A bacterial binary toxin system that kills both insects and aquatic crustaceans: Photorhabdus insect-related toxins A and B

Hao Ching Wang, Shin Jen Lin, Han-Ching Wang, Ramya Kumar, Phuoc Thien Le, Jiann Horng Leu

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

AU Photorhabdus: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly insect-related toxins A and B (PirA and PirB):were first recognized as insecticidal toxins from Photorhabdus luminescens. However, subsequent studies showed that their homologs from Vibrio parahaemolyticus also play critical roles in the pathogenesis of acute hepatopancreatic necrosis disease (AHPND) in shrimps. Based on the structural features of the PirA/PirB toxins, it was suggested that they might function in the same way as a Bacillus thuringiensis Cry pore-forming toxin. However, unlike Cry toxins, studies on the PirA/PirB toxins are still scarce, and their cytotoxic mechanism remains to be clarified. In this review, based on our studies of V. parahaemolyticus PirAvp/PirBvp, we summarize the current understanding of the gene locations, expression control, activation, and cytotoxic mechanism of this type of toxin. Given the important role these toxins play in aquatic disease and their potential use in pest control applications, we also suggest further topics for research. We hope the information presented here will be helpful for future PirA/PirB studies.

Original languageEnglish
Article numbere1011330
JournalPLoS pathogens
Volume19
Issue number5
DOIs
Publication statusPublished - 2023 May

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Molecular Biology
  • Genetics
  • Virology

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