A cohort study of behavioral problems and intelligence in children with high prenatal polychlorinated biphenyl exposure

Te Jen Lai, Xianchen Liu, Yueliang Leon Guo, Nai-Wen Guo, Mei Lin Yu, Chen Chin Hsu, Walter J. Rogan

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: In 1978, about 2000 persons in Taiwan were poisoned when their cooking oil was contaminated during manufacture with heat-degraded polychlorinated biphenyls, which are toxic, very widespread pollutant chemicals. The chemicals cannot be metabolized or excreted, and 8 of the first 39 children born to affected women died. When examined in 1985, 117 surviving children were found to have ectodermal defects, developmental delay, and disordered behavior. We have continued to observe the children. Methods: From 1992 through 1995, 118 children born between 1978 and 1985 (during or after their mothers' exposure) and 118 matched neighborhood control children had cognitive function measured yearly with the Wechsler Intelligence Scale for Children-Revised and behavioral problems measured with the Achenbach Child Behavior Checklist and the Rutter Child Behavior Scale A. Results: The exposed children scored 3 points (P = .05) lower than control children for IQ; 3 points (P = .002) higher on the Child Behavior Checklist (an effect size similar to the sex difference); and 6 points (P<.001) higher on the Rutter scale (3 times the sex difference). Birth year X exposure interactions, testing whether children born long after the exposure were as affected as those born soon after, were small and not significant. Age X exposure interactions, testing whether the children improved relative to control children as they got older, were significant only for the Rutter scale. Conclusions: Prenatal exposure to these compounds produces long-lasting cognitive and behavioral damage, but there is some evidence of recovery.

Original languageEnglish
Pages (from-to)1061-1066
Number of pages6
JournalArchives of General Psychiatry
Volume59
Issue number11
DOIs
Publication statusPublished - 2002 Nov 1

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Polychlorinated Biphenyls
Intelligence
Cohort Studies
Child Behavior
Checklist
Sex Characteristics
Problem Behavior
Cohort
Wechsler Scales
Poisons
Cooking
Taiwan
Cognition
Oils
Hot Temperature
Mothers
Parturition

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Lai, Te Jen ; Liu, Xianchen ; Guo, Yueliang Leon ; Guo, Nai-Wen ; Yu, Mei Lin ; Hsu, Chen Chin ; Rogan, Walter J. / A cohort study of behavioral problems and intelligence in children with high prenatal polychlorinated biphenyl exposure. In: Archives of General Psychiatry. 2002 ; Vol. 59, No. 11. pp. 1061-1066.
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A cohort study of behavioral problems and intelligence in children with high prenatal polychlorinated biphenyl exposure. / Lai, Te Jen; Liu, Xianchen; Guo, Yueliang Leon; Guo, Nai-Wen; Yu, Mei Lin; Hsu, Chen Chin; Rogan, Walter J.

In: Archives of General Psychiatry, Vol. 59, No. 11, 01.11.2002, p. 1061-1066.

Research output: Contribution to journalArticle

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N2 - Background: In 1978, about 2000 persons in Taiwan were poisoned when their cooking oil was contaminated during manufacture with heat-degraded polychlorinated biphenyls, which are toxic, very widespread pollutant chemicals. The chemicals cannot be metabolized or excreted, and 8 of the first 39 children born to affected women died. When examined in 1985, 117 surviving children were found to have ectodermal defects, developmental delay, and disordered behavior. We have continued to observe the children. Methods: From 1992 through 1995, 118 children born between 1978 and 1985 (during or after their mothers' exposure) and 118 matched neighborhood control children had cognitive function measured yearly with the Wechsler Intelligence Scale for Children-Revised and behavioral problems measured with the Achenbach Child Behavior Checklist and the Rutter Child Behavior Scale A. Results: The exposed children scored 3 points (P = .05) lower than control children for IQ; 3 points (P = .002) higher on the Child Behavior Checklist (an effect size similar to the sex difference); and 6 points (P<.001) higher on the Rutter scale (3 times the sex difference). Birth year X exposure interactions, testing whether children born long after the exposure were as affected as those born soon after, were small and not significant. Age X exposure interactions, testing whether the children improved relative to control children as they got older, were significant only for the Rutter scale. Conclusions: Prenatal exposure to these compounds produces long-lasting cognitive and behavioral damage, but there is some evidence of recovery.

AB - Background: In 1978, about 2000 persons in Taiwan were poisoned when their cooking oil was contaminated during manufacture with heat-degraded polychlorinated biphenyls, which are toxic, very widespread pollutant chemicals. The chemicals cannot be metabolized or excreted, and 8 of the first 39 children born to affected women died. When examined in 1985, 117 surviving children were found to have ectodermal defects, developmental delay, and disordered behavior. We have continued to observe the children. Methods: From 1992 through 1995, 118 children born between 1978 and 1985 (during or after their mothers' exposure) and 118 matched neighborhood control children had cognitive function measured yearly with the Wechsler Intelligence Scale for Children-Revised and behavioral problems measured with the Achenbach Child Behavior Checklist and the Rutter Child Behavior Scale A. Results: The exposed children scored 3 points (P = .05) lower than control children for IQ; 3 points (P = .002) higher on the Child Behavior Checklist (an effect size similar to the sex difference); and 6 points (P<.001) higher on the Rutter scale (3 times the sex difference). Birth year X exposure interactions, testing whether children born long after the exposure were as affected as those born soon after, were small and not significant. Age X exposure interactions, testing whether the children improved relative to control children as they got older, were significant only for the Rutter scale. Conclusions: Prenatal exposure to these compounds produces long-lasting cognitive and behavioral damage, but there is some evidence of recovery.

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