A combination of rough-based feature selection and RBF neural network for classification using gene expression data

Jung Hsien Chiang, Shing Hua Ho

Research output: Contribution to journalArticle

46 Citations (Scopus)


This paper presents a novel rough-based feature selection method for gene expression data analysis. It can find the relevant features without requiring the number of clusters to be known a priori and identify the centers that approximate to the correct ones. In this paper, we attempt to introduce a prediction scheme that combines the rough-based feature selection method with radial basis function neural network. For further consider the effect of different feature selection methods and classifiers on this prediction process, we use the Naive Bayes and linear support vector machine as classifiers, and compare the performance with other feature selection methods, including information gain and principle component analysis. We demonstrate the performance by several published datasets and the results show that our proposed method can achieve high classification accuracy rate.

Original languageEnglish
Pages (from-to)91-99
Number of pages9
JournalIEEE Transactions on Nanobioscience
Issue number1
Publication statusPublished - 2008 Mar 1


All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Pharmaceutical Science
  • Computer Science Applications
  • Electrical and Electronic Engineering

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