A canine non-weight-bearing model with radial neurectomy for rotator cuff repair

Xiaoxi Ji, Nirong Bao, Kai Nan An, Peter C. Amadio, Scott P. Steinmann, Chunfeng Zhao

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Background: The major concern of using a large animal model to study rotator cuff repair is the high rate of repair retears. The purpose of this study was to test a non-weight-bearing (NWB) canine model for rotator cuff repair research. Methods: First, in the in vitro study, 18 shoulders were randomized to 3 groups. 1) Full-width transections repaired with modified Mason-Allen sutures using 3-0 polyglactin suture, 2) Group 1 repaired using number 2 (#2) polyester braid and long-chain polyethylene suture, and 3) Partial-width transections leaving the superior 2 mm infraspinatus tendon intact without repair. In the in vivo study of 6 dogs, the infraspinatus tendon was partially transected as the same as the in vitro group 3. A radial neurectomy was performed to prevent weight bearing. The operated limb was slung in a custom-made jacket for 6 weeks. Results: In the in vitro study, mean ultimate tensile load and stiffness in Group 2 were significantly higher than Group 1 and 3 (p<0.05). In the in vivo study, gross inspection and histologyshowed that the preserved superior 2-mm portion of the infraspinatus tendon remained intact with normal structure. Conclusions: Based on the biomechanical and histological findings, this canine NWB model may be an appropriate and useful model for studies of rotator cuff repair.

Original languageEnglish
Article numbere0130576
JournalPloS one
Volume10
Issue number6
DOIs
Publication statusPublished - 2015 Jun 24

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Fingerprint Dive into the research topics of 'A canine non-weight-bearing model with radial neurectomy for rotator cuff repair'. Together they form a unique fingerprint.

Cite this