TY - JOUR
T1 - A CD14 monocyte receptor polymorphism and genetic susceptibility to Parkinson's disease for females
AU - Lin, J. J.
AU - Chen, Chih-Hung
AU - Yueh, K. C.
AU - Chang, C. Y.
AU - Lin, S. Z.
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Recent studies suggest that inflammation may play an important role in the pathogenesis of Parkinson's disease (PD). Because the C(-260)→T polymorphism in the promoter of the CD14 monocyte receptor gene (pCD14) could affect the predisposition to the inflammatory response, we conducted a case-control study to investigate a possible genetic susceptibility of the pCD14 polymorphism in patients with PD. This study included 200 sporadic PD patients and 200 controls, matched by sex and case-control pairs for age at onset in the case. All observed genotype frequencies were in Hardy-Weinberg equilibrium. Results revealed that the CD14-T allele of the pCD14 polymorphism in the female PD patients existed statistically significant difference from that of the female controls (OR=1.262, P=0.038), but not for male. Female individuals with homozygote CD14-TT genotype were significantly increased risk of PD by 1.28 time (P=0.027). Furthermore, a logistic regression analysis confirmed that the homozygote CD14-TT genotype was an independent risk factor for PD (OR=1.576, P=0.030). In conclusion, results of this study indicate the pCD14 polymorphism to be a genetic risk factor for PD in females.
AB - Recent studies suggest that inflammation may play an important role in the pathogenesis of Parkinson's disease (PD). Because the C(-260)→T polymorphism in the promoter of the CD14 monocyte receptor gene (pCD14) could affect the predisposition to the inflammatory response, we conducted a case-control study to investigate a possible genetic susceptibility of the pCD14 polymorphism in patients with PD. This study included 200 sporadic PD patients and 200 controls, matched by sex and case-control pairs for age at onset in the case. All observed genotype frequencies were in Hardy-Weinberg equilibrium. Results revealed that the CD14-T allele of the pCD14 polymorphism in the female PD patients existed statistically significant difference from that of the female controls (OR=1.262, P=0.038), but not for male. Female individuals with homozygote CD14-TT genotype were significantly increased risk of PD by 1.28 time (P=0.027). Furthermore, a logistic regression analysis confirmed that the homozygote CD14-TT genotype was an independent risk factor for PD (OR=1.576, P=0.030). In conclusion, results of this study indicate the pCD14 polymorphism to be a genetic risk factor for PD in females.
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U2 - 10.1016/j.parkreldis.2005.07.010
DO - 10.1016/j.parkreldis.2005.07.010
M3 - Article
C2 - 16337421
AN - SCOPUS:29844440184
VL - 12
SP - 9
EP - 13
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
SN - 1353-8020
IS - 1
ER -