S. J., Su, W. C., Lai, M. D., Kim, S. Y., Wang, Q., Qian, K., Goto, M., Zhao, Y., Kashiwada, Y., Lee, K. H., Chang, W. C. & Hung, J. J., 2019, In: Oncotarget. 10, 60, p. 6536-6537 2 p.Research output: Contribution to journal › Comment/debate › peer-review
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Establishment of an orthotopic transplantable gastric cancer animal model for studying the immunological effects of new cancer therapeutic modules
Shan, Y-S., Fang, J. H., Lai, M-D., Yen, M. C., Lin, P. W., Hsu, H-P., Lin, C. Y. & Chen, Y. L., 2011 Oct 1, In: Molecular Carcinogenesis. 50, 10, p. 739-750 12 p.Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus) -
Fatty acid metabolic enzyme acyl-CoA thioesterase 8 promotes the development of hepatocellular carcinoma
Hung, Y. U. H., Chan, Y. I. S., Chang, Y. S., Lee, K. T., Hsu, H. P., Yen, M. C., Chen, W. C., Wang, C. Y. & Lai, M. D., 2014 Jun, In: Oncology Reports. 31, 6, p. 2797-2803 7 p.Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus) -
Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short- and long-term models
Liu, H. L., Yeh, I. J., Phan, N. N., Wu, Y. H., Yen, M. C., Hung, J. H., Chiao, C. C., Chen, C. F., Sun, Z., Jiang, J. Z., Hsu, H. P., Wang, C. Y. & Lai, M. D., 2020 Nov, In: Infection, Genetics and Evolution. 85, 104438.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation
Weng, T. Y., Wu, H. F., Li, C. Y., Hung, Y. H., Chang, Y. W., Chen, Y. L., Hsu, H. P., Chen, Y. H., Wang, C. Y., Chang, J. Y. & Lai, M. D., 2018 Dec 1, In: Scientific reports. 8, 1, 8216.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
Hypoxia promotes nuclear translocation and transcriptional function in the oncogenic tyrosine kinase RON
Chang, H. Y., Liu, H. S., Lai, M. D., Tsai, Y. S., Tzai, T. S., Cheng, H. L. & Chow, N. H., 2014 Aug 15, In: Cancer Research. 74, 16, p. 4549-4562 14 p.Research output: Contribution to journal › Article › peer-review
24 Citations (Scopus) -
Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein
Lee, J. W., Liao, P. C., Young, K. C., Chang, C. L., Chen, S. S. L., Chang, T. T., Lai, M. D. & Wang, S. W., 2011 Oct 7, In: Journal of Proteome Research. 10, 10, p. 4522-4534 13 p.Research output: Contribution to journal › Article › peer-review
30 Citations (Scopus) -
Increased expression of argininosuccinate synthetase protein predicts poor prognosis in human gastric cancer
Shan, Y. S., Hsu, H. P., Lai, M. D., Yen, M. C., Luo, Y. P. & Chen, Y. L., 2015 Jan 1, In: Oncology Reports. 33, 1, p. 49-57 9 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence
Cheng, L. C., Chao, Y. J., Overman, M. J., Wang, C. Y., Phan, N. N., Chen, Y. L., Wang, T. W., Hsu, H. P., Shan, Y. S. & Lai, M. D., 2020 Dec 1, In: Scientific reports. 10, 1, 13255.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Increase of Zinc Finger Protein 179 in Response to CCAAT/Enhancer Binding Protein Delta Conferring an Antiapoptotic Effect in Astrocytes of Alzheimer’s Disease
Wang, S. M., Lee, Y. C., Ko, C. Y., Lai, M. D., Lin, D. Y., Pao, P. C., Chi, J. Y., Hsiao, Y. W., Liu, T. L. & Wang, J. M., 2014 Feb, In: Molecular Neurobiology. 51, 1, p. 370-382 13 p.Research output: Contribution to journal › Article › peer-review
27 Citations (Scopus) -
Induction of indoleamine 2,3-dioxygenase (IDO) enzymatic activity contributes to interferon-gamma induced apoptosis and death receptor 5 expression in human non-small cell lung cancer cells
Chung, T. W., Tan, K. T., Chan, H. L., Lai, M. D., Yen, M. C., Li, Y. R., Lin, S. H. & Lin, C. C., 2014, In: Asian Pacific Journal of Cancer Prevention. 15, 18, p. 7995-8001 7 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Membrane bile acid receptor TGR5 predicts good prognosis in ampullary adenocarcinoma patients with hyperbilirubinemia
Chen, M. C., Chen, Y. L., Wang, T. W., Hsu, H. P. & Lai, M. D., 2016 Oct, In: Oncology Reports. 36, 4, p. 1997-2008 12 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Meta-analysis of public microarray datasets reveals voltage-gated calcium gene signatures in clinical cancer patients
Wang, C. Y., Lai, M. D., Phan, N. N., Sun, Z. & Lin, Y. C., 2015 Jul 6, In: PloS one. 10, 7, e0125766.Research output: Contribution to journal › Article › peer-review
39 Citations (Scopus) -
MST3 promotes proliferation and tumorigenicity through the VAV2/Rac1 signal axis in breast cancer
Cho, C. Y., Lee, K. T., Chen, W. C., Wang, C. Y., Chang, Y. S., Huang, H. L., Hsu, H. P., Yen, M. C., Lai, M. Z. & Lai, M. D., 2016 Mar 22, In: Oncotarget. 7, 12, p. 14586-14604 19 p.Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus) -
Nestin predicts a favorable prognosis in early ampullary adenocarcinoma and functions as a promoter of metastasis in advanced cancer
Shan, Y. S., Chen, Y. L., Lai, M. D. & Hsu, H. P., 2015 Jan 1, In: Oncology Reports. 33, 1, p. 40-48 9 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
Optimization protein productivity of human interleukin-2 through codon usage, gene copy number and intracellular tRNA concentration in CHO cells
Ou, K. C., Wang, C. Y., Liu, K. T., Chen, Y. L., Chen, Y. C., Lai, M. D. & Yen, M. C., 2014 Nov 14, In: Biochemical and Biophysical Research Communications. 454, 2, p. 347-352 6 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
PODXL2 maintains cellular stemness and promotes breast cancer development through the Rac1/Akt pathway
Lin, Y. Y., Wang, C. Y., Phan, N. N., Chiao, C. C., Li, C. Y., Sun, Z., Hung, J. H., Chen, Y. L., Yen, M. C., Weng, T. Y., Hsu, H. P. & Lai, M. D., 2020, In: International Journal of Medical Sciences. 17, 11, p. 1639-1651 13 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Potential significance of EMP3 in patients with upper urinary tract urothelial carcinoma: Crosstalk with ErbB2-PI3K-Akt pathway
Wang, Y. W., Li, W. M., Wu, W. J., Chai, C. Y., Liu, H. S., Lai, M. D. & Chow, N. H., 2014 Jul, In: Journal of Urology. 192, 1, p. 242-251 10 p.Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus) -
Regulation of oncogenic KRAS signaling via a novel KRAS-integrin-linked kinase-hnRNPA1 regulatory loop in human pancreatic cancer cells
Chu, P. C., Yang, M. C., Kulp, S. K., Salunke, S. B., Himmel, L. E., Fang, C. S., Jadhav, A. M., Shan, Y. S., Lee, C. T., Lai, M. D., Shirley, L. A., Bekaii-Saab, T. & Chen, C. S., 2016 Jul 28, In: Oncogene. 35, 30, p. 3897-3908 12 p.Research output: Contribution to journal › Article › peer-review
19 Citations (Scopus) -
RNAi compound targeted to thrombospondin-1 and applications thereof
Lai, M-D., 2011 Jul 7, Patent No. 8377902Research output: Patent
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SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor
Chiang, C. Y., Pan, C. C., Chang, H. Y., Lai, M. D., Tzai, T. S., Tsai, Y. S., Ling, P., Liu, H. S., Lee, B. F., Cheng, H. L., Ho, C. L., Chen, S. H. & Chow, N. H., 2015 Dec 15, In: Clinical Cancer Research. 21, 24, p. 5601-5611 11 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells
Sun, Z., Wang, C. Y., Lawson, D. A., Kwek, S., Velozo, H. G., Owyong, M., Lai, M. D., Fong, L., Wilson, M., Su, H., Werb, Z. & Cooke, D. L., 2018, In: Oncotarget. 9, 13, p. 10945-10961 17 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
Skin delivery of short hairpin RNA of indoleamine 2,3 dioxygenase induces antitumor immunity against orthotopic and metastatic liver cancer
Huang, T. T., Yen, M. C., Lin, C. C., Weng, T. Y., Chen, Y. L., Lin, C. M. & Lai, M. D., 2011 Dec, In: Cancer Science. 102, 12, p. 2214-2220 7 p.Research output: Contribution to journal › Article › peer-review
25 Citations (Scopus) -
Suppression of mucin 2 promotes interleukin-6 secretion and tumor growth in an orthotopic immune-competent colon cancer animal model
Shan, Y. S., Hsu, H. P., Lai, M. D., Yen, M. C., Fang, J. H., Weng, T. Y. & Chen, Y. L., 2014 Dec 1, In: Oncology Reports. 32, 6, p. 2335-2342 8 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
Systematic analysis of gene expression alterations and clinical outcomes for long-chain acyl-coenzyme A synthetase family in cancer
Chen, W. C., Wang, C. Y., Hung, Y. H., Weng, T. Y., Yen, M. C. & Lai, M. D., 2016 May 1, In: PloS one. 11, 5, e0155660.Research output: Contribution to journal › Article › peer-review
46 Citations (Scopus) -
The iNOS/Src/FAK axis contributes to lithium chloride-mediated macrophage migration
Chen, H. C., Chien, W. C., Chang, M. Y., Hsieh, M. Y., Lai, M. D., Maa, M. C. & Leu, T. H., 2015 May 1, In: Nitric Oxide - Biology and Chemistry. 47, p. 58-64 7 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer
Chen, W. C., Chang, Y. S., Hsu, H. P., Yen, M. C., Huang, H. L., Cho, C. Y., Wang, C. Y., Weng, T. Y., Lai, P. T., Chen, C. S., Lin, Y. J. & Lai, M. D., 2015, In: Oncotarget. 6, 40, p. 42923-42937 15 p.Research output: Contribution to journal › Article › peer-review
30 Citations (Scopus) -
The significance of the co-existence of osteopontin and tumor-associated macrophages in gastric cancer progression
Lin, C. N., Wang, C. J., Chao, Y. J., Lai, M. D. & Shan, Y. S., 2015 Mar 15, In: BMC cancer. 15, 1, 128.Research output: Contribution to journal › Article › peer-review
39 Citations (Scopus)