TY - JOUR
T1 - A comparative study of the physical and mechanical properties of three natural corals based on the criteria for bone-tissue engineering scaffolds
AU - Wu, Yu Chun
AU - Lee, Tzer Min
AU - Chiu, Kuo Hsun
AU - Shaw, Shyh Yu
AU - Yang, Chyun Yu
N1 - Funding Information:
Acknowledgements This work was supported in part by grant NSC 93-2320-B-006-071 from the National Science Council, Taiwan. We thank Mr. Bill Franky for help in manuscript preparation and Mr. Chung-Kai Liang for providing the natural photos of Acropora and Porites. We also thank Dr. Keryea Soong for reviewing the manuscript and providing helpful comments.
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009/6
Y1 - 2009/6
N2 - Coral has been used for bone grafts since 1970. Because coral has the advantages of good osteoconduction, biocompatibility, and biodegradation, it is also suitable for scaffolds used in bone-tissue engineering. However, the skeletons of different species of corals often vary significantly, and very few studies focus on the assessment of the permeability and mechanical properties of coral structure. In order to better understand the use of coral in bone tissue-engineering, we selected three typical models (Acropora sp., Goniopora sp., and Porites sp.) to analyze for pore size, porosity, permeability, and mechanical strength. We found Goniopora and Porites had homogenous structure and Acropora had oriented pores and irregular pore size. Acropora had the largest permeability, however, the transverse section was closed and the useful size was limited because of its habitat type. Porites had the smallest pore size and had the lowest permeability. Our data indicated that Goniopora sp. can be considered as the most promising source of scaffolds for bone-tissue engineering because of its high porosity (73%) and that its permeability and mechanics were similar to those in human cancellous bone. In conclusion, we analyzed the impact of the macroporous structure of coral on the permeability and mechanical properties that provide indicators for designing the optimal scaffold for bone-tissue engineering.
AB - Coral has been used for bone grafts since 1970. Because coral has the advantages of good osteoconduction, biocompatibility, and biodegradation, it is also suitable for scaffolds used in bone-tissue engineering. However, the skeletons of different species of corals often vary significantly, and very few studies focus on the assessment of the permeability and mechanical properties of coral structure. In order to better understand the use of coral in bone tissue-engineering, we selected three typical models (Acropora sp., Goniopora sp., and Porites sp.) to analyze for pore size, porosity, permeability, and mechanical strength. We found Goniopora and Porites had homogenous structure and Acropora had oriented pores and irregular pore size. Acropora had the largest permeability, however, the transverse section was closed and the useful size was limited because of its habitat type. Porites had the smallest pore size and had the lowest permeability. Our data indicated that Goniopora sp. can be considered as the most promising source of scaffolds for bone-tissue engineering because of its high porosity (73%) and that its permeability and mechanics were similar to those in human cancellous bone. In conclusion, we analyzed the impact of the macroporous structure of coral on the permeability and mechanical properties that provide indicators for designing the optimal scaffold for bone-tissue engineering.
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U2 - 10.1007/s10856-009-3695-3
DO - 10.1007/s10856-009-3695-3
M3 - Article
C2 - 19267261
AN - SCOPUS:67349282020
VL - 20
SP - 1273
EP - 1280
JO - Journal of Materials Science: Materials in Electronics
JF - Journal of Materials Science: Materials in Electronics
SN - 0957-4522
IS - 6
ER -