A capillary dielectrophoretic chip for real-time blood cell separation from a drop of whole blood

Shu Hsien Liao, Ching Yu Chang, Hsien Chang Chang

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

This study proposes a capillary dielectrophoretic chip to separate blood cells from a drop of whole blood (approximately 1 μl) sample using negative dielectrophoretic force. The separating efficiency was evaluated by analyzing the image before and after dielectrophoretic force manipulation. Blood samples with various hematocrits (10%-60%) were tested with varied separating voltages and chip designs. In this study, a chip with 50 μm gap design achieved a separation efficiency of approximately 90% within 30 s when the hematocrit was in the range of 10%-50%. Furthermore, glucose concentration was electrochemically measured by separating electrodes following manipulation. The current response increased significantly (8.8-fold) after blood cell separation, which was attributed not only to the blood cell separation but also to sample disturbance by the dielectrophoretic force.

Original languageEnglish
Article number024110
JournalBiomicrofluidics
Volume7
Issue number2
DOIs
Publication statusPublished - 2013 Apr 5

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Fluid Flow and Transfer Processes
  • Colloid and Surface Chemistry

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