A CD14 monocyte receptor polymorphism and genetic susceptibility to Parkinson's disease for females

J. J. Lin, Chih-Hung Chen, K. C. Yueh, C. Y. Chang, S. Z. Lin

Research output: Contribution to journalArticle

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Abstract

Recent studies suggest that inflammation may play an important role in the pathogenesis of Parkinson's disease (PD). Because the C(-260)→T polymorphism in the promoter of the CD14 monocyte receptor gene (pCD14) could affect the predisposition to the inflammatory response, we conducted a case-control study to investigate a possible genetic susceptibility of the pCD14 polymorphism in patients with PD. This study included 200 sporadic PD patients and 200 controls, matched by sex and case-control pairs for age at onset in the case. All observed genotype frequencies were in Hardy-Weinberg equilibrium. Results revealed that the CD14-T allele of the pCD14 polymorphism in the female PD patients existed statistically significant difference from that of the female controls (OR=1.262, P=0.038), but not for male. Female individuals with homozygote CD14-TT genotype were significantly increased risk of PD by 1.28 time (P=0.027). Furthermore, a logistic regression analysis confirmed that the homozygote CD14-TT genotype was an independent risk factor for PD (OR=1.576, P=0.030). In conclusion, results of this study indicate the pCD14 polymorphism to be a genetic risk factor for PD in females.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalParkinsonism and Related Disorders
Volume12
Issue number1
DOIs
Publication statusPublished - 2006 Jan 1

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Genetic Predisposition to Disease
Parkinson Disease
Monocytes
Genotype
Homozygote
Age of Onset
Case-Control Studies
Logistic Models
Alleles
Regression Analysis
Inflammation
Genes

All Science Journal Classification (ASJC) codes

  • Ageing
  • Clinical Neurology
  • Neurology

Cite this

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abstract = "Recent studies suggest that inflammation may play an important role in the pathogenesis of Parkinson's disease (PD). Because the C(-260)→T polymorphism in the promoter of the CD14 monocyte receptor gene (pCD14) could affect the predisposition to the inflammatory response, we conducted a case-control study to investigate a possible genetic susceptibility of the pCD14 polymorphism in patients with PD. This study included 200 sporadic PD patients and 200 controls, matched by sex and case-control pairs for age at onset in the case. All observed genotype frequencies were in Hardy-Weinberg equilibrium. Results revealed that the CD14-T allele of the pCD14 polymorphism in the female PD patients existed statistically significant difference from that of the female controls (OR=1.262, P=0.038), but not for male. Female individuals with homozygote CD14-TT genotype were significantly increased risk of PD by 1.28 time (P=0.027). Furthermore, a logistic regression analysis confirmed that the homozygote CD14-TT genotype was an independent risk factor for PD (OR=1.576, P=0.030). In conclusion, results of this study indicate the pCD14 polymorphism to be a genetic risk factor for PD in females.",
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A CD14 monocyte receptor polymorphism and genetic susceptibility to Parkinson's disease for females. / Lin, J. J.; Chen, Chih-Hung; Yueh, K. C.; Chang, C. Y.; Lin, S. Z.

In: Parkinsonism and Related Disorders, Vol. 12, No. 1, 01.01.2006, p. 9-13.

Research output: Contribution to journalArticle

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