A 23(cm) × 11(cm) tissue cancer detector based on frequency-domain photon migration (FDPM) technique is studied in this paper. The high cost and bulky network analyzer-based FDPM was implemented on PCB with high phase sensitivity. A Network Analyzer costs over one million NT dollars however the proposed detector costs only about several thousand NT dollars. So the proposed FDPM architecture features on compact, low cost, and portable advantages. A down-converted technique and a zero detector phase error elimination improve both resolution and accuracy of phase measurement. The optical receiver with improvement of both the resolution and the accuracy on amplitude and phase difference measurement are presented in details. The results are compared to a commercial Network Analyzer. Phase and amplitude measured errors compared to commercially Network Analyzer are less than 7 %. It proves that the proposed detector has the capability to replace a commercially Network Analyzer.