A cellular ELISA to screen lectin-like compounds for cancer cell binding

Chih-Peng Chang, W. C. Cheng, H. Y. Lei

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Lectins are carbohydrate-binding proteins that can modulate cellular activity through cell membrane glycoproteins. A cell-based binding was set up to screen the lectin-like substances in natural products. Lectins, after binding to tumor cells, are detected with a biotinylated carbohydrate-polyacrylamide complex by ELISA. Sugar specificity can also be determined within the assay.

Original languageEnglish
Pages (from-to)182-188
Number of pages7
JournalLetters in Drug Design and Discovery
Volume2
Issue number3
DOIs
Publication statusPublished - 2005 May 1

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Lectins
Enzyme-Linked Immunosorbent Assay
Neoplasms
Membrane Glycoproteins
Biological Products
Carbohydrates
Cell Membrane

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

Cite this

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A cellular ELISA to screen lectin-like compounds for cancer cell binding. / Chang, Chih-Peng; Cheng, W. C.; Lei, H. Y.

In: Letters in Drug Design and Discovery, Vol. 2, No. 3, 01.05.2005, p. 182-188.

Research output: Contribution to journalArticle

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