A Case Report of Posttransplant Lymphoproliferative Disorder After AstraZeneca Coronavirus Disease 2019 Vaccine in a Heart Transplant Recipient

Wen Ruei Tang; Che Wei Hsu; Chia Chi Lee; Wei Li Huang; Chia Ying Lin; Ya Ting Hsu; Chen Chang; Meng Ta Tsai; Yu Ning Hu; Chih Hsin Hsu; Po Lin Chen; Nan Haw Chow; Jun Neng Roan

doi:10.1016/j.transproceed.2021.09.006

A Case Report of Posttransplant Lymphoproliferative Disorder After AstraZeneca Coronavirus Disease 2019 Vaccine in a Heart Transplant Recipient

Wen Ruei Tang, Che Wei Hsu, Chia Chi Lee, Wei Li Huang, Chia Ying Lin, Ya Ting Hsu, Chen Chang, Meng Ta Tsai, Yu Ning Hu, Chih Hsin Hsu, Po Lin Chen, Nan Haw Chow, Jun Neng Roan

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

We report a case of a heart transplant recipient who presented with a rapidly growing Epstein-Barr virus (EBV)–positive, diffuse large B-cell lymphoma 7 days after receiving the first dose of the ChAdOx1 nCoV-19 vaccine. Because of the atypical radiologic presentation, the initial tentative diagnosis was a mediastinal abscess. This observation indicates a potential risk of EBV reactivation after coronavirus disease 2019 (COVID-19) vaccination, which might lead to or aggravate the presentation of posttransplant lymphoproliferative disorder in transplantation patients. Transplant surgeons should be aware of the potential immunomodulatory effects of the COVID-19 vaccination.

Original language	English
Pages (from-to)	1575-1578
Number of pages	4
Journal	Transplantation Proceedings
Volume	54
Issue number	6
DOIs	https://doi.org/10.1016/j.transproceed.2021.09.006
Publication status	Published - 2022 Jul 1

All Science Journal Classification (ASJC) codes

Surgery
Transplantation

Access to Document

10.1016/j.transproceed.2021.09.006

Cite this

Tang, W. R., Hsu, C. W., Lee, C. C., Huang, W. L., Lin, C. Y., Hsu, Y. T., Chang, C., Tsai, M. T., Hu, Y. N., Hsu, C. H., Chen, P. L., Chow, N. H., & Roan, J. N. (2022). A Case Report of Posttransplant Lymphoproliferative Disorder After AstraZeneca Coronavirus Disease 2019 Vaccine in a Heart Transplant Recipient. Transplantation Proceedings, 54(6), 1575-1578. https://doi.org/10.1016/j.transproceed.2021.09.006

@article{85eb9429a3124045a6221b7bbbb4a8c1,

title = "A Case Report of Posttransplant Lymphoproliferative Disorder After AstraZeneca Coronavirus Disease 2019 Vaccine in a Heart Transplant Recipient",

abstract = "We report a case of a heart transplant recipient who presented with a rapidly growing Epstein-Barr virus (EBV)–positive, diffuse large B-cell lymphoma 7 days after receiving the first dose of the ChAdOx1 nCoV-19 vaccine. Because of the atypical radiologic presentation, the initial tentative diagnosis was a mediastinal abscess. This observation indicates a potential risk of EBV reactivation after coronavirus disease 2019 (COVID-19) vaccination, which might lead to or aggravate the presentation of posttransplant lymphoproliferative disorder in transplantation patients. Transplant surgeons should be aware of the potential immunomodulatory effects of the COVID-19 vaccination.",

author = "Tang, {Wen Ruei} and Hsu, {Che Wei} and Lee, {Chia Chi} and Huang, {Wei Li} and Lin, {Chia Ying} and Hsu, {Ya Ting} and Chen Chang and Tsai, {Meng Ta} and Hu, {Yu Ning} and Hsu, {Chih Hsin} and Chen, {Po Lin} and Chow, {Nan Haw} and Roan, {Jun Neng}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2022",

month = jul,

day = "1",

doi = "10.1016/j.transproceed.2021.09.006",

language = "English",

volume = "54",

pages = "1575--1578",

journal = "Transplantation Proceedings",

issn = "0041-1345",

publisher = "Elsevier USA",

number = "6",

}

Tang, WR, Hsu, CW, Lee, CC, Huang, WL , Lin, CY , Hsu, YT , Chang, C , Tsai, MT , Hu, YN , Hsu, CH , Chen, PL, Chow, NH & Roan, JN 2022, 'A Case Report of Posttransplant Lymphoproliferative Disorder After AstraZeneca Coronavirus Disease 2019 Vaccine in a Heart Transplant Recipient', Transplantation Proceedings, vol. 54, no. 6, pp. 1575-1578. https://doi.org/10.1016/j.transproceed.2021.09.006

TY - JOUR

T1 - A Case Report of Posttransplant Lymphoproliferative Disorder After AstraZeneca Coronavirus Disease 2019 Vaccine in a Heart Transplant Recipient

AU - Tang, Wen Ruei

AU - Hsu, Che Wei

AU - Lee, Chia Chi

AU - Huang, Wei Li

AU - Lin, Chia Ying

AU - Hsu, Ya Ting

AU - Chang, Chen

AU - Tsai, Meng Ta

AU - Hu, Yu Ning

AU - Hsu, Chih Hsin

AU - Chen, Po Lin

AU - Chow, Nan Haw

AU - Roan, Jun Neng

PY - 2022/7/1

Y1 - 2022/7/1

N2 - We report a case of a heart transplant recipient who presented with a rapidly growing Epstein-Barr virus (EBV)–positive, diffuse large B-cell lymphoma 7 days after receiving the first dose of the ChAdOx1 nCoV-19 vaccine. Because of the atypical radiologic presentation, the initial tentative diagnosis was a mediastinal abscess. This observation indicates a potential risk of EBV reactivation after coronavirus disease 2019 (COVID-19) vaccination, which might lead to or aggravate the presentation of posttransplant lymphoproliferative disorder in transplantation patients. Transplant surgeons should be aware of the potential immunomodulatory effects of the COVID-19 vaccination.

AB - We report a case of a heart transplant recipient who presented with a rapidly growing Epstein-Barr virus (EBV)–positive, diffuse large B-cell lymphoma 7 days after receiving the first dose of the ChAdOx1 nCoV-19 vaccine. Because of the atypical radiologic presentation, the initial tentative diagnosis was a mediastinal abscess. This observation indicates a potential risk of EBV reactivation after coronavirus disease 2019 (COVID-19) vaccination, which might lead to or aggravate the presentation of posttransplant lymphoproliferative disorder in transplantation patients. Transplant surgeons should be aware of the potential immunomodulatory effects of the COVID-19 vaccination.

UR - http://www.scopus.com/inward/record.url?scp=85117827132&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85117827132&partnerID=8YFLogxK

U2 - 10.1016/j.transproceed.2021.09.006

DO - 10.1016/j.transproceed.2021.09.006

M3 - Article

C2 - 34702598

AN - SCOPUS:85117827132

SN - 0041-1345

VL - 54

SP - 1575

EP - 1578

JO - Transplantation Proceedings

JF - Transplantation Proceedings

IS - 6

ER -

A Case Report of Posttransplant Lymphoproliferative Disorder After AstraZeneca Coronavirus Disease 2019 Vaccine in a Heart Transplant Recipient

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this