A cellular ELISA to screen lectin-like compounds for cancer cell binding

C. P. Chang; W. C. Cheng; H. Y. Lei

doi:10.2174/1570180053765228

A cellular ELISA to screen lectin-like compounds for cancer cell binding

C. P. Chang, W. C. Cheng, H. Y. Lei

Department of Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Lectins are carbohydrate-binding proteins that can modulate cellular activity through cell membrane glycoproteins. A cell-based binding was set up to screen the lectin-like substances in natural products. Lectins, after binding to tumor cells, are detected with a biotinylated carbohydrate-polyacrylamide complex by ELISA. Sugar specificity can also be determined within the assay.

Original language	English
Pages (from-to)	182-188
Number of pages	7
Journal	Letters in Drug Design and Discovery
Volume	2
Issue number	3
DOIs	https://doi.org/10.2174/1570180053765228
Publication status	Published - 2005 May

All Science Journal Classification (ASJC) codes

Molecular Medicine
Pharmaceutical Science
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2174/1570180053765228

Cite this

@article{11076d44511d4d4eaa86e55a0bf59aa4,

title = "A cellular ELISA to screen lectin-like compounds for cancer cell binding",

abstract = "Lectins are carbohydrate-binding proteins that can modulate cellular activity through cell membrane glycoproteins. A cell-based binding was set up to screen the lectin-like substances in natural products. Lectins, after binding to tumor cells, are detected with a biotinylated carbohydrate-polyacrylamide complex by ELISA. Sugar specificity can also be determined within the assay.",

author = "Chang, {C. P.} and Cheng, {W. C.} and Lei, {H. Y.}",

year = "2005",

month = may,

doi = "10.2174/1570180053765228",

language = "English",

volume = "2",

pages = "182--188",

journal = "Letters in Drug Design and Discovery",

issn = "1570-1808",

publisher = "Bentham Science Publishers B.V.",

number = "3",

}

TY - JOUR

T1 - A cellular ELISA to screen lectin-like compounds for cancer cell binding

AU - Chang, C. P.

AU - Cheng, W. C.

AU - Lei, H. Y.

PY - 2005/5

Y1 - 2005/5

N2 - Lectins are carbohydrate-binding proteins that can modulate cellular activity through cell membrane glycoproteins. A cell-based binding was set up to screen the lectin-like substances in natural products. Lectins, after binding to tumor cells, are detected with a biotinylated carbohydrate-polyacrylamide complex by ELISA. Sugar specificity can also be determined within the assay.

AB - Lectins are carbohydrate-binding proteins that can modulate cellular activity through cell membrane glycoproteins. A cell-based binding was set up to screen the lectin-like substances in natural products. Lectins, after binding to tumor cells, are detected with a biotinylated carbohydrate-polyacrylamide complex by ELISA. Sugar specificity can also be determined within the assay.

UR - http://www.scopus.com/inward/record.url?scp=18844428114&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18844428114&partnerID=8YFLogxK

U2 - 10.2174/1570180053765228

DO - 10.2174/1570180053765228

M3 - Article

AN - SCOPUS:18844428114

SN - 1570-1808

VL - 2

SP - 182

EP - 188

JO - Letters in Drug Design and Discovery

JF - Letters in Drug Design and Discovery

IS - 3

ER -

A cellular ELISA to screen lectin-like compounds for cancer cell binding

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this