TY - GEN
T1 - A closed-loop brain computer interface for real-time seizure detection and control
AU - Liang, Sheng Fu
AU - Shaw, Fu Zen
AU - Young, Chung Ping
AU - Chang, Da Wei
AU - Liao, Yi Cheng
PY - 2010/12/1
Y1 - 2010/12/1
N2 - The worldwide prevalence of epilepsy is approximately 1%, and 25% of epilepsy patients cannot be treated sufficiently by available therapies. Brain stimulation with closed-loop seizure control has recently been proposed as an innovative and effective alternative. In this paper, a portable closed-loop brain computer interface for seizure control was developed and shown with several aspects of advantages, including high seizure detection rate (92-499% during wake-sleep states), low false detection rate (1.2-2.5%), and small size. The seizure detection and electrical stimulation latency was not greater than 0.6 s after seizure onset. A wireless communication feature also provided flexibility for subjects freeing from the hassle of wires. Experimental data from freely moving rats supported the functional possibility of a real-time closed-loop seizure controller.
AB - The worldwide prevalence of epilepsy is approximately 1%, and 25% of epilepsy patients cannot be treated sufficiently by available therapies. Brain stimulation with closed-loop seizure control has recently been proposed as an innovative and effective alternative. In this paper, a portable closed-loop brain computer interface for seizure control was developed and shown with several aspects of advantages, including high seizure detection rate (92-499% during wake-sleep states), low false detection rate (1.2-2.5%), and small size. The seizure detection and electrical stimulation latency was not greater than 0.6 s after seizure onset. A wireless communication feature also provided flexibility for subjects freeing from the hassle of wires. Experimental data from freely moving rats supported the functional possibility of a real-time closed-loop seizure controller.
UR - http://www.scopus.com/inward/record.url?scp=78650832088&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650832088&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2010.5627243
DO - 10.1109/IEMBS.2010.5627243
M3 - Conference contribution
C2 - 21096670
AN - SCOPUS:78650832088
SN - 9781424441235
T3 - 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
SP - 4950
EP - 4953
BT - 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
T2 - 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
Y2 - 31 August 2010 through 4 September 2010
ER -