A CD14 promoter polymorphism is associated with CD14 expression and Chlamydia-stimulated TNFα production

H. L. Eng, C. H. Wang, C. H. Chen, M. H. Chou, C. T. Cheng, T. M. Lin

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

CD14, a pattern recognition receptor on monocyte and macrophage, plays a central role in innate immunity through recognition of bacterial lipopolysaccharide and initiation of inflammatory response. Recently, CD14/-260C> T promoter gene polymorphism has been found to be related to a risk of inflammatory diseases. Our results showed that the C allele frequency among Chinese in Taiwan was lower than those in Western countries. The membrane CD14 expression was significantly higher in TT as compared with CT and CC genotypes (P= 0.034, 0.044, respectively). There was a higher level of soluble CD14 in TT and CT genotypes than in CC genotypes. In addition, TNFα production in whole blood was significantly higher in TT genotype than in CC genotype after stimulation by Chlamydiae. In conclusion, the single base pair polymorphism of CD14 promoter gene is associated with CD14 expression, and Chlamydia-stimulated TNFα production, and may thus play some role in the chlamydia-induced inflammatory response.

Original languageEnglish
Pages (from-to)426-430
Number of pages5
JournalGenes and Immunity
Volume5
Issue number5
DOIs
Publication statusPublished - 2004 Aug 1

Fingerprint

Chlamydia
Genotype
Pattern Recognition Receptors
Taiwan
Innate Immunity
Gene Frequency
Base Pairing
Genes
Lipopolysaccharides
Monocytes
Macrophages
Membranes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics
  • Genetics(clinical)

Cite this

Eng, H. L. ; Wang, C. H. ; Chen, C. H. ; Chou, M. H. ; Cheng, C. T. ; Lin, T. M. / A CD14 promoter polymorphism is associated with CD14 expression and Chlamydia-stimulated TNFα production. In: Genes and Immunity. 2004 ; Vol. 5, No. 5. pp. 426-430.
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A CD14 promoter polymorphism is associated with CD14 expression and Chlamydia-stimulated TNFα production. / Eng, H. L.; Wang, C. H.; Chen, C. H.; Chou, M. H.; Cheng, C. T.; Lin, T. M.

In: Genes and Immunity, Vol. 5, No. 5, 01.08.2004, p. 426-430.

Research output: Contribution to journalArticle

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